Use Of Medical Subject Headings Research Articles

Association between Mesenchymal Stem Cells and COVID-19 Therapy: Systematic Review and Current Trends.

Background The novel coronavirus first emerged in Wuhan, China, and quickly spread across the globe, spanning various countries and resulting in a worldwide pandemic by the end of December 2019. Given the current advances in treatments available for COVID-19, mesenchymal stem cell (MSC) therapy seems to be a prospective option for management of ARDS observed in COVID-19 patients. This present study is aimed at exploring the therapeutic potential and safety of using MSC obtained by isolation from health cord tissues in the treatment of patients with COVID-19. Methods A systematic search was done based on the guidelines of the PRISMA 2020 statement. A literature search was executed using controlled vocabulary and indexing of trials to evaluate all the relevant studies involving the use of medical subject headings (MeSH) in electronic databases like PubMed, Embase, Scopus, Cochrane Central Register of Controlled Trials (CENTRAL), and clinicaltrials.gov up to 31 December 2021. The protocol was registered in the PROSPERO register with ID CRD42022301666. Findings. After screening finally, 22 remaining articles were included in this systematic review. The studies revealed that MSC exosomes are found to be superior to MSC alone in terms of safety owing to being smaller with a lesser immunological response which leads to free movement in blood capillaries without clumping and also cannot further divide, thus reducing the oncogenic potential of MSC-derived exosomes as compared to MSC only. The studies demonstrated that the lungs healed with the use of exosomes compared to how they presented initially at the hospital. MSCs are found to increase the angiogenesis process and alveolar reepithelization, reducing markers like TNF alpha, TGF beta, and COL I and III, reducing the growth of myofibroblasts and increasing survivability of endothelium leading to attenuated pulmonary fibrosis and even reversing them. Interpretation. We can conclude that the use of mesenchymal stem cells or their derived exosomes is safe and well-tolerated in patients with COVID-19. It improves different parameters of oxygenation and helps in the healing of the lungs. The viral load along with different inflammatory cells and biomarkers of inflammation tend to decrease. Chest X-ray, CT scan, and different radiological tools are used to show improvement and reduced ongoing destructive processes.

Epidemiology of multimorbidity among people living with HIV in sub-Saharan Africa: a systematic review protocol

IntroductionSub-Saharan Africa remains the epicentre of the HIV pandemic, yet enormous knowledge gaps still exist to elicit a comprehensive portrait of multimorbidity and HIV linkage. This study aims to conduct...

Prolotherapy and Low Level Laser Therapy: A Synergistic Approach to Pain Management in Chronic Osteoarthritis.

Regenerative injection therapy and low level laser therapy are alternative remedies known for their success in the treatment and symptomatic management of chronic musculoskeletal conditions. In response to the growing demand for alternative therapies in the face of the opioid epidemic, the authors conduct a literature review to investigate the potential for prolotherapy and LLLT to be used adjunctively to manage chronic osteoarthritis (OA). OA is a degenerative chronic musculoskeletal condition on the rise in North America, and is frequently treated with opioid medications. The regenerative action of prolotherapy and pain-modulating effects of LLLT may make these two therapies well-suited to synergistically provide improved outcomes for osteoarthritis patients without the side effects associated with opioid use. A narrative descriptive review through multiple medical databases (Google Scholar, PubMed, and MedLine) is conducted, restricted by the use of medical subject headings. 71 articles were selected for reading in full, and 40 articles were selected for use in the study after reading in full. A review of the literature revealed good clinical results in the use of prolotherapy and LLLT separately to manage chronic musculoskeletal pain due to osteoarthritis and other chronic conditions. It is also recognized in the literature that prolotherapy works most effectively when used adjunctively with other treatments. Downsides to the use of prolotherapy include mild side effects of pain, stiffness and bruising and potential adverse events as a result of injection. This study is limited by the lack of clinical trials available involving both LLLT and prolotherapy injections used adjunctively, and by the low number of high impact literature concerning the treatment of (specifically) osteoarthritis by alternative methods. The authors suggest that practicing health care providers consider utilizing LLLT and prolotherapy together as a supplementary method in the management of chronic pain due to osteoarthritis, to minimize the long-term prescription of opioids and emphasize a less invasive treatment for this debilitating condition.

Self-management and patient activation in COPD patients: An evidence summary of randomized controlled trials

BackgroundChronic Obstructive Pulmonary Disease (COPD) is associated with multiple health problems including physical and psychological impairment as well as socioeconomic deprivation. COPD can be managed if self-management efficiency and disease management knowledge of patients is improved. Patient activation is believed to improve patients’ quality of life (QOL) and health outcomes through enhancing self-management skills. This review is an attempt to identify the benefits and knowledge gaps in self-management and patient-activation position in COPD self-management interventions MethodsFour electronic databases (Medline, Pubmed, Google Scholar and Cochrane Airways Group Specialized Register of Trials) were systematically searched from 1 January 2011 to 30 November 2016. The search strategy included the combined use of Medical SubjectHeadings (MeSH) term, which are as follows; “Self-management”, “Self-care”, “Self-treat”, “Pulmonary disease”, “Chronic Obstructive Pulmonary Disease”, “Patient activation”, “Patient Activation Measure”, “Personalized support”, “Chronic Obstructive Pulmonary Disease”, “COPD”. The screening of the abstracts and full texts of the papers, data extraction and quality assessment were independently done by three reviewers. ResultsThe results of this review showed that health outcomes (QOL, perceived quality of care, knowledge and severity on disease, lower rate of exacerbation, patient activation level) can be improved by self-management interventions with well cleared content on self-care guidelines and targeted behavior change models that possibly can increase self-efficacy of the patients. However, most of the studies have not applied patient activation which is shown to play a central role in COPD self-management behaviors. ConclusionsThis review has identified that there is paucity of literature on patient activation in tailored COPD self-management intervention. As a way forward, there is need to test a well-designed randomized controlled trial considering key points like patients characteristics, compliance, intervention delivery period, multi-morbidity conditions and measurement of the outcomes with standardized tools, might help to arrive at enable scientific conclusions.

Use of Medical Subject Headings (MeSH) in the Journal of the Korean Orthopaedic Association

Purpose: The purpose of this study was to analyze the equality between author key words used in the Journal of the Korean Orthopaedic Association and controlled vocabulary or medical subject headings (MeSH). Materials and Methods: A total of 1,058 English key words in 320 papers (average 3.3 words in a paper) from 2009 to 2012 were eligible for this study. We classified them according to matched, partially matched, and non-matched terms. The partially matched terms were further dissected into entry terms, qualifiers, anteriorly or posteriorly matched, abbreviations, and pleurals. After descriptive analysis, we assayed patterns of errors in using MeSH, and reviewed frequently used non-MeSH terms. Results: The rate of matched terms was 23.5% for an average of four years, and 34.8% for 2013, which is on the rise by year. The rate of partially matched terms was 34.8%, and that of non-matched terms was 41.7% for an average of four years. The most frequently used key words were Knee and Total knee arthroplasty (17 times), followed by Osteoarthritis (9), Femur, Hip, and Total hip arthroplasty (8). Conclusion: Use of proper keywords aligned with the international standards such as MeSH is important to be properly cited. The authors should pay attention and be educated on correct use of MeSH as key words.

Knowledge, Perception, and Behaviors of Relatives of People With Premature Heart Disease

Familial aggregation of coronary heart disease (CHD) is thought to account for 50% to 60% of total documented CHD before the age of 60 years.1 First-degree relatives of people with premature CHD (proband) exhibit a risk that is 2 to 12 times greater than that of the general population.2 The National Cholesterol Education Program's Adult Treatment Panel recommends screening patients with a recognized family history of premature CHD, defined as heart disease in men <55 years and women <65 years.3 However, a number of recent surveys have demonstrated that these guidelines are not widely implemented.4–6 Reasons for lack of screening based on family history are thought to exist at both the individual and provider levels. On the individual level, family members deny or are unaware of the familial aggregation of CHD and its risk factors. On the provider level, healthcare providers may not be engaged to identify high-risk families, conduct the screening, and intervene with relatives. To better understand the impact of a proband's premature CHD on first-degree relatives, we conducted a literature review to assess relatives' knowledge of CHD risk factors, risk perception, and implementation of and adherence to risk-reducing behaviors and their management by healthcare providers. The goal of this review is to identify gaps in the literature and provide recommendations for future research. The study design for this review was developed by a working group composed of individuals from 6 member institutions of the Centers for Disease Control and Prevention's Cardiovascular Health Intervention Research and Translation Network. We conducted a systematic literature search within MEDLINE, PsychInfo, Embase, and the Cochrane Database. Syntaxes were constructed with the use of Medical Subject Headings for the following combination: ( coronary heart disease AND [early onset or premature]) AND (mass screening OR risk OR family) AND …

Use of Medical Subject Headings (MeSH) in Portuguese for categorizing web-based healthcare content

IntroductionInternet users are increasingly using the worldwide web to search for information relating to their health. This situation makes it necessary to create specialized tools capable of supporting users in their searches. ObjectiveTo apply and compare strategies that were developed to investigate the use of the Portuguese version of Medical Subject Headings (MeSH) for constructing an automated classifier for Brazilian Portuguese-language web-based content within or outside of the field of healthcare, focusing on the lay public. Methods3658 Brazilian web pages were used to train the classifier and 606 Brazilian web pages were used to validate it. The strategies proposed were constructed using content-based vector methods for text classification, such that Naive Bayes was used for the task of classifying vector patterns with characteristics obtained through the proposed strategies. ResultsA strategy named InDeCS was developed specifically to adapt MeSH for the problem that was put forward. This approach achieved better accuracy for this pattern classification task (0.94 sensitivity, specificity and area under the ROC curve). ConclusionsBecause of the significant results achieved by InDeCS, this tool has been successfully applied to the Brazilian healthcare search portal known as Busca Saúde. Furthermore, it could be shown that MeSH presents important results when used for the task of classifying web-based content focusing on the lay public. It was also possible to show from this study that MeSH was able to map out mutable non-deterministic characteristics of the web.

Searching the Literature Using Medical Subject Headings versus Text Word with PubMed

This study was conducted to investigate the performance of two search strategies in the retrieval of information from the National Library of Medicine (NLM) on otolaryngology-head and neck surgery related conditions and diagnoses using PubMed. Two search strategies-one based on the use of Medical Subject Headings (MeSH) and the second based on text word searching-were compared. The MeSH search provided a more efficient search than the text word search. Head and neck surgeons can most efficiently search the NLM using PubMed as a search engine by initiating the search with MeSH terms. Once a key article is identified, the searcher should use the "Related Articles" feature.

An analysis of transaction logs to evaluate the educational needs of end users.

End users at the University of Southern California (USC) have free access to the last ten years of MEDLINE through a local online system known as USCInfo. Librarians at USC Norris Medical Library provide documentation and offer formal and informal training on the use of the system to search MEDLINE. To assess the educational needs of the end users, 643 searches were analyzed. Although a high proportion (84%) of the searches were judged to be successful, the use of medical subject headings (MeSH) to obtain optimal results was low; only 20% of all successful subject searches employed MeSH. Also, the advanced features of the system were underutilized. While it is promising to learn that many end users are obtaining positive results, methods which will encourage end users improve their retrievals need to be developed.

End-user training: does it make a difference?

Although database access has been available via search intermediaries for some time, online services are now encouraging end users to search databases directly. In response to this trend, librarians are taking on new end-user training and support roles. But is this training effort worthwhile? The relationship between online training received and the level of implementation of end-user searching is discussed using survey data from 124 Canadian health professionals (response rate 83%). There was a positive relationship between the number of training events reported and implementation level. Several different kinds of training, in addition to formal courses, were reported by end users. The use of Medical Subject Headings (MeSH) was related to more positive perceptions of online searching which, in turn, predicted higher implementation levels. Variability in the implementation levels of the respondents suggests that end users are a diverse group with different information needs and degrees of searching expertise. Various types of both formal and informal training will continue to be required by end users.