Use Of Brain-computer Interface Research Articles

BCI for Exoskeletons and Prostheses from Rehabilitation to Human Enhancement

Brain-computer interface (BCI) technology has revolutionized the development of motor rehabilitation and body enhancement. However, a significant gap exists between the limited use of BCI for exoskeletons and prosthetics in healthy individuals and its wide application in motor-impaired patients. This literature review aims to bridge that gap and highlight the potential of BCI technology for future applications in body enhancement for healthy individuals. We review the literature across neuroscience, biomedical engineering, and robotics, focusing on BCI applications in prosthetics and exoskeletons for both motor-impaired and healthy individuals. We summarize the methods for adapting and transferring prosthetic structures designed for individuals with disabilities to healthy individuals and identify the most suitable model for the healthy population. Our findings highlight the transformative potential of BCI technology to significantly enhance human capabilities, inspire innovation in assistive devices, and improve productivity and quality of life.

Connecting the Brain with Augmented Reality: A Systematic Review of BCI-AR Systems

The increasing integration of brain–computer interfaces (BCIs) with augmented reality (AR) presents new possibilities for immersive and interactive environments, particularly through the use of head-mounted displays (HMDs). Despite the growing interest, a comprehensive understanding of BCI-AR systems is still emerging. This systematic review aims to synthesize existing research on the use of BCIs for controlling AR environments via HMDs, highlighting the technological advancements and challenges in this domain. An extensive search across electronic databases, including IEEEXplore, PubMed, and Scopus, was conducted following the PRISMA guidelines, resulting in 41 studies eligible for analysis. This review identifies key areas for future research, potential limitations, and offers insights into the evolving trends in BCI-AR systems, contributing to the development of more robust and user-friendly applications.

A click-based electrocorticographic brain-computer interface enables long-term high-performance switch scan spelling.

Brain-computer interfaces (BCIs) can restore communication for movement- and/or speech-impaired individuals by enabling neural control of computer typing applications. Single command click detectors provide a basic yet highly functional capability. We sought to test the performance and long-term stability of click decoding using a chronically implanted high density electrocorticographic (ECoG) BCI with coverage of the sensorimotor cortex in a human clinical trial participant (ClinicalTrials.gov, NCT03567213) with amyotrophic lateral sclerosis. We trained the participant's click detector using a small amount of training data (<44 min across 4 days) collected up to 21 days prior to BCI use, and then tested it over a period of 90 days without any retraining or updating. Using a click detector to navigate a switch scanning speller interface, the study participant can maintain a median spelling rate of 10.2 characters per min. Though a transient reduction in signal power modulation can interrupt usage of a fixed model, a new click detector can achieve comparable performance despite being trained with even less data (<15 min, within 1 day). These results demonstrate that a click detector can be trained with a small ECoG dataset while retaining robust performance for extended periods, providing functional text-based communication to BCI users.

Prospectively identifying risks and controls for advanced brain-computer interfaces: A Networked Hazard Analysis and Risk Management System (Net-HARMS) approach

The introduction of advanced digital technologies continues to increase system complexity and introduce risks, which must be proactively identified and managed to support system resilience. Brain-computer interfaces (BCIs) are one such technology; however, the risks arising from broad societal use of the technology have yet to be identified and controlled. This study applied a structured systems thinking-based risk assessment method to prospectively identify risks and risk controls for a hypothetical future BCI system lifecycle. The application of the Networked Hazard Analysis and Risk Management System (Net-HARMS) method identified over 800 risks throughout the BCI system lifecycle, from BCI development and regulation through to BCI use, maintenance, and decommissioning. High-criticality risk themes include the implantation and degradation of unsafe BCIs, unsolicited brain stimulation, incorrect signals being sent to safety-critical technologies, and insufficiently supported BCI users. Over 600 risk controls were identified that could be implemented to support system safety and performance resilience. Overall, many highly-impactful BCI system safety and performance risks may arise throughout the BCI system lifecycle and will require collaborative efforts from a wide range of BCI stakeholders to adequately control. Whilst some of the identified controls are practical, work is required to develop a more systematic set of controls to best support the design of a resilient sociotechnical BCI system.

Gesture encoding in human left precentral gyrus neuronal ensembles.

Understanding the cortical activity patterns driving dexterous upper limb motion has the potential to benefit a broad clinical population living with limited mobility through the development of novel brain-computer interface (BCI) technology. The present study examines the activity of ensembles of motor cortical neurons recorded using microelectrode arrays in the dominant hemisphere of two BrainGate clinical trial participants with cervical spinal cord injury as they attempted to perform a set of 48 different hand gestures. Although each participant displayed a unique organization of their respective neural latent spaces, it was possible to achieve classification accuracies of ~70% for all 48 gestures (and ~90% for sets of 10). Our results show that single unit ensemble activity recorded in a single hemisphere of human precentral gyrus has the potential to generate a wide range of gesture-related signals across both hands, providing an intuitive and diverse set of potential command signals for intracortical BCI use.

User Evaluation of a Shared Robot Control System Combining BCI and Eye Tracking in a Portable Augmented Reality User Interface.

This study evaluates an innovative control approach to assistive robotics by integrating brain-computer interface (BCI) technology and eye tracking into a shared control system for a mobile augmented reality user interface. Aimed at enhancing the autonomy of individuals with physical disabilities, particularly those with impaired motor function due to conditions such as stroke, the system utilizes BCI to interpret user intentions from electroencephalography signals and eye tracking to identify the object of focus, thus refining control commands. This integration seeks to create a more intuitive and responsive assistive robot control strategy. The real-world usability was evaluated, demonstrating significant potential to improve autonomy for individuals with severe motor impairments. The control system was compared with an eye-tracking-based alternative to identify areas needing improvement. Although BCI achieved an acceptable success rate of 0.83 in the final phase, eye tracking was more effective with a perfect success rate and consistently lower completion times (p<0.001). The user experience responses favored eye tracking in 11 out of 26 questions, with no significant differences in the remaining questions, and subjective fatigue was higher with BCI use (p=0.04). While BCI performance lagged behind eye tracking, the user evaluation supports the validity of our control strategy, showing that it could be deployed in real-world conditions and suggesting a pathway for further advancements.

Stability of ECoG high gamma signals during speech and implications for a speech BCI system in an individual with ALS: a year-long longitudinal study

Objective. Speech brain–computer interfaces (BCIs) have the potential to augment communication in individuals with impaired speech due to muscle weakness, for example in amyotrophic lateral sclerosis (ALS) and other neurological disorders. However, to achieve long-term, reliable use of a speech BCI, it is essential for speech-related neural signal changes to be stable over long periods of time. Here we study, for the first time, the stability of speech-related electrocorticographic (ECoG) signals recorded from a chronically implanted ECoG BCI over a 12 month period. Approach. ECoG signals were recorded by an ECoG array implanted over the ventral sensorimotor cortex in a clinical trial participant with ALS. Because ECoG-based speech decoding has most often relied on broadband high gamma (HG) signal changes relative to baseline (non-speech) conditions, we studied longitudinal changes of HG band power at baseline and during speech, and we compared these with residual high frequency noise levels at baseline. Stability was further assessed by longitudinal measurements of signal-to-noise ratio, activation ratio, and peak speech-related HG response magnitude (HG response peaks). Lastly, we analyzed the stability of the event-related HG power changes (HG responses) for individual syllables at each electrode. Main Results. We found that speech-related ECoG signal responses were stable over a range of syllables activating different articulators for the first year after implantation. Significance. Together, our results indicate that ECoG can be a stable recording modality for long-term speech BCI systems for those living with severe paralysis. Clinical Trial Information. ClinicalTrials.gov, registration number NCT03567213.

From lab to life: assessing the impact of real-world interactions on the operation of rapid serial visual presentation-based brain-computer interfaces

Objective. Brain-computer interfaces (BCI) have been extensively researched in controlled lab settings where the P300 event-related potential (ERP), elicited in the rapid serial visual presentation (RSVP) paradigm, has shown promising potential. However, deploying BCIs outside of laboratory settings is challenging due to the presence of contaminating artifacts that often occur as a result of activities such as talking, head movements, and body movements. These artifacts can severely contaminate the measured EEG signals and consequently impede detection of the P300 ERP. Our goal is to assess the impact of these real-world noise factors on the performance of a RSVP-BCI, specifically focusing on single-trial P300 detection. Approach. In this study, we examine the impact of movement activity on the performance of a P300-based RSVP-BCI application designed to allow users to search images at high speed. Using machine learning, we assessed P300 detection performance using both EEG data captured in optimal recording conditions (e.g. where participants were instructed to refrain from moving) and a variety of conditions where the participant intentionally produced movements to contaminate the EEG recording. Main results. The results, presented as area under the receiver operating characteristic curve (ROC-AUC) scores, provide insight into the significant impact of noise on single-trial P300 detection. Notably, there is a reduction in classifier detection accuracy when intentionally contaminated RSVP trials are used for training and testing, when compared to using non-intentionally contaminated RSVP trials. Significance. Our findings underscore the necessity of addressing and mitigating noise in EEG recordings to facilitate the use of BCIs in real-world settings, thus extending the reach of EEG technology beyond the confines of the laboratory.

Интерфейсы «мозг–компьютер» и «мозг–мозг» в структуре конвергирующих технологий (на основе экспериментальных данных НИТЦ нейротехнологий ЮФУ)

The article presents a conceptual analysis of the main directions and methods of studying the human psyche, consciousness and brain in contemporary domestic and foreign research. The concept of “converging technologies” is considered in context of the creation of Artificial General Intelligence (AGI). It describes programs for the neuroscientific study of organization of psychic processes in the field of visualization of brain processes and the mapping method, which helps to understand how different parts of the brain can be structurally and functionally separated from each other. The publication pays special attention to understanding the possible use of Brain-Computer Interfaces (BCI) and Brain-to-Brain Interfaces (BMI) in the creation of AGI, “hybrid intelligence”. Brain interfaces are presented as fundamentally new channels of communication and control. An example of a biohybrid odor recognition system developed at the Research Center of Neurotechnology of the Southern Federal University is given. We are talking about the implementation of control through the BMI and mental commands of a bio­logical object – a rat. From the position of a body-oriented approach this work reveals the prob­lem of co-evolution of the body, consciousness, technology and social environment in the post-non-classical paradigm. It is concluded that modern neuroscience has a significant impact on understanding the functioning of the human brain, consciousness and cognitive processes. The feasibility of studying the possible use of BCI and BMI technologies in stimulating brain areas to create sensations equivalent to touch, etc. is noted. We are also talking about the use of biohybrid systems controlled through BMI technology as systems that combine the advan­tages of natural and artificial intelligence (with further elaboration of ethical issues).

Advancements in brain-computer interfaces for the rehabilitation of unilateral spatial neglect: a concise review.

This short review examines recent advancements in neurotechnologies within the context of managing unilateral spatial neglect (USN), a common condition following stroke. Despite the success of brain-computer interfaces (BCIs) in restoring motor function, there is a notable absence of effective BCI devices for treating cerebral visual impairments, a prevalent consequence of brain lesions that significantly hinders rehabilitation. This review analyzes current non-invasive BCIs and technological solutions dedicated to cognitive rehabilitation, with a focus on visuo-attentional disorders. We emphasize the need for further research into the use of BCIs for managing cognitive impairments and propose a new potential solution for USN rehabilitation, by combining the clinical subtleties of this syndrome with the technological advancements made in the field of neurotechnologies.

Understanding the Ethical Issues of Brain-Computer Interfaces (BCIs): A Blessing or the Beginning of a Dystopian Future?

In recent years, scientific discoveries in the field of neuroscience combined with developments in the field of artificial intelligence have led to the development of a range of neurotechnologies. Advances in neuroimaging systems, neurostimulators, and brain-computer interfaces (BCIs)are leading to new ways of enhancing, controlling, and "reading" the brain. In addition, although BCIs were developed and used primarily in the medical field, they are now increasingly applied in other fields (entertainment, marketing, education, defense industry). We conducted a literature review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to provide background information about ethical issues related to the use of BCIs. Among the ethical issues that emerged from the thematic data analysis of the reviewed studies included questions revolving around human dignity, personhood and autonomy, user safety, stigma and discrimination, privacy and security, responsibility, research ethics, and social justice (including access to this technology). This paper attempts to address the various aspects of these concerns. A variety of distinct ethical issues were identified, which, for the most part, were in line with the findings of prior research. However, we identified two nuances, which are related to the empirical research on ethical issues related to BCIs and the impact of BCIs on international relationships. The paper also highlights the need for the cooperation of all stakeholders to ensure the ethical development and use of this technology and concludes with several recommendations. The principles of bioethics provide an initial guiding framework, which, however, should be revised in the current artificial intelligence landscape so as to be responsive to challenges posed by the development and use of BCIs.

A toolbox for decoding BCI commands based on event-related potentials.

Commands in brain-computer interface (BCI) applications often rely on the decoding of event-related potentials (ERP). For instance, the P300 potential is frequently used as a marker of attention to an oddball event. Error-related potentials and the N2pc signal are further examples of ERPs used for BCI control. One challenge in decoding brain activity from the electroencephalogram (EEG) is the selection of the most suitable channels and appropriate features for a particular classification approach. Here we introduce a toolbox that enables ERP-based decoding using the full set of channels, while automatically extracting informative components from relevant channels. The strength of our approach is that it handles sequences of stimuli that encode multiple items using binary classification, such as target vs. nontarget events typically used in ERP-based spellers. We demonstrate examples of application scenarios and evaluate the performance of four openly available datasets: a P300-based matrix speller, a P300-based rapid serial visual presentation (RSVP) speller, a binary BCI based on the N2pc, and a dataset capturing error potentials. We show that our approach achieves performances comparable to those in the original papers, with the advantage that only conventional preprocessing is required by the user, while channel weighting and decoding algorithms are internally performed. Thus, we provide a tool to reliably decode ERPs for BCI use with minimal programming requirements.

Ethical considerations for medical applications of implantable brain-computer interfaces

Implantable brain-computer interfaces (BCIs) have potentially important clinical applications due to the high spatial resolution and signal-to-noise ratio of electrodes that are closer to or implanted in the cerebral cortex. However, the surgery and electrodes of implantable BCIs carry safety risks of brain tissue damage, and their medical applications face ethical challenges, with little literature to date systematically considering ethical norms for the medical applications of implantable BCIs. In order to promote the clinical translation of this type of BCI, we considered the ethics of practice for the medical application of implantable BCIs, including: reducing the risk of brain tissue damage from implantable BCI surgery and electrodes, providing patients with customized and personalized implantable BCI treatments, ensuring multidisciplinary collaboration in the clinical application of implantable BCIs, and the responsible use of implantable BCIs, among others. It is expected that this article will provide thoughts and references for the research and development of ethics of the medical application of implantable BCI.

Adaptive LDA Classifier Enhances Real-Time Control of an EEG Brain-Computer Interface for Decoding Imagined Syllables.

Brain-Computer Interfaces (BCIs) aim to establish a pathway between the brain and an external device without the involvement of the motor system, relying exclusively on neural signals. Such systems have the potential to provide a means of communication for patients who have lost the ability to speak due to a neurological disorder. Traditional methodologies for decoding imagined speech directly from brain signals often deploy static classifiers, that is, decoders that are computed once at the beginning of the experiment and remain unchanged throughout the BCI use. However, this approach might be inadequate to effectively handle the non-stationary nature of electroencephalography (EEG) signals and the learning that accompanies BCI use, as parameters are expected to change, and all the more in a real-time setting. To address this limitation, we developed an adaptive classifier that updates its parameters based on the incoming data in real time. We first identified optimal parameters (the update coefficient, UC) to be used in an adaptive Linear Discriminant Analysis (LDA) classifier, using a previously recorded EEG dataset, acquired while healthy participants controlled a binary BCI based on imagined syllable decoding. We subsequently tested the effectiveness of this optimization in a real-time BCI control setting. Twenty healthy participants performed two BCI control sessions based on the imagery of two syllables, using a static LDA and an adaptive LDA classifier, in randomized order. As hypothesized, the adaptive classifier led to better performances than the static one in this real-time BCI control task. Furthermore, the optimal parameters for the adaptive classifier were closely aligned in both datasets, acquired using the same syllable imagery task. These findings highlight the effectiveness and reliability of adaptive LDA classifiers for real-time imagined speech decoding. Such an improvement can shorten the training time and favor the development of multi-class BCIs, representing a clear interest for non-invasive systems notably characterized by low decoding accuracies.

Brain-Computer Interfaces for Communication in Patients with Disorders of Consciousness: A Gap Analysis and Scientific Roadmap.

We developed a gap analysis that examines the role of brain-computer interfaces (BCI) in patients with disorders of consciousness (DoC), focusing on their assessment, establishment of communication, and engagement with their environment. The Curing Coma Campaign convened a Coma Science work group that included 16 clinicians and neuroscientists with expertise in DoC. The work group met online biweekly and performed a gap analysis of the primary question. We outline a roadmap for assessing BCI readiness in patients with DoC and for advancing the use of BCI devices in patients with DoC. Additionally, we discuss preliminary studies that inform development of BCI solutions for communication and assessment of readiness for use of BCIs in DoC study participants. Special emphasis is placed on the challenges posed by the complex pathophysiologies caused by heterogeneous brain injuries and their impact on neuronal signaling. The differences between one-way and two-way communication are specifically considered. Possible implanted and noninvasive BCI solutions for acute and chronic DoC in adult and pediatric populations are also addressed. We identify clinical and technical gaps hindering the use of BCI in patients with DoC in each of these contexts and provide a roadmap for research aimed at improving communication for adults and children with DoC, spanning the clinical spectrum from intensive care unit to chronic care.

Brain–Computer Interface Using Functional Near-Infrared Spectroscopy for Post-Stroke Motor Rehabilitation: Case Series

Introduction. Non-invasive brain–computer interfaces (BCIs) enable feedback motor imagery [MI] training in neurological patients to support their motor rehabilitation. Nowadays, the use of BCIs based on functional near-infrared spectroscopy (fNIRS) for motor rehabilitation is yet to be investigated.&#x0D; Objective: To evaluate the potential fNIRS BCI use in hand MI training for comprehensive post-stroke rehabilitation.&#x0D; Materials and methods. This pilot study included clinically stable patients with mild-to-moderate post-stroke hand paresis. In addition to the standard rehabilitation, the patients underwent 10 nine-minute MI fNIRS BCI training sessions. To evaluate the quality of fNIRS BCI control, we assessed the percentage of time during which the classifier accurately detected patient's mental state. We scored the hand function using the Action Research Arm Test (ARAT) and the Fugl-Meyer Assessment (FMA).&#x0D; Results. The study included 5 patients at 1 day to 12 months of stroke. All the participants completed the study. All study participants achieved BCI control rates higher than random (41–68%). While three patients demonstrated the clinically significant improvements in their ARAT scores, one of them also showed an improvement in the FMA score. All the participants reported experiencing drowsiness during training.&#x0D; Conclusions. Post-stroke patients can operate the fNIRS BCI system under investigation. We suggest adjusting the feedback system, extending the duration of training, and incorporating functional electromyostimulation to enhance training effectiveness.

Rapid-IAF: Rapid Identification of Individual Alpha Frequency in EEG Data Using Sequential Bayesian Estimation.

Rapid and robust identification of the individual alpha frequency (IAF) in electroencephalogram (EEG) is an essential factor for successful brain-computer interface (BCI) use. Here we demonstrate an algorithm to determine the IAF from short-term resting-state scalp EEG data. First, we outlined the algorithm to determine IAF from short-term resting scalp EEG data and evaluated its reliability using a large-scale dataset of scalp EEG during motor imagery-based BCI use and independent dataset for generalizability confirmation (N = 147). Next, we characterized the relationship between IAF and responsive frequency band of sensorimotor rhythm, which exhibits prominent event-related desynchronization (SMR-ERD) while attempting unilateral and movement. The proposed sequential Bayesian estimation algorithm (Rapid-IAF) determined IAF from less than 26-second resting EEG data among 95% of participants, indicating a clear advance over the conventional methods, which uses 2-15 minutes of data in previous literatures. We confirmed that the determined IAF corresponded to the frequency of SMR, which exhibits the most prominent event-related desynchronization during BCI use (individual SMR-ERD frequency, ISF). Moreover, intraclass correlation revealed that the estimated IAF was more stable than ISF across sessions, suggesting its reliability and utility for robust BCI use without intermittent recalibration. Conclusion In summary, our method rapidly and reliably determined IAF compared to the conventional method using the spectral power change based on task-related response. The method can be utilized to quick BCI initialization. The demonstration of rapid, task-free parametrization of individual variability of neural responses would be of importance for future BCI systems including neural communication via a cursor, an avatar or robots, and closed-loop neurofeedback training.

A large database towards user-friendly SSVEP-based BCI

Background: Brain-computer interfaces (BCIs) have gained considerable attention for their potential in assisting individuals who have motor impairments with communication and rehabilitation. Among BCIs, steady-state visual evoked potential (SSVEP)-based systems have demonstrated high efficiency in interactive applications. However, ergonomic design challenges have limited their practical implementation in industrial settings. Issues such as visual and mental fatigue caused by flickering stimuli and the time-consuming preparation process hinder user adoption of such systems. Methods: To evaluate these BCI solutions, we introduced an open database comprising Electroencephalogram (EEG) data collected from 59 healthy volunteers using ergonomically designed semi-dry electrodes and grid stimuli. The database was acquired without electromagnetic shielding, and the preparation time for each participant was &lt;5 min. A 40-target SSVEP speller system with cues was used in the experiment. Results: We validate the database by temporal and spectral analyzing methods. To further investigate the database, filter bank canonical correlation analysis (FBCCA), ensemble task-related component analysis (e-TRCA) and multi-stimulus task-related component analysis (msTRCA) were used for classification. The database can be downloaded from the following link: https://drive.google.com/drive/folders/1TXuxU863nZoniZRgNWZy0PRuL8lhBuP4?usp=sharing . Conclusions: This research contributes to enhancing the use of SSVEP-based BCIs in practical settings by addressing user experience and system design challenges. The proposed user-friendly visual stimuli and ergonomic electrode design improve comfort and usability. The open dataset serves as a valuable resource for future studies, enabling the development of robust and efficient SSVEP- BCI systems suitable for industrial applications.

DiSCIoser: unlocking recovery potential of arm sensorimotor functions after spinal cord injury by promoting activity-dependent brain plasticity by means of brain-computer interface technology: a randomized controlled trial to test efficacy

BackgroundTraumatic cervical spinal cord injury (SCI) results in reduced sensorimotor abilities that strongly impact on the achievement of daily living activities involving hand/arm function. Among several technology-based rehabilitative approaches, Brain-Computer Interfaces (BCIs) which enable the modulation of electroencephalographic sensorimotor rhythms, are promising tools to promote the recovery of hand function after SCI. The “DiSCIoser” study proposes a BCI-supported motor imagery (MI) training to engage the sensorimotor system and thus facilitate the neuroplasticity to eventually optimize upper limb sensorimotor functional recovery in patients with SCI during the subacute phase, at the peak of brain and spinal plasticity. To this purpose, we have designed a BCI system fully compatible with a clinical setting whose efficacy in improving hand sensorimotor function outcomes in patients with traumatic cervical SCI will be assessed and compared to the hand MI training not supported by BCI.MethodsThis randomized controlled trial will include 30 participants with traumatic cervical SCI in the subacute phase randomly assigned to 2 intervention groups: the BCI-assisted hand MI training and the hand MI training not supported by BCI. Both interventions are delivered (3 weekly sessions; 12 weeks) as add-on to standard rehabilitation care. A multidimensional assessment will be performed at: randomization/pre-intervention and post-intervention. Primary outcome measure is the Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP) somatosensory sub-score. Secondary outcome measures include the motor and functional scores of the GRASSP and other clinical, neuropsychological, neurophysiological and neuroimaging measures.DiscussionWe expect the BCI-based intervention to promote meaningful cortical sensorimotor plasticity and eventually maximize recovery of arm functions in traumatic cervical subacute SCI. This study will generate a body of knowledge that is fundamental to drive optimization of BCI application in SCI as a top-down therapeutic intervention, thus beyond the canonical use of BCI as assistive tool.Trial registrationName of registry: DiSCIoser: improving arm sensorimotor functions after spinal cord injury via brain-computer interface training (DiSCIoser). Trial registration number: NCT05637775; registration date on the ClinicalTrial.gov platform: 05-12-2022.

Subcortical implantation of a passive microchip in rodents – an observational proof-of-concept study

ABSTRACT The use of brain-computer interface (BCI) technologies is a rapidly developing area of interest in neurosurgery. Studies investigating the use of BCIs have primarily focused on surface electrodes; however, subcortically implanted microchips may provide novel, non-pharmacological approaches for managing nervous system disorders. Accessing subcortical regions without disrupting surrounding tissues remains a significant challenge. Accordingly, we conducted an observational, proof-of-concept study to evaluate the use of a modified BrainPath® device to implant subcortical microchips in a rodent model. All animals survived the procedure and lived with a microchip in situ for one or three months with no apparent neurological effects. Histological examination revealed that implantation of a small chip was associated with some tissue damage, tract formation, and surrounding reactive changes. Gliosis and hemosiderin-laden macrophages were evident surrounding tract marks after one month and focal cystic cavitation consistent with infarcted tissue was evident after three months. While a more extensive cellular proliferation response was apparent one month after implantation of a large microchip, there was no significant collagen deposition suggestive of fibrosis. This study is the first demonstration of subcortical microchip implantation using a novel neurosurgical technique that may facilitate the development of BCI technologies for treatment of neurological disorders.