You have accessJournal of UrologyOutstanding Posters: Benign Disease1 Apr 2014OP2-02 URINARY PHYTOESTROGENS ARE ASSOCIATED WITH LOWER URINARY TRACT SYMPTOMS IN WOMEN Evgeniy Kreydin, Glen Barrisford, Dayron Rodriguez, Yahir Santiago-Lastra, Alejandro Sanchez, Mark Preston, Hillary Keenan, and Dicken Ko Evgeniy KreydinEvgeniy Kreydin More articles by this author , Glen BarrisfordGlen Barrisford More articles by this author , Dayron RodriguezDayron Rodriguez More articles by this author , Yahir Santiago-LastraYahir Santiago-Lastra More articles by this author , Alejandro SanchezAlejandro Sanchez More articles by this author , Mark PrestonMark Preston More articles by this author , Hillary KeenanHillary Keenan More articles by this author , and Dicken KoDicken Ko More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.2552AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Phytoestrogens are a class of plant-derived compounds that have selective estrogen receptor modulator properties. Links have been established between urinary phytoestrogen levels and a number of sex hormone-dependent pathologic states, such as breast and endometrial cancer, vaginal atrophy and osteoporosis. We examined whether urinary levels of isoflavone-type (daidzein, o-desmethylangolensin, equol, and genistein) and lignan-type phytoestrogens (enterodiol and enterolactone) were associated with urinary symptoms in women. METHODS National Health and Nutrition Examination Survey (NHANES) data collected from 2000 to 2010 was used to identify cohorts of 4104, 1648, and 2161 women, who responded to urinary incontinence, nocturia, and urinary symptom bother questionnaires, respectively. Urinary phytoestrogen levels were log transformed. Association between phytoestrogen levels, urge incontinence, stress incontinence, nocturia, bother from urinary incontinence, and the degree of effect of urinary incontinence on daily living was assessed using weighted multivariate logistic regression adjusting for age, race, smoking status, body mass index, diabetes, parity, and menopausal status. RESULTS Increasing concentration of lignan phytoestrogens enterolactone and enterodiol was associated with decreased likelihood of urge incontinence, bother from incontinence, and effect of urinary incontinence on daily living (p < 0.05). Increasing concentration of enterolactone was also associated with decreased likelihood of nocturia (p < 0.05). None of the isoflavone phytoestrogens were associated with urinary symptoms. Odds ratios per unit change in phytoestrogen concentration are given in Table 1. CONCLUSIONS This is the first study to demonstrate an association between urinary phytoestrogen levels and urinary symptoms in a large population-based cohort of women. We demonstrate that members of the lignan phytoestrogen family may have a protective effect on urinary symptoms in women. Prospective clinical and laboratory studies are warranted to investigate the mechanism of this relationship. Table 1. Odds ratios and 95% confidence intervals for urinary symptoms per unit change in urinary phytoestrogen concentrations. Phytoestrogen Type Phytoestrogen Urge Incontinence Nocturia Incontinence Bother Incontinence Effect on Daily Activities Isoflavone Daidzein 1.01 (0.95-1.07) 0.99 (0.89-1.09) 1.04 (0.97-1.12) 1.02 (0.90-1.15) Isoflavone O-Desmethylangolensin 1.02 (0.98-1.07) 0.95 (0.87-1.03) 1.02 (0.97-1.07) 0.96 (0.86-1.04) Isoflavone Equol 0.95 (0.88-1.02) 1.06 (0.89-1.25) 1.02 (0.94-1.11) 0.88 (0.74-1.05) Isoflavone Genistein 0.88 (0.47-1.62) 1.03 (0.93-1.15) 1.08 (0.95-1.17) 1.54 (0.43-5.41) Lignan Enterodiol 0.93 (0.88-0.98)∗ 1.03 (0.90-1.17) 0.92 (0.85-0.99)∗ 0.86 (0.77-0.96)∗ Lignan Enterolactone 0.95 (0.89-0.99)∗ 0.86 (0.76-0.97)∗ 0.92 (0.86-0.98)∗ 0.90 (0.81-0.99)∗ ∗p < 0.05 © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e387 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Evgeniy Kreydin More articles by this author Glen Barrisford More articles by this author Dayron Rodriguez More articles by this author Yahir Santiago-Lastra More articles by this author Alejandro Sanchez More articles by this author Mark Preston More articles by this author Hillary Keenan More articles by this author Dicken Ko More articles by this author Expand All Advertisement Advertisement PDF DownloadLoading ...