Unwanted States Research Articles

Adding metabolic tasks to human GEM models to improve the study of gene targets and their associated toxicities

Genetic minimal cut sets (gMCS) are genes that must be deactivated simultaneously to avoid unwanted states in a metabolic model. The concept of gMCS can be applied to two different scenarios. First, it can be used to identify potential gene toxicities in generic or healthy cell models. Second, it can be used to develop genetic strategies to target cancer cells and prevent their proliferation. Up to now, gMCS have been evaluated using the traditional procedure of preventing biomass production. This paper proposes an additional way: using essential metabolic tasks, which any human cell should perform, to enlarge the set of unwanted states. Including this addition can significantly improve the study of toxicities and reveal targets that can be used to treat unhealthy cells. Excluding metabolic tasks can cause important information to be overlooked, which could impact the study’s success. Regarding toxicities, using the generic Human model, the number of detected generic toxicities with metabolic tasks increases from 106 to 281 (136 gMCSs of length 1 and 49 of length 2). We have used the following context-specific models to evaluate specific toxicities in different healthy tissues: blood, pancreas, liver, heart, and kidney. Again, considering metabolic tasks, we have found new toxicities (lengths 1 and 2) whose inactivation could damage these healthy tissues.Our research strategy has been applied to identify new cancer drug targets in two myeloma cell lines. We obtained new therapeutic targets of lengths 1 and 2 for each cell line. After analyzing the data, we conclude that incorporating metabolic tasks into cancer models can reveal important therapeutic targets previously disregarded by the conventional method of inhibiting biomass production. This approach also improves the evaluation of potential drug toxicities.

Quadratic acceleration of multistep probabilistic algorithms for state preparation

Quantum state preparation is a fundamental building block for various problems on a quantum computer. A nonunitary operator is typically designed to decay unwanted states contained in an initial state using ancilla qubits and a probabilistically action. In this Letter, we clarify that this probabilistic nature is a drag for quantum advantages: The probabilistic algorithms do not accelerate the computational process compared to classical ones. Combining quantum amplitude amplification (QAA) with multistep probabilistic algorithms is proposed to address this drawback, achieving quadratic acceleration and quantum advantages. We also find that the multistep probabilistic method with QAA exhibits advantages over quantum phase estimation in terms of infidelity. We also demonstrate it to confirm the quadratic acceleration, using a probabilistic imaginary-time evolution method as an example. Published by the American Physical Society 2024

Систематизація та обґрунтування рекреаційних механізмів сміху в системі особистості

B a c k g r o u n d . A theoretical and methodological analysis of approaches to recreational laughter mechanisms is presented. Laughter is regarded as an individual psycho-physiological reaction to a certain unexpected situation that is formed based on emotionally colored personal senses and value ideas, shown in various expressions of joy. M e t h o d s . Given the multilevel phenomenon, the mechanisms of its influence on the individual are analyzed in the context of philosophical, theological, cultural, pedagogical, psychophysiological, and psychological (social) approaches. Theoretical research methods were used: analysis of scientific sources on the research topic, system analysis, synthesis, generalization of scientific approaches, classification and specification of laughter mechanisms in the personality system. R e s u l t s . In the context of the restorative mechanisms of laughter, its connection with direct play and joy arising in the process and accompanied by release, relief, satisfaction, and relaxation, helping to go beyond the ordinary, is considered. It has been revealed that laughter is also one of the ways for the soul to realize and liberate itself through release from fears and mental tension. It has also been proven that laughter serves as a certain stimulator of brain activity, activates imagination and fantasy, that is, promotes creativity. It is substantiated that laughter is a necessary element of stress relief, has a restorative and regenerative effect on the physical and psycho-emotional state, acts on the physiological and hormonal levels, activates the frontal, motor lobes, brain stem and cortex, hippocampus, thalamus and limbic system. It is argued that during laughter a spastic effect is realized, it affects the regulation of breathing, unites the physical and mental principle. C o n c l u s i o n s . It was determined that laughter, as an important personal resource of interaction with other people, plays a special role in the prevention and correction of unwanted stress states of the individual. It has been found that it greatly helps a person to adapt to various unexpected situations, because laughter unites people, helps to free oneself from the influence of fears, anxieties and doubts and allows to manifest the true qualities laid down from birth, such as love, clarity of perception, compassion, joy, enthusiasm, gratitude and wisdom. Laughter can help you make good decisions and show kindness in your actions.

Stochastic optimal control of mesostructure of supramolecular assemblies using dissipative particle dynamics and dynamic programming with experimental validation

The self-assembly process, where molecules form complex structures through interaction forces, has broad applications in various fields. However, controlling the dynamics of self-assembling molecules presents challenges, such as kinetic trapping, and the stochastic and nonlinear nature of governing equations. Recent studies have used Markov decision processes to control self-assemblies, but this approach may not be suitable for more complex systems and may result in disassembly or irreversible changes. To address these limitations, a novel integrated framework for the systematic development of control schemes for self-assembling systems is proposed. The framework uses a dissipative particle dynamics model to accurately capture self-assembly and generate a high-fidelity representation of relevant nanostructures. The probabilities of transitioning between states are calculated, which enables the formulation of a stochastic optimal control problem. To solve this problem, dynamic programming is employed. The framework is applied to a case study involving dynamic binary complexes with multiple unwanted metastable states, which serves to experimentally demonstrate the efficacy of the controller in driving the system towards desired morphologies. Finally, the closed-loop simulation results highlight that the proposed framework can drive the system of thermosensitive DBCs towards target morphologies while avoiding kinetic traps.

Excited State Dynamics of a Conformationally Fluxional Copper Coordination Complex.

The conversion of solar energy into chemical fuel represents a capstone goal of the 21st century and has the potential to supply terawatts of power in a globally distributed manner. However, the disparate time scales of photodriven charge separation (∼fs) and steps in chemical reactions (∼μs) represent an inherent bottleneck in solar-to-fuels technology. To address this discrepancy, we are developing earth-abundant coordination complexes that undergo light-induced conformational rearrangements such that charge separation (CS) is hastened, while charge recombination (CR) is slowed. To these ends, we report the preparation and characterization of a new series of conformationally fluxional copper coordination complexes that contain a twisted intramolecular charge transfer (TICT) fluorophore as part of their ligand scaffold. Structural and spectroscopic characterization of the Cu(I) and Cu(II) complexes formed with these ligands in their ground states establish oxidation state-dependent conformational dynamicity, while time-resolved emission and transient absorption spectroscopies define the photophysical parameters of photo-induced excited states. Building on initial reports with a related set of molecules, the improved ligand design presented here greatly simplifies the observed photophysics, effectively shutting down unwanted ligand-centered excited states previously observed. Time-dependent density functional theory (TDDFT) analyses reveal an unusual metal-to-TICT electronic transition only reported once before, and though the formation of a CS state is not observed directly through experiments, TDDFT geometry optimizations in the excited states support the formation of transient Cu(II) CS species, lending credence to the potential success of our approach. These studies establish a clear model for the excited state dynamics at play in proof-of-concept systems and clarify key design parameters for future optimizations toward achieving long-lived CS via photoinduced conformational gating.

Achushana (sucking of blood): An emergency management of snakebite

Snakebite has been considered as a burning and difficult situation not only for the affected individuals but also for the doctors. An individual, seeing the snake feels terrified. When there is bite by a snake one feels that the life is in danger now and death is unavoidable. This is, as evidence say, the main cause of death due to snakebite. So a patient with snakebite when comes to the physician shows the serious signs and symptoms and the physician also faces dilemma in diagnosis which is the prime important factor to become success. A patient of snakebite commonly visits the physician with a huge number of attendants with anxiety, fear and lots of questions. This makes the situation more confusing and even the physician has to take tension. Ayurveda is unanimously agreed to be the most ancient health science dealing with almost all unwanted states of health (disease). The great scholars and founders of Ayurveda, along with the medical and surgical disease conditions, also discuss poisoning with priority. Among all the poisonings snakebite is considered to be potent one which need prompt action of the physician in absence of which the life of the patient may be lost. The Ayurvedic scholars Charaka, Susruta and Bagbhata very nicely describe the seriousness of snakebite (SARPADANGSA) and advice to take step to prevent the spread of the bisha by following a number of procedures. Out of all one procedure is (ACHUSHANA) which is said to apply with the aim to expel out the poison contaminated blood by applying sucking. This procedure is not supported by the modern Toxicologists. Hence, a discussion on the topic is seemed to have importance. Hope this discussion will be able to convey information not only to the Ayurvedic fraternity but also to the Modern field with a message to re-evaluate the concept in modern scientific character.

The establishment, maintenance, and adaptation of high- and low-impact chronic pain: a framework for biopsychosocial pain research.

The establishment, maintenance, and adaptation of high- and low-impact chronic pain: a framework for biopsychosocial pain research.

Tickling and its effects on the affective states of laying hens

Human-animal interactions may significantly influence the productivity and welfare of animals in the livestock industry. The nature of manipulation influences the physiology and behaviour of animals positively or negatively. To improve animal welfare, it is important to not only reduce unwanted negative states (fear, pain, suffering) but also to induce positive affective states in animals. Tickling has been described in multiple studies to evoke positive affective states in rats. We tested whether a similar form of tactile stimulation induces changes in the valence of affective states of laying hens using an operant judgement bias test. Sixteen laying hens housed in deep litter pens were divided into two groups with different forms of manipulation: a handled group (n = 8) or a tickled group (n = 8). First, the animals were trained to discriminate between the positive (PS, pecks rewarded with mealworms) and negative stimuli (NS, pecks punished with white noise) in a visual discrimination task (Go/NoGo). They were then subjected to the judgement bias test, in which responses to PS, NS and ambiguous middle stimulus (MS) were recorded. All hens successfully learned to discriminate between PS and NS. The treatment did not induce changes in judgement bias test performance. Tickling in the manner we administered it and applied in adulthood, did not appear to be perceived by hens as a positive event. The treatment did not affect judgement because the behavioural assay was not sensitive enough to detect a possible effect, or chickens did not find the tickling as administered to be positive enough. Perhaps the other more playful interactions with hens, a larger dosage or the treatment at an early period of life could have greater impact.

Methods for high-precision determinations of radiative-leptonic decay form factors using lattice QCD

We present a study of lattice-QCD methods to determine the relevant hadronic form factors for radiative-leptonic decays of pseudoscalar mesons. We provide numerical results for ${D}_{s}^{+}\ensuremath{\rightarrow}{\ensuremath{\ell}}^{+}\ensuremath{\nu}\ensuremath{\gamma}$. Our calculation is performed using a domain-wall action for all quark flavors and on a single RBC/UKQCD lattice gauge-field ensemble. The first part of the study is how to best control two sources of systematic error inherent in the calculation, specifically the unwanted excited states created by the meson interpolating field and unwanted exponentials in the sum over intermediate states. Using a 3D sequential propagator allows for better control over unwanted exponentials from intermediate states, while using a 4D sequential propagator allows for better control over excited states. We perform individual analyses of the 3D and 4D methods, as well as a combined analysis using both methods, and find that the 3D sequential propagator offers good control over both sources of systematic uncertainties for the smallest number of propagator solves. From there, we further improve the use of a 3D sequential propagator by employing an infinite-volume approximation method, which allows us to calculate the relevant form factors over the entire allowed range of photon energies. We then study improvements gained by performing the calculation using a different three-point function, using ratios of three-point functions, averaging over positive and negative photon momentum, and using an improved method for extracting the structure-dependent part of the axial form factor. The optimal combination of methods yields results for the ${D}_{s}^{+}\ensuremath{\rightarrow}{\ensuremath{\ell}}^{+}\ensuremath{\nu}\ensuremath{\gamma}$ structure-dependent vector and axial form factors in the entire kinematic range with statistical plus fitting uncertainties of order 5%, using 25 gauge configurations with 64 samples per configuration.

Negative urgency, PTSD symptoms, and alcohol risk in college students

IntroductionTheoretical models of trauma and alcohol use suggest that trauma-exposed individuals with higher levels of PTSD symptoms are at increased risk of problematic and coping-oriented alcohol use to alleviate unwanted internal states. The goal of the current study was to evaluate whether these associations are enhanced among young adults who report engaging in impulsive behavior in the context of negative affect (i.e., high negative urgency). It was hypothesized that (a) higher negative urgency would be associated with problematic alcohol use; and that (b) negative urgency would moderate the association between PTSD symptoms and problematic alcohol use. Methods: This studyused across-sectional, secondary data analysisdesign run on 213 participants: college students, ages 18–25, who endorsed both having an interpersonal traumatic event and current weekly alcohol use. Participants completed a series of assessments and self-report questionnaires. Results: Results of hierarchical linear regression models indicated that greater negative urgency was significantly associated with greater negative alcohol-related consequences and greater coping motives for alcohol, but not past 30-day binge frequency or past 30-day alcohol quantity. Negative urgency did not moderate associations between PTSD symptoms and alcohol outcomes. Conclusions: PTSD symptoms and negative urgency are uniquely associated with indices of alcohol risk in college students with a history of trauma exposure. However, individuals high in negative urgency are not necessarily consuming more alcohol, nor does negative urgency increase the association between PTSD symptoms and drinking outcomes in this population.

Tunter: Assessing Exploitability of Vulnerabilities with Taint-Guided Exploitable States Exploration

Assessing the exploitability of vulnerabilities is critical for defenders. But the vulnerability-triggering samples available for analysts often do not trigger exploitable states, making it hard to accurately assess whether the underlying vulnerabilities are exploitable. Several customized fuzzing solutions have been proposed to address this problem, by searching for new vulnerability-triggering test cases that can enter exploitable program states. However, such solutions are inefficient and in general take an overwhelmingly long time to find exploitable states, due to the large number of program paths to explore and complicated path constraints to satisfy. In this paper, we present a new automated solution Tunter to assess the exploitability of vulnerabilities. It could explore exploitable program states and generate working exploits, even if only non-exploitable vulnerability-triggering samples are given. It adopts two novel techniques: (1) a taint-guided exploration procedure to explore candidate exploitable states; and (2) a pruning mechanism to prune unwanted states for exploitation to alleviate the state explosion issue faced by symbolic execution. We have implemented a prototype of Tunter and evaluated it on 14 capture-the-flag (CTF) programs and two real-world applications. The experimental results demonstrate that it has significant performance than state-of-the-art solution Revery (Wang et al., 2018). Specifically, it finds exploitable states for these 16 programs with a 75% recall and an 88.9% precision, and eventually generates working exploits for 11 out of these 16 programs. Moreover, Tunter is 41.02 times faster than Revery.

Robust quantum state transfer by optimal invariant-based reverse engineering

Shortening the operation time of implementing scheme and reducing the influence of harmful factors have always been the research objectives pursued by people. Based on invariant-based reverse engineering, we present a general scheme for implementing robust population transfer in a three-level system via optimal shortcut to adiabatic passage. The systematic error sensitivity is introduced to measure the robustness of the process. The smooth Rabi frequencies are expressed with some coefficients, which are also related to the systematic error sensitivity and the population of intermediate state. When the amplitude of control field is given, the transfer can be optimized within as small systematic error sensitivity as possible, i.e., the robustness against systematic errors is further improved by choosing suitable correlation coefficient. Additionally, we apply the technique to achieve robust excitation fluctuation transfer between two membranes in an optomechanical system. The relation between the fidelity of excitation fluctuation transfer and variation of effective optomechanical coupling strengths is analysed. Numerical result shows that the fidelity keeps over 0.95 even if the coupling strengths deviates from 20% of the theoretical value. Moreover, comparison with existing literature [Opt. Express29, 7998 (2021)10.1364/OE.417343], the proposed scheme possesses stronger robustness against variations of effective optomechanical coupling strengths and lower population of unwanted states. The idea may provide a promising approach for quantum information processing.

Efficient state-symmetric beamsplitters and mirrors for atom interferometers using optimized pulses

Atom interferometers that employ atoms in superpositions of different electronic states are sensitive to any noise that affects these superposed states differently. Resilience to such noise results from using superpositions where the atomic states differ in momentum only, but implementation of such ‘state-symmetric’ diffraction can lead to population loss into unwanted states and restricts the atomic velocity acceptance of the interferometer. In this paper, by varying the laser intensities and phases as functions of time, we present optimized pulses designed for use in state-symmetric interferometers that overcome these restrictions. We extend this optimization to multi-pulse sequences designed to increase the interferometer area and demonstrate significant improvements in the fringe visibility compared with sequences of π/2 and π pulses. We discuss the limits on the temperature of the atomic source required for efficient atomic diffraction and show how optimized pulse sequences enable efficient diffraction with considerably warmer clouds, hence reducing the need for velocity selection and increasing the measurement signal-to-noise ratio.

Curiosity as a Moderator of the Relationship Between Entrepreneurial Orientation and Perceived Probability of Starting a Business.

Although the correlation between Entrepreneurial Orientation (EO) and concrete actions to set up a business or the Probability of Starting a Business (PSB) has been widely studied, the psychological factors that can affect this relationship have not yet been sufficiently addressed in the field of entrepreneurship. One of them is curiosity. Both at theoretical and empirical level, a distinction are usually made between two types of curiosity. I-type curiosity is associated with the anticipated pleasure of discovering something new, and D-type curiosity is associated with reducing uncertainty and eliminating unwanted states of ignorance. Consequently, this paper aims to analyze the moderating role that the types of curiosity play in the relationship between EO and PSB, considering their interaction with sociodemographic variables. The sample of this cross-sectional study consisted of 1,761 participants (convenience sampling of active workers; 49.8% men; mean age 38.88 years, SD = 12.53 years; 22.9% Colombian and 77.1% Spanish). The EO scale and a curiosity scale were applied. In addition, participants were asked, based on their perception, how likely they were to start their own business within the next 5 years. A simple moderation analysis was considered to test the moderating role of both types of curiosity in the relationship between EO and PSB. Next, a double moderation analysis was carried out in order to identify, which sociodemographic variables moderate the moderating effect of curiosity. The results show that only the D-type component moderates the relationship between EO and PSB: The higher the D-type curiosity, the stronger the association between EO and PSB. In terms of sociodemographic variables, neither culture nor gender showed a moderating effect on the moderation exerted by D-type curiosity. While, age did moderate the moderating effect of D-type curiosity on the relationship between EO and PSB. Results are discussed in terms of spirituality (attitudes, practices, and behaviors) and the resolution of problems associated with the entrepreneurial process, considering cognitive and psychological factors, particularly with an emphasis on explaining why only D-type curiosity shows a moderating effect. Finally, the limitations of the study and potential future lines of research are pointed out.

Asymmetrical-Dendronized TADF Emitters for Efficient Non-doped Solution-Processed OLEDs by Eliminating Degenerate Excited States and Creating Solely Thermal Equilibrium Routes.

The mechanism of thermally activated delayed fluorescence (TADF) in dendrimers is not clear. We report that fully‐conjugated or fully‐nonconjugated structures cause unwanted degenerate excited states due to multiple identical dendrons, which limit their TADF efficiency. We have synthesized asymmetrical “half‐dendronized” and “half‐dendronized‐half‐encapsulated” emitters. By eliminating degenerate excited states, the triplet locally excited state is ≥0.3 eV above the lowest triplet charge‐transfer state, assuring a solely thermal equilibrium route for an effective spin‐flip process. The isolated encapsulating tricarbazole unit can protect the TADF unit, reducing nonradiative decay and enhancing TADF performance. Non‐doped solution‐processed devices reach a high external quantum efficiency (EQEmax) of 24.0 % (65.9 cd A−1, 59.2 lm W−1) with CIE coordinates of (0.24, 0.45) with a low efficiency roll‐off and EQEs of 23.6 % and 21.3 % at 100 and 500 cd m−2.

Asymmetrical‐Dendronized TADF Emitters for Efficient Non‐doped Solution‐Processed OLEDs by Eliminating Degenerate Excited States and Creating Solely Thermal Equilibrium Routes

AbstractThe mechanism of thermally activated delayed fluorescence (TADF) in dendrimers is not clear. We report that fully‐conjugated or fully‐nonconjugated structures cause unwanted degenerate excited states due to multiple identical dendrons, which limit their TADF efficiency. We have synthesized asymmetrical “half‐dendronized” and “half‐dendronized‐half‐encapsulated” emitters. By eliminating degenerate excited states, the triplet locally excited state is ≥0.3 eV above the lowest triplet charge‐transfer state, assuring a solely thermal equilibrium route for an effective spin‐flip process. The isolated encapsulating tricarbazole unit can protect the TADF unit, reducing nonradiative decay and enhancing TADF performance. Non‐doped solution‐processed devices reach a high external quantum efficiency (EQEmax) of 24.0 % (65.9 cd A−1, 59.2 lm W−1) with CIE coordinates of (0.24, 0.45) with a low efficiency roll‐off and EQEs of 23.6 % and 21.3 % at 100 and 500 cd m−2.

Rate-dependent bifurcation dodging in a thermoacoustic system driven by colored noise

Tipping in multistable systems occurs usually by varying the input slightly, resulting in the output switching to an often unsatisfactory state. This phenomenon is manifested in thermoacoustic systems. The thermoacoustic instability may lead to the disintegration of rocket engines, gas turbines and aeroengines, so it is necessary to design control measures for its suppression. It was speculated that such unwanted instability states may be dodged by changing the bifurcation parameters quickly enough, and compared with the white noise discussed in [1], colored noise with nonzero correlation time is more practical and important to the system. Thus, in this work, based on a fundamental mathematical model of thermoacoustic systems driven by colored noise, the corresponding Fokker–Planck–Kolmogorov equation of the amplitude is derived by using a stochastic averaging method. A transient dynamical behavior is identified through a probability density analysis. We find that both a relatively higher rate of change of parameters and change in the correlation time of the noise are beneficial to dodge thermoacoustic instability, while a relatively large noise intensity is a disadvantageous factor. More interestingly and importantly, power-law relationships between the maximum amplitude and the noise parameters are uncovered, and the probability of successfully dodging a thermoacoustic instability is calculated. These results serve as a guidance for the design of engines and to propose an effective control strategy, which is of great significance to aerospace-related fields.

Low-energy 14C and multi-element HVE AMS systems

Two sub-MV accelerator mass spectrometers based on vacuum-insulated accelerators were designed, built, and tested by High Voltage Engineering Europa B.V. The first one is dedicated to 14C measurements. Both low- and high-energy mass analysis is done with permanent magnets. Unique to the 14C AMS system is that the accelerator terminal is equipped with a charge state selector suppressing ions of unwanted charge states, thereby reducing the system background for the 14C/12C ratio to the low 10−15 level. The 14C/12C precision is measured to be 0.16%. The second AMS system is a multi-element for 10Be, 14C, 26Al, and 129I measurements. The analysis of actinides is supported as well. It is equipped with two analyzing magnets in the high-energy spectrometer. The measured machine background for carbon is 7 × 10−16, for beryllium 5 × 10−15, for aluminum < 5 × 10−15 and for iodine 4 × 10−14.

Stabilization of p-GaAs electrode surfaces in organic solvent by bi-phenyl rings for spin dependent electron transfer studies

Biphenyl-4-thiol (B4t) functionalised p-GaAs photocathodes were compared to non-functionalised p-GaAs ones in the presence of methyl viologen cation radical (MV+) as a redox mediator. Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) studies revealed that at bare p-GaAs photocathodes the radical interacts strongly with the electrode surface, displaying unwanted surface states (SS) mediated electron transfer (ET) even in the dark. Functionalising the electrode with B4t passivated the interface against this unwanted process, while ensuring that the conduction band (CB) electrons still facilitated faradaic reduction of MV+ to MV0 with unhindered efficiency.

Efficient continuous wave accelerating structure for ion beams

The Facility for Rare Isotope Beams driver linac was designed for acceleration of multiple-charge-state beams after the stripping at ion beam energies of 17 to $20\text{ }\text{ }\mathrm{MeV}\mathrm{/u}$ depending on the ion species. The linac includes a 180\ifmmode^\circ\else\textdegree\fi{} achromatic bend to select multiple charge states for further acceleration and to dump unwanted charge states after the first 45\ifmmode^\circ\else\textdegree\fi{} magnet. Two rf rebunchers between the stripper and the linac segment 2 (LS2) are required to minimize the effective emittance growth of the multiple-charge-state beams and provide matching to the LS2. Recent studies have shown that the best choice for these two rebunchers is a room-temperature (RT) accelerating structure capable of providing robust operation in the presence of the stripped heavy ion beam contaminants. The latter can result in uncontrolled losses of contaminant ions after the passage off the stripper. Therefore, using a superconducting (SC) rebuncher after the stripper is not rational due to possible contamination and performance degradation of SC cavities over a long period of operation. For the beam bunching in the energy range from 13 to $22\text{ }\text{ }\mathrm{MeV}\mathrm{/u}$, two 161 MHz rebunchers based on interdigital H-type (IH) structure were developed, built, installed and commissioned with beam at the FRIB linac. This is the first experimental demonstration for application of a cw RT drift tube accelerating structure in this energy range.