Updated Literature Research Articles

Long-Term Efficacy and Safety of Bimekizumab and Other Biologics in Moderate to Severe Plaque Psoriasis: Updated Systematic Literature Review and Network Meta-analysis.

Biologic treatments have made complete skin clearance in moderate to severe plaque psoriasis a real possibility. Although clinical trials demonstrated the superiority of bimekizumab over secukinumab, adalimumab, and ustekinumab, direct comparisons with other biologics are not available. This systematic literature review (SLR) and network meta-analysis (NMA) aimed to evaluate the 1-year efficacy and safety of bimekizumab versus other biologic systemic therapies for moderate to severe plaque psoriasis. We conducted an SLR to retrieve published randomised controlled trials (RCTs) in patients with moderate to severe plaque psoriasis. We searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials and Cochrane Database of Systematic Reviews and PsycINFO on 13 January 2022. Two NMA types were used to analyse the long-term achievement of 100% improvement from baseline in Psoriasis Area and Severity Index (PASI100): (1) NMA of cumulative clinical benefits, based on the area under the curve, from week0 to 52; (2) multinomial NMA at weeks44‒60. Binomial NMA was used to evaluate long-term serious adverse events (SAEs). The SLR identified 38 RCTs, of which 19 were included in the NMA. Bimekizumab 320mg administered every 4weeks to week16 then every 8weeks (Q4W/Q8W) showed a greater cumulative average number of days of PASI100 response compared with all other biologics. These differences were statistically significant versus all biologics, except risankizumab 150mg. The multinomial NMA demonstrated that interleukin (IL)-17 and IL-23 inhibitors were the most efficacious treatments. No significant differences were found in long-term occurrence of SAEs. Bimekizumab 320mg Q4W/Q8W was superior to most other treatments in maintaining complete skin clearance during the first year of treatment. It demonstrated a greater cumulative average number of days with completely clear skin while displaying a comparable safety profile compared with all other biologics.

Variant reclassification over time decreases the level of diagnostic uncertainty in monogenic obesity: Experience from two centres.

The diagnosis of monogenic obesity is burdened by frequent variants of uncertain significance (VUS). We describe our real-life approach of variant reassessment over time and we assess whether inconclusive variants are decreasing in monogenic obesity. We tested for monogenic obesity (genes: LEPR, POMC, ADCY3, PCSK1, CARTPT, SIM1, MRAP2, LEP, NTRK2, BDNF, KSR2, MAGEL2, SH2B1, MC4R, MC3R) in 101 children/adolescents (11.7 [7.3-13.7] years, 3.6 [3.3-4.0] z-BMI) in Verona and 183 (11.3 [8.4-12.2] years, 3.2 [2.7-3.9] z-BMI) in Naples from January 2020 to February 2023. In March-July 2024 we reassessed the baseline variants by updated software interpretation and literature renavigation. We initially found 20 VUS, 4 Likely Pathogenic (LP), 5 Likely Benign (LB) and 1 benign variant in 33 individuals. At follow-up, 6 VUS were reclassified as benign/LB, one LP as pathogenic and 3 LB as benign. Overall, 10/30 variants (6/18 in Verona, 3/11 in Naples and a variant found in both centres) were reclassified, leading to a less uncertain report for 13 of 33 variant-carrying patients. Monogenic obesity was diagnosed in 3 probands in Verona and 4 in Naples, carrying variants at MC4R or NTRK2. Our variant reassessment was effective to improve classification certainty for the 39% of patients and suggested that the molecular diagnosis of monogenic obesity is becoming more accurate over time.

Customized Genioplasty and Advantages of 3D Virtual Planning: An Updated Literature Review.

Genioplasty is a surgical technique that modifies the projection of the chin in three dimensions to achieve symmetry and facial harmonization. Virtual 3D planning is increasingly used, supplanting the conventional surgical technique due to the precise and predictable results obtained.The definition of the objective of the study was first carried out using the PICO (Patient, Intervention, Comparison, Outcome) question method. Posteriorly, an updated literature review was carried out in the "PubMed" database using the keywords "Genioplasty and Virtual 3D Planning," obtaining 11 articles for the study with the objective of defining the advantages and disadvantages of performing a virtually planned genioplasty, comparing it with the conventional technique.In the results, it is observed that virtually planned genioplasty presents greater precision, a reduction in surgical time, and a lower rate of complications than the conventional technique. Virtual planning using computer-aided design/computer-aided manufacturing technology presents good reproducibility in the patient with <2 mm variations between what was planned and what was obtained postoperatively, with statistically significant results (p < 0.001).In conclusion, virtually planned genioplasty with customized cutting guides and osteosynthesis plates achieves very precise surgery results with good reproducibility, reducing surgical time, intraoperative complications, and the difficulty of the surgical technique.

Accelerating Evidence Synthesis in Observational Studies: Development of a Living Natural Language Processing-Assisted Intelligent Systematic Literature Review System.

Systematic literature review (SLR), a robust method to identify and summarize evidence from published sources, is considered to be a complex, time-consuming, labor-intensive, and expensive task. This study aimed to present a solution based on natural language processing (NLP) that accelerates and streamlines the SLR process for observational studies using real-world data. We followed an agile software development and iterative software engineering methodology to build a customized intelligent end-to-end living NLP-assisted solution for observational SLR tasks. Multiple machine learning-based NLP algorithms were adopted to automate article screening and data element extraction processes. The NLP prediction results can be further reviewed and verified by domain experts, following the human-in-the-loop design. The system integrates explainable articificial intelligence to provide evidence for NLP algorithms and add transparency to extracted literature data elements. The system was developed based on 3 existing SLR projects of observational studies, including the epidemiology studies of human papillomavirus-associated diseases, the disease burden of pneumococcal diseases, and cost-effectiveness studies on pneumococcal vaccines. Our Intelligent SLR Platform covers major SLR steps, including study protocol setting, literature retrieval, abstract screening, full-text screening, data element extraction from full-text articles, results summary, and data visualization. The NLP algorithms achieved accuracy scores of 0.86-0.90 on article screening tasks (framed as text classification tasks) and macroaverage F1 scores of 0.57-0.89 on data element extraction tasks (framed as named entity recognition tasks). Cutting-edge NLP algorithms expedite SLR for observational studies, thus allowing scientists to have more time to focus on the quality of data and the synthesis of evidence in observational studies. Aligning the living SLR concept, the system has the potential to update literature data and enable scientists to easily stay current with the literature related to observational studies prospectively and continuously.

Pharmacological interventions for co-occurring psychopathology in people with borderline personality disorder: secondary analysis of the Cochrane systematic review with meta-analyses.

Medications are commonly used to treat co-occurring psychopathology in persons with borderline personality disorder (BPD). To systematically review and integrate the evidence of medications for treatment of co-occurring psychopathology in people with BPD, and explore the role of comorbidities. Building on the current Cochrane review of medications in BPD, an update literature search was done in March 2024. We followed the methods of this Cochrane review, but scrutinised all identified placebo-controlled trials post hoc for reporting of non BPD-specific ('co-occurring') psychopathology, and explored treatment effects in subgroups of samples with and without defined co-occurring disorders. GRADE ratings were done to assess the evidence certainty. Twenty-two trials were available for quantitative analyses. For antipsychotics, we found very-low-certainty evidence (VLCE) of an effect on depressive symptoms (standardised mean difference (SMD) -0.22, P = 0.04), and low-certainty evidence (LCE) of an effect on psychotic-dissociative symptoms (SMD -0.28, P = 0.007). There was evidence of effects of anticonvulsants on depressive (SMD -0.44, P = 0.02; LCE) and anxious symptoms (SMD -1.11, P < 0.00001; VLCE). For antidepressants, no significant findings were observed (VLCE). Exploratory subgroup analyses indicated a greater effect of antipsychotics in samples including participants with co-occurring substance use disorders on psychotic-dissociative symptoms (P = 0.001). Our findings, based on VLCE and LCE only, do not support the use of pharmacological interventions in people with BPD to target co-occurring psychopathology. Overall, the current evidence does not support differential treatment effects in persons with versus without defined comorbidities. Medications should be used cautiously to target co-occurring psychopathology.

The Role of International Normalized Ratio (INR) in Heart Failure Patient With Sepsis: Hidden in Plain Sight

Heart failure is a clinical syndrome characterized by symptoms and signs caused by a structural and/or functional impairment of the heart. Sepsis in heart failure may cause significant mortality and morbidity rates. Clinically, the presence of heart dysfunction in heart failure worsens outcomes in unstable hemodynamic conditions, for instance, in cases of sepsis, particularly in patients with HFrEF. This research aims to survey the blend of heart failure and sepsis and current updates regarding using the International Normalized Ratio (INR) to detect sepsis. Information was collected from various sources, and updated literature was compiled into a review article. The presence of heart failure with sepsis is associated with horrible clinical results. If fluid alone is insufficient to restore perfusion, the fundamental structure of sepsis includes strong fluid recovery followed by vasopressor association (and possibly inotropic support). In any case, in patients with heart failure, high-portion fluid boluses and vasoactive experts might deteriorate the condition. Heart failure and sepsis can overlap and lead to hemodynamic disturbances and challenging treatment. Meanwhile, aggressive fluid resuscitation is necessary for sepsis; conventional heart failure management requires reducing fluid intake. The International Normalized Ratio (INR) is one of the coagulation parameters that may help determine sepsis in patients with heart failure, thus improving appropriate diagnosis and treatment.

A Report of a Rare Case of Vagococcus fluvialis Isolated From Urine: Clinical Significance of Vagococcus Species With an Update of the Available Literature

A Report of a Rare Case of Vagococcus fluvialis Isolated From Urine: Clinical Significance of Vagococcus Species With an Update of the Available Literature

Patient motivation: A concept analysis.

Patient motivation is crucial in maintaining health-improving activities and helping patients recover from illnesses. Despite extensive research on patient motivation, this concept has not been clearly defined and remains ambiguous. The latest analysis of patient motivation was over two decades ago, thus necessitating the need to reexamine it in more updated literature. This study aims to explore the concept of patient motivation. The eight-step approach of Walker and Avant was used: concept selection, determining analysis aim, identifying concept use, defining attributes, model case identification, borderline and contrary case identification, antecedents and consequences identification, and empirical referent identification. Five databases, CINAHL, Cochrane, Medline, PubMed, ProQuest, and ScienceDirect, were searched for published works between 2014 and 2024 using the keywords "patient" and "motivation." The identified attributes of patient motivation are a psychological drive, a desire to adopt healthy behaviors, and goal-directed action. Antecedents of patient motivation are self-efficacy, provider-patient communication, and social support. Patient motivation leads to consequences, including healthier lifestyles and greater adherence and compliance. The present concept analysis draws upon current literature to suggest the antecedents, attributes, and consequences of patient motivation. Nurses can promote healthier lifestyles and greater adherence and compliance among patients by employing techniques to raise self-efficacy and provide social support while enhancing patient-centered interactions.

Little-known Saniculeae genera: phytochemical studies and pharmaceutical activities

AbstractThis work initiates the original and updated literature review of the current state of research on the Saniculoideae subfamily, emphasizing the selected genera Saniculeae, namely Sanicula, Hacquetia, Astrantia, and Eryngium. Various parts of these plants, especially aerial parts and roots, have an immense range of medicinal uses in traditional medicine for a number of ailments. Phytochemical studies conducted on the Saniculeae species indicate that these plants synthesize metabolites belonging to diverse groups of compounds. These include triterpenoid saponins, flavonoids, phenolic acids, coumarins, volatile organic compounds, polyacetylenes, ecdysteroids, phytosterols, lignans, betaines, carotenoids, and anthraquinones. Some of the structures of these compounds are rare in the plant kingdom. The pharmacological potential of the Saniculeae species as antioxidant, anti-inflammatory, antimicrobial, antiviral, antiprotozoal, antitumor, antidiabetic, hypocholesterolemic, and neuroprotective agents has been explored in several studies. In addition, traditional medicinal uses have been discussed to provide a comprehensive picture of this subfamily. It is known that these plants have been used to treat dermatological diseases, respiratory issues, gastrointestinal problems, inflammations, wound healing, and cancers. As far as the author is aware, this is the first study conducted on this subfamily. Therefore, this review paper is the first to examine the little-known Saniculeae genera regarding their phytochemical and pharmacological characteristics. Studies showed that Saniculeae genera synthesize distinct secondary metabolites. Therefore, further research should be conducted on the exploration of these metabolites. The pharmacological investigation should also validate their potential efficacy in treating specific ailments and support their inclusion in modern healthcare practices.

Analysis of the Midwifery Profession According to the Fields of Philosophy: Qualitative Study

Objective: Philosophy contributes to the formation of new strategies by affecting the development of questioning ability. Philosophy should be utilized to question the current situation and develop new strategies in midwifery. The study analyzes the midwifery profession according to the fields of philosophy, ontology, epistemology, and axiology. Methods: The qualitative type of research is conducted between May 20, 2021, and August 30, 2021. The research is carried out with 12 participants who were selected by the maximum diversity sampling technique. The data are collected face-to-face with the participant information form and the semi-structured interview form. The data recorded during the interview is evaluated thematically through content analysis. Results: In the research, three themes are identified: professional health discipline from an ontological point of view; development of midwifery knowledge and practices from an epistemological point of view; and professional and individual values from an axiological point of view. Conclusion: In this study, it is stated that the midwifery profession is essential and sacred, that it should have professional knowledge and updated literature, and that women should be with them every period since birth.

Multidisciplinary Management of Pregnancy-Associated Breast Cancer.

Breast cancer during pregnancy is uncommon; however, it is one of the most common malignancies affecting pregnant women. Pregnancy-associated breast cancer (PABC) is a complex entity characterized by unique risk factors, presentation, and pathology. Furthermore, although management generally aims to mirror that for nonpregnant patients, there are distinct aspects of oncologic care delivery specific to PABC. The focus is on optimizing maternal outcomes while maximizing maternal and fetal safety. A multidisciplinary approach is key, and the timing of various treatment modalities is critical. Postdelivery care and counseling are also imperative to address issues such as contraception, breastfeeding, and future fertility. In the present review, we discuss the current knowledge base and the diagnostic and treatment landscape for PABC, including recent literature and practice pattern updates.

Athletic Identity and Sport Injury Processes and Outcomes in Young Athletes: A Supplemental Narrative Review.

Background: Identity formation, a primary developmental task of adolescence, may be particularly relevant to another commonly occurring event for young athletes-sport injury. Relationships between a subdimension of self-identity-athletic identity-and sport injury processes and outcomes have been documented in the general athlete population. The purpose of this supplemental narrative review is to explore the potential role of athletic identity in the risk of injury occurrence and responses to and consequences of injury among young athletes. Methods: Studies on athletic identity in relation to sport injury, with a focus on young athletes, were extracted from a recent scoping review and identified through an updated literature search from April 2020 through June 2024. A total of 23 studies were examined. Results: Across the studies reviewed, high levels of athletic identity were associated with a reluctance to report injury-related symptoms, a tendency to endorse attitudes and behaviors reflecting a willingness to play through pain and injury, intensified physical and psychological symptoms after injury, a disposition toward over-adhering to rehabilitation, high levels of postinjury coping skills, and better functional and return-to-sport outcomes after injury among young athletes. Conclusions: Athletic identity may, therefore, be a source of both strength and vulnerability in young athletes in terms of sport injury processes and outcomes.

Seprafilm® and adhesive small bowel obstruction in colorectal/abdominal surgery: an updated systematic review

BackgroundThe efficacy of Seprafilm® in preventing clinically significant adhesive small bowel obstruction (ASBO) is controversial and deserves further review. The aim of this review was to assess the utility of Seprafilm® in preventing clinically significant adhesive bowel obstruction after abdominal operations, with separate focus on colorectal resections. The secondary aim was to provide an updated literature review on the safety profile of this implant.MethodsAn up-to-date systematic review was performed on the available literature between 2000 and 2023 on PubMed, EMBASE, Medline, and Cochrane Library databases. The main outcome measures were rates of adhesive bowel obstruction, as well as rates of intervention. The secondary outcome was the clinical safety profile of Seprafilm® as described in current literature.ResultsA total of 17 observational studies were included, accounting for 62,886 patients. Use of Seprafilm® was associated with a significant reduction in adhesive bowel obstruction events (OR 0.449, 95% CI: 0.3271 to 0.6122, p < 0.001), with preserved efficacy seen in laparoscopic cases. This did not translate into a reduced rate of reintervention. Clinicians should also be aware of isolated reports of a paradoxical inflammatory reaction leading to fluid collections after Seprafilm® use, although they appear uncommon.ConclusionSeprafilm® can be considered in select patients although further study to determine which patients will benefit most is required.

Scaphocapitate Arthrodesis for Wrist Deformities: A Systematic Review.

Scaphocapitate arthrodesis (SCA) is a described technique for chronic wrist pathology such as Kienbock disease and carpal instability. The technique aims to preserve motion, while maintaining carpal height, preserving the radioscaphoid articulation, and offloading the lunate. Limited case series evaluate the outcomes of this previously described technique. We aim to determine if the collective, updated literature on outcomes of SCA support its continued application by the wrist surgeon. Furthermore, we investigated if any technical variations offer an advantage in improving patient-reported outcomes after SCA. A literature search was performed using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Articles selected for critical review were examined for patient demographic data, functional outcomes, radiographic outcomes, and complications. A qualitative analysis was then performed to synthesize the available date. A total of 18 unique articles published between 1991 and 2022 were identified, representing a total of 285 individual cases of SCA. Nonunion rate ranged 0%-22%. Preoperative visual analog scale pain scores ranged from 3.2 to 10, whereas postoperative visual analog scale pain scores ranged from 0 to 4. Patient-reported outcomes are reported by validated instruments, including the Disabilities of the Arm, Shoulder, and Hand, QuickDASH, Patient-rated Wrist Evaluation, and Mayo Wrist Score. SCA is a viable treatment option for patients with Kienbock disease. SCA offers reliable improvements in patient pain, grip strength, and patient-reported outcomes.

Updates to Incontinence After Prostate Treatment: AUA/GURS/SUFU Guideline (2024).

In 2023 the American Urological Association (AUA) requested an Update Literature Review (ULR) to incorporate new evidence generated since the 2019 publication of this Guideline. The resulting 2024 Guideline Amendment addresses updated recommendations to provide guidance for the care of patients with incontinence after prostate treatment (IPT). In 2023, the IPT Guideline was updated through the AUA amendment process in which newly published literature is reviewed and integrated into previously published guidelines. There were 82 studies of interest initially identified in preliminary abstract review. Following full-text review, 17 studies met inclusion criteria and ultimately informed the statements of interest. The Panel developed evidence- and consensus-based statements based on an updated review to provide guidance for the care of patients who experience IPT. These updates are detailed herein. As prostate treatments are refined, a decreasing incidence of incontinence is anticipated. This Guideline will require further review as the diagnostic and treatment options for patients with IPT continue to evolve.

Major Publications in the Critical Care Pharmacotherapy Literature: 2023.

We aimed to summarize the most significant and impactful publications describing the pharmacotherapeutic care of critically ill patients in 2023. PubMed/MEDLINE and the Clinical Pharmacy and Pharmacology Pharmacotherapy Literature Update. Randomized controlled trials and prospective studies of adult critically ill patients assessing a pharmacotherapeutic intervention and reporting clinical endpoints published between January 1, 2023, and December 31, 2023, were eligible for inclusion in this article. Articles from a systematic search and the Clinical Pharmacy and Pharmacology Pharmacotherapy Literature Update were included. An a priori defined three-round modified Delphi process was employed to achieve consensus on the most impactful publications based on the following considerations: 1) overall contribution to scientific knowledge and 2) novelty to the literature. The systematic search and Clinical Pharmacy and Pharmacology Pharmacotherapy Literature Update returned a total of 1202 articles, of which 1164 were excluded. The remaining 38 articles underwent a three-round modified Delphi process. In each round, articles were independently scored based on overall contribution to scientific knowledge and novelty to the literature. Included articles are summarized and their impact discussed. Article topics included hydrocortisone for severe community-acquired pneumonia, inhaled amikacin for prevention of ventilator-associated pneumonia, methylene blue for septic shock, restrictive vs. liberal fluid management for sepsis-induced hypotension, andexanet alfa for major bleeding associated with factor Xa inhibitors, and early administration of four-factor prothrombin complex concentrate in patients with trauma at risk for massive transfusion. This review provides a summary and perspective on the potential impact of the most relevant articles in 2023 describing advances in the pharmacotherapeutic care of critically ill patients.

Sustainable public procurement for supply chain resilience and competitive advantage

Public procurement plays a crucial role in national economies, as it represents a significant share of public spending. Governments can thus use this considerable purchasing power to promote environmental sustainability, social responsibility, and economic efficiency, while encouraging the supplier market to innovate and adopt more sustainable practices to remain competitive, and to generate more resilient supply chains. Given the interdisciplinary nature of the subject of sustainable public procurement (SPP), the documentation is abundant and diverse, hence the need for an updated literature review especially in the aftermath of the COVID-19 crisis period. This article consists of a systematic literature review focusing on articles with an empirical approach. The results reveal, among other things, 8 main research themes subdivided into 19 sub-themes, with a dominance of literature on the obstacles and incentives related to the implementation of SPP, while those concerning e-procurement and the analysis of the social life cycle remain relatively limited. The study also underscores the role of local economies and SMEs in public procurement strategies. It highlights a trend towards geographical diversification, indicating the global significance of SPP, with noticeable differences in adoption between developed and developing countries. The review calls for future research to focus on developing practical frameworks and tools for integrating sustainability more comprehensively in public procurement. The findings illuminate the pivotal role of SPP as a mechanism steering societies towards a sustainable, resilient, and equitable future, particularly in a post-pandemic world.

The Effects of Smoking on Dental Implant Failure: A Current Literature Update.

Background: This systematic review assesses the current literature (2020-2024) evaluating the impact of smoking on dental implant failure rates. Methods: A non-funded Pubmed database review was conducted according to PRISMA guidelines, and the results were tabulated to extract the study design, patient characteristics, follow-up time, comparison, outcome, and strengths and weaknesses, including risk of bias. This review included 33 studies with 29,519 implants placed in over 18,301 patients. We included prospective and retrospective clinical studies, randomized and non-randomized controlled trials, cohort studies, and observational studies that examined smoking's effects on implant failure rates. Studies had to classify individuals into two groups, smokers and non-smokers, with at least ten implants. Exclusions included reviews, case reports, experimental studies, guidelines, non-English publications, studies lacking comparative data on failure rates, those excluding smokers, and studies focusing on head and neck cancer patients or specialized implants. Results: Our findings indicate a significant correlation in 25 out of 33 studies between smoking and increased implant failure rates, affecting both early and late stages of implant integration and survival as well as revealing a dose-response relationship, with higher daily cigarette consumption significantly increasing the risk of implant failure. Conclusions: This review highlights the importance of smoking cessation efforts, patient education, and tailored patient care in dental implantology. Future research should explore the effects of smoking frequency and alternative tobacco products, such as e-cigarettes, aiming to improve success rates among smokers.

Peritonsillar Abscess: An Update on Diagnosis and Medical-Surgical Management. A Review of the Literature and Case Report

Introduction: Peritonsillar abscess is an acute pharyngeal infection located between the tonsillar capsule and the aponeurosis of the superior constrictor muscle of the pharynx, being an important cause of consultation in emergency services. Its management includes antibiotic treatments and/or emptying of the abscess. Objective: To describe the diagnosis and medical-surgical management of a 47-year-old male patient with peritonsillar abscess; Regarding the case, a review of the updated literature on the topic was carried out. Method: Presentation of the case report: 47-year-old male patient, who attended the Libertador Bernardo O'Higgins Regional Hospital due to increased tonsillar volume. Sudden onset. Clinically, guttural voice, odynophagia, dysphagia, trismus and intermittent fever were notable. Discussion: After the clinical, imaging and laboratory study, a diagnosis of peritonsillar abscess was reached, which underwent medical-surgical management, presenting satisfactory evolution of this case, a review of the literature was carried out in the last 10 years in Spanish. English in the search engines PubMed and Science Direct. Conclusions: Surgical management of peritonsillar abscess continues to be the treatment of choice; however, based on the review of the literature that was carried out, medical management can also be chosen in some cases.

Review of best practices for global cogeneration policy: Benchmarking and recommendations for Malaysia

Despite the Malaysian government's efforts to promote cogeneration technology, it constitutes a mere 4.2 % of the country's total electricity generation. To address this issue, this review article aims to identify and benchmark global best practices for bolstering cogeneration implementation in Malaysia. While previous studies in this domain have centered on examining government policies within the specific regions, this paper underscores the imperative for an updated and comprehensive literature review to systematically collect and categorise best practices from around the world. This work examines the adoption of cogeneration energy systems within nations characterised by a substantial presence in their energy composition, simultaneously exploring the roles of regulatory frameworks in promoting their uptake. The scope of the literature review includes statistical data, reports, and other relevant scholarly works on cogeneration policies. Based on the findings, the review paper concludes that well-crafted policies are instrumental in encouraging rapid technology advocacy. The legislative landscape pertaining to cogeneration implementation in Malaysia is scrutinised, followed by a comparative analysis against global best practices to identify opportunities for improvement. Three crucial elements emerge as paramount to expediting the adoption: (i) administrative recognition, (ii) financial initiatives, and (iii) regulatory improvements. Several recommendations for the Malaysian cogeneration roadmap are presented. Overall, this paper offers insights into the chronological evolution of cogeneration policy development and provides actionable guidelines for developing effective policies in Malaysia and other South-East Asian countries.