This paper studies the distributed adaptive neural network (NN) predefined-time (PT) fault-tolerant consensus tracking control for unknown non-strict feedback nonlinear multi-agent systems (MASs) with time-varying full state constraints (TVFSCs), arbitrary switching behavior functions (possibly asynchronous), actuator faults and high powers. Compared with existing results, the convergence time estimation bound in this paper is less conservative due to the upper bound of convergence time presents as a tuning parameter. This paper avoids the control gain of each virtual controller to appear in the next virtual controller by using separable function technique, so it can reduce the control action complexity. Besides, this paper does not use any filters or piecewise continuous function in the controller design process, which can effectively avoid the potential singularity problem. An adaptive NN fault-tolerant consensus tracking controller is designed via backstepping technique and tangent barrier Lyapunov functions (BLF-Tans), which can ensure that all the closed-loop signals are bounded within a PT and the TVFSC bounds are not violated. Finally, numerical simulation and practical example further verify the effectiveness of the presented control algorithm. <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Note to Practitioners</i> —Many practical (underactuated, weakly coupled and unstable mechanical systems) control systems can be modeled as uncertain high-order MAS with high powers. Due to the influence of environment and other factors, the values of some variables in the practical systems are limited and cannot be arbitrarily selected. In addition, the actual systems may fail due to human factors and in most of the relevant literatures, it is often assumed that the powers are equal to 1 and only achieve the controlled systems asymptotic stability as time approaches infinity. Therefore, in this paper, an adaptive PT fault-tolerant control scheme is developed for MASs with high powers, time-varying full state constraints and actuator faults. The effectiveness of the control scheme is illustrated based on simulation study.