To explore the thermal performance parameters of substation enclosure parameters and interaction and influence degree, using the DeST software simulation and orthogonal test method to building load minimum as the target parameters, select external wall heat transfer coefficient, roof heat transfer coefficient, outer window heat transfer coefficient and orthogonal test factors, carry out the four factors three level L9 (34) Orthogonal test analysis, studied the influence of each factor and its interaction on the building load, and finally obtained the optimal combination of factors under the comprehensive boundary conditions. At the same time, the correlation between load and outdoor temperature in the optimal scheme of unmanned substation and the carbon emission results before and after optimization are also explored. The results show that through univariate analysis, with the heat transfer coefficient of exterior wall, roof and window, the cumulative cooling load is not linear. Through the orthogonal experimental analysis, the significance of substation building is> roof exterior wall> south Angle> window, and the optimal is A1-B1-C2-D2The annual cumulative building cooling load is 20165.59 kW h, and the peak cooling load appears on July 24. The operating condition of 0 ~ 9kW accounts for 90.6% of the annual operating time. There is a strong linear correlation between the building cooling load and the outdoor temperature (R2=0.65), the energy saving rate of the final optimized scheme is 17.71%, and the carbon saving rate is 26.72%. The research content of this paper provides reference for the renovation of existing buildings and the design of new buildings in substation buildings.