Unwanted Hair Growth Research Articles

5048 A Rare Cause of Hyperandrogenism in Postmenopausal Women: Ovarian Stromal Hyperplasia

Abstract Disclosure: S. Mark: None. M.H. Shanik: None. I.J. Romao: None. Ovarian stromal hyperplasia (OSH) is a rare cause of hyperandrogenism. It is a non-neoplastic proliferation of ovarian stromal cells that leads to the overproduction of testosterone. This case report highlights that OSH should be considered in patients who present with hyperandrogenism.A 49-year-old postmenopausal woman with a past medical history of polycystic ovary syndrome, type 2 diabetes and obesity complained of unwanted hair growth. On the physical exam her BMI was 51. She had an obese body habitus, hirsutism of her chin, chest and back and acanthosis nigricans on her neck. Blood work showed a total testosterone of 203 (2-45 ng/dL) and free testosterone 29 (0.1-6.pg/dL). FSH, LH, DHEAS, estradiol, SHBG and 17 hydroxyprogesterone (17 OHP) were in the normal range. She completed a 1 mg dexamethasone suppression test that was normal. She took spironolactone for hirsutism with minimal relief. Pelvic ultrasound was limited due to body habitus. CT of the abdomen and pelvis showed no adrenal or ovarian masses. The patient had a family history of pancreatic, ovarian, and breast cancer. Given her symptoms and her family history, the patient underwent genetic testing that was negative. She underwent bilateral salpingo-oophorectomy. Pathology revealed bilateral ovarian stromal hyperplasia. After surgery, her total testosterone normalized to 18 ng/dL and free testosterone was 1.6ng/dL with improvement in hair distribution. The patient continued to struggle with her weight and diabetes management.OSH is a non-malignant proliferation of ovarian stromal cells which leads to overproduction of testosterone. It occurs more in postmenopausal women and rarely in women of reproductive age. There is approximately 1 case of OSH in every 1000 cases of hirsutism. Clinical features include obesity, insulin resistance, acanthosis nigricans, acne, and hirsutism. Testosterone levels are usually greater than 150 ng/dL. Differential diagnosis includes PCOS, Cushing’s disease, adrenal or ovarian tumor and non-classic adrenal hyperplasia. Transvaginal ultrasound can be used to assess the ovaries for tumors or increase in size. If negative a pelvic MRI or CT can be done for further assessment. The gold standard for diagnosis would be histological evaluation following bilateral oophorectomy which is curative. Pathology usually shows stromal hyperplasia that is nodular or diffuse. Alternative treatment options include GNRH agonist therapy in patients who are not surgical candidates. Complications of this condition include insulin resistance, acanthosis nigricans and diabetes mellitus. After treatment hyperandrogenism skin changes improve. It is important that clinicians consider OSH as a cause of hyperandrogenism to ensure timely diagnosis and treatment. Presentation: 6/2/2024

Study of risk factors for insulin resistance in women with a burdened metabolic history

Insulin Resistance (IR) is a state of insufficient biological response of the body's cells to insulin, which leads to further disruption of carbohydrate metabolism and increased blood glucose levels. Early detection of IR risk factors improves the prognosis and prevention of severe metabolic syndrome, preservation and restoration of women's reproductive potential, and becomes the foundation for the health of the future generation. Aim of the study was the influence of potential risk factors on the development of latent IR manifestations 82 women of early reproductive age who signed an informed consent for the study were examined. A specially designed questionnaire was used for the study, and anthropometric parameters and laboratory data (including insulin, glucose tolerance test), and calculation of indices (HOMA-IR (Homeostasis Model Assessment of Insulin Resistance) and Matsuda). According to the results of the study, in accordance with the indicators of Relative Risk (RR) and Odds Ratio (OR), we consider the following potential factors to be developmental bad habits (tobacco smoking regardless of the amount, regular alcohol abuse) (RR=1.299; p=0.00321), burdened hereditary history of cardiovascular diseases (essential hypertension, heart attacks and strokes) (RR=1.313; p=0.0041), type I and type II diabetes mellitus (RR=1.340; p=0.0038), obesity (RR=1.641; p=0.0043), thyroid diseases (hypothyroidism, hyperthyroidism, hyperparathyroidism) (RR=1.565; RR=1.565; p=0.00284) and adrenal (Itzen-Cushing's syndrome, adrenal cortex insufficiency) (RR=1.348; p=0.0025). The manifestations of IR should be skin rashes (OR=3.542; p=0.0033) and unwanted hair growth (OR=3.670; p=0.0029). Keywords: overweight, obesity, metabolic syndrome, vaginal microbiome, ovulation, infertility.

Intraoral laser hair removal: A scoping review.

Intraoral hair growth is a debilitating side effect of flap or graft-based oropharyngeal reconstruction. There is no standardized treatment, but groups have successfully eradicated unwanted hair growth with intraoral laser hair removal. This scoping review assesses the utility of laser therapy in managing this condition. This scoping review followed PRISMA-ScR guidelines. Ovid Medline, Embase (Ovid) and Scopus were queried using index terms and keywords. Resulting articles were reviewed for inclusion by two independent reviewers against inclusion criteria and relevant data were extracted. The literature search yielded 297 articles, 22 of which met inclusion criteria. In total, 77 patients were treated: 38 patients with an Alexandrite laser, 19 with an Nd:YAG laser, 18 with a diode laser, and two with a CO2 laser. Complete response defined as 80% or more reduction in hair count was achieved in 70 patients (90%) and six patients (8%) achieved a partial response (10%-79% reduction in hair count). One patient (1%) with gray hair saw less than a 10% reduction in hair count. On average, 3.84 treatment sessions were needed, spaced 5.4 weeks apart. Treatments were well tolerated without major side effects. This is the first scoping review assessing the utility of intraoral laser hair therapy and suggests it may be a safe and effective treatment. However, surgeons should advise preoperative hair removal when clinically feasible to mitigate this side effect as much as possible.

Predicting the Therapeutic Results of Unwanted Hair Growth with the Alexandrite Laser Device

The growth of excess hair on the chin, under the neck, near the navel, around the chest, etc. is one of the main disorders that both women and men face. The best, most efficient and least invasive way to remove thick and dark hair is to use a laser. It is important to check the effectiveness of laser in removing unwanted hair after treatment sessions. In this study, the treatment of unwanted hair in the armpit or thigh area in 14 patients was investigated. The participants with skin type I and III were aged 27-37 years and were treated with 755 nm alexandrite laser. Examination of each area (armpit and thigh) was done with a camera system specifically to count the number of hairs at 1 and 3 months after the treatment period. In this study, Monte Carlo modeling was used to estimate the density of excess hair remaining after treatment sessions, and the results showed that the number of excess hair decreased both by Monte Carlo method and manual counting method, and the accuracy rate of the simulation was 75%.

Comparative Efficacy of Diode Laser System versus Intense Pulse Light (Ipl) In Management of Unwanted Hair

Unwanted hair growth can be caused by several factors, including genetics, systemic illness, and even drug reactions. According to the underlying medical condition, excessive hair growth was labelled as either hirsutism or hypertrichosis. Objective: To compare the efficacy of diode laser system versus intense pulse light in the management of unwanted hair among female patients. Methods: Patients in this randomized controlled study had hirsutism. Group A received powerful pulse light therapy for three sessions, one month apart, while Group B received diode laser treatment. To determine the effectiveness and side effects in both groups, patients were monitored for four months and subsequently assessed clinically. Results: Out of these total 60 patients, intense pulse light system was more efficacious in achieving patient satisfaction (73.3%) at the end of three months as compared to diode laser (26.7%) (p value < 0.001). Conclusions: This randomized controlled trial showed that intense pulse light therapy was more efficacious in management of unwanted hair compared to diode laser therapy.

Comparison of Modified Ferriman-Gallwey Score and Biochemical Parameters in the Estimation of the Prevalence of Idiopathic Hirsutism Among Women in the Kurdistan Region

The word "hirsutism" describes the development of terminal hairs at androgen-controlled body locations in women, which has distress and adverse psychosocial affects. The diagnosis of hirsutism is the key point in the treatment of unwanted hair growth in women’s body. Present study aimed to evaluate the modified Ferriman-Gallwey (mFG) score and the biochemical hyperandrogenism parameters among Iraqi hirsute women and their association with hirsutism in outpatients clinics in Kalar city, Garmian region, Iraq. This was a cross-sectional study of 100 hirsute women were collected from the outpatients clinic and 26 healthy women in Kalar city. After detailed history taking by using structured questionnaire, physical examination, and the relevant investigations were done, the scoring of hirsutism was indexed according to (mFG) scoring system. Moreover, sera of hormonal markers were measured; which included 17-hydroxyprogesterone (17-OHP), total testosterone (TT), free testosterone (FT), dehydroepiandrosterone (DHEA), s. prolactin, and thyroid stimulating hormone (TSH). No statistically significant differences were found in the median of the sex and related hormones between control subjects and the hirsutism group. Likewise, there were no significant relation between hormonal markers and the rate of hirsutism. While, an intrinsic statistical association was seen between the mFG score with the hirsutism and the rate of hirsutism. Our findings imply that the mFG score system is a significance screening tool and has tremendous importance and utility in establishing the diagnosis of hirsutism.

Association of free testosterone, glucose level and obesity among women with polycystic ovary syndrome in Soran city, Kurdistan-Iraq

BackgroundPolycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting approximately 5–10% of women of reproductive age and it is also a major cause of anovulatory infertility. PCOS is associated with obesity and conditions like hirsutism, acne, diabetes, and irregular periods. AimThe present study aimed to evaluate the serum-free testosterone (FT) levels of women afflicted with hirsutism, one of the main physical manifestations of PCOS versus healthy women and determine whether their serum testosterone levels correlate with polycystic ovaries, glucose levels, menstrual abnormalities, and obesity. MethodsThis study assessed 180 women; this included 140 females who suffered from excessive and unwanted hair growth on the chin and 40 healthy women as a control group. Free testosterone levels and fasting blood glucose levels were taken. Prior to the study, ultrasonographic (US) tests were performed for all patients to diagnose polycystic ovaries. ResultsPatients with hirsutism exhibited a significant elevation in free testosterone (FT) compared to the control group. Approximately half of these women were confirmed to have a polycystic ovary, and 42.8% of them were overweight and obese. Additionally, women between 18 and 20 years old (G1) present with the highest level of FT. ConclusionSerum FT levels were significantly increased in hirsute women, and this positively correlated with BMI and glucose levels in women with PCOS. Glucose levels may serve as a potentially effective biomarker in evaluating the severity of hirsutism in women suspected of having PCOS.

Novel laser hair removal in all skin types.

Laser has been long accepted as a solution for excess or unwanted hair growth yet traditional lasers are not always ideal for safe and effective outcome for all skin types and hair characteristics. A diode laser module combining three wavelengths (755, 810, and 1064 nm) in a single pulse was developed to provide a fast and long-term solution for subjects with various profiles. To evaluate the safety and efficacy of a Triple wavelength diode laser module for hair removal treatment in all skin types (Fitzpatrick I-VI). This was a prospective, dual centered, single-arm study. Subjects were treated with a novel diode laser module. Thirty-six subjects were enrolled, sixteen with Fitzpatrick skin types I-IV (46%) and twenty with Fitzpatrick skin types V-VI (54%). Treatment areas were axilla and bikini lines. Subjects underwent 4 treatment sessions at 6 weeks ± 5 days intervals and attended a follow-up visit 3months after the last treatment session. 2D digital photographs were taken at baseline and at the follow-up visit, and a hair count was conducted by three blinded evaluators. A significant reduction in hair count between baseline and the 3-month follow-up visit was observed in both axilla and bikini lines for all skin types. The mean hair reduction was 41.5± 19.4% and 48.1± 20.9% in the axilla and bikini line, respectively. A significant hair reduction was also observed within skin type groups; mean hair reduction 45.5± 16.9% and 40.3± 17.2% in skin types I-IV and V-VI, respectively, indicating similar efficacy for both light and dark skin types. No serious adverse events were reported. This study demonstrates that the Soprano Titanium laser platform is safe and effective for hair removal treatment in all skin types.

A Global Survey of Ethnic Indian Women Living with Polycystic Ovary Syndrome: Co-Morbidities, Concerns, Diagnosis Experiences, Quality of Life, and Use of Treatment Methods

Polycystic ovary syndrome (PCOS) is a common endocrinopathy that is highly prevalent in women of Indian ethnicity. Clinical practice guidelines do not adequately consider ethnic-cultural differences in the diagnosing and care of women with PCOS. This study aimed to understand co-morbidities, key concerns, quality of life (QoL), and diagnosis experiences of ethnic Indian women living with PCOS. Global online survey of ethnic Indian women of reproductive age living with PCOS. Respondents (n = 4409) had a mean age of 26.8 (SD 5.5) years and reported having a family history of type 2 diabetes (43%) and PCOS (18%). Most of them (64%) were diagnosed with one or more co-morbidities (anxiety/depression being the most common). Irregular periods, cysts on the ovaries, and excess unwanted facial hair growth were their three top concerns. On average, women experienced symptoms of PCOS at the age of 19.0 (SD 5.0) and were diagnosed at the age of 20.8 years (SD 4.8). We report a one-year delay in seeking medical help and a seven-month diagnostic delay, which were associated with poor satisfaction with the information provided related to PCOS and its treatment options (p < 0.01). Women living outside India reported difficulty losing weight as their most key concern; however, they had higher dissatisfaction with the information provided on diet (OR, 0.74; 95% CI, 0.6 to 0.8; p = 0.002), exercise (OR, 0.74; 95% CI, 0.6 to 0.9; p = 0.002) and behavioural advice (OR, 0.74; 95% CI, 0.6 to 0.9; p = 0.004) than women living in India. Most women reported poor QoL in weight and emotion domains. Ethnic Indian women experience early onset of PCOS symptoms and delay in seeking professional help. Timely diagnosis, providing cultural-specific education related to lifestyle and weight management, and improving psycho-emotional support are key areas that should be addressed in clinical practice and future research.

The Relation of the SHBG Gene Polymorphism (rs1799941) with PCOS in a Group of Iraqi Women

Polycystic Ovary Syndrome (PCOS) is the most common and complex endocrine disorder that affects women of childbearing age. However, the causes of PCOS are still unknown, however, there is strong evidence supporting the role of genetics in causing it, because PCOS has a strong familial predisposition. More than one gene contributes to the heterogeneous phenotype and clinical and biochemical presentation. Patients with PCOS may complain of irregular menstruation, unwanted hair growth in multiple areas of the body, acne and scalp hair loss, unexplained weight gain, and infertility. This study explores the polymorphism of the SHBG gene locus (rs1799941) in Iraqi women with PCOS that may cause the onset of this disease. Genomic DNA was extracted from blood samples of women with and without PCOS. The SHBG gene was amplified by Tetra_ARMS PCR technology, after which the PCR product was migrated onto the agarose jells at a concentration of 2%. Three genotypes appeared, the homozygous (normal) homozygous GG which is represented by (404 + 270 bp) genotype, the heterozygous (GA) which is represented by (404 + 270 + 210) bp and the homozygous mutant AA genotype. (Which is represented by the bundle (404 + 210 bp). Among the 70 women with PCOS included in the molecular study, (4) of them were carriers of the normal homozygous genotype GG, (44) of them were carriers of the heterozygous genotype GA and (22) were carrying the mutated genotype AA. In the current study, the (OR) value of the mixed GA genotype appeared (12.833) and this indicates that the mixed genotype is a risk factor for the disease, while the (OR) value of the AA mutant genotype was (9.250), and this indicates that the mutant genotype is Homozygous is a risk factor for the disease. The frequency of the A allele was higher in the infection group compared to the control group, and this indicates that the A allele is responsible for the disease association. These results indicated that the locus SHBG gene polymorphism (rs1799941) is associated with PCOS in Iraqi women.

743 Hair follicles can “taste”: Stevioside stimulation of the bitter taste receptor, TAS2R4, inhibits human hair growth ex vivo

Besides taste buds, many other tissues express taste receptors (TR), where they exert various, often ill-explored non-gustatory functions, e.g. in immunity and metabolism. These evolutionary ancient functions of human TRs can be optimally interrogated in human skin, whose keratinocytes express selected TRs, and its dominant appendage, the hair follicle (HF). However, the role of TRs in human skin physiology is unknown. Therefore, we have asked whether TRs are expressed in human scalp HFs and if their specific stimulation or silencing affects hair growth. Here, we show that human scalp HF keratinocytes prominently and hair cycle-dependently express the bitter taste receptor, TAS2R4 (mRNA, protein). When TAS2R4 was stimulated in organ-cultured anagen scalp HFs by the sweet-tasting steviol-glycoside TAS2R4 agonist, rebaudioside A (Reb A), this significantly inhibited hair matrix keratinocyte proliferation and induced premature catagen development ex vivo. These RebA effects could be reversed by TAS2R4 knockdown ex vivo. Mechanistically, these HF effects are mainly caused by TAS2R4-mediated enhanced expression/ secretion of the key catagen-promoting growth factor, TGFβ2, since TGFß-neutralization counteracted RebA-induced catagen induction and since RNAseq analysis showed upregulation of TGFß-related signaling pathways. Thus, we introduce here TRs as important, ancestral chemosensory regulators of human skin physiology, human (mini-)organ remodeling (=HF cycling), and growth factor production (TGFß). We also identify a novel, drug-free, “gustatory” strategy for the therapeutic inhibition of unwanted hair growth (hirsutism, hypertrichosis) with a natural sweetener.

Folklore Herbal Plants as a Safe and Natural Hair Depilatories

Hair is one of the distinguishing characteristics of mammals, and it serves a variety of functions including protection from external forces, production of sebum, apocrine sweat, and pheromones. However, the unwanted hair growth is always a worrying aspect among teenage girls and women. The present study is the need of selecting herbal depilatories over chemical depilatories due to its high efficacy, safety and lesser side effects. The various types of hair removal process, herbs showing depilatory action and their composition for herbal cream are studied. According to statistics, the use of depilatories has been steadily expanding, and the global hair removal products market was valued at USO 2.2 billion in 2018, with a CAGR of 5.5 percent predicted from 2019 to 2025. Depilatories are the cosmetic preparation which is used to remove the hair from skin, in chemical depilatories the main active ingredients are salts of thioglycolic acids, sulphides and stannites which can produce rashes and side effects on long time usage, whereas herbal depilatories include active ingredients like Turmeric, Indian neetle, Neem, Tanner’s cassia, Apple cider vinegar, Paw-paw extract etc. which are tremendously safe to use. Hence in this study we have been discussed about importance of few folklore herbal medicine and preparation methods of both chemical and herbal depilatories.

Triple wavelength diode laser for hair removal: A perspective

Unwanted hair growth on certain body parts is a common aesthetic concern. Different options including shaving, waxing, and chemicals are used for hair removal. These options provide temporary results; hence, laser therapy has become a popular option for hair removal among people. Significant advancements have taken place in laser devices for improving the results of hair removal. One of the recent developments in this area is introduction of triple wavelength diode laser for hair removal. This technology combines the benefits of three wavelengths in a single device. The triple wavelength laser device may particularly be beneficial for people with darker skin. Available limited evidence from small clinical studies suggests its efficacy and safety for hair removal in people with skin type III to V. Studies in Indian population are needed to provide further insights about its efficacy and safety in patients and acceptance by the clinicians.

A comparative study on the action of homoeopathic medicine oleum jecoris aselli for treating unwanted facial hair growth in females: Internal vs. external application

Statistical observation of American Laser center states that females on an average spend over $10,207 in their lifetime to remove unwanted hairs. This study was aimed to evaluate the action of homoeopathic medicine Oleum jecoris aselli as a homoeopathic internal (3X and 30C) and external medicine (Q, 6C and 30C) in treatment of abnormal upper lip hair growth. The whole study was conducted on female volunteers eventually determining the efficacy of external application over administration of internal medicine in treatment of abnormal hair growth or Hirsutism.

Laser therapy is a safe and effective treatment for unwanted hair in adults undergoing male to female sex reassignment.

Reduction in unwanted facial and body hair is an important goal in the process of sex reassignment. Laser treatment is a popular, well-established safe and effective method of reducing unwanted hair growth. In the UK a limited number of laser treatment and electrolysis sessions are publically funded for people undergoing sex reassignment. To date, published evidence on efficacy and adverse effects (AEs) has focused on treatment of women and men not undergoing sex reassignment. In the current study, data were collected prospectively from 2015 to 2020 at a UK regional laser centre. Patients were included if they were transgender women aged >16years old and seeking laser treatment for unwanted hair at any body site. The study demonstrated significant reductions in hair growth and significant patient satisfaction, with no AEs. Laser treatment is a safe and effective method of managing unwanted hair growth in the transgender transfeminine population.

Routine circumcision? The role of prepuce in syndactyly repair

Circumcisions are among the most commonly performed procedures in the pediatric population, but the value of the preputial skin often goes unrecognized as a potential graft (Ehrlichman et al., 2018). We highlight three patients who underwent coordinated circumcision and use of the excised preputial skin as a graft for syndactyly repair. Syndactyly, a condition where fingers are fused together, is often repaired utilizing skin from the groin region, which can result in unwanted hair growth and subcutaneous fat growth. The utilization of the prepuce is a convenient alternative that may have fewer undesirable qualities.

Laser Treatment in Hirsutism: An Update.

Unwanted hair growth, which is a common aesthetic problem, has traditionally been treated using various techniques such as shaving, waxing, and epilation, but most of these provide only a temporary solution. Laser and light-based technology for hair removal has become one of the fastest growing procedures in modern cosmetic dermatology in the last decade. Clinical experience suggests that in the ideal subject with fair skin and dark hair, laser treatment can reduce hair growth significantly. This article reviews the various laser and light-based devices used for hair removal along with the various laser and patient parameters that affect the outcome of laser treatment for hair removal. Photoepilation, when properly used, offers clear advantages when compared with older, traditional techniques.

Efficacy and Safety of Long-Pulsed Nd-Yag Laser in Treatment of Hirsutism

Introduction: Hirsutism is a condition of unwanted malepattern hair growth in women. Perception of hirsutism is subjective and it is a common condition affecting 5-10% of unselected women.&#x0D; Objectives: To find out the efficacy and safety of long-pulsed Nd-YAG laser in the treatment of hirsutism.&#x0D; Materials and Methods: Fifty females of age between 18- 50 years with dark terminal facial hair and normal hormonal profile were treated with long-pulsed Nd-YAG laser (1064nm, 10mm spot size, pulse duration of 25-30 minutes and fluence of 25-40J/cm2). Six consecutive sessions of laser treatment were delivered to all the patients at 4 to 6 weeks’ interval. Photographic evaluations and percentage of hair reduction were done before each session and final assessment noted at the end ofninemonths.&#x0D; Results: All the patients completed the study. Good hair reduction (50-75%) was seen in 52% of patients after the first treatment session. After six consecutive treatment sessions at the end of nine-month excellent hair reduction (&gt;75%) was noted in 86% of patients and good hair reduction (50-75%) seen in 12% patients. Side effects in our study were post-operative erythema in 40% and perifollicular oedema in 33.33%.&#x0D; Conclusion: The study supportslong-pulsed Nd-YAG laser with multiple six sessionsis safe and effective in the treatment of hirsutism.&#x0D; Journal of Armed Forces Medical College Bangladesh Vol.14 (2) 2018: 169-172

An osteopontin-derived peptide inhibits human hair growth at least in part by decreasing fibroblast growth factor-7 production in outer root sheath keratinocytes.

Given that unwanted hair growth (hirsutism, hypertrichosis) can cause major psychological distress, new pharmacological treatment strategies with safe and effective hair growth inhibitors that do not destroy the hair follicle (HF) and its stem cells need to be developed. To establish if osteopontin-derived fragments may modulate human hair growth given that human HFs express the multifunctional, immunomodulatory glycoprotein, osteopontin. Our hypothesis was tested exvivo and invivo by using a newly generated, toxicologically well-characterized, modified osteopontin-derived peptide (FOL-005), which binds to the HF. In organ-cultured human HFs and scalp skin, and in human scalp skin xenotransplants onto SCID mice, FOL-005 treatment (60 nmol L-1 to 3 μmol L-1 ) significantly promoted premature catagen development without reducing the number of keratin 15-positive HF stem cells or showing signs of drug toxicity. Genome-wide DNA microarray, quantitative reverse-transcriptase polymerase chain reaction and immunohistochemistry revealed decreased expression of the hair growth promoter, fibroblast growth factor-7 (FGF7) by FOL-005, while cotreatment of HFs with recombinant FGF7 partially abrogated FOL-005-induced catagen promotion. With caveats in mind, our study identifies this osteopontin-derived peptide as an effective, novel inhibitory principle for human hair growth exvivo and invivo, which deserves systematic clinical testing in hirsutism and hypertrichosis. What's already known about this topic? The treatment of unwanted hair growth (hypertrichosis, hirsutism) lacks pharmacological intervention, with only few and often unsatisfactory treatments available. Osteopontin is prominently expressed in human HFs and has been reported to be elevated during catagen in the murine hair cycle. What does this study add? We tested the effects on hair growth of a novel, osteopontin-derived fragment (FOL-005) exvivo and invivo. In human hair follicles, high-dose FOL-005 significantly reduces hair growth both exvivo and invivo. What is the translational message? High-dose FOL-005 may provide a new therapeutic opportunity as a treatment for unwanted hair growth.

Hair removal treatment using 1,064 nm long-pulsed Nd:YAG laser in auricular post reconstruction of microtia patient: two case reports

Microtia is a congenital anomaly of the external and middle ear with various degrees of severity. The hair growth on the reconstructed auricle causes aesthetic problems. We describe two cases about the successful epilation of unwanted hair in postauricular reconstruction of microtia patients using 1,064 nm long-pulsed neodymium: ytrium-alumunium-garnet (LP Nd:YAG) laser in Fitzpatrick skin type IV patients, using 6x6 mm tip, 35 J/cm2 fluence, 10 ms pulse, and 1 Hz frequency with burnt of hair as an endpoint. On the follow up day 11 of case one and day 7 of case two, the hair reductions on treated auricles were 46% and 58%, respectively, with no adverse effects. Minimal 6 repeated sessions are recommended for optimal result. In these case reports, LP Nd:YAG laser treatment is considered effective for the unwanted hair growth on the reconstructed auricle in dark skin type patients with minimal risk of adverse effect.