Balloon atrial septostomy (BAS) is a life-saving palliative procedure for patients with d-transposition of the great arteries (d-TGA). 1 Rashkind W.J. Miller W.W. Creation of an atrial septal defect without thoracotomy a palliative approach to complete transposition of the great arteries. JAMA. 1966; 196: 991-992 Crossref PubMed Scopus (599) Google Scholar , 2 Hijazi Z.M. Abu A.ta I. Kuhn M.A. Cheatham J.P. Latson L. Geggel R.L. Balloon atrial septostomy using a new low-profile balloon catheter initial clinical results. Cathet Cardiovasc Diagn. 1997; 40: 187-190 Crossref PubMed Scopus (18) Google Scholar Typically performed in the cardiac catheterization laboratory under fluoroscopic guidance with hemodynamic monitoring, this procedure involves transport of a sick, cyanotic infant to the cardiac catheterization laboratory, often with some time delay from diagnosis to the start of BAS. The anatomy of the atrial septum, however, is well seen by 2-dimensional echocardiography, and the site of the restrictive atrial septal defect can be precisely located by imaging and the use of color flow Doppler. In addition, the balloon of the balloon septostomy catheter can be seen within the cardiac structures using echocardiography, making echocardiography an ideal imaging tool for this procedure. 3 Jamjureeruk V. Sangtawesin C. Layangool T. Balloon atrial septostomy under two-dimensional echocardiographic control a new outlook. Pediatr Cardiol. 1997; 18: 197-200 Crossref PubMed Scopus (15) Google Scholar , 4 Allan L.D. Leanage R. Wainwright R. Joseph M.C. Tynan M. Balloon atrial septostomy under two-dimensional echocardiographic control. Br Heart J. 1982; 47: 41-43 Crossref PubMed Scopus (52) Google Scholar Although the concept of bedside BAS was first discussed in 1984, 5 Baker E.J. Allan L.D. Tynan M.J. Jones O.D. Joseph M.C. Deverall P.B. Balloon atrial septostomy in the neonatal intensive care unit. Br Heart J. 1984; 51: 377-378 Crossref PubMed Scopus (28) Google Scholar cardiac catheterization remained an integral part of the evaluation of d-TGA in the early era of the arterial switch operation, and in patients who still have unanswered critical questions after full echocardiographic evaluation. We hypothesized that bedside BAS would significantly reduce the cost to the patient without a change in efficacy and might be safer by obviating the need for transport of a sick infant to the cardiac catheterization laboratory. In this report, we compare our results with BAS performed in the cardiac catheterization laboratory with those performed at the bedside over the past 4 years, with emphasis on the change in cost to the patient, efficacy, safety, and any change in morbidity or mortality.