Rural areas are characterized by sparse population, low population density, remoteness, and population aging, which can discourage startups and undermine their financial performance, as the theory of urban agglomeration economies suggests. However, many studies have shown that companies created in rural areas survive longer than those created in urban areas, which seems contradictory. This paper aims to identify the factors that explain this rural resilience. We analyzed all of the startups founded in Spain over 10 years. We used statistical matching methods to test for the effect of the location while controlling for founding conditions and environmental factors. Our study confirmed that few startups are created in rural areas and they grow less, but their survival rate is slightly higher than those established in urban areas. We found that high subsidies, low operating costs, high labor intensity, a slow but low-risk growth pattern, and other foundational conditions and external factors contribute to explaining rural resilience. Nonetheless, additional factors, including the traits of rural entrepreneurs and the lack of alternatives to bankruptcy, as proposed by the entrepreneurial opportunity theory, also matter.