Use Of Machine Learning Algorithms Research Articles

Algorithms for predicting COVID outcome using ready-to-use laboratorial and clinical data

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging crisis affecting the public health system. The clinical features of COVID-19 can range from an asymptomatic state to acute respiratory syndrome and multiple organ dysfunction. Although some hematological and biochemical parameters are altered during moderate and severe COVID-19, there is still a lack of tools to combine these parameters to predict the clinical outcome of a patient with COVID-19. Thus, this study aimed at employing hematological and biochemical parameters of patients diagnosed with COVID-19 in order to build machine learning algorithms for predicting COVID mortality or survival. Patients included in the study had a diagnosis of SARS-CoV-2 infection confirmed by RT-PCR and biochemical and hematological measurements were performed in three different time points upon hospital admission. Among the parameters evaluated, the ones that stand out the most are the important features of the T1 time point (urea, lymphocytes, glucose, basophils and age), which could be possible biomarkers for the severity of COVID-19 patients. This study shows that urea is the parameter that best classifies patient severity and rises over time, making it a crucial analyte to be used in machine learning algorithms to predict patient outcome. In this study optimal and medically interpretable machine learning algorithms for outcome prediction are presented for each time point. It was found that urea is the most paramount variable for outcome prediction over all three time points. However, the order of importance of other variables changes for each time point, demonstrating the importance of a dynamic approach for an effective patient’s outcome prediction. All in all, the use of machine learning algorithms can be a defining tool for laboratory monitoring and clinical outcome prediction, which may bring benefits to public health in future pandemics with newly emerging and reemerging SARS-CoV-2 variants of concern.

Analysis of Traditional and Agile Software Development Process for Developing Recommender Model using Machine Learning

Objective: To create an AI-powered recommendation system that is designed for IT professionals to help them choose the best software development approaches. Through the use of specified data parameters. Methods: The recommendation system will make use of machine learning algorithms and data analysis methods to examine team dynamics, project needs, and other variables. The technology will enable developers to improve the quality of products and speed up the development process by recommending suitable development methodologies. Data parameters considered for the development of the recommendation model fall into four categories: requirements, user involvement, development team, type of project, and risk associated with it. Findings: Existing recommendation systems developed by different researchers are applicable for only requirement elicitation and to recommend different phases of the development process, whereas systems that will help select development methodology are not available in the existing systems. Among the five machine learning algorithms applied in the recommender system building process, the DecisionTree Classifier and RandomForest Classifier exhibit superior performance, achieving 100% accuracy, while the Kneighbors Classifier indicates 94.74% accuracy. Novelty: This study of systems introduces a novel approach to software development methodology, a recommender system, which helps IT developers select the best appropriate development approach for the development of a software product or project based on the type of project to be built and other data parameters. Keywords: Agile, Development, Requirements, Methodology, User, Customer

Surface water quality prediction in the lower Thoubal river watershed, India: A hyper-tuned machine learning approach and DNN-based sensitivity analysis

The accurate and efficient monitoring, assessment, and prediction of water resources is crucial for the sustenance of life and health of the environment. Traditional methods for assessing water quality can be laborious and time-consuming, but the use of machine learning algorithms can improve the speed and precision of these predictions. The study aimed to evaluate the quality of surface water in the lower Thoubal river using a comprehensive approach that analyzed 12 physico-chemical properties of the water samples collected from 16 different sites. Four machine learning algorithms namely, deep neural network (DNN), gradient boost model (GBM), generalized linear model (GLM), and random forest (RF) were applied and compared for the prediction efficiency of a water quality index (WQI). Sensitivity and uncertainty analysis of the parameters were carried out using a DNN-based model. The study incorporated model evaluation using learning curve along with five key performance assessors. The findings revealed marked variation in the WQI in the watershed. Of the samples tested, about 70 % were found to have good water quality, 18 % had excellent water quality, 11 % had poor water quality, 1 % had very poor water quality, and less than 1 % were deemed unsuitable. Turbidity, BOD, and COD were found to be the most influential parameter towards WQI prediction. The effectiveness of the predictive models ranked as GLM>DNN>RF>GBM, GLM>GBM>DNN>RF, and GLM>DNN>RF>GBM; based on testing, training and 5-fold cross-validation. The GLM model consistently showed superior performance with the lowest RMSEs of 0.14783 in training, 0.15936 in validation, and 0.26115 in 5-fold cross-validation. Conversely, during the training, RF displayed the worst RMSEs of 5.38354, 4.79754 by GBM in validation, and 7.04887 by GBM in 5-fold cross-validation. The analysis using the Taylor diagram and learning curve further supported that GLM was the most effective model for predicting surface water quality. Biological oxygen demand, chemical oxygen demand, electrical conductivity, turbidity and total hardness were found to be the key parameters influencing the water quality. Unregulated and illegal sand mining from the riverbed, garbage dumping into the water bodies, runoffs from agricultural fields have significantly deteriorated the water quality in the study area. The scalable approach of the study and its results can benefit the local water managers and water research community.

Machine Learning Approach to Predict the Strength of Concrete Confined with Sustainable Natural FRP Composites

Recent earthquakes have highlighted the need to strengthen existing structures with substandard designs. NFRPs provide a sustainable, cost-effective alternative for strengthening, but accurately predicting their performance remains a challenge. This study investigates the use of machine learning algorithms for predicting the compressive strength concrete specimens confined with various NFRPs. Four algorithms were employed: decision tree, random forest, neural network, and gradient boosting regressor. A diverse dataset encompassing various geometries, material properties, and confinement configurations was used to train and evaluate the models. Gradient boosting regressor (GBR) achieved the highest performance, with an average R-squared value of 0.94 and low mean absolute error (MAE) and root mean squared error (RMSE) during training and k-fold cross-validation. Neural network and random forest also demonstrated satisfactory performance, with average R-squared values of 0.88 and 0.86, respectively, during cross-validation. These results suggest that machine learning holds promise for predicting the compressive strength of concrete confined with NFRPs. GBR offers the most accurate predictions, making it a valuable tool for engineers seeking to optimize the design and performance of strengthened structures using sustainable materials.

Portfolio Optimization with Prediction-Based Return Using Long Short-Term Memory Neural Networks: Testing on Upward and Downward European Markets

AbstractIn recent years, artificial intelligence has helped to improve processes and performance in many different areas: in the field of portfolio optimization, the inputs play a crucial role, and the use of machine learning algorithms can improve the estimation of the inputs to create robust portfolios able to generate returns consistently. This paper combines classical mean–variance optimization and machine learning techniques, concretely long short-term memory neural networks to provide more accurate predicted returns and generate profitable portfolios for 10 holding periods that present different financial contexts. The proposed algorithm is trained and tested with historical EURO STOXX 50® Index data from January 2015 to December 2020, and from January 2021 to June 2022, respectively. Empirical results show that our LSTM neural networks are able to achieve minor predictive errors since the average of the MSE of the 10 holding periods is 0.00047, the average of the MAE is 0.01634, and predict the direction of returns with an average accuracy over the 10 investment periods of 95.8%. Our prediction-based portfolios consistently beat the EURO STOXX 50® Index, achieving superior positive results even during bear markets.

A Comparative study of the Envisaged and Definite Stock Prices of BSE SMEs Using RNN during the COVID-19 Pandemic

The stock market is unstable, but the use of machine learning algorithms allows to predict its future dynamics before spending. The most popular area of scientific research right nowadays is machine learning, which involves enabling computers to perform tasks that often require human intelligence. The purpose of this paper is to construct a model using a network of Long-Short Term Memory model (LSTM) to forecast future stock market values. The paper presents the advantages and disadvantages of machine learning for assessing and forecasting the stock market. A review of literature on the application of machine learning models in key areas of finance using methodological model assessment and data manipulation is also available. This paper focuses on the losses of the SME sector due to COVID-19 by doing a comparative study using secondary data collection between the predicted closed stock prices and actual stock prices of the BSE SME IPO index for the period from 1 January 2018 to 30 April 2021.The LSTM network of Recurrent Neural Networks (RNNs) most effective deep learning model, is used to predict stock prices. The study provides insight and direction on where lockdown has a massive impact on the stock prices of BSE SME IPOs. The authors developed a model for predicting the future value of stock in the market, the application of which gave some positive results, demonstrating the need for machine learning and how it can change the world of finance. The novelty of the study is that in India, machine learning and deep learning methods in the field of finance are used much less often than in other countries.

On the Generalizability of Machine Learning Classification Algorithms and Their Application to the Framingham Heart Study

The use of machine learning algorithms in healthcare can amplify social injustices and health inequities. While the exacerbation of biases can occur and be compounded during problem selection, data collection, and outcome definition, this research pertains to the generalizability impediments that occur during the development and post-deployment of machine learning classification algorithms. Using the Framingham coronary heart disease data as a case study, we show how to effectively select a probability cutoff to convert a regression model for a dichotomous variable into a classifier. We then compare the sampling distribution of the predictive performance of eight machine learning classification algorithms under four stratified training/testing scenarios to test their generalizability and their potential to perpetuate biases. We show that both extreme gradient boosting and support vector machine are flawed when trained on an unbalanced dataset. We then show that the double discriminant scoring of type 1 and 2 is the most generalizable with respect to the true positive and negative rates, respectively, as it consistently outperforms the other classification algorithms, regardless of the training/testing scenario. Finally, we introduce a methodology to extract an optimal variable hierarchy for a classification algorithm and illustrate it on the overall, male and female Framingham coronary heart disease data.

The Grading System for Lung Adenocarcinoma: Brief Review of its Prognostic Performance and Future Directions.

Histologic grading of tumors is associated with prognosis in many organs. In the lung, the most recent grading system proposed by International association for the Study of Lung Cancer (IASLC) and adopted by the World Health Organization (WHO) incorporates the predominant histologic pattern, as well as the presence of high-grade architectural patterns (solid, micropapillary, and complex glandular pattern) in proportions >20% of the tumor surface. This system has shown improved prognostic ability when compared with the prior grading system based on the predominant pattern alone, across different patient populations. Interobserver agreement is moderate to excellent, depending on the study. IASLC/WHO grading system has been shown to correlate with molecular alterations and PD-L1 expression in tumor cells. Recent studies interrogating gene expression has shown correlation with tumor grade and molecular alterations in the tumor microenvironment that can further stratify risk of recurrence. The use of machine learning algorithms to grade nonmucinous adenocarcinoma under this system has shown accuracy comparable to that of expert pulmonary pathologists. Future directions include evaluation of tumor grade in the context of adjuvant and neoadjuvant therapies, as well as the development of better prognostic indicators for mucinous adenocarcinoma.

ОПТИМІЗАЦІЯ КИСНЕВО-КОНВЕРТЕРНОГО ПРОЦЕСУ ЗАСОБАМИ АЛГОРИТМІВ МАШИННОГО НАВЧАННЯ

Traditional methods for optimising the BOF process in steelmaking are based on experience and rules of thumb, but do not always achieve maximum efficiency. As part of the Industry 4.0 concept, the use of machine learning algorithms is becoming a promising way to optimise production processes. They allow you to analyse large amounts of data collected by a variety of different sensors that operate during an industrial process and find complex relationships between parameters to achieve the best results. The created models can work automatically, analysing data in real time and responding to changes in the process. The use of machine learning algorithms can improve the accuracy of results and the quality of steel production by optimising the BOF process with a large number of parameters and their interrelationships.

Classification of sugarcane areas in Landsat images using machine learning algorithms

Monitoring sugarcane areas through remote sensing is essential for planning and management of the national sugarcane industry. The use of machine learning algorithms has provided many benefits to remote sensing. This article aims to compare the prediction quality of three important machine learning methods in identifying sugarcane areas using Landsat images: Logistic Regression (LR), Decision Tree (DT) and RandomForest (RF). LR was applied in three versions: LR without penalization, LR with Ridge penalization (LR-R) and LR with Lasso penalization (LR-L). Data obtained in this study refer to a region of approximately 306,000 ha located in the state of São Paulo, Brazil, which was segmented into approximately 46,000 polygons (observations). Six spectral bands and vegetation indices observed along 17 months resulted in 102 covariates, which were reduced via Principal Component Analysis (PCA). In total, 19 Principal Components were chosen to account for 94.61% of the cumulative explained variance ratio and were used in machine learning methods to classify each polygon as sugarcane or other land covers. The method with the highest accuracy considering testing sample of 20% of data was RF (78.51%), followed by DT (72.30%), LR-L (69.64%), LR-R (69.64%), and LR (69.52%).

Heart Disease Prediction Using ML

Machine Learning and artificial intelligence have found valuable on variety of disciplines during their growth, particularly in the light of massive increase in data in recent years. It has the potential to be more dependable in terms of producing quicker and more accurate illness prediction judgments. Therefore, the use of machine learning algorithms to forecast different diseases is growing. Building a model can also aid in the visualization and analysis of diseases to increase the accuracy and consistency of reporting. This article has looked into using several machine learning algorithms to identify cardiac disease. This article's study has demonstrated a step procedure. In a dataset on heart disease initially prepared in the format needed to run machine learning algorithms. The UCI is the source of patient medical records and other data. The presence are absence of heart disease in patients is then ascertained using the heart disease dataset. Second, this paper presents a number of noteworthy findings. The confusion matrix is used to validate the accuracy rate of machine learning methods, including Gradient Boosting Classifier, Support Vector Machine, and Logistic Regression. According to recent research, the Logistic Regression method outperforms other algorithms in terms of accuracy, yielding a high 95% rate. It also outperforms the other four algorithms in terms of recall, precision, and f1-score correctness. The difficult and future research component of this project will be raising the accuracy rates of the machine learning algorithms to between 97% and 100%.

Revolutionizing Drug Discovery: Harnessing Machine Learning Algorithms

Drug discovery is a crucial element of biomedical research, with the goal of finding and creating new medical treatments for a variety of illnesses. Yet, the conventional process of finding new drugs is frequently impeded by its intrinsic difficulties, such as expensive expenses, long durations, and poor success rates in trials with patients. Recently, the incorporation of machine learning (ML) algorithms has become a revolutionary method to streamline and improve different phases of drug discovery. This summary offers a glimpse into the rapidly growing area of drug discovery using machine learning algorithms, emphasizing its potential to transform the process of developing treatments. The usual process of discovering drugs involves various stages such as identifying the target, finding lead compounds, conducting preclinical tests, undergoing clinical trials, and obtaining regulatory approval. All these phases require a lot of labor, time, and resources, leading to high attrition rates and limited success in turning potential compounds into approved therapies. Nevertheless, researchers can enhance and speed up crucial parts of the drug discovery process by using ML algorithms. ML algorithms use data to aid in drug discovery by utilizing computational models to examine large quantities of biological, chemical, and clinical data. These algorithms can learn from various types of data, such as genomic data, chemical structures, protein interactions, and clinical outcomes, to discover hidden patterns, find new targets for drugs, and forecast the effectiveness and safety of potential treatments. Moreover, machine learning algorithms allow for the investigation of intricate connections between molecular structures and biological effects, making it easier to create improved drug candidates with better effectiveness and specificity. Important uses of machine learning in pharmaceutical research involve finding and confirming targets, screening compounds and improving leads, repurposing drugs, and tailoring treatments for individuals. Commonly used for classification and regression tasks, supervised learning algorithms like support vector machines and random forests predict compound activity, toxicity, and pharmacokinetic properties. Clustering and dimensionality reduction techniques utilized in unsupervised learning algorithms help analyze vast datasets and discover new drug-target interactions. Advanced abilities for analyzing molecular structures, virtual screening, and designing new drugs are provided by deep learning models like convolutional neural networks and recurrent neural networks. Multiple case studies demonstrate how ML algorithms can significantly impact drug discovery. Collaboration among academia, industry, and research institutions has resulted in the creation of new ML-based methods for drug development, identifying targets, and categorizing patients. Nevertheless, there are challenges accompanying the widespread use of ML in drug discovery. In healthcare, it is crucial to address ethical considerations, regulatory hurdles, and data privacy concerns to ensure the responsible and ethical use of ML algorithms. The potential for transforming drug discovery and therapeutic development is immense with the incorporation of machine learning algorithms. Through utilizing data-driven methods, researchers can speed up the discovery of new potential drugs, enhance the effectiveness of treatments, and ultimately enhance the results for patients. Ongoing innovation, teamwork, and cross-disciplinary studies are crucial to fully leverage the potential of ML in revolutionizing drug discovery and precision medicine.

Machine Learning based Early-detection of Lung Cancer Using CT Scan for the early Identification and Classification

The current research is aimed at studying the application of machine learning algorithms for the early prediction and detection of lung cancer taking the images of CT scans and MR scans. In this respect, the dataset from kaggle includes 3200 images from diverse sources, which are pre-processed and applied for the process of feature extraction, using traditional methods and deep learning systems, which include Convolutional Neural Networks, VGG-16, VGG-19, and RNN, while after the training the systems are evaluated in accordance with precision, recall, f1 score, and accuracy. As a result, it is evidenced that the best model is VGG-19 with the highest accuracy of 97.86%, while follows VGG-19 the VGG-16 the CNN model, and the RNN, implying effective implications for clinical practice. Certainly, the results of the research help to create a non-invasive, effective, and fast tool, using by clinicians in their practice. The use of machine learning algorithms for the process of early prediction and detection would be helpful for the timely treatment of patients and personalized treatment plans. In such a way, based on the current research, it could be summarized that the best models are constantly developed and gradually implemented in practice. However, more significant collaboration between the researchers, clinicians, and the industry is needed to have the full implementation of applied methods in practice, having fast results and timely actions taken by clinicians.

Comparative Analysis of use of Machine Learning Algorithm for Prediction of Sales

Predicting sales holds immense importance for businesses, particularly for large retailers. It significantly influences decision-making processes and their subsequent execution. For big retail stores engaged in marketing and sales, accurate sales prediction is crucial for effectively allocating resources, estimating sales revenue, and devising future strategies. It empowers these stores to grasp market trends, make informed decisions, and adapt to evolving conditions, ensuring long-term viability and prosperity. Given the dynamic nature of trends and market conditions, traditional forecasting methods face significant challenges in keeping pace with rapid changes. This is where the application of machine learning algorithms becomes indispensable, especially when dealing with large and complex datasets. This paper delves into the exploration of various machine learning algorithms and models to predict sales, conducting comparative analyses to assess their performance.The overarching aim is to identify the most suitable algorithm or combination of algorithms through comprehensive analysis. Furthermore, the paper scrutinizes how the characteristics of the dataset impact the performance of these algorithms, offering valuable insights for selecting the most appropriate machine learning algorithm based on performance analysis. By leveraging these insights, businesses can enhance their sales prediction capabilities and make informed decisions, thereby maximizing their success in the marketplace.

Predicting Male Infertility Using Artificial Neural Networks: A Review of the Literature.

Male infertility is a relevant public health problem, but there is no systematic review of the different machine learning (ML) models and their accuracy so far. The present review aims to comprehensively investigate the use of ML algorithms in predicting male infertility, thus reporting the accuracy of the used models in the prediction of male infertility as a primary outcome. Particular attention will be paid to the use of artificial neural networks (ANNs). A comprehensive literature search was conducted in PubMed, Scopus, and Science Direct between 15 July and 23 October 2023, conducted under the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We performed a quality assessment of the included studies using the recommended tools suggested for the type of study design adopted. We also made a screening of the Risk of Bias (RoB) associated with the included studies. Thus, 43 relevant publications were included in this review, for a total of 40 different ML models detected. The studies included reported a good quality, even if RoB was not always good for all the types of studies. The included studies reported a median accuracy of 88% in predicting male infertility using ML models. We found only seven studies using ANN models for male infertility prediction, reporting a median accuracy of 84%.

Solar Irradiance Forecasting with Natural Language Processing of Cloud Observations and Interpretation of Results with Modified Shapley Additive Explanations

Forecasting the generation of solar power plants (SPPs) requires taking into account meteorological parameters that influence the difference between the solar irradiance at the top of the atmosphere calculated with high accuracy and the solar irradiance at the tilted plane of the solar panel on the Earth’s surface. One of the key factors is cloudiness, which can be presented not only as a percentage of the sky area covered by clouds but also many additional parameters, such as the type of clouds, the distribution of clouds across atmospheric layers, and their height. The use of machine learning algorithms to forecast the generation of solar power plants requires retrospective data over a long period and formalising the features; however, retrospective data with detailed information about cloudiness are normally recorded in the natural language format. This paper proposes an algorithm for processing such records to convert them into a binary feature vector. Experiments conducted on data from a real solar power plant showed that this algorithm increases the accuracy of short-term solar irradiance forecasts by 5–15%, depending on the quality metric used. At the same time, adding features makes the model less transparent to the user, which is a significant drawback from the point of view of explainable artificial intelligence. Therefore, the paper uses an additive explanation algorithm based on the Shapley vector to interpret the model’s output. It is shown that this approach allows the machine learning model to explain why it generates a particular forecast, which will provide a greater level of trust in intelligent information systems in the power industry.

Phishing Detection Using Machine Learning Algorithm

Phishing is a criminal scheme to steal the user’s personal data and other credential information. It is a fraud that acquires victim’s confidential information such as password, bank account detail, credit card number, financial username and password etc. and later it can be misuse by attacker. The use of machine learning algorithms in phishing detection has gained significant attention in recent years. This research paper aims to evaluate the effectiveness of various machine learning algorithms in detecting phishing URL’s/website. The algorithms tested in this study are Decision Tree, Random Forest, Multilayer Perceptron, XGBoost, Autoencoder Neural Network, and Support Vector Machines. A dataset of phishing URLs is used to train and test the algorithms, and their performance is evaluated based on metrics such as accuracy, precision, recall, and F1 Score. The paper takes in data of phished URL from Phishtank and legitimate URL from University of New Brunswick. The results of this study demonstrate that the Random Forest and XGBoost algorithms outperforms other algorithms in terms of accuracy and other performance metrics and the system has an overall accuracy of 98 %.

A review of the use of machine learning in predictive analytics for patient health outcomes in pharmacy practice

Predictive analytics, empowered by machine learning, has emerged as a transformative force in healthcare, offering unparalleled opportunities for enhancing patient outcomes. The primary focus is on understanding the implications, applications, and challenges associated with the use of machine learning algorithms in predicting patient health outcomes. The paper begins by establishing the context with an overview of predictive analytics in healthcare and its evolution. Emphasis is placed on the critical role of patient health outcomes in pharmacy practice. The review explores the current landscape of predictive analytics in pharmacy practice, detailing traditional approaches, their limitations, and the advantages that machine learning brings to the forefront. An in-depth examination of applications follows, focusing on areas such as medication adherence prediction, disease progression modeling, and personalized medication regimens. Real-world case studies and success stories illustrate the practical impact of machine learning on patient outcomes. Addressing the importance of data sources, the paper discusses the diverse types of data employed in predictive analytics, ranging from electronic health records to patient-generated data and wearables. Ethical and privacy concerns are thoroughly explored, emphasizing the need for responsible data usage. The implications for pharmacists and healthcare providers are discussed, highlighting the evolving role of pharmacists in predictive analytics and the potential benefits and challenges for healthcare providers. The conclusion summarizes key findings and issues a call to action, encouraging further research and adoption of machine learning in pharmacy practice to harness its potential for improving patient outcomes.

Efficient Training of Colorectal Cancer Diagnosis Model through Unsupervised Learning Composite Network

The use of machine learning algorithms for precise and effective colorectal cancer diagnosis has gained popularity as a result of advancements in medical imaging. Through the use of an Unsupervised Learning Composite Network (ULCN) model this study suggests a novel method for training a diagnosis model. Conventional training techniques for these models frequently rely on sizable labelled datasets, which can be labour and resource-intensive to create. The ULCN, on the other hand, incorporates unsupervised learning into the training process, decreasing the need on labelled input. In order to address this issue, our study offers a revolutionary method known as the DL-Kmeans (Deep Learning with Unsupervised K-Means Clustering), which combines the effectiveness of the unsupervised K-means clustering algorithm with the power of deep learning. When compared to manual screening and annotation techniques, the DL-Kmeans ability to more quickly refine medical images serves as evidence of its effectiveness. The use of DL- Kmeans processed photos resulted in a two-fold acceleration in the training process for deep learning models used to diagnose colorectal cancer, which is very notable. Notably, this speeding up did not degrade performance quality; the DL- Kmeans enhanced method showed superior results in terms of training loss and accuracy attained. DL- Kmeans importance goes beyond only improving images. It is a useful tool for handling the growing volume of medical photos, which will help with the later creation of artificial intelligence models.

Evaluation of machine learning models for cytochrome P450 3A4, 2D6, and 2C9 inhibition.

Cytochrome P450 (CYP) enzymes are involved in the metabolism of approximately 75% of marketed drugs. Inhibition of the major drug-metabolizing P450s could alter drug metabolism and lead to undesirable drug-drug interactions. Therefore, it is of great significance to explore the inhibition of P450s in drug discovery. Currently, machine learning including deep learning algorithms has been widely used for constructing in silico models for the prediction of P450 inhibition. These models exhibited varying predictive performance depending on the use of machine learning algorithms and molecular representations. This leads to the difficulty in the selection of appropriate models for practical use. In this study, we systematically evaluated the conventional machine learning and deep learning models for three major P450 enzymes, CYP3A4, CYP2D6, and CYP2C9 from several perspectives, such as algorithms, molecular representation, and data partitioning strategies. Our results showed that the XGBoost and CatBoost algorithms coupled with the combined fingerprint/physicochemical descriptor features exhibited the best performance with Area Under Curve (AUC) of 0.92, while the deep learning models were generally inferior to the conventional machine learning models (average AUC reached 0.89) on the same test sets. We also found that data volume and sampling strategy had a minor effect on model performance. We anticipate that these results are helpful for the selection of molecular representations and machine learning/deep learning algorithms in the P450 model construction and the future model development of P450 inhibition.