The article will discuss the architectural features of industrial buildings that are resistant to potential terrorist and other attacks. The most typical threats will be considered (external attacks, threat of explosion from outside and inside) and the corresponding protection goals (protection of the site perimeter, control of entry points, use of sustainable structural systems, safe finishing elements, use of protective structures at the landscape level). A brief historical excursion will show what fortification techniques may be relevant in our time. Modern analogues of industrial buildings are studied, new innovative protection measures are analyzed. As conclusions, architectural means that must be taken into account in the layout of industrial buildings and the master plan of industrial zones in general will be described to create a safe environment that is protected from possible attacks.