The study investigated the relationship between small scale enterprises and employments generation in Uyo Local Government Area, Akwa Ibom State. A cross-sectional survey research method was adopted for the study. A sample of 361 respondents was drawn from the population of 3725 using Taro Yamane’s scientific sampling formula. For the objectives of the study to be achieved, three hypotheses were formulated and tested. The study utilized structured questionnaire as a major instrument for data collection. 361 questionnaire were distributed and 334 were returned in useable form. Data collected were analyzed using simple percentage and regression. The results of the regression analysis indicated positive relationship between the variables of small scale enterprises and employment generation in Uyo, Akwa Ibom State. It was recommended that; there should be simplified loan application processes and reduced collateral requirements for small scale enterprises to encourage access to funding, there should be government policies that promote and ensure regular maintenance of existing infrastructure to prevent deterioration and reduce disruptions to business operations, and there should be development of entrepreneurship and business management training programs tailored for small scale enterprise owners, covering essential skills like book-keeping, marketing and customer service.