Perioperative reperfusion injury, acute right heart failure, and massive pulmonary hemorrhage are the most important factors determining mortality following pulmonary endarterectomy operation (PEA). Our approach for the treatment of intraoperative pulmonary hemorrhage following pulmonary endarterectomy is discussed. We retrospectively studied a PEA case with massive pulmonary hemorrhage that occurred in 2017. We used endobronchial blocker to ensure that the bleeding is stopped and used extracorporeal membrane oxygenation (ECMO) for respiratory and hemodynamic requirements. ECMO is a good alternative for most of the pre- and postoperative major complications of PEA. Combined use of endobronchial blocker and ECMO could be a useful treatment method for massive pulmonary hemorrhage following pulmonary endarterectomy.