The objective of this study is to determine risk factors for transient ureteral obstruction at the time of transvaginal uterosacral ligament vault suspension. This was a retrospective chart review with a nested case-control analysis. Patients were included if they underwent transvaginal uterosacral ligament vault suspension (CPT code 57283) at the time of hysterectomy for uterovaginal prolapse. One of 5 FPMRS surgeons performed all of the procedures between December 2007 and December 2012. Once patients were identified, perioperative data were collected. For the retrospective cohort study, the incidence of intraoperative and delayed ureteral injury for all patients was described. Delayed ureteral injury was defined as those with a negative cystoscopy (presence of bilateral ureteral efflux) at the time of surgery who then developed postoperative pyelonephritis, hydronephrosis, and/or acute renal failure immediately after the index surgery. For the nested case-control analysis, cases were defined as patients with transient ureteral obstruction at the time of surgery. Controls were defined as those who did not have a transient ureteral obstruction. Cases and controls were matched 1:4 by date of surgery. During the study period, 551 patients underwent uterosacral ligament vault suspension. Of these patients, 527 (95.6%) had a negative cystoscopy, with 2 (0.38% [95% CI 0.09-1.31]) patients experiencing a delayed ureteral injury. Twenty-four (4.4% [95% CI 2.94-6.40]) patients had a ureteral obstruction on cystoscopy. Obstruction was determined to be a result of the uterosacral vault suspension in 19 (79.2%) cases and the anterior repair in 2 (8.3%) of cases, while the etiology of obstruction was unclear in 3 (12.5%) cases. Resuspension of the vaginal vault once obstruction was resolved was performed in 12 (54.6%) cases. The 24 cases of transient ureteral obstruction were matched to 96 controls. Cases were significantly older (65 vs 58 years, p=0.008), and had lower BMI (26.2 vs 28.9 kg/m2, p=0.03) when compared to controls. The right ureter was more commonly obstructed than the left (47.8% vs. 39.1%). There were otherwise no other differences between the groups. On logistic regression, increased age remained associated with a transient ureteral obstruction (adj OR 1.06, 95% CI 1.02-1.11, p=0.004) and a higher BMI had lower odds of ureteral obstruction (adj OR 0.89, 95% CI 0.79-0.98, p=0.015). In this retrospective study, the incidence of transient ureteral obstruction after uterosacral ligament vault suspension was 4.4%. The incidence of delayed ureteral injury was 0.38%. Older age was associated with higher odds of obstruction while a higher BMI was protective.