Use Of Rolling Research Articles

Evolution of the Innovative Therapies for Children With Cancer Consortium Trial Portfolio for Drug Development for Children With Cancer.

The aim of the Innovative Therapies for Children with Cancer (ITCC) consortium is to improve access to novel therapies for children and adolescents with cancer. The evolution of the ITCC clinical trial portfolio since 2003 was reviewed. All ITCC-labeled phase I/II trials opened between January 1, 2003 and February 3, 2018 were analyzed in two periods (2003-2010 and 2011-2018), and data were extracted from the ITCC database, regulatory agencies' registries, and publications. Sixty-one trials (62% industry-sponsored) enrolled 3,198 patients. The number of trials in the second period increased by almost 300% (16 v 45). All biomarker-driven trials (n = 14) were conducted in the second period. The use of rolling six and model-based designs increased (1 of 9, 11% v 21 of 31, 68%), and that of 3 + 3 designs decreased (5 of 9, 55% v 5 of 31, 16%; P = .014). The proportion of studies evaluating chemotherapeutics only decreased (5 of 16, 31% v 4 of 45, 9%), the proportion of single-agent targeted therapies did not change (9 of 16, 56.2% v 24 of 45, 53.3%), the proportion of combination targeted therapies trials increased (2 of 16, 12%, v 17 of 45, 38%), the proportion of randomized phase II trials increased (1 of 7, 14% v 8 of 14, 57%). More trials were part of a pediatric investigation plan in the second period (4 of 16, 25% v 21 of 45, 46%). The median time for Ethics Committees' approvals was 1.7 times longer for academic compared with industry-sponsored trials. This study reports a shift in the paradigm of early drug development for childhood cancers, with more biologically relevant targets evaluated in biomarker-driven trials or in combination with other therapies and with more model-based or randomized designs and a greater focus on fulfilling regulatory requirements. Improvement of trial setup and recruitment could increase the number of patients benefiting from novel agents.

Expressiveness in metronomic rolls for player piano: A new field of research?

Between the last years of the nineteenth century and the first two decades of the twentieth century, the production and use of rolls for player piano became widespread. These were strips of perforated paper wrapped around a cylinder, capable of activating in the instrument a pneumatic mechanism for the automatic operation of the piano keys. The metronomic-type rolls were produced manually, by transposing the piece's score into the paper's perforation. In this contribution, we propose a solution based on the automatic identification of peaks in the distribution of the Inter-Onset-Intervals (IOIs) of the notes for the detection, within metronomic rolls, of timing-related expressive areas, i.e. of musical passages in which deviations in the length of the holes with respect to what is prescribed in the score are operated intentionally to add expressiveness. The identified algorithm, applied to a dataset of approximately 700 rolls converted into MIDI format, showed good sensitivity, and made it possible to identify in a relatively short time numerous examples of intentional expressiveness in the analyzed repertoire, commonly and erroneously considered a mere mechanical transposition of the score. In the conclusions, some reflections on the relevance of this research in the musicological field are proposed.

Budgeting changes and success: abandonment, reform or stability in Finnish manufacturing firms?

PurposeThe need to change budgeting has been frequently debated. Drawing on the literature on management accounting and budgeting change, this study aims to explore changes in budgeting and whether experienced success of budgeting varied with time and budget type. Changes in the use of the following budget types were investigated: fixed, revised, rolling, flexible and hybrid budgets.Design/methodology/approachThis study uses a mixed research methodology. Survey data was collected from the same business units of large Finnish manufacturing firms in 2004 (Time 1) and 2016/2017 (Time 2) (N = 28). In addition, some of the respondents of the latter survey were interviewed in 2023 (Time 3).FindingsAlmost all business units were found to have remained loyal to budgeting. However, changes in budget types were not uncommon and varied considerably. Overall, the use of fixed budgets continued strongly, the use of revised and hybrid budgets declined, and the use of rolling budgets increased over time. Moreover, the joint use of budgets declined. The perceived success of budgetary processes was, initially, weakened by the use of fixed budgets and, later, by the use of revised budgets. The interview data further illustrates some of the patterns of, and reasons behind, the changes.Originality/valueLongitudinal analysis of change in the same business units was useful in revealing the patterns of change in budgeting and on relationships between the variables analysed over time. Further research could be carried out using more extensive case studies in companies or sector-focused surveys longitudinally.

FEATURES OF THE CALCULATION OF ROLLS ON THE FATIGUE STRENGTH

On modern rolling mills, manufacturers have the possibility to use a wide range of materials with technologically determined properties, which allows for effective use of rolls and improvement of technical and economic indicators of production processes. Reasonable choice of materials and properties of rolls is impossible without reliable methods of calculating the strength and predicting the service life of the rolls. In particular, increasing of the reliability of methods for calculating the fatigue strength of rolls is an urgent task, both for scientists and for technologists and specialists of rolling mills.
 The purpose of the work is to study the features of fatigue calculation of rolls based on the predicted number of load cycles. The work solves the problem of assessing the possibility of applying a known method of determining the predicted number of load cycles and studying the features of such a method for rollsofrolling mills.
 The method of calculation based on the approximation of Woehler curves for the roll material by Beskin's power dependence within the zone of high cycle fatigue, which was determined by the number of cycles from 1·103 to 5·106, was considered. It has been proven that such a technique can be used for rolls into account the identified features. The main features of the calculation of rolls for fatigue strength include: a symmetrical cycle of changes in bending stresses and a pulsating cycle of changes in torsional stresses; mandatory consideration of working conditions due to the modified endurance limit of the material; compliance with the condition that the working stresses exceed the modified endurance limit, but are less than the admissible stresses for the roll material; taking into account the stress concentration depending on the shape of the grooves that form the passes. Consider influence the effect of stress concentration in the grooves of the rolls requires clarification based on empirical data of a certain rolling mill.
 The application of the fatigue calculation method for rolls, with considerthe identified features, will allow to increase the accuracy of determining the predicted terms of operation of the rolls and determining their consumption.

ANALYSIS OF DIMENSIONAL PARAMETERS OF ROLLS OF LONG PRODUCTS MILLS

For long products rolling mills, which in most cases have a significant number of sequentially located working stands, the tasks of choosing the optimal materials, structures and roll sizes are quite relevant. The dimensional parameters of the rolls, which are chosen at the stage of design of the mills, largely determine the efficiency of the technological process. Therefore, the tasks of substantiating the choice of roll sizes for long products rolling mills are relevant and have important practical significance.
 The purpose of the work is to analyze the dimensional parameters of rolls of modern long products rolling mills, to identify the characteristic features of size ratios and to develop recommendations for choosing the main sizes according to the most significant criteria.
 An analysis of the dimensional parameters of rolls of typical modern mills of long products of several leading manufacturers was performed. It was established that the actual ratios of the sizes of the main elements of the rolls only partially correspond to those given in the technical and educational literature.
 The ratio of the nominal diameter of the rolls to the initial rolling thickness varies from 3.75 to 38.5. These values indicate that over the past few decades, the range of changes in this indicator has shifted towards smaller values.
 For the ratio of the length of the barrel to the nominal diameter of the rolls, the most common range of values is from 0.93 to 2.56. That is, there is a decrease in the lower limit of this range for stands of housing and housingless type. The use of rolls with approximately the same barrel length and diameter is due to the characteristics of roll materials and the desire to reduce operating costs by simplifying equipment designs.
 The ratio of the diameters of the necks and the barrel of the rolls varies from 0.40 to 0.57. Such values indicate significant progress, both in the use of new rolls materials and in the improvement of modern bearing assemblies and stands.
 Recommendations have been developed for the selection of the main sizes of rolls by groups of stands of long products rolling mills. From the calculations of the admissible rolling force according to the conditions of the strength of the necks of the rolls, it is proved that according to the criteria of strength and wear resistance, the minimum diameter of the rolls of finishing stands is 350 mm.
 The limits of changes in the dimensional parameters of the rolls determined from the analysis and the recommendations for choosing such dimensions can be used in the design of new rolling mills.

ANALYSIS OF MECHANICAL METHODS OF CONTROLLING THE POSITION OF FLAT SHOE PARTS BY SURFACE PROPERTIES

The article considers ways to solve the problem of orientation of flat parts with different properties of surfaces that come to the working position of technological equipment. Mechanical methods of controlling the position of flat parts of footwear on the properties of surfaces are based on the use of asymmetry of their frictional properties or the magnitude of surface irregularities. In some cases, in the process of position control with the help of devices that implement these methods, it is possible to simultaneously transport the part to the working position of the process equipment or to the position of reorientation. Frictional properties of surfaces of any materials are characterized by the coefficient of friction, which depends on the elastic properties of the material, surface roughness, specific load and many other parameters that characterize the molecular interaction of surfaces in the contact zone. Most shoe materials have different frictional properties of the front and back surfaces. This provides the ability to automatically orient parts made of such materials on the basis of “front side – reverse side” using the differences in the frictional properties of the surfaces of the part. The use of rolls as sensors to control the position of flat shoe parts on the frictional properties of surfaces and simultaneous transportation of parts from the control position to the loading or reorientation position greatly simplifies the control operation, increases productivity and reliability of control devices. For correct installation of details on technological processing it is necessary to reveal their position and, in case of incorrect, to reorient. For this purpose, devices for position control on frictional properties and asymmetry of surface topography, as well as their design calculations are proposed.

Capabilities of grooves forming articulated profiles for rolling – separation technology

The emerging growth of industrial and civil construction in Russia and introduction of new technologies have caused the need to increase the production of construction rolled products and, especially, rebar. One of the ways to increase rebar production at existing mills in the shortest possible time without serious capital investments is the use of rolling – separation technology. For successful implementation of this technology, the conditions for the feasibility of this process are given in this report. New dependences were obtained for determining the longitudinal force provided by the reserve of friction forces during formation of an articulated profile taking into account the profile shape and the conditions of shape change.

Big Data as a Tool for Building a Predictive Model of Mill Roll Wear

Big data analysis is becoming a daily task for companies all over the world as well as for Russian companies. With advances in technology and reduced storage costs, companies today can collect and store large amounts of heterogeneous data. The important step of extracting knowledge and value from such data is a challenge that will ultimately be faced by all companies seeking to maintain their competitiveness and place in the market. An approach to the study of metallurgical processes using the analysis of a large array of operational control data is considered. Using the example of steel rolling production, the development of a predictive model based on processing a large array of operational control data is considered. The aim of the work is to develop a predictive model of rolling mill roll wear based on a large array of operational control data containing information about the time of filling and unloading of rolls, rolled assortment, roll material, and time during which the roll is in operation. Preliminary preparation of data for modeling was carried out, which includes the removal of outliers, uncharacteristic and random measurement results (misses), as well as data gaps. Correlation analysis of the data showed that the dimensions and grades of rolled steel sheets, as well as the material from which the rolls are made, have the greatest influence on the wear of rolling mill rolls. Based on the processing of a large array of operational control data, various predictive models of the technological process were designed. The adequacy of the models was assessed by the value of the mean square error (MSE), the coefficient of determination (R2), and the value of the Pearson correlation coefficient (R) between the calculated and experimental values of the mill roll wear. In addition, the adequacy of the models was assessed by the symmetry of the values predicted by the model relative to the straight line Ypredicted = Yactual. Linear models constructed using the least squares method and cross-validation turned out to be inadequate (the coefficient of determination R2 does not exceed 0.3) to the research object. The following regressions were built on the basis of the same operational control database: Linear Regression multivariate, Lasso multivariate, Ridge multivariate, and ElasticNet multivariate. However, these models also turned out to be inadequate to the object of the research. Testing these models for symmetry showed that, in all cases, there is an underestimation of the predicted values. Models using algorithm composition have also been built. The methods of random forest and gradient boosting are considered. Both methods were found to be adequate for the object of the research (for the random forest model, the coefficient of determination is R2 = 0.798; for the gradient boosting model, the coefficient of determination is R2 = 0.847). However, the gradient boosting algorithm is recognized as preferable thanks to its high accuracy compared with the random forest algorithm. Control data for symmetry in reference to the straight line Ypredicted = Yactual showed that, in the case of developing the random forest model, there is a tendency to underestimate the predicted values (the calculated values are located below the straight line). In the case of developing a gradient boosting model, the predicted values are located symmetrically regarding the straight line Ypredicted = Yactual. Therefore, the gradient boosting model is preferred. The predictive model of mill roll wear will allow rational use of rolls in terms of minimizing overall roll wear. Thus, the proposed model will make it possible to redistribute the existing work rolls between the stands in order to reduce the total wear of the rolls.

Forecasting building permits with Google Trends

We propose a useful way to predict building permits in the USA, exploiting rich data from web search queries. The relevance of our work relies on the fact that the time series on building permits is used as a leading indicator of economic activity in the construction sector. Nevertheless, new data on building permits are released with a lag of a few weeks. Therefore, an accurate nowcast of this leading indicator is desirable. In this paper, we show that models including Google search queries nowcast and forecast better than many of our good, not naive benchmarks. We show this with both in-sample and out-of-sample exercises. In addition, we show that the results of these predictions are robust to different specifications, the use of rolling or expanding windows and, in some cases, to the forecasting horizon. Since Google queries information is free, our approach is a simple and inexpensive way to predict building permits in the USA.

Research into in-service deterioration of ball-rolling rolls

This work features research findings on causes of deterioration occurring in ball-rolling rolls. The causes of such deterioration may originate not only in the excessive loads application and the use of bottleneck operating parameters but also in the specific process being implemented and the equipment used to heat-treat the rolling rolls. The deterioration occurring in roll flanges having a relatively small thickness was used to demonstrate that, to prevent the deterioration of ball-rolling roll flanges, the mill design must accommodate the minimum allowable flange widths obtained as a function of maximum allowable loads and the roll pass calculations. The next example of roll deterioration involved the use of a gas furnace to implement the heating stage of the quench hardening process for rolls made of 35KhGSA steel, which, as a result, developed roll deterioration. The use of rolls of the same steel grade, which were heat-treated in an arc furnace prior to being quenched, has been shown to deliver long-lasting positive results evidenced by many years of their operation. Rolls made of 5KhNM steel have also been shown to respond well to the heat treatment preceding the quenching process, but this time, the treatment was implemented in a gas furnace.

Technological pecularities of producing cast iron with spherical graphite using a fast-cooled copper-magnesium ligature

Various modifiers are used for non-furnace processing of cast iron. Some of them are designed for inoculating modification, which improves mechanical properties and eliminates the appearance of whiteness in castings, while others are designed for spheroidizing processing, in particular for producing cast iron with spherical and vermicular graphite. Some have both spheroidizing and inoculating properties. The main part of inoculating and spheroidizing modifiers is made on iron-silicon, Nickel and copper bases.In addition to the chemical composition, the size of the modifier particles, as well as their shape, are of great importance for modification. The optimal size of the fraction depends significantly on the non-furnace processing technology. Thus, for the larger the bucket and the longer the casting the longer the modification effect is required. One of the methods to achieve this is to increase the particle size of the modifier to 50 mm. When intraform processing of cast iron with spherical and vermicular graphite, magnesium-containing modifiers have strict limits on the upper size (4...5 mm), and in addition, the content of small fractions (less than 0.6...1 mm) is not allowed.The use of «heavy» magnesium-containing ligatures for spheroidizing modification of cast iron in order to obtain higher physical and mechanical properties has scientific and practical interest. Numerous studies show that for maximum effect the formation of the structure of the spheroidal graphite, dispersed pearlite metallic base of SGI (spheroidal graphite iron) relevant question is not only selection of the chemical composition of magnesium alloys, but also of the fractional composition, as well as effective method of input into the liquid melt.The purpose of this work was to study the technological features of obtaining cast iron with spherical graphite by bucket modification of copper-magnesium ligature.The researchers used a Leo–1420 scanning microscope, a Polam l-213 optical microscope, and a VEGA II LMU electron microscope with an INCA ENERGY 350 microanalyzer. High-speed induction melting plant, a set of equipment for analyzing the technological and mechanical properties of high-strength cast iron were used.Earlier experimental studies have shown the real possibility of obtaining in the laboratory a «heavy» copper-magnesium alloys as the alloying of magnesium metal with copper, followed by rapid cooling with use of rolling and plastic deformation of powder alloys. Analysis of test results of samples of such alloys showed that it depends on the value of its additives into liquid iron in the structure of formed graphite phase in compacted and globular form. At the same time, the metal base of cast iron is additionally alloyed with copper, which has a favorable effect on the strength characteristics of SGI.However, an urgent problem is the possibility of the appearance of a cementite phase in the structure of high-strength cast iron as a result of its increased supercooling due to the process of spheroidization of the graphite phase. This phenomenon is compounded by the fact that the copper-magnesium ligature, in contrast to the «light» ligature, does not contain silicon active graphitizer. This feature must be taken into account when obtaining high-strength cast iron of high grades.

Feasibility of Administering Anti-CD45 Iodine (131I) Apamistamab [Iomab-B] for Re-Induction and Targeted Conditioning in Older Patients with Active, Relapsed or Refractory AML without Lead-Lined Rooms: Sierra Trial Experience at MSKCC

Background: Patients ≥55 years of age with active, relapsed or refractory acute myeloid leukemia (R/R AML) who have failed standard induction and salvage therapies do not routinely undergo allogeneic hematopoietic cell transplantation (HCT) due to their inability to receive myeloablative conditioning and lack of efficacy. The SIERRA trial is a prospective, randomized, phase 3, open-label, multicenter trial designed to address this significant unmet need. Preliminary results have shown the re-induction and targeted conditioning therapy with Iomab-B can lead to successful engraftment. Because of the administered activity of 131I (300-1030 mCi, mean ~600 mCi), patients are isolated for several days after the drug administration before being discharged. Radiation safety procedures with rolling lead shields and blankets were implemented to ensure compliance with local regulations for therapeutic radioisotopes and the safe administration of Iomab-B. Methods: A corner room with private bathroom was selected as the patient room for drug administration and patient isolation. The room was prepared to prevent radioactive contamination. Rolling lead shields were utilized depending on the room configuration: 2 shields against the patient emitting radiation and closer to the door, or 3 shields total with 1 additional shield by the nurses' work station in the room. Lead blankets were placed under the patient bed. Extensive radiation safety training was provided to nursing staff who interacted with Iomab-B patients. The administration was performed in the room using an automatic pump system with Iomab-B drug vial placed in a lead pig during infusion (4-5 hours). Radiation dose rates at several locations were measured at the completion of administration. Radiation doses to nurses who provided care to patients were monitored with personal dosimeters throughout the course of treatment, while the patients remained in radiation isolation. Results: 10 Iomab-B patients were treated with 788 ± 192 (range: 543-1069 mCi). Exposure survey results were taken within 2 hours after therapeutic infusion outside the patient door (mean 0.64, range 0.06-1.95 mrem/hr) the hallway (0.01 mrem/hr, background levels) adjacent rooms (mean 0.747, range 0.2-1.82 mrem/hr) as well as above (mean 0.986, range 0.5-1.6 mrem/hr) and below (mean 1.398, range 0.81-1.88 mrem/hr) the room. All the exposure survey results were below the regulated public area limit, 2 mrem/hr. The dose to inpatient nurses caring for the patient was 9.42 ± 6.6 (range: 1-27 mrem), which is minimal comparing to annual occupational dose limit of 5,000 mrem. The rooms were surveyed for contamination after the patient was cleared from radiation isolation and removable surface contamination was below 200 dpm/100cm2, lower than the limit of 24,00 dpm/100cm2 Conclusion: The use of rolling lead shields and implementation of specific radiation safety procedures allows for the safe administration of Iomab-B and enable treatment of patients without the need for lead-lined rooms. Table Disclosures Pandit-Taskar: Y Mabs: Consultancy, Honoraria; Fusion Pharmaceuticals: Consultancy, Honoraria; Progenics: Consultancy, Honoraria; Medimmune: Consultancy, Honoraria; Actinium Pharmaceuticals, Inc: Consultancy, Honoraria. Gyurkocza:Actinium Pharmaceuticals: Research Funding. Liang:Actinium Pharmaceuticals: Employment. Reddy:Actinium Pharmaceuticals: Employment. Berger:Actinium Pharmaceuticals, Inc: Employment, Equity Ownership. Dauer:Actinium Pharmaceuticals, Inc: Other: MSKCC - NIH/NCI Cancer Center Support Grant P30 CA008748, Research Funding.

Heart Rate Variability Monitoring During Strength and High-Intensity Interval Training Overload Microcycles.

Objective: In two independent study arms, we determine the effects of strength training (ST) and high-intensity interval training (HIIT) overload on cardiac autonomic modulation by measuring heart rate (HR) and vagal heart rate variability (HRV).Methods: In the study, 37 well-trained athletes (ST: 7 female, 12 male; HIIT: 9 female, 9 male) were subjected to orthostatic tests (HR and HRV recordings) each day during a 4-day baseline period, a 6-day overload microcycle, and a 4-day recovery period. Discipline-specific performance was assessed before and 1 and 4 days after training.Results: Following ST overload, supine HR, and vagal HRV (Ln RMSSD) were clearly increased and decreased (small effects), respectively, and the standing recordings remained unchanged. In contrast, HIIT overload resulted in decreased HR and increased Ln RMSSD in the standing position (small effects), whereas supine recordings remained unaltered. During the recovery period, these responses were reversed (ST: small effects, HIIT: trivial to small effects). The correlations between changes in HR, vagal HRV measures, and performance were weak or inconsistent. At the group and individual levels, moderate to strong negative correlations were found between HR and Ln RMSSD when analyzing changes between testing days (ST: supine and standing position, HIIT: standing position) and individual time series, respectively. Use of rolling 2–4-day averages enabled more precise estimation of mean changes with smaller confidence intervals compared to single-day values of HR or Ln RMSSD. However, the use of averaged values displayed unclear effects for evaluating associations between HR, vagal HRV measures, and performance changes, and have the potential to be detrimental for classification of individual short-term responses.Conclusion: Measures of HR and Ln RMSSD during an orthostatic test could reveal different autonomic responses following ST or HIIT which may not be discovered by supine or standing measures alone. However, these autonomic changes were not consistently related to short-term changes in performance and the use of rolling averages may alter these relationships differently on group and individual level.

α1-Antichymotrypsin Present in Therapeutic C1-Inhibitor Products Competes with Selectin-Sialyl LewisX Interaction.

C1-inhibitor (C1-inh) therapeutics can reduce neutrophil activity in various inflammatory conditions. This 'novel' anti-inflammatory effect of C1-inh is attributed to the tetrasaccharide sialyl LewisX (SLeX) present on its N-glycans. Via SLeX, C1-inh is suggested to interact with selectins on inflamed endothelium and prevent neutrophil rolling. However, C1-inh products contain plasma glycoprotein α1-antichymotrypsin (ACT) as a co-purified protein impurity. This article investigates the contribution of ACT to the effects observed with C1-inh. We have separated C1-inh and ACT from a therapeutic C1-inh preparation and investigated the influence of these proteins on SLeX-selectin interactions in a specific in vitro model, which makes use of rolling of SLeX-coated beads on immobilized E-selectin. We find that ACT and not C1-inh, shows a clear sialic acid-dependent interference in SLeX-selectin interactions, at concentrations present in C1-inh therapeutics. Furthermore, we do not find any evidence of SLeX on C1-inh using either Western blotting with anti-SLeX antibodies (CSLEX1 and KM93) or by mass spectrometric analysis of N-glycans. C1-inh reacts weakly to antibody HECA-452, which detects a broad range of selectin ligands, but ACT gives a much stronger signal, suggesting the presence of a selectin ligand on ACT. The 'novel' anti-inflammatory effects of C1-inh are unlikely due to SLeX on C1-inh and can in fact be due to SLeX-like glycans on ACT, present in C1-inh products. In view of our results, it is important to assess the role of ACT in vivo and revisit past studies performed with commercial C1-inh.

Calibration of ball-rolling rollers with continuously variable pitch

Presented is the state of ball rolling production, review of existing techniques for roll pass design ball-rolling today development. Possibilities of roll pass design with regard to the existing metal cutting equipment and variation of pitch parameters. The priority is set for the use of rolling rolls with a continuously varying pitch, in comparison with rolls with discretely varying pitch. Possibility of using 5-axis milling equipment for obtaining a given profile, with several variable values, is shown. Model is developed for calculating the roll pass design for rolls with a continuously varying pitch, the save constant amounts of metall of workpiece between the rolls in every moments. Pitch change functions for roll pass design of ball rolling with a constant and variable flange width are derived, using which it is possible to determine the theoretical pitch at any rolls rotation angle. Technique for constructing a 3-D model is developed, based use on obtained curve of the 2nd order, which is the basis helical surface with a continuously varying pitch. Production of profile on a 5-axis machining center, according to the the 3D models suggest. Roll pass design was used ob the experience practical, with production example ball with a diameter of 120 mm, which were calculated from the deduced function for rolls with a constant width of the flange. He was tested in the conditions of the newly introduced ball-rolling mill of JSC "EVRAZ-NTMK". After introduction of a new roll pass design, were resived technical results: the reduction in force rolling, in contrast at use operating rolls with discretely varying pitch, by 25–30%, obtaining ball sizes that are as close to nominal values GOST standard, decreased of defects, uniformity forge along entire length of the rolls forming-part obtaining.The analytical solutions presented in this article, in combination with industrial approbation, make it possible to use a new method roll pass design rolls of a ball rolling mill with a continuously changing pitch for educational and production purposes.

Review on Cold Rolling Mill Roll Deformation

There are various reasons by which the damage in the cold rolling mill rolls occurs. The main objective is to highlight those reasons which are responsible for the breakage. The parameters considered during the manufacturing and during the regular use of rolls in cold rolling in the past researches and the effect of these parameters to increase the life of a roll. These are based upon the various factors and summarize the effect of parameters responsible for the deformation concluded by the various researchers in the past history of cold rolling mill.

Now-Casting Building Permits with Google Trends

We propose a useful way to predict building permits in the US, exploiting rich real-time data from web search queries. The time series on building permits is usually considered as a leading indicator of economic activity in the construction sector. Nevertheless, new data on building permits are released with a lag close to two months. Therefore, an accurate now-cast of this leading indicator is desirable. We show that models including Google search queries now-cast and forecast better than our good, not naive, univariate benchmarks both in-sample and out-of-sample. We also show that our results are robust to different specifications, the use of rolling or recursive windows and, in some cases, to the forecasting horizon. Since Google queries information is free, our approach is a simple and inexpensive way to predict building permits in the United States.

In Defense of DW-NOMINATE

Several of the articles in this volume criticize the use of DW-NOMINATE in historical work in American politics and suggest alternative approaches to the use of roll call voting data. While many of criticisms are certainly valid, their practical implications are often overstated. Moreover, the suggested alternatives are either impractical for most historically oriented scholars and or do not adequately address the underlying problems. Almost all of the criticisms can be addressed by correct application of DW-NOMINATE results or those of other closely related measures.

Notes toward a speculative methodology of everyday life

This article considers the sociological role of activities that seem to make no sense: what can be learnt from episodes ‘unhinged’ from the routines of everyday life? In particular, stressing a processual framework for the study of everyday life, these unhinged episodes are regarded as useful for accessing its virtuality. The paper draws on literatures on everyday life, the object and the event in order, firstly to contrast critique to speculation, and secondly to sketch out what a speculative method for the study of everyday life might look like. Along the way, a number of concepts are developed: including affordance (the combination of plan, body and object); idiocy (a positive responsiveness to that which makes no sense); and affect (an ‘exquisite sensitivity to the world’). This perspective is illustrated through a discussion of how everyday practical issues raised by the use of rolling or wheeled luggage might evoke new forms of sociality – a ‘technosociality’.

Multiscale structural changes of atomic order in severely deformed industrial aluminum

The regularities of multiscale structural changes in the atomic order of the aluminum alloy AD-1 after a severe cold plastic deformation by conventional rolling in smooth rolls or in rolls with relief recesses favorable for shear deformation have been investigated. It has been found that there are four types of structural fractions that differ in scale and perfection of atomic order: crystallographic planes with a long-range order; nanoscale fragments of the planes (D = 100–300 A) with an incipient long-range order; smaller groups of atoms (D = 20–30 A) of amorphized structure; and the least ordered structural fraction of intercluster medium, keeping only a short-range atomic order (2–3 interatomic distances, 10 A). The presence of diffuse halo bands in the region of intense Debye lines indicates phase transitions of the order → disorder type with the formation of one to three groups of amorphous clusters with the dominance, in the nanometer scale, of the atomic order characteristic of the family of planes (111), (220), and (311) of crystalline aluminum. We have found a dynamic phase transition with the changing crystallographic order of aluminum, with the matrix structure of a face-centered cubic (FCC) lattice, in the form of nanosized local groups of atoms, that is, the deformation clusters of aluminum with a simple cubic K6 lattice. In the case of conventional rolling, the development of large clusters 50–500 A in size is observed; however, in the use of rolls with relief recesses, the difference in the sizes of the clusters is one half as much: 50–250 A. Based on the analysis of the integrated intensity of incoherent X-ray scattering by the samples, we have elucidated the nature of the lowest measured density for the sample subjected to conventional rolling, which consists in the volume concentration of disorderly arranged atoms, the highest of the compared structures, which indicates the formation therein of the greatest amount of fluctuation “voids.”