As transitional territories where urban and rural functions interpenetrate, suburban areas have multiple values such as recreation, ecology, agriculture and landscape. Promoting their benign development is the key to realizing global sustainable development of urban and rural areas. Planning control is based on precisely defining the spatial extent of suburban areas, and understanding suburban area differentiation and its driving forces scientifically is a key component in raising the bar for focused planning. However, there are currently few research on fine-scale quantitative identification of suburban regions because of their spatial complexity, ambiguous boundaries, and structural dynamic features. Based on this, this paper develops a multi-dimensional identification index system for suburban areas by using multi-source big data and remote sensing information technology, employs the random forest model and the K-Medoids clustering algorithm, identifies the distribution of suburban areas and their subdivided types, analyzes spatial differentiation characteristics, and conducts empirical research using Chengdu City as an example. The findings demonstrate that: (1) The majority of suburban areas in Chengdu City are concentrated in groups or belts surrounding the urban centers of various districts and counties, and the higher the functional class of a district or county, the denser the distribution of suburban areas. (2)The distribution pattern of suburban areas in Chengdu basically conforms to its planned urban hierarchy system.(3)Urban-oriented, suburban-interacted and rural-oriented suburban areas have their own characteristics in land use level, economic development and regional population characteristics.(4)Regional openness, government behavior, social development and geographical location are the core driving factors of spatial differentiation of suburban areas in Chengdu, and the interaction between urban and rural systems, the flow of social resources and the transformation of development models are the spatial mapping dimensions that affect its differentiation.(5)Chengdu can draw up detailed regulatory planning of suburban units to standardize and guide the overall development of suburban areas. In support of the global sustainable development goals, this study offers a methodology for precisely and impartially defining suburban areas, assisting in the implementation of integrated urban-rural development globally.