In comparison with other infectious diseases of dogs, parvovirus enteritis is quite common. The infection is periodically detected in animals in veterinary clinics. Observations have shown that unvaccinated puppies of 3-4 months are more often admitted to the clinic with parvovirus enteritis. In contrast to the 70 % rate indicated in the literature, the mortality rate among sick dogs reaches 50 to 93.3 %. Parvovirus enteritis can be treated with specific immune serums alongside symptomatic and pathogenetic therapies which increases the treatment efficiency up to 25 %. Additionally the combined use of immune serums and dexamethasone along with the described preparations – up to 50 %, which indicates the need for long-lasting use of glucocorticoids to increase adaptive functions of the body in dogs with parvovirus enteritis.