You have accessJournal of UrologyProstate Cancer: Localized: Surgical Therapy V1 Apr 2016MP69-09 TOPOGRAPHY OF RECURRENT PROSTATE CANCER BASED ON SALVAGE RADICAL PROSTATECTOMY TUMOR MAPS Toshikazu Takeda, Amy Tin, Renato Corradi, Maha Mamoor, Nicole Benfante, Daniel Sjoberg, Samson Fine, James Eastham, Peter Scardino, and Karim Touijer Toshikazu TakedaToshikazu Takeda More articles by this author , Amy TinAmy Tin More articles by this author , Renato CorradiRenato Corradi More articles by this author , Maha MamoorMaha Mamoor More articles by this author , Nicole BenfanteNicole Benfante More articles by this author , Daniel SjobergDaniel Sjoberg More articles by this author , Samson FineSamson Fine More articles by this author , James EasthamJames Eastham More articles by this author , Peter ScardinoPeter Scardino More articles by this author , and Karim TouijerKarim Touijer More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.1387AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES When administering radiotherapy (RT) and/or ablation therapy for prostate cancer, physicians seek to preserve the surrounding structure such as the urinary sphincter, neurovascular bundle, bladder, rectal wall, and urethra to reduce toxicity. We hypothesize that the area adjacent to these structures may be undertreated as a result and thus we assessed the patterns of tumor recurrence by reviewing tumor maps from patients undergoing salvage radical prostatectomy (SRP) after RT and/or ablation therapy for prostate cancer. METHODS We identified 236 patients who underwent RT and/or ablation therapy for prostate cancer and proceeded to SRP between 2000 and 2014. Among these 236 patients, 83 had available tumor maps from whole mount slides. We evaluated the detailed pathological characteristics of recurrent prostate cancer in these 83 patients. RESULTS In the 83 patients with tumor maps, median age at SRP was 66 years and median time from primary treatment to SRP was 4.6 years. One third of patients had undergone hormonal therapy with or after the primary treatment and 6% of patients had not undergone RT as their primary treatment, instead opting for cryosurgery or high-intensity focused ultrasound. Pathological Gleason score ≥ 8 was present in 37% of these recurrent prostate cancer cases and pathological stage ≥ T3 in 60%. A single cancer focus was found in 60%, while 88% had tumor in the apex, and 94% had tumor in the mid-gland. Median tumor volume was 1.4 cm3; median minimum distance from the tumor to the urethra was 0.3 cm. Fifty nine patients (71%) had cancer ≤ 0.5cm from the urethra. Six patients (7%) had tumor directly involving the urethra, and 5 of them had urethral invasion at the apex. One patient who had undergone both RT and cryosurgery did not have any tumor and two patients who underwent RT had tumor only in the seminal vesicle. CONCLUSIONS Our results show that many of the recurrences are solitary and in locations near the urethra. This suggests that the technique of preserving the surrounding structure during RT and/or ablation therapy influences the pattern of post-treatment recurrence. Therefore, when recurrence is suspected after RT and/or ablation therapy, biopsy of the area near the urethra and seminal vesicle is needed when considering salvage treatment for curative intent. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e900-e901 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Toshikazu Takeda More articles by this author Amy Tin More articles by this author Renato Corradi More articles by this author Maha Mamoor More articles by this author Nicole Benfante More articles by this author Daniel Sjoberg More articles by this author Samson Fine More articles by this author James Eastham More articles by this author Peter Scardino More articles by this author Karim Touijer More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...