The development of high-performance nano-luminophores based on luminescent nanomaterials, such as Carbon Nanotubes (CNT) and Quantum Dots (QDs), opens the doors for many potential improvements in luminescent systems and notably Optical Wireless Communication (OWC) systems. Other side, Cu2CdSnS4 quaternary alloy nanostructure has attracted attention in solar cell applications owing to the high optical absorption in visible range. This work presents the feasibility of the infrared uplink Visible Light Communication (VLC) system using Near Infrared Light Emitting Diode (NIR-LED) operating at 780 nm. The used NIR-LED-based Cu2CdSnS4 quaternary alloy nanostructure is to investigate the performance of NIR uplink transmission according to Line of Sight (LOS) channel model. In this transmission, the effect of transmitter orientation and transmitted optical power level with respect to Tx–Rx uplink distance are taken into consideration. For this purpose, performance evaluation will be achieved in terms of Bit Error Rate (BER) where we demonstrated satisfactory BER performance (BER≥10−9) over the entire typical room configuration. In addition, an optimal semi-angle interval and optimal Tx power level has been selected. We further investigated the performance improvement by using several transceivers, compared with a single one on the center of the ceiling.