Further evidence is presented for the production of a thermolabile nondialyzable uterine luteolytic factor (ULF) on the 6th and 7th days of pseudopregnancy in the hamster. Injection of the equivalent of uterine horn/day was ineffective, but dosages of and 1 horn/day were maximally effective in shortening pseudopregnancy in the hysterectomized animal. The submitochondrial particulate fraction of homogenized tissue after centrifugation in 0.25M sucrose at 8400 g contained all ULF activity. Pregnancy abolished synthesis of ULF and active extracts were incapable of interfering with established pregnancies. Immature uterine horns did not produce ULF. Evidence for some local (non-blood-vascular) transport of this factor is presented. (Endocrinology 83: 1065, 1968)
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