Abstract It is well-known that humans spend most of their time in indoor spaces: what it is sometimes underestimated; however, is how much the space in which someone is can affect their abilities, feelings and even their mental and physical health. A team developed a methodology to allow the collection of useful data and giving rise to management strategies for guaranteeing healthy spaces, in terms of Indoor Environmental Quality (IEQ). In particular, the methodology is based on a quali-quantitative analysis of Indoor Air Quality (IAQ) supported by a questionnaire on users’ perception and well-being, based on a scoping review, and low-cost sensors for IAQ monitoring air contaminants (carbon dioxide, temperature, relative humidity, volatile organic compounds, etc.). In particular, for the quantitative analysis, the team adopted a method that considers the location of the sensors in different typology of settings with various solar exposures, ventilation systems, human occupancy, type of activity, etc. with the scope of testing the trends in different seasons. As well as the qualitative data collect several information about the users’ perceived comfort and the symptoms (headache, fatigue, etc.) during their stay. The data analysis highlights how the different users’ perceptions affect the conditions of the environmental units, in particular in crowded rooms (4-6 people). Adequate lifestyles, such as door and window-openings, regular air-changes, etc. can highly affect the performances and the productivity, as well as the quality of the spaces. In that sense the use of low-cost sensors with light signals can be helpful as strategy for informing the user of the state of the air and any actions to be implemented. In conclusion, starting from the methodology, the team gives rise to a decalogue of strategies and good habits that permits -through the support of low-cost sensors - to inform the users on how to guarantee healthy living and working spaces.