The drilling process is among the most crucial steps in exploration and production activities in the petroleum industry. It consists of using mechanical mechanisms to crush rocks by the drill bit to pass through the different geological layers. The drill-string continuously transforms the rotational movement from the top drive motor to the drill bit through the drill pipes. Due to the strong interactions with the rocks, aggressive vibrations can arise in the drill-string in its three dimensions, and consequently, this may create three types of synchronous vibrations: axial, lateral, and torsional. The severe status of the latter is known as the stick-slip phenomenon, and is the most common in rotary drilling systems. Based on field observations, it has been inferred that the high frequency stick-slip vibrations may lead to drill-string fatigues and even to premature rupture. In the best case, it reduces the drilling efficiency by decreasing the rate of penetration, due to which the drilling operations become proportionally expensive. The main novelties of this research work are the design of an H∞ observer-based controller to mitigate the high frequency stick-slip vibrations, and the quantitative analysis of the vibrations’ severity for ten degrees of freedom model. The observer is designed to estimate the non-measurable rotational velocity of the drill bit due to the severity of the vibrations, while the controller is dedicated to suppressing the vibrations by using the top drive inputs. Thus, many scenarios have been considered to test and analyze the observer performance and the controller robustness. Furthermore, a comparison with the LQG observer-based controller has been conducted, where H∞ has demonstrated better efficiency in suppressing the stick-slip vibrations under unstructured perturbations.