The future of obesity care in the UK will partly be shaped by the National Institute for Health and Care Excellence (NICE) endorsement of semaglutide (Wegovy) to treat obesity in March, 2023. 1 National Institute for Health and Care ExcellenceSemaglutide for managing overweight and obesity. Technology appraisal guidance [TA875]. https://www.nice.org.uk/guidance/ta875Date: March 8, 2023 Date accessed: May 25, 2023 Google Scholar Semaglutide joins another glucagon-like peptide 1 (GLP-1) receptor agonist liraglutide as an obesity treatment, together with behavioural interventions and bariatric surgery. Although semaglutide as an obesity treatment has been hailed as a game changer, 2 Lenharo M Game-changing obesity drugs go mainstream: what scientists are learning. Nature. 2023; (published online May 23.)https://doi.org/10.1038/d41586-023-01712-8 Crossref Google Scholar the implications of this pharmaceutical focus in obesity management will unfold in UK general practice over the coming months. Lessons can be learnt from the USA, where semaglutide was licensed in 2021 and demand shortly outstripped supply and led to reduced availability of GLP-1 agents licensed for type 2 diabetes. 3 Novo NordiskUpdates about Wegovy. https://www.novonordisk-us.com/products/product-supply-update.htmlDate: May 4, 2023 Date accessed: May 25, 2023 Google Scholar Wegovy also became a popular social media topic involving celebrities, leading Novo Nordisk to respond to criticism about inequitable access and unlicensed use of semaglutide. 4 Goodman B As the market for new weight loss drugs soars, people with diabetes pay the price. CNN, Dec 28, 2022https://edition.cnn.com/2022/12/28/health/weight-loss-diabetes-drug-shortages/index.htmlDate accessed: May 30, 2023 Google Scholar An investigation by The Guardian highlighted similar risky prescribing in the UK, for example, to people with a healthy weight or with previous eating disorders. 5 Davis N Online UK pharmacies prescribing weight loss jabs to people with healthy BMI. The Guardian, May 10, 2023https://www.theguardian.com/society/2023/may/10/online-uk-pharmacies-prescribing-weight-loss-jabs-to-people-with-healthy-bmi-investigationDate accessed: May 25, 2023 Google Scholar There are major challenges for the effective, equitable, safe, and sustainable use of these newer obesity medications in the UK.