With the rapid development of urban rail transit, the environmental vibration and secondary noise induced by metro train operation have become increasingly serious, posing stricter requirements on the vibration and secondary noise of sensitive building office (SBO) and sensitive building school (SBS). To predict and control the vibrations and secondary noise in sensitive buildings along the metro line induced by metro train operations. A prediction method for the vibration and secondary noise of sensitive buildings along the metro line during metro train operation has been proposed. The sub-model of train-track system coupled dynamics and the sub-model of track-tunnel-soil-building system dynamics are included. The influence of metro train operation on the vibration and secondary noise of SBO and SBS is studied. The influence of the distance between the metro line and the building on the vibration and secondary noise of the sensitive building is discussed, and an effective control scheme of vibration and secondary noise is proposed. Results show that the vibration frequencies of the SBS and the SBO caused by the metro train operation are concentrated at about 8[Formula: see text]Hz and 63[Formula: see text]Hz. The vibration below the second floor of SBO caused by the metro train operation exceeds the limit, and the secondary noise below the third floor of SBS exceeds the limit. The secondary noise inside the building of each floor of SBO exceeded the limit. Using secondary noise to evaluate the environmental impact of metro train operations is more stringent than relying solely on vibration assessments. secondary noise is recommended in engineering to assess the impact of metro train operation on sensitive buildings along line. Combined with vibration, secondary noise and construction requirements, SBS and SBO are recommended to be no less than 72[Formula: see text]m and 74[Formula: see text]m away from the metro line, respectively.