Unvariate Analysis Research Articles

Synchronous endometrial and ovarian cancer and its recurrent risk factors: Case series

BackgroundSynchronous endometrial and ovarian cancer (SEOC) is a relatively rare entity with indistinct clinical manifestation but have a better prognosis compared to metastatic malignancy of each organ. The aim of the study is to determine the prognosis and factors associated with recurrence of SEOC. MethodsThis case-series study was performed on 37 histologically confirmed SEOC, diagnosed and treated in our tertiary hospital from March 2009 to September 2021. Disease-free survival (DFS) and overall survival (OS) rates following indicated procedure were calculated using the Kaplan-Meier method. Univariate and multivariate Cox regression analysis were used to determine risk factors of recurrence. ResultsThe mean age of participants was 49.38 (age range: 26–78). The most common complaints and symptoms were abdominal pain (40.5%), followed by abnormal uterine bleeding (29.7%). Most common histological presentation was endometroid type for both ovarian (46%) and endometrial (97.3%) cancers. Over the mean follow-up period of 85.54 months, 11 patients developed recurrence without mortality. Non-endometrioid histology of ovarian cancer, higher grade and stage of ovarian cancer, and omentum invasion were significantly associated with worse DFS in unvariate analysis. Lymphovascular invasion was the sole predictor of DFS in multivariate analysis. ConclusionWhile this study was not able to investigate the risk factors of overall survival associated with SEOC, the results of this study provides an overview of clinicopathological presentation of the disease and emphasizes the importance of lymphovascular invasion in determining prognosis and DFS in SEOC.

A cross-sectional survey and analysis of influencing factors of humanistic of the current status of humanistic care ability of burn specialist nurses

Objective: To investigate the current status of humanistic care ability of burn specialist nurses and to analyze the influencing factors. Methods: A single-center cross-sectional research method was conducted. From May to August 2020, 63 burn specialist nurses who met the inclusion criteria in Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine were selected. Self-made general data questionnaire was used to investigate 17 indexes, including gender, age, professional title, working years, whether received humanistic care training, academic qualification, and caring ability inventory (CAI) was used to evaluate their humanistic care ability. After the nurses were classified by the general data, independent sample t test and one-way analysis of variance were performed on the data to analyze the total score of CAI. The CAI total scores and scores of cognition, courage, and patience of the nurses were compared with the international norm. The factors with statistically significant differences in unvariate analysis were selected for multiple linear regression analysis to screen the independent influencing factors of humanistic care ability of burn specialist nurses. Results: A total of 63 questionnaires were collected in this survey, all of which were valid. Among the 63 nurses, there were 4 males and 59 females, with the age mainly ranging from 20 to 30 years (30 nurses, 47.62%), the professional titles mainly being nurse practitioner (36 nurses, 57.14%), the working years mainly being more than 10 years (28 nurses, 44.44%), 32 nurses not receiving humanistic care training, and academic qualifications mostly being junior college (37 nurses, 58.73%). There were significant differences in the total scores of CAI among nurses with different ages, professional titles, working years, whether received humanistic care training, and academic qualifications (with F values of 53.95, 49.14, and 75.42, t values of 6.08 and -2.82, respectively, P<0.01). The scores of cognition, courage, and patience and the total scores of CAI of nurses in this group were significantly lower than those of international norm (with t values of -2.02, -2.04, -6.19, and -3.89, respectively, P<0.05 or P<0.01). Multiple linear regression analysis showed that age, working years, professional title, and whether received humanistic care training were the independent influencing factors of humanistic care ability of burn specialist nurses (with 95% confidence intervals of 1.91-23.23, 16.25-31.48, 1.05-19.09, and 6.72-31.82, unstandardized coefficient values of 12.57, 23.86, 10.07, and 19.27, respectively, P<0.05 or P<0.01). Conclusions: The humanistic care ability of burn specialist nurses is relatively weak. Age, professional title, working years, and whether received humanistic care training are the independent influencing factors of humanistic care ability of burn specialist nurses.

Pengetahuan Penatalaksanaan Dismenore Remaja Putri

&#x0D; &#x0D; &#x0D; &#x0D; Dysmenorrhea is pain during menstruation in the lower abdomen that radiates to the waist which can be accompanied by headaches that last until menstruation ends, which is characterized by emotional changes, difficulty sleeping, disturbed activities and difficulty concentrating. Based on data from the Profile of the Central Java Provincial Health Office in 2017, the number of young women aged 10-19 years was 2,899,120 people. Meanwhile, those experiencing dysmenorrhea reached 1,465,876 people.&#x0D; The purpose of this study was to determine the characteristics of the respondents and to describe the knowledge of young women in overcoming dysmenorrhea.&#x0D; This research design is a quantitative descriptive study. This study was conducted to describe the knowledge of adolescent girls in overcoming dysmenorrhea. The sampling technique in this research is purposive sampling. The sample in this study was 98 young women. The instrument used in this research is a questionnaire and analyzed using unvariate analysis.&#x0D; The results of the study of Knowledge of Adolescent girls in overcoming dysmenorrhea at SMP N 4 Klaten obtained the average age of 14 years ± SD (.44907), Knowledge of how to overcome dysmenorrhea was good as many as 77 (78.6%) students, Enough 17 students (17.3 %), Less 4 students (4.1%).&#x0D; &#x0D; &#x0D; &#x0D; &#x0D; The implication of this research is that knowledge on how to overcome dysmenorrhea needs to be socialized from an early age so that the problem of dysmenorrhea can be addressed immediately.

Hubungan Pengetahuan Dan sikap Masyarakat Dengan Keikutsertaan Vaksinasi COVID - 19 Di Dusun Surau Munai Kecamatan Rambah Hilir Kabupaten Rokan Hulu

COVID 19 (Coronavirus Disease 2019) is a large group of viruses that can cause illness with mild to severe symptoms. The government's strategy to reduce the death rate from COVID 19 is by being vaccinated. The purpose of this study was to determine the relationship between community knowledge and attitudes with participation in COVID-19 vaccination. This type of research is quantitative analytic with Cross Sectinal design, data analysis using chi square test. The sample in this study was 154 respondents, who were selected by simple random sampling technique. Data were collected through direct questionnaires and google forms. The results of the unvariate analysis based on the level of the majority (114 people /74%) of the community have less knowledge while having good knowledge (40 people/26%). Based on the attitude of the majority of the community (90 people/(58.4)) being positive while being positive (90 people/58.4%) Furthermore, based on the participation of respondents who took part 122 (79.2%) and respondents who did not follow 32 (20 The results of the bivariate analysis showed that there was no relationship between public knowledge and participation in the vaccine with a p-value of 0.069 (&gt;0.05), while for attitudes there was a relationship between attitudes and participation, a p-value of 0.001 (&lt;0.05) towards the COVID 19 vaccine. Suggestions for the Surau Munai Village Government to collaborate with the health team to provide counseling about the COVID 19 vaccine to find out what vaccines are, the goals and benefits of vaccines, by conducting counseling.&#x0D; &#x0D;

Prognostic value of a new systemic inflammation-nutrition index in patients admitted with acute decompensated heart failure; a comparison with malnutrition

Abstract Background Systemic inflammation plays a critical role in the outcomes of heart failure. Malnutrition is also associated with poor outcome in heart failure patients. It has been recently reported that advanced lung cancer inflammation index (ALI), which is calculated as body mass index × serum albumin / neutrophil to lymphocyte ratio (NLR), is an independent prognostic marker in several types of cancer. However, there is no information available on the prognostic impact of ALI in patients admitted with acute decompensated heart failure (ADHF), especially in comparison with malnutrition. Methods and results We studied 263 ADHF patients discharged with survival. At the discharge, we measured ALI. Malnutrition was assessed by prognostic nutritional index (PNI) and controlling nutritional status score (CONUT). During a follow up period of 5.1±4.3 yrs, 67 patients had cardiovascular death (CVD). ALI was significantly smaller in patients with than without CVD (32.5±18.2 vs 52.2±30.2, p&amp;lt;0.0001). At multivariate Cox regression analysis, ALI was significantly associated with CVD, independently of prior heart failure hospitalization, systolic blood pressure and eGFR, although PNI and CONUT showed the association with CVD at unvariate analysis. By receiver-operator curve analysis, AUC of ALI was 0.733 (0.664–0.803), which was significantly greater than that of PNI (0.664 [0.590–0.739]) and CONUT (0.591 [0.509–0.672]). Patients with lowest tertile of ALI (&amp;lt;32.0) had a increased risk of mortality than middle tertile (NLR=32.0–53.6; HR 2.06 [1.15–3.71]) and highest tertile (ALI&amp;gt;53.6: HR 5.80 [2.60–12.94]) (48% vs 21% vs 9%, p&amp;lt;0.0001, respectively). Conclusion ALI, a systemic inflammation-nutrition index, is more useful prognostic marker than malnutrition in patients admitted with ADHF. Funding Acknowledgement Type of funding sources: None.

Relationship Between Mother's Knowledge Level on Monitoring Behavior of Toddler Growth and Development at Gunung Alam Public Health Center, Arga Makmur City District, North Bengkulu Regency

A good knowledge of mother will influence the behavior of observing the growth and development of the under five year’s old children, so that the children achieve an optimal growth and development. The aim of the research is to know the relation between mother’s knowledge toward the behavior of observing growth and development of fewer than five years old children at the Gunung Alam health centre in the area of Argamakmur. The design of the research is Analytic Survey with Cross Sectional approach. The population of the research is 300 mothers and the sample was taken Randomly (Simple Random Sampling) the result got 171 sample by using Corelative Product Moment Statistic. The result of unvaried analysis at the stage of knowledge shows 56 mothers (32,7%) have moderate knowledge. The distribution of the behavior of observing growth and development of under five years old children mostly ‘sometimes’ behavior 87 (50,9%). Bivariat analysis with the result of correlative product moment test (r test) with a 0,05 and CL 95% shows that all independent variabele; mother’s knowledge and dependent _ariable that is behavior of observing growth and development under five years old children shows that they have positive relation and significant 0,606 with a 0,05 its got ro = 0,606 and t test got 9,892. Since r account higher than r table (0,148), thus behavior of observing growth and development under five years old children. The category of the relation is significant (moderate relation). It can be concluded that the higher mother’s knowledge, the higher mother’s in observing the growth and development of the under five years old children.

DETERMINATION OF RISK FACTORS ASSOCIATED WITH WALKING DISORDERS AFTER ANTERIOR CRUCIATE LIGAMENT SURGERY WITH HAMSTRING GRAFT : A CONTROLLED MULTICENTER STUDY

Background: Today, anterior cruciate ligament rupture is the most common injury in sportsmen and women, but it can also occur in sedentary subjects. Its treatment, always adapted to the patient's lifestyle, age, and will, often remains surgical. However, despite its frequency and universality, we still find gait disorders after the surgery and can up to several months or even several years after the surgery. Therefore, the present study is interested in determining the risk factors associated with gait disorders after an anterior cruciate ligament reconstruction (ACLR). This study aims to determine the risk factors associated with gait disorders after surgerywith hamstring autograft. We are interested in the factors that may exist at 3 and 6 months postoperatively.Methods: Two populations participate in this study, a healthy population and a population with ACLR subjects. The ACLR test group is divided into two subgroups, one with a post-operative delay of 3 months and the second with a delay of 6 months. All subjects are subjected to the same protocol; their gait on the treadmill was analyzed and evaluated by the device OptoGait®.A united and varied analysis was first conducted, and then a multivariate analysis by adjustment method was carried out to eliminate potential confounding factors.Results: Comparison of the results across populations in the unvaried analysis shows an absence of significant results (p&gt;0,05); however, there are trends. The statistical results of the multivariate analysis showed interactions in the two subgroups of the ACLR population. At three months after surgery, there is a tendency for gait disorders to worsen in subjects with a BMI reflecting overweight, when an associated surgical procedure on the meniscus was realized, in subjects over 35 years old and in males subjects. In contrast, at six months after surgery, the worsening trend is only seen in the subgroups represented by subjects with BMI reflecting overweight subjects with meniscal repair associated with ACLR.Conclusion: The present study results show certain factors tend to aggravate these gait disorders after ACLR with hamstring autograft; these factors are different depending on the post-operative delay.

Long-term prognostic value of the combination of malnutrition and pulmonary-systemic pressure ratio in patients admitted with acute decompensated heart failure

Abstract Background Malnutrition is associated with increased mortality risk in patients (pts) with acute decompensated heart failure (ADHF). On the other hand, concomitant presence of pulmonary hypertension in heart failure is associated with increased adverse events and may be related to interventricular uncoupling and impaired cardiac efficiency. It has recently been shown that an increased mean pulmonary artery pressure to mean systemic arterial pressure ratio (MPS ratio), a marker of interventricular coupling and efficiency, is associated with worse clinical outcomes in patients with advanced heart failure. However, there is no information available on the long-term prognostic value of the combination of malnutrition and MPS ratio in pts admitted for ADHF. Methods and results We studied 248 pts admitted for ADHF, who underwent right heart catheterization at the admission and were discharged with survival. Malnutrition was assessed by geriatric nutritional risk index (GNRI), prognostic nutritional index (PNI) and controlling nutritional status score (CONUT). During a mean follow-up period of 5.2±4.4 yrs, 62 pts had cardiovascular death (CVD). MPS ratio was significantly greater in pts with than without CVD (0.408±0.114 vs 0.347±0.102, p=0.0001). GNRI and PNI were significantly lower, CONUT was significantly greater in pts with than without CVD. At multivariate Cox regression analysis, GNRI and MPS ratio were significantly associated with CVD, independently of prior heart failure hospitalization, eGFR, and serum sodium level and anemia, although PNI and CONUT showed the association with CVD at unvariate analysis. Pts with malnutrition (GNRI≤median value=96.5) and greater MPS ratio (≥median value=0.346) had a significantly higher CVD risk than those with either and none of them (51% vs 20% vs 12%, p&amp;lt;0.0001, respectively). Conclusions The combination of malnutrition and MPS ratio might be useful for stratifying pts at risk for CVD in patients with ADHF. Funding Acknowledgement Type of funding source: None

Surveillance active du cancer de prostate : facteurs prédictifs d’échecs après 5 ans de suivi

The objective of this work was to identify the risk factors (RFs) of active surveillance (AS) interruption in a prostate cancer (PCa) single-center retrospective cohort of patients. All patients in AS between January 2011 and October 2019 were retrospectively included in a computerized database. The group of patients who had an AS interruption was compared to the one still under AS, in order to identify potential risk factors for the interruption of the surveillance protocol. Two hundred and two patients have been included in the AS cohort with a median follow-up of 32months. At the time of analysis, 72 patients (36%) were not under the AS protocol anymore, 118 (58%) were still under AS and 12 (6%) were lost of follow-up. Sixty-six patients (92%) had left SA due to PCa progression, 4 (5%) by personal choice and 2 (3%) switched to watchful waiting. A PSA doubling Time<3years (PSADT<3years) has been identified as the only statistically significant RF for AS interruption, both in the unvaried (P<0.001) and multivariate (OR=5.403, P<0.01) analysis. It was also the only RF of AS interruption in the early analysis in the first three years of AS, in the unvaried analysis (P=0.021) and the multivariate analysis (OR=3.612, P=0.018). PSADT was the only RF of AS early and late interruption in our study. It represents a major inclusion criterion in AS protocol during the initial assessment. 3.

Analysis of Related Factors Affecting the Nosopoiesis of Childhood Acute Leukemia

To analyze the related factors affecting the nosopoiesis of childhood acute leukemia from the perspective of indoor environmental exposure, behavior and lifestyle. The clinical data of 64 children with acute leukemia were retrospectively analyzed, and 50 healthy children were selected as the control group during the same period. The basic data of children, indoor environment, behavior and lifestyle of parents in 2 groups were recorded. Univariate and multivariate logistic regression analysis were used to analyze the related factors affecting the incidence of childhood acute leukemia, and the OR (95%CI) value was calculated. The unvariate analysis showed that the daily wine-drinking rate of father and pesticide use rate in acute leukemia group were significantly higher than those in control group (P<0.05). Multivariate Logistic regression analysis showed that indoor ventilation during summer sleep of children (OR=0.35, 95%CI: 0.14-0.88) and contact with other children before 3 years old (OR=0.34, 95%CI: 0.18-0.65) were protective factors for provention of childhood acute leukemia (P<0.05). Mothers had a history of exposure to chemical substances (OR=3.68, 95%CI: 1.64-8.27), and children had a history of exposure to chemical substances (OR=3.84, 95%CI: 1.64-9.01), family had internal decoration history after child birth (OR = 1.38, 95%CI: 1.05-1.81) and family uses of pesticides (OR=2.17, 95%CI: 1.08-4.36), all these factors were independent risk factors for acute leukemia (P<0.05). Indoor environmental exposure, behavior and lifestyle of children and parents may be closely related with the nosopoiesis of childhood acute leukemia.

Analysis of Related Factors Affecting the Nosopoiesis of Childhood Acute Leukemia

To analyze the related factors affecting the nosopoiesis of childhood acute leukemia from the perspective of indoor environmental exposure, behavior and lifestyle. The clinical data of 64 children with acute leukemia were retrospectively analyzed, and 50 healthy children were selected as the control group during the same period. The basic data of children, indoor environment, behavior and lifestyle of parents in 2 groups were recorded. Univariate and multivariate logistic regression analysis were used to analyze the related factors affecting the incidence of childhood acute leukemia, and the OR (95%CI) value was calculated. The unvariate analysis showed that the daily wine-drinking rate of father and pesticide use rate in acute leukemia group were significantly higher than those in control group (P<0.05). Multivariate Logistic regression analysis showed that indoor ventilation during summer sleep of children (OR=0.35, 95%CI: 0.14-0.88) and contact with other children before 3 years old (OR=0.34, 95%CI: 0.18-0.65) were protective factors for provention of childhood acute leukemia (P<0.05). Mothers had a history of exposure to chemical substances (OR=3.68, 95%CI: 1.64-8.27), and children had a history of exposure to chemical substances (OR=3.84, 95%CI: 1.64-9.01), family had internal decoration history after child birth (OR = 1.38, 95%CI: 1.05-1.81) and family uses of pesticides (OR=2.17, 95%CI: 1.08-4.36), all these factors were independent risk factors for acute leukemia (P<0.05). Indoor environmental exposure, behavior and lifestyle of children and parents may be closely related with the nosopoiesis of childhood acute leukemia.

Hubungan Pengetahuan dan Sikap Ibu Tentang Gizi Dengan Status Gizi Balita Di Puskesmas Bandar Khalipah Kec. Percut Sei Tuan Kab. Deli Serdang Tahun 2019

Nutritional status is a state of status on a person's body that is related to food consumption, and is influenced by various internal and external factors such as age, sex, physical activity, illness, and socio-economic conditions. The purpose of this study was to determine the relationship between knowledge and attitudes with nutritional status of children in the Puskesmas Bandar Khalipah. The design of this study used a cross sectional design. The samples in the study were 50 respondents using random sampling techniques. Research analysis uses unvariate analysis and bivariate analysis. The results showed the relationship between maternal knowledge about nutrition and the nutritional status of children using the chi-square test obtained p value = 0.001 (p &lt;a) where 0.001 &lt;0.05 which means there is a relationship between maternal knowledge of nutrition and nutritional status of toddlers at Puskesmas Bandar Khalipah in 2019. The relationship between maternal attitudes about nutrition and the nutritional status of children using the chi-square test obtained a value of p = 0.002 (p &lt; a) where 0.002 &lt;0.05, which means there is a relationship between maternal attitudes about nutrition and the nutritional status of children at Puskesmas Bandar Khalipah in 2019. The results of this study can be suggested to be developed and broaden the horizons in the field of services and so on the basic data for the development of further research related to the Relationship between Knowledge and Attitudes of Mothers with Nutritional Status of Toddlers.

Optimalisasi Kader Sebagai Pmo (Petugas Minum Obat) dalam Mengkonsumsi Tablet Fe terhadap Pencegahan Anemia Berbasis Android di wilayah Kerja Puskesmas Simpang Kawat

Anemia due to malnutrition of pregnant woman in Indonesia is 70%. On further observation, shows that anemia that suffered by the community due to lake of Fe intake which is can be solved by consume iron regulary. This research is analytic research with quasi experiment design which uses control group which aims to know the difference of hemoglobin level between before and after supervised by cadres as a PMO (Petugas Minum Obat) in consuming Fe tablet agains anemia prevention android based. This research was on July 11 until August 15, 2019. The sample of the study are 30 respondents as the experiment group and 30 respondents as the control group. Begin with the mesurement of respondent’s hemoglobin, then the monitoring given intervention by cadres as the PMO through an android based application. After that, the respondent’s hemoglobin level will be measured again. The data of this research are analized by univariate and bivariate t-test with a = 0,05. The reseach results on unvariate analysis shows the average age af the mother, parity and gestational age are homogeneus with the p-value &gt; 0,05 which means nothing difference on the characteristic of the cadres as the PMO and without cadres as the PMO. Beside that, the result on bivariate analysis shows that p-value &lt; 0,001, so it can be concluded that there is a difference on the level of cadres as the PMO and without cadres as the PMO. With the result, can be interpret that the cadres as the PMO are optimal for enhancement of hemoglobin level in the prevention of anemia on pregnant woman. The efforts made towards the prevention if anemia is to activate all the health worker and the cadres to increase the regularity on consuming the Fe tablet of pregnant woman.

Significance of Peripheral Blood Lymphatic to Monocyte Ratio in the Progress of PGI-DLBCL

To explore the significance of lymphocyte to monocyte ratio (LMR) in the disease progress of primary gastrointestinal diffuse large B-cell lymphoma (PGI-DLBCL). The clinical data of 43 patients diagnosed as PGI-DLBCL in our hospital from January 2011 to December 2015 were collected, and the disease progress was followed up. According to the ROC curve, the threshold value of LMR for 2 years PFS (%) of PGI-DLBCL patients was 2.6. Unvariate analysis showed that LMR (P＜0.05), large enclosed mass lesion (P＜0.01) and IPI (P＜0.05) were prognostic factors affecting PFS, the COX regression model multivariate analysis showed that LMR＜2.6 [ (risk ratio (RR)=3.083, 95%CI 1.828-8.313, P＜0.01], and large enclosed mass lesions (RR=2.718, 95%CI 1.339-6.424, P＜0.05) were the independent adverse prognostic factor for two years PFS. Both LMR＜2.6 and large enclosed mass lesions relate with the progress of PGI-DLBCL.

High blood pressure in a type 2 diabetic population of the city of Sidi Bel Abbes, Algeria

The association of type 2 diabetes and high blood pressure (HT) results in increased cardiovascular risk and accelerated degenerative complications of diabetes. We aimed to determine the frequency of HT in type 2 diabetic patients and to evaluate the relationship between this association with the micro-angiopathy complications. A cross sectional study was conducted in 279 type 2diabetic patients (67.7% women, 32.3% men), mean age: 60.16 ± 0.60 years old, diabetes duration: 11 ± 0.47 years, body mass index: 28.70 kg/m 2 ; 47.9% of patients were overweight and 32.3% were obese. HT was found in 58.9% of patients (62.7% women, 50.6% men). This percentage significantly increased with age ( P < 0.001): 20% of patients younger than 40 years old, 40% aged 40–50 years, 47% aged 50–60 years and 74% over 60 years old. HT also significantly increased with duration of diabetes ( P = 0.001): 40% of patients whose duration of diabetes did not exceed 5 years, 55% between 5 and 10 years, 67% between 10 and 20 years, and 74% among those whose duration of diabetes exceeded 20 years. HT occurred in 60% of patients with normal weight, in 55% of overweight patients and in 62% of obese patients without significant difference. HT was found in 59% of patients with normal HDL plasma levels versus 50% of patients with low HDL levels, in 58% with a normal triglyceride vs. 56% in those with high levels of TG. For degenerative complications, retinopathy was found in 34% of patients (36.6% men, 29% women) without significant difference between sexes. Nephropathy was found in 9% of patients, all those were women. Using unvaried analysis, these complications were significantly correlated with HT with P = 0, 013 and 0,011 respectively. Retinopathy was found in 40% of hypertensive diabetics vs. 24% in normotensive diabetics. Nephropathy was found in 13% of hypertensive diabetics vs. 3% in normotensive diabetics. Our study confirms the association between diabetes and HT. We observed a high prevalence of HT in our diabetic population increasing with age and duration of diabetes. High risk of degenerative complications requires intensive management of HT in diabetic patients.

Impact of Occupational Stress on Turnover Intention of Machine Operators in Selected Apparel Manufacturing Companies in Sri Lanka

Area of the Study This study has been conducted to identify the impact of occupational stress on turnover intention of machine operators in selected apparel manufacturing companies in Sri Lanka. Problem of the Study Due to the lack of empirical findings on the relationship between occupational stress on employee turnover intention, this study is aimed to investigate the relationship between occupational stress and turnover intention of machine operators. Method of the study The data were collected from machine operators in selected apparel manufacturing firms and the questionnaire which consisted of included 23 questions were used to gather primary data from 178 machine operators. Data were analyzed through SPSS package and it included unvariate and bivariate analyses. Findings of the Study The finding of the study shows that there is a significant positive relationship between occupational stress and turnover intention among the sample. Furthermore results indicate that supervisory support, work overload, job autonomy, role conflict, role ambiguity and unfairness of reward have significant impact on turnover intention. Conclusion of the Study It is concluded that occupational stress is one of the significant factors that determine turnover intention of machine operators in the apparel sector organizations. Thus for the future success of the organization, it is advisable for apparel manufacturing firms to formulate strategies to manage the stress of machine operatorsin order to enhance employee retention. Keywords: Occupational Stress, Turnover Intention, Supervisory Support, Work Overload, Job Autonomy, Role Conflict, Role Ambiguity, Unfairness of Reward

Effect of PD-1, FOXP3 and CSF-1R Protein Expression on the Prognosis of Patients with Hodgkin's Lymphoma

To investigate the effect of the expression of colony-stimulating factor 1 receptor (CSF-1R), forkhead box protein 3 (FOXP3) and programmed death 1 (PD-1) protein on the prognosis of patients with Hodgkin's lymphoma. The clinical features and treatment schemes of 54 patients with Hodgkin's lymphoma treated in our hospital were recorded, the specimens were collected and the relevant micro-environment prognostic factors such as the protein expression of CSF-1R, FOXP3 and PD-1 were detected by immunohistochemical staining, and EB virus and EB virus-encoded RNA (EBER) were detected by in situ hybridization; the correlation between CSF-1R, FOXP3, PD-1 protein expression with prognosis of patients with Hodgkin lymphoma were analyzed; both the unvariate analysis and multivariate analysis (using Cox proportional hazard model) were uased to analyze the influence factors of prognosis. Among the 54 cases of Hodgkin's lymphoma, 22 cases (40.74%) were positive for CSF-1R, 28 cases (51.85%) showed high expression of FOXP3 and 9 cases (16.67%) were positive for PD-1. Unvariate analysis revealed that the international prognostic index (IPI) score, EBER and FOXP3 protein expression were the effecting factors of progression-free survival (PFS) of patients with Hodgkin's lymphoma (all P<0.05); clinical staging (Ann Arbor stage), IPI score, EBER, CSF-1R and FOXP3 protein expression were the effecting factors of overall survival (OS) (all P<0.05). Multivariate analysis (Cox proportional hazard model) results showed that the EBER state was the effecting factors of PFS and OS in patients with Hodgkin's lymphoma (P<0.05); the expression of FOXP3 protein was the effecting factors of PFS (P<0.05); Ann Arbor stage and the expression of CSF-1R protein were the effecting factors for OS (both P<0.05). CSF-1R and FOXP3 closely relate with the prognosis of the patients with Hodgkin's lymphoma, which can provide a basis for targeted therapy of this disease.

Effect of Autologous Hematopoietic Stem Cell Transplantation on Recurrent Refractory B Cell NHL and Its Factors Influencing Prognosis

To analyze the effect of autologous hematopoietic stem cell transplantation in the treatment of patients with recurrent refractory B cell non-Hodgkin's lymphoma (NHL) and the related factors affecting the prognosis. The clinical data of 47 cases of recurrent refractory B cell NHL treated in our hospital were retrospectively analyzed. Survival curves were drawn by Kaplan-Meier, and survival analyses were performed. Univariate and multivariate analyses were used to analyze the prognostic factors. The complete remission rate was 51.06% before autologous hematopoietic stem cell transplantation, but it increased to 65.96% after transplantation. The median survival time was 21 months, the 3 years progression-free survival rate was 40.43%, and the 3 years overall survival rate was 48.94%. The results of unvariate analysis showed that no using the rituximab in the first treatment and incomplete remission shown by PET/CT before transplantation all were the risk factors (P<0.05) affecting the prognosis. By multifactor analysis, it was found that the incomplete remission shown by PET/CT before transplantation was a risk factor for the prognosis(P<0.05). The application of autologous hematopoietic stem cell transplantation for patients with relapsed and refractory B cell NHL can improve the clinical efficacy, and the incomplete remission shown by PET/CT before transplantation is more adverse to the patients' prognosis.

Efficacy and Influencing Factors of Autologous Hematopoietic Stem Cell Transplantation for Multiple Myeloma: Retrospective Analysis

To analyze the clinical efficacy and possible influencing factors of autologous hematopoietic Stem cell transplantation (auto-HSCT) in the treatment of patients with multiple myeloma (MM). Clinical data of 40 MM patients received auto-HSCT in the Department of Hematology of Henan Cancer Hospital from September 2010 to November 2017 were retrospectively analyzed, the clinical curative efficiency was summarized and the related factors were analyzed. The curative efficiency of the patients before transplantation was 9(22.5%) with complete remission(CR), 5(12.5%) with very good partial remission(VGPR), 26(65%) with partial remission(PR), respectively, one of them was PR after 3 recurrences. The curative efficiency after transplantation was 22(55%) with complete remission(CR), 12(30%) with very good partial remission(VGPR), 6(15%) with partial remission(PR), respectively. And 2 cases were CR after double transplantation. Median follow-up time was 28.4 (3.1 to 88) months,15 cases presented disease progression, 7 cases were dead, 3-year estimated progression-free survival(PFS) and overall survival(OS) rate were 45.1% and 82% respectively. Unvariate analysis showed that the OS was affected by ISS stage (P<0.05), CR and VGPR (P<0.05) after transplantation; PFS was affected by ISS stage (P<0.01), before transplantation induction therapy (27 cases with bortezomizomi or thalidomide) (P<0.05), disease risk stratification (6 cases in high risk group) (P<0.05) , CR and VGPR (P<0.05) before transplantation, CR and VGPR (P<0.01) after transplantation. Cox multivariate regression analysis showed that the independent prognostic factors for OS were ISS stage, CR and VGPR after transplantation; the independent prognostic factors for PFS were the CR, VGPR, ISS stage after transplantation and induction therapy before transplant. Auto-HSCT can improve the clinical efficacy and survival rate of MM patients; ISS stage, CR and VGPR after transplantation are independent prognostic factors for OS and PFS, and induction therapy before transplantation is also an independent prognostic factor for PFS.

Factors Affecting Safety and Efficacy of PCNL in Lower Calyceal Stones

AbstractBackground: The management of lower calyceal stones is still one of today's topics in endourology. Percutaneous nephrolithotomy (PCNL) is found to be a highly effective procedure in treatment of lower pole calculi. However, many factors are affecting the stone free rate and complication rate.Aim of the Study: The aim of this study was to evaluate the factors that affect the safety and efficacy of PCNL in lower calyceal stones more than 2cm.Patients and Methods: Forty eight patients with lower pole calculi more than 2 cm underwent percutaneous nephro-lithotomy. Preoperative, operative and postoperative data were reported. Multivariate analyses as well as univariate analyses were used to investigate the effects of different variables on residual stones and blood transfusion rate. These factors include age, sex, laterality, body mass index, history of ipsilateral open renal surgery, operative time, lower pole parenchymal thickness, presence of hydronephrosis, stone burden and stone density.Results: Unvariate analysis determined that stone burden (p<0.001), stone count (p<0.02), lower pole parenchymal thickness (p<0.03), presence of hydronephrosis (p<0.001) and operative time (p<0.04) were statistically significant with the stone free rate. Multivariate analysis revealed that, presence of hydronephrosis (odds ratio [OR]: 0.365, 95% confidence interval [CI]: 0.104-0.652, p=0.034), lower pole parenchymal thickness (OR: 0.347, 95% CI: 0.241-0.874, p=0.04), the operative time (OR: 0.587, 95% CI: 0.149-0.857, p=0.032), stone count (OR: 0.647, 95% CI: 0.205-0.874, p=0.028) and stone burden (OR: 0.428, 95% CI: 0.169-0.985, p=0.021) were significant independent factors influence stone residual. Univariate analysis determined that stone burden (p<0.001), body mass index (p<0.015), history of ipsilateral open renal surgery (p<0.017), lower pole parenchymal thickness (p<0.001) and operative time (p<0.015) correlated with blood transfusion rate. Multivariate analysis revealed that stone burden (OR: 0.628, 95% CI: 0.149-0.852, p=0.014), operative time (OR: 0.452, 95% CI: 0.125-0.856, p=0.002), lower pole parenchymal thickness (OR: 0.365, 95% CI: 0.014-0.836, p=0.002), body mass index (OR: 0.589, 95% CI: 0.159-0.744, p=0.038) and history of ipsilateral surgery (OR: 0.635, 95% CI: 0.258- 0.825, p=0.017) were significant independent factors influence blood transfusion rate. Conclusion: PCNL is a safe and effective procedure for lower calyceal stones more than 2cm. The stone free rate in the study was affected mainly by the stone burden and the operative time, the stone count, the degree of hydronephrosis and the lower pole parenchymal thickness were also involved. The blood transfusion rate was also affected by the stone burden, the operative time, the BMI, history of ipsilateral open renal surgery and the lower pole parenchymal thickness.