Urinary tract infections (UTIs) are a significant global health concern affecting millions annually. In India, UTIs linked to various bacterial pathogens, particularly and present a formidable challenge. This study aimed to evaluate the occurrence of these bacteria in urine samples obtained from UTI patients in Indian settings. Our investigation identified a notable proportion of UTIs associated with and highlighting the necessity for customized therapeutic approaches. Additionally, we conducted antibiotic susceptibility testing to guide appropriate antibiotic selection. Our findings revealed that 90% of isolates exhibiting additional resistance to Azithromycin (AZK). These results emphasize the importance of judicious antibiotic use and continuous monitoring of antibiotic resistance in UTI-causing pathogens in Indian healthcare settings. This study contributes to UTI management strategies and the development of tailored treatment modalities for the Indian population.