Over the recent years unmanned aerial vehicles (UAVs) have been utilized extensively in mission-critical operations, especially as it relates to disaster management scenarios. Clearly, during these missions, the UAVs should be able to communicate effectively (amongst themselves and with the ground control station (GCS)) in order to transmit and receive commands and other related information. Moreover, accurate positioning is paramount during this type of operations. This has motivated the exploration of a number of alternative navigation methods to address robustness issues that arise when the global positioning system (GPS) becomes unavailable, due to GNSS disruption or sensor malfunction. This work addresses these issues by initially developing and implementing an integrated LoRa-ROS-based (long range communication - robot operating system) system for UAV-to-X communications. Subsequently, it presents a novel cooperative positioning approach, where a group of autonomous UAVs employ various algorithms (detection, tracking, communication, and localization) for cooperative positioning in order to counter any GPS/sensor malfunction. For evaluation purposes, a prototype multi-agent system is designed and implemented, utilizing the proposed integrated ROS-LoRa-based communication architecture, as well as sensor (inertial measurement unit - IMU) fusion. Specifically, LoRA mesh networking (using a custom printed circuit board - BALORA), is incorporated to maintain communication and distribute the sensor information between the UAVs. The prototype of the proposed communications architecture and cooperative relative positioning system (CRPS) is subsequently tested in a real-world environment, demonstrating the feasibility and effectiveness of the proposed communications solution, as well as the robust and accurate localization that is analogous to the ground truth (GPS+IMU).