Shear instabilities at the interface of two fluids, such as classical Kelvin–Helmholtz instability (KHI), is the precursor of interface destabilization, leading to fluid fragmentation critical in a wide range of applications. While many insights into such instabilities are derived for steady background forcing flow, unsteady impulse flows are ubiquitous in environmental and physiological processes. Yet, little is understood on how unsteadiness shapes the initial interface amplification necessary for the onset of its topological change enabling subsequent fragmentation. In this combined theoretical, numerical and experimental study, we focus on an air-on-liquid interface exposed to canonical unsteady shear flow profiles. Evolution of the perturbed interface is formulated theoretically as an impulse-driven initial value problem using both linearized potential flow and nonlinear boundary integral methods. We show that the unsteady airflow forcing can amplify the interface's inherent gravity–capillary wave, up to wave-breaking transition, even if the configuration is classically KH stable. For impulses much shorter than the gravity–capillary wave period, it is the cumulative action, akin to total energy, that determines amplification, independent of the details of the impulse profile. However, for longer impulses, the details of the impulse profile become important. In this limit, akin to a resonance, it is the entangled history of the interaction of the forcing, i.e. the impulse, that changes rapidly in amplitude, and the response of the oscillating interface that matters. The insights gained are discussed and experimentally illustrated in the context of interface distortion and destabilization relevant for upper respiratory mucosalivary fluid fragmentation in violent exhalations.