The aim of this research was to explore the current factors influencing the effective use of eProcurement system in public sectors in Tanzania so that areas which need improvement can be identified, this is because, despite the adoption of eProcurement system, together with the efforts and initiatives undertaken by government in improving the same, still the use of the system is less effective in many public sectors in Tanzania. Quantitative and qualitative approaches were adopted whereby primary data were collected through questionnaires, in-depth interview and documentary review based on the purposive and simple random sampling method, population of 50 respondents with sample size of 30 respondents were included in this study. Moreover, quantitative data collected were entered in the Statistical Package for Social Science (SPSS) software, cleaned and then descriptive statistics analysis were calculated. However, qualitative data were be transcribed, cleaned and analyzed using Nvivo software for content analysis, finally mean, standard deviations and voice quotations focused on content analysis were presented. Preliminary literature review depicts that factors influencing eProcurement use rotated around to ICT infrastructures, staff competency as well as top management support and these lays the benchmark of this study. The findings of this study will facilitate recommendation to the government on establishment of more effective policies and strategies towards eProcurement usage. Moreover, the study will also be useful to various stakeholders from public and private companies, in setting the appropriate procurement policies and strategies towards eProcurement use at their work places.