Background: Dental caries is a major global health problem. According to Basic Health Research 2018, the prevalence of caries in Indonesia reached 45.3%, therefore preventions are needed to reduce the prevalence of caries. One of the preventions that can be done is the use of CO2 lasers combined with topical fluoride. Objective: To determine the effectiveness of CO2 laser conjugation with topical fluoride for caries prevention. Methods: In this article review, a method of finding theories and research articles was implemented using the keywords "CO2 laser, topical fluoride, enamel caries, microhardness, prevention" on sites Google Scholar and PubMed. Results: From the article search, 8 journals that met our requirements were found, included in them are 3 literature reviews and 5 research articles. Discussion: In several studies, it was found that a CO2 laser with a wavelength of 10.6 μm is effective to reduce the solubility of hydroxyapatite crystals on the enamel surface under acidic conditions. Meanwhile, the use of topical fluoride can also reduce demineralization and increase enamel remineralization through physical and chemical prevention. However, the effect of topical fluoride is partial and depends on its constant presence in the oral cavity. Conclusion: CO2 laser with the application of topical fluoride can work synergistically in increasing the microhardness of the enamel as an effort to prevent caries.
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