Introduction: In the context of modern communication networks, the increasing demand for high data rates, minimal latency, and improved reliability—especially in scenarios involving Unmanned Aerial Vehicles (UAVs)—calls for innovative solutions. Millimeter-wave (mmWave) communication emerges as a fitting choice due to its capacity to offer ample bandwidth and high data rates. Methods: This research paper presents a comprehensive study that compares the performance of mmWave communication links across four different frequencies (6, 28, 60, and 120 GHz) for UAV-to-Base Station (BS) communication. The investigation, conducted through simulations, adheres to atmospheric conditions such as rain and fog, different environments (urban and rural) scenarios. It evaluates the suitability of mmWave frequencies using critical performance metrics: latency, received power, Bit Error Rate (BER) and Signal-to-Interference plus Noise Ratio (SINR). These metrics play a fundamental role in assessing communication link quality. Results: Our findings reveal that leveraging higher mmWave frequencies—specifically 60 and 120 GHz—significantly enhances UAV-to-BS communication performance. Compared to lower frequencies, these higher bands exhibit reduced latency, higher data rates, and improved throughput. Consequently, mmWave frequencies beyond 60 GHz prove well-suited for UAV communication, facilitating efficient data exchange with minimal delay. Conclusion: Furthermore, the potential for reduced interference and enhanced reliability at these elevated frequencies makes them particularly advantageous in applications requiring seamless connectivity. Examples include UAV-assisted emergency response, surveillance, and remote sensing. These insights hold substantial implications for the design and deployment of UAV communication systems, highlighting mmWave technology’s transformative potential in the emerging era of aerial communication.