University College Hospital Ibadan Research Articles

Molecular detection and genotyping of HBV from HBsAg positive patients in a tertiary hospital in Nigeria.

Nigeria remains one of the countries with a high hepatitis B virus (HBV) burden in Africa. Reports have indicated the presence of mixed HBV genotypes in Nigeria; however, there is still paucity of data regarding mixed genotype infections particularly in the Southern part of the country. Our aim is to determine the HBV genotype distribution among HBsAg-positive gastroenterology patients at the University College Hospital Ibadan, Nigeria. Serum samples were screened for HBsAg by ELISA, and positive samples were genotyped by semi-nested multiplex PCR for HBV genotypes A, B, C, D, E and F. Data generated were analyzed in R-studio. A total of 81/90 (90%) of HBsAg-positive samples were successfully genotyped, and genotype A was most prevalent with 15.7%, while genotypes B and E were the least with 1.2% each. Genotypes A/C infection was the highest among mixed infections with 40% prevalence, while genotypes A/D were the least prevalent mixed infection with 4.8%. We advocate for a comprehensive genotype analysis in larger cohorts across Nigeria, to give a more comprehensive understanding of the distribution and prevalence of different HBV genotypes population wide.

Assessment of Body Image Perception and Quality of Life of Breast Cancer Patients Accessing Care at the University College Hospital, Southwest Nigeria.

Breast cancer is the most prevalent cancer type globally. The female breasts are important for beauty and sexuality, comprising the body image, which includes the individual self-perception and others. This varied perception may influence the quality of life of individuals with breast cancer. To assess the body image perception and quality of life of breast cancer patients accessing care at the University College Hospital Ibadan. Eligible female adults (18 years and above), with a confirmed histologic diagnosis of breast cancer participated in this study after obtaining informed consent. The participants were without other debilitating conditions and had access to care for at least 12 months. We used a questionnaire to collect information on body image perception and quality of life (QoL) from all the participants. Data were analyzed using descriptive and inferential statistics. One hundred sixty (160) female participants were recruited, with 74.38% having been diagnosed with breast cancer for 3 years or more, and 84.38% of them detected abnormality during breast self-examination. Over 50% of the participants had negative body image perceptions. Educational level, social/family well-being, and physical well-being were significantly associated with the QoL. There was a three-fold increase in the social and family well-being subscale score among participants with higher education levels. Negative body image results in poorer QoL in breast cancer patients, and this underscores the importance of addressing body image concerns as part of comprehensive care for breast cancer patients.

Advancing inclusive research (AIR) in Africa: Strengthening healthcare systems to enhance access on the continent through the Africa AIR site alliance model.

e13778 Background: While Africa makes up 17% of the total world population, it has 24% of the global disease burden. Furthermore, although Africa is rich in genomic diversity, Africans make up <4% of the patients in global pharma studies and 1% of the global genomic database. In 2020 there were only 63 African patients in Roche global clinical trials. The Africa AIR Site Alliance model was undertaken to address the growing importance of interventional clinical trials with advanced diagnostics and therapies in Africa, as well as the lack of representation of the African population in global datasets, which contribute to continued health disparities, poor outcomes and existing inequities. Methods: In countries with a legal research framework, no clinical trial holds and who have conducted at least 1 Roche clinical trial during the last 5 years potential Centers of Excellence for the Africa AIR Site Alliance were identified. For patients, sites had invoiceable services to ensure they were supported and could potentially include education about clinical trial participation, reasonable travel and accommodation, or covering the cost of missed work or childcare. Sites participated in training on how to conduct clinical trials, including opportunities to share best practices across sites. Results: Four pilot countries were selected and had Centers of Excellence identified to work as partners with Roche for global clinical trials: Morocco (Marrakech University Hospital Center), Nigeria (University College Hospital Ibadan), Kenya (University of Nairobi Institute of Tropical and Infectious Diseases) and South Africa (Limpopo Cancer Research Institute). After entering the Africa AIR Site Alliance, sites reported consistent application of standard operating procedures and manuals, trained and empowered staff, increased organization and appropriate patient support, plus knowledge and experience with industry trials. Sites are successfully participating in an increased number of global clinical trials in various therapeutic areas with 23 patients enrolled at the Africa AIR Site Alliance sites in oncology and ophthalmology studies. Conclusions: The Africa AIR Site Alliance model is a groundbreaking initiative that has the potential to revolutionize clinical research in Africa with a positive long-term impact on the African healthcare ecosystem and clinical care delivery. Limited diversity and representation in genomic, safety and efficacy data have hampered scientific and medical progress on the continent. The Africa AIR Site Alliance provides critical support, knowledge and skills for conducting clinical trials and assists in removing barriers for underrepresented patients to participate in these trials. Future work will focus on expanding to additional countries in Africa and creating a robust network of Centers of Excellence for innovative research.

Attitude towards medication deprescribing among older patients attending the geriatric centre: a cross-sectional survey in Southwest Nigeria

ObjectivesThis study set out to assess older people’s perception of their medications, attitude towards medication use and their willingness to have medications deprescribed in a geriatric centre in Southwestern Nigeria.Design...

Management of Secondary Glaucoma Postscleral Buckle Surgery: A Tertiary Hospital Experience in Southwest Nigeria

Abstract Purpose: To evaluate the rate of postoperative intraocular pressure (IOP) elevation and its management in patients who have undergone scleral buckle surgery as a primary intervention for retinal detachment. Materials and Methods: This was a retrospective review of hospital files of scleral buckle surgeries for retinal detachment from January 2016 to December 2021 at the University College Hospital Ibadan. All patients with a previous history of glaucoma, vitreoretinal surgery, or a combination of vitrectomy and scleral buckling procedures were excluded from the review. An IOP of ≥22 mmHg after surgery was considered elevated. Results: A total of 148 patients’ charts were reviewed with 125 patients (131 eyes) included in the study. There were 81 males (64.8%) and the mean age of patients was 45.2 (±18.8) years, with a range of 5–81 years. Rhegmatogenous retinal detachment accounted for 97.7% (128 eyes) of all cases and 118 eyes (90.1%) were recent detachments. Seventy-nine eyes (60.3%) recorded elevated IOP postscleral buckle surgery. The mean elevated IOP postbuckle surgery was 27.9 (±6.2) mmHg and the mean antiglaucoma medications prescribed was 2.4 (±2) with a range of 2–5 medications. Four eyes (5.1%) needed surgical intervention for the elevated IOP. The last follow-up mean IOP was 14.3 (±4.1) mmHg. Conclusion: Elevated IOP frequently complicates scleral buckle procedure and medical treatment is usually sufficient. As a common complication, this should be considered in advance when planning for the procedure, especially in low-income countries like Nigeria where scleral buckling surgery is still in common practice.

Multiple Brain Abscesses In A Child With Infective Endocarditis

Background: Infective endocarditis is a lethal infection affecting the endocardium of the heart and the valves.The causes are varied with staphylococcus aureus and streptococcus as the major causative agents.The triad of fever exceeding 38oc,vegetation in the heart and blood culture of the causative agents are the hallmarks of the diagnosis .The disease is known to be affect all ages with the very young age group, those with congenital heart disease and those on cardiac prosthesis as the most vulnerable. Septic emboli from the septic vegetation can spread to the brain, kidney, spleen, and lungs resulting in massive metastatic infections.It therefore has multisystemic manifestations and complications. Though neurological complications are common, brain abcess is known to be rare constituting only 1.0% of neurological complications. Objective: The study aimed at reporting occurrence of both cerebral and cerebellar micro- and macro-abscesses in a 3 year boy with infective endocarditis; a rare occurrence in the literature. Methods: This case report was carried out at University College Hospital Ibadan. Results: The boy presented with fever of 38oc for five weeks, convulsions and altered state of consciousness for ten days..In course of treatment patient however developed irritability and aggressive behaviour, which attracted the use of largactil to which he reacted with extrapyramidal signs and convulsions. Within the week he developed yellowness of the eyes and increase in abdominal girth. Patient had cranial computed tomography (CT) after plain skull X-rays and was referred to University College Hospital Ibadan as a result of the radiologically diagnosed brain abscess seen on CT images. child had grunting respiration with dyspnea, and the respiratory rate was 50/mm. However, the chest was clinically clear. In the cardiovascular system (CVS); the pulse was 140/mm, with moderate volume. The blood pressure (BP) was l60/110 mmHg. The first and second heart sounds were heard with a gallop rhythm. Cranial CT scan showed multiple ring enhancing hypodense lesions with surrounding hypodensity measuring 1cm in diameter and above with only a few measuring less than 1.0cm in both cerebral hemispheres and cerebelli in keeping with multiple cerebral and cerebellar abscesses. An echocardiography showed a brightly echogenic spot attached to the papillary muscle in the left ventricle suggesting vegetation consistent with an infective endocarditis. Retroviral test was negative for both type I and II.Blood culture — was negative, however urine culture yielded klebsiella sp. Serum urea, creatinine, Ca2+ and P04 were all elevated.The abdominal ultrasound scan confirmed the hepatosplenomegaly with decreased echogenicity but both kidneys appeared normal.There was no demonstrable ascitis. The boy was placed on antimicrobials; and had craniotomy for the drainage of the macroabscesses. He improved significantly. His renal and cardiac condition equally improved; he was subsequently discharged to continue treatment in the the paediaric outpatient. The infective endorcarditis still poses enormous challenge in management and the condition calls for multi disciplinary approach. It requires high index of suspicion for early detection; as well deployment of multiple imaging modalities by the cardiologists and radiologists to arrive at a more accurate diagnosis for effective patient management. This may save financial and material resources on part of the patients, care givers, the facility managers and the society at large.

Craniofacial fibrous dysplasia mimicking sinunasal mucocele: Case report

Background: Fibrous Dysplasia is a congenital, non-inherited, benign intra-medullary bone lesion in which the normal bone marrow is replaced by abnormal fibro-osseous tissue. It can manifest in axial and extra -axial skeleton and tissues. The wide range of clinical manifestations from skeletal changes to soft tissues swellings and skin discoloration makes it a disease of note in the clinical settings. Some of its complications include malignant transformation, gastrointestinal reflux to cardiac involvement with arrhythmias and even sudden death. Until recently with advent of modern imaging modalities, it was a disease of diagnostic debacle as it was often misdiagnosed .This is a case report of a 17 year old male who was misdiagnosed as sinunasal mucocele until histology proved it to be fibrous dysplasia. Objective: The objective of the report is to draw attention to the diagnostic challenge posed at CT imaging. Methods: This case report was carried out at University College Hospital Ibadan. Results: Showed right sided facial swelling measuring about 15x10cm. The mass was firm to hard in consistency, non-tender and not attached to the overlying skin. There was no loss of sensation in the skin over it. The right eye was displaced superiorly and laterally. A nasal aspect of the mass was seen to occupy the whole of the ipsilateral nasal cavity which it occluded deviating the nasal septum to the left and narrowing the left nasal cavity. It was fleshy and showed contact bleeding. The attending ENT Surgeons made a working diagnosis of right sinunasal tumour with possible malignant transformation. The radiographs of the sinuses showed expansile sclerotic lesion involving the nasal bones, the right maxillary bone, right ethmoidal and maxillary sinuses. The inferior aspect of the right frontal sinus was also affected. A cranial computed tomography (CT) scan (Fig 2-4) showed a multi-loculated hypodense mass with mildly enhancing septations (HU16) within the right frontal, ethmoidal, sphenoidal and maxillary sinuses. There was associated expansion of the affected sinuses with thinning of their cortices. No evidence of aggressive bony destruction was seen. The radiologists made a diagnosis of benign sinunasal tumour most likely mucocele. After right maxillectomy, histology proved the lesion to be fibrous dysplasia. This report goes further to support the need for application of more imaging modalities especially the modern and higher slices CT scanner, higher Tesla(2T )MRI , PET and fusion CT/PET scanners in arriving at radiological diagnosis that will be more compatible with the pathological condition of the patients as against what was in place at the time of this case report .Radiologists are also encouraged to have a high index of suspicion for the disease and to explore the possibilities of the differentials in order not to miss the diagnosis of FD

Familial Cataracts: Profile of Patients and Their Families at a Child Eye Care Tertiary Facility in a Developing Country.

The aim of this study is to describe the clinical profile, pedigree charting, and management of children with familial cataracts at a child eye health tertiary facility in southwest Nigeria. The clinical records of children ≤16 years diagnosed with familial cataracts at the Pediatric Ophthalmology Clinic, University College Hospital Ibadan (Ibadan, Nigeria) from January 1, 2015, to December 31, 2019, were retrospectively reviewed. Information on demographic data, family history, visual acuity, mean refractive error (spherical equivalent), and surgical management was retrieved. The study included 38 participants with familial cataract. The mean age at presentation was 6.30 ± 3.68 years, with a range of 7 months to 13 years. Twenty-five patients (65.8%) were male. All patients had bilateral involvement. The mean duration from onset of symptoms to presentation at the hospital was 3.71 ± 3.20 years, with a range of 3 months to 13 years. In 16 of the 17 pedigree charts obtained, at least one individual was affected in each generation. The most common cataract morphology was cerulean cataract, observed in 21 eyes (27.6%). The most common ocular comorbidity was nystagmus which was observed in seven patients (18.4%). Sixty-seven eyes of 35 children underwent surgery within the period of the study. The proportion of eyes that had best-corrected visual acuity ≥6 / 18 before surgery was 9.1%; this proportion had increased to 52.7% at the last postoperative visit. Autosomal dominant inheritance appears to be the major pattern among our patients with familial cataract. The most common morphological type found in this cohort was cerulean cataract. Genetic testing and counseling services are vital for the management of families with childhood cataract.

Impact of Training Programs on Awareness and Practice of Lifestyle Modifications among Hypertensive Patients Attending Outpatient Clinic of the University College Hospital, Ibadan, Nigeria

Aim: This study sought to investigate the impact of training programs on hypertensive patients' awareness and practice of lifestyle modifications in out-patient clinics of the University College Hospital (UCH) Ibadan, Nigeria.
 Methodology: The study design was a cross-sectional survey conducted at the out-patient clinics of the University College Hospital (UCH), Ibadan, Nigeria. This setting was chosen due to the accessibility of hypertensive patients receiving regular care and follow-up. The sample size comprised 274 hypertensive patients attending the out-patient clinics for regular hypertension management. A simple random sampling method was employed to select study participants, ensuring a fair representation of the target population. A structured questionnaire was used to collect data from the participants and results were analysed using SPSS.
 Results: Findings indicate that the training programs greatly increased awareness of hypertension and lifestyle factors affecting hypertension for most participants (74.42%), with all participants recommending the programs. A significant majority of participants (95.74%) reported being on hypertension medication, while nearly all (99.22%) had received some form of training or counselling on lifestyle modification for hypertension management. Notably, all participants reported having made lifestyle changes following the training programs, with the majority rating the effectiveness of the programs as highly effective (57.36%). Further analysis indicated a statistically significant relationship between the effectiveness of the training programs and the participants' age, sex, educational level, and occupation. The most frequent lifestyle modification post-training was dietary changes, with 54.65% of participants reporting that they always engage in a healthy diet for hypertension management. However, the frequency of engagement in other lifestyle modifications, such as regular physical activity and weight management, was not as high. The majority of participants reported significant improvements in hypertension symptoms following the lifestyle modifications.
 Conclusion: These findings demonstrate that targeted training programs can significantly enhance hypertensive patients' awareness and practice of beneficial lifestyle modifications, thus improving health outcomes. Further, the study underscores the need for such training programs to be tailored according to the age, sex, educational level, and occupation of the patients to maximize their impact.

Evaluation of side effects and compliance to chemotherapy in breast cancer patients at a Nigerian tertiary hospital.

Chemotherapy improves tumour control and survival, but it may be associated with side effects (SEs) which can impair treatment compliance and worsen outcomes. Assessment of patients in routine clinical practice, outside clinical trials, may provide the information on effects of chemotherapy on patients and its impacts on treatment compliance. To assess the SE and compliance to chemotherapy in breast cancer patients. A prospective study involving 120 breast cancer patients receiving chemotherapy was carried out at the oncology clinics of the University College Hospital Ibadan. SEs reported were recorded and graded using Common Toxicity Criteria for Adverse Events version 5. Compliance was defined as a receipt of planned cycles of chemotherapy in the planned doses within the planned duration. The data collected were analysed using the Statistical Package for the Social Sciences software version 25. The patients were all females with a mean age of 51.2 ± 11.8 years. Patients reported between 2 and 13 SE with a median of 8 SE. Forty-two (35.0%) missed at least one course of chemotherapy while 78 (65%) were compliant. The reasons for non-compliance were deranged blood test 17 (14.2%), chemotherapy SE symptoms related 11 (9.1%), financial constraints 10 (8.3%), disease progression 2 (1.7%) and transportation-related 2 (1.7%). Breast cancer patients encounter multiple SEs from chemotherapy which led to non-compliance with the treatment. Early identification and prompt treatment of these SEs will improve compliance with chemotherapy.

Appendiceal Base Ligation With The Hand-Made Polydioxanone (Pds) Extracorporeal Knot

Objective: This study describes our experience with a low cost handmade polydioxanone (PDS) extracorporeal knot to reduce the cost of laparoscopic appendectomy in a surgical practice.
 Methodology: This retrospective study was conducted from January 2018 to December 2019 in a general surgical unit of the University College Hospital Ibadan. The files of 20 patients with complete data for whom extracorporeal hand-made PDS’0’ knots were used for appendiceal stump closure during laparoscopic appendectomy were retrieved.
 Results: The mean age was 28.4 ± 13.2 years. There were nine male and eleven female patients. All the operations were performed by the same surgical team. The mesoappendix was coagulated with bipolar cautery and cut with scissors. The appendix base was double ligated with two extracorporeal knots and divided. The mean duration of surgery was 59.2 ± 31.2minutes. The median length of hospital stay was 2days. The mean duration of follow up was 2.80 ± 0.50 months. One patient developed superficial port site infection.
 Conclusion: The handmade extracorporeal knot used in this retrospective study for securing appendicular stump was found to be safe and cheaper than pre-tied extracorporeal loop. This will reduce dependency upon preformed endoloops making the procedure cheaper. There was no incidence of failed application of the handmade extracorporeal knot.

Assessment of anxiety and depression, and coping mechanisms during COVID-19 lockdown among pregnant women

BackgroundCOVID-19 lockdown was associated with disruption of daily life, economy, essential health services including maternal health service, and psychological reflexes such as panic, sleep disorders, fear, anxiety, and depression. AimTo assess the perception of pregnant women on the COVID-19 pandemic lockdown and the prevalence of common mental health disorders (CMHD) among pregnant women. MethodsA cross-sectional study was conducted among 380 pregnant women at the University College Hospital (UCH) Ibadan; participants were enrolled using a simple random sampling technique. Data was collected using pretested interviewer-administered questionnaire. Information obtained – sociodemographic and obstetric characteristics, perception and reaction to the COVID-19 pandemic and lockdown, effect on ANC, coping mechanisms, and presence of CMHD (anxiety and depression) were measured using Hospital Anxiety and Depression Scale (HADS). Data were analysed using STATA 16.0 Software. Descriptive and bivariate statistics were performed. The level of significance was p-value < 0.05. ResultsThe mean age was 32 ± 4.78 years, most respondents were <35 years (75%), married (97.1%), had a higher education (89%) and multiparous (70%). About 43.9% were worried that COVID-19 would affect pregnancy care, 42.9% reported it affected care and 81.6% were not worried it would affect the delivery care. Among respondents, 96.6% were able to cope with the effects of the pandemic and 96.8% enjoyed good social support. Respondents did not have CMHD (88.16%), 7.9% had CMHD (4.74% had depression and 3.16% had anxiety) and 3.95% had co-morbid depression and anxiety. On multinomial regression analysis, relative to anxiety or depression only, respondents with combined depression and anxiety had higher odds of having no delivery plan and thought COVID-19 may affect their delivery. ConclusionOnly a few women reported anxiety and depression symptoms during the lockdown and those with anxiety or combined symptoms of anxiety and depression had no birth plan and believed that COVID-19 would affect their delivery.

Factors Influencing the Compliance to Facemask Usage among University College Hospital (UCH) Commuters

Background: The Covid-19 pandemic has globally impacted how people interact, communicate and work. Facemask use has been advocated by the World health organization (WHO) and several global bodies with growing studies linking its accurate use to decreasing COVID-19 variant cases and associated deaths. For it to be effective in preventing further transmission of Covid-19 and its variants, they have to be worn properly and correctly. Health experts globally and the Nigerian Center for Disease Control (NCDC) have also issued guidelines on the use of facemask within the hospital environment in combination with regular hand hygiene and physical and social distancing to curtail the spread of the virus. Unfortunately information is scanty on the extent to which commuters visiting hospitals comply with this regulatory preventive behaviour. This study therefore assessed the level of compliance with the use of face masks and influencing factors among University College Hospital (UCH) Ibadan commuters. Methods: A descriptive cross-sectional study design and observatory survey was used. The sample population was calculated using the Cochran formula and a standard normal value of 1.96 at 95% confidence interval and 5% marginal error with a prevalence of 50%. A simple random sampling technique was adopted in selecting the target population of 260 commuters within UCH premises. Data collection was carried out within 3days from the hours of 8 am -10 am and 12 pm–2 pm. The information obtained from respondents includes the socio-demographic characteristics, knowledge of Covid-19, adherence to the use of facemask, factors promoting and hindering use among users and non-users, satisfaction towards the use of facemask, and the willingness to use facemask in the future. Data was coded and entered into the IBM statistical package for social sciences (SPSS 22nd edition) to analyze and interpret the data collected. Tables, inferences and charts were used for data representation. ...........

The Burden of Geriatric Trauma at the University College Hospital, Ibadan Nigeria.

Geriatric populations presently account for 9% of the world population and this is expected to increase. Injuries to the elderly accounted for 5.8 million accident and emergency visits in the US as well as 4% of patients treated for traumatic injuries in Abuja, Nigeria. Traumatic injury is therefore a major cause of morbidity in the elderly as such the need for the study in our environment. The aim of this study was to review the incidence and types of traumatic injury among the elderly population that presented at the University College Hospital Ibadan and to determine the causes of traumatic injury involving the geriatric age group in our environment. A retrospective hospital-based study involving the records of geriatric patients that presented with traumatic injuries between January 2014 and June 2021 at the geriatric center and the accident and emergency department of the hospital. The record was retrieved from the Total Quality Management Unit of the hospital. Approximately 7.61% of the traumatic injury that presented at the accident and emergency department within the study period involved geriatric patients with a male-to-female ratio of 1:1.08, whereas 0.3% of the patients for inpatient care at the geriatric center had a traumatic injury. Fall was the most common cause of traumatic injury observed and fracture was the most common traumatic injury observed. Less than 10% of the patients with the traumatic injury that presented at the University College Hospital Ibadan are in the geriatric age group. Most of the traumatic injury involving geriatric patients in our environment is due to low energy falls and fracture is the most common injury observed with the femur being the most affected bone. Therefore, interventions directed at reducing the incidence of falls in our environment will hopefully help in reducing the incidence of traumatic injuries in older person.

Paediatric Dialysis at a Tertiary Hospital in South-West Nigeria: A 4-Year Report

Introduction: Dialysis is potentially lifesaving in children with acute kidney injury (AKI) or chronic kidney disease (CKD), but availability is limited in low-income countries and lower-middle-income countries (LMICs). Methods: In the present study, we perform a 4-year study of patients who received peritoneal dialysis (PD) or haemodialysis (HD) at the Paediatric Nephrology Unit of the University College Hospital Ibadan, Nigeria. Subgroup analysis was performed on patients with sepsis or malaria AKI who underwent HD or PD for predictors of in-hospital mortality. Results: A total of 167 children aged 7 days to 18 years, median 7 (interquartile range 3–12) years, (60.5% males) were studied. In total, 129 (77.2%) had AKI, while 38 had CKD. Regarding AKI, 83 children (64.3%) received HD only, 42 underwent PD only, while 4 underwent both HD and PD. Malaria AKI was treated with HD in 43 (51.8%) or PD in 8 (10.5%), while sepsis AKI was treated with HD in 20 (21.4%) or PD in 33 (78.6%). Mortality in AKI was 16.3% overall, 10.8% in children on HD only, and 26.2% in children on PD only. Patients with sepsis AKI had higher mortality compared to patients with malaria AKI (RR 7.96 [1.70–37.37]). Subgroup analysis showed that age, diagnosis, and dialysis modality were not independent risk factors for mortality. The aetiology of CKD was glomerulonephritis in 26 (68.4%): treatment was HD in 36 and PD in 2 with mortality being 26.3%. Conclusions: PD for AKI showed relatively good outcomes in a LMIC. However, funding and support for a formal dialysis program for the management of AKI and CKD are needed.

Chlamydia Trachomatis Infection Amonginfertile Women At The University College Hospital, Ibadan

Background: Chlamydia trachomatis infection is reported as the commonest cause of tubal and pelvic infection and by proxy, the commonest cause of tubal damage and female infertility. Serotypes D-K are known to cause sexually transmitted genital tract and neonatal infection. Testing for the presence of Chlamydia trachomatis has been revolutionized by the development of monoclonal antibodies. This study sought to determine the prevalence of Chlamydia trachomatis infection among infertile women at the University College Hospital Ibadan and to determine the diagnostic value of Chlamydia antibody testing.&#x0D; Methodology: A cross-sectional study conducted among two hundred and seventy-three women with infertility attending the gynaecology clinic of the University College Hospital Ibadan. Hysterosalpingography (HSG) was performed on all patients as part of their routine evaluation for infertility. Venous blood was obtained to detect Chlamydia Ig G antibodies using the diagnostic bio-probe (DIA.PROBE) enzyme-linked immunoassay (ELIZA) for the quantitative determination of IgG antibodies specific to chlamydia trachomatis.&#x0D; Results: Positive test results for Chlamydia trachomatis were recorded amongst 136 women, giving a prevalence of 49.8%. 46(33.8%) women with normal tubal appearance and 90(66.2%) with tubal disease tested positive for Chlamydia antibodies. Bilateral tubal blockage was seen in 77(28.2%), while left and right tubal blockages were seen in 35(12.8%) and 21(7.7%) respectively. The accuracy of Chlamydia antibody testing in predicting tubal patency revealed a sensitivity of 67.7% and positive predictive value of 66.1% using HSG as the gold standard. Chlamydia trachomatis infection was found to be associated with age at sexual debut, history of ectopic pregnancy and previous history of abortion (P&lt;0.05).&#x0D; Conclusion: This study revealed a high prevalence of Chlamydia trachomatis amongst infertile women especially those with tubal disease. Risk factors associated with the infection such as early age of sexual debut, ectopic pregnancy and abortion further support the role of infectious morbidity especially with Chlamydia trachomatis.

Chlamydia Trachomatis Infection Amonginfertile Women At The University College Hospital, Ibadan

Background: Chlamydia trachomatis infection is reported as the commonest cause of tubal and pelvic infection and by proxy, the commonest cause of tubal damage and female infertility. Serotypes D-K are known to cause sexually transmitted genital tract and neonatal infection. Testing for the presence of Chlamydia trachomatis has been revolutionized by the development of monoclonal antibodies. This study sought to determine the prevalence of Chlamydia trachomatis infection among infertile women at the University College Hospital Ibadan and to determine the diagnostic value of Chlamydia antibody testing.&#x0D; Methodology: A cross-sectional study conducted among two hundred and seventy-three women with infertility attending the gynaecology clinic of the University College Hospital Ibadan. Hysterosalpingography (HSG) was performed on all patients as part of their routine evaluation for infertility. Venous blood was obtained to detect Chlamydia Ig G antibodies using the diagnostic bio-probe (DIA.PROBE) enzyme-linked immunoassay (ELIZA) for the quantitative determination of IgG antibodies specific to chlamydia trachomatis.&#x0D; Results: Positive test results for Chlamydia trachomatis were recorded amongst 136 women, giving a prevalence of 49.8%. 46(33.8%) women with normal tubal appearance and 90(66.2%) with tubal disease tested positive for Chlamydia antibodies. Bilateral tubal blockage was seen in 77(28.2%), while left and right tubal blockages were seen in 35(12.8%) and 21(7.7%) respectively. The accuracy of Chlamydia antibody testing in predicting tubal patency revealed a sensitivity of 67.7% and positive predictive value of 66.1% using HSG as the gold standard. Chlamydia trachomatis infection was found to be associated with age at sexual debut, history of ectopic pregnancy and previous history of abortion (P&lt;0.05).&#x0D; Conclusion: This study revealed a high prevalence of Chlamydia trachomatis amongst infertile women especially those with tubal disease. Risk factors associated with the infection such as early age of sexual debut, ectopic pregnancy and abortion further support the role of infectious morbidity especially with Chlamydia trachomatis.&#x0D;

Work-Related Quality of Life; A Case Study of Resident Doctors at the University College Hospital Ibadan, Nigeria

Work-Related Quality of Life; A Case Study of Resident Doctors at the University College Hospital Ibadan, Nigeria

Prevalence of Obesity and its primary comorbidities among patients attending the dietetics out-patient clinic in a tertiary health institution in southwestern Nigeria

Objective: The study assessed the prevalence of obesity and its co-morbidities among patients attending the dietetics outpatient clinic of the hospital. Methods: The prevalence of obesity and its co-morbidities were assessed in this retrospective study from the available in the outpatient clinic of the Dietetics Department in University College Hospital Ibadan, Oyo State. Age, gender, occupation, religion, height, weight, diagnosed diseases were extracted from the record of individuals who presented at the clinic over 72 months. Data obtained was analyzed using the Statistical Package for Social Sciences (SPSS) version 20. Result: A total of 3248 patients’ records were assessed. Of these, 1174 (36.15%) patients met the criteria for obesity according to their recorded BMI; 614(52.3%) had obesity class I (BMI 30–34.9), 343(29.2%) had obesity class II (BMI 35–39.9) and 217(18.5%) had obesity class III (BMI ≥40). Obesity was significantly higher amongst females than males (p&lt;0.05). The most prevalent single co-morbidity was diabetes 22.3%, while the most prevalent double co-morbidity was hypertension/diabetes 22.9%. Conclusion: The prevalence of obesity amongst patients was significant. Diabetes and hypertension were the most dominant co-morbidity. Interventions should be developed to combat the increasing prevalence of the diseases and these should involve educating the public and clinical management of the diseases upon identification.

Relationship between Vitamin D Status, Dyslipaedemia and Antioxidant Status in Children with Idiopathic Nephrotic Syndrome in South West, Nigeria

Dysregulated lipid metabolism and oxidative stress are strong factors that are implicated in the development of proteinuria and glomerular injury in Nephrotic Syndrome (NS). Vitamin D seems to be a promising tool in influencing lipid metabolism and antioxidant status in NS.&#x0D; Aim: This study aims at investigating the relationship between Vitamin D, dyslipaedemia and oxidative stress in NS.&#x0D; Study Design: This is a case-control study.&#x0D; Place and Duration of Study: Children’s Outpatient Clinic (CHOP) of University College Hospital (UCH) Ibadan, Nigeria between year 2019-2021.&#x0D; Methods: This study involves fifty children aged 5 to 12 years, freshly diagnosed with Idiopathic NS and fifty apparently healthy children as control. Blood samples were taken from them and analytes quantified by standard laboratory methods. Students’ t test and Pearson correlation were used to compare variables between the two groups respectively.&#x0D; Results: Results showed significant decrease (P &lt;.001) in Vit. D levels, GPX, SOD and CAT in NS. A significant decrease (P&lt;.001) occurred in HDL, a significant increase (P &lt;.001) in TG, TC and LDL levels in children with NS when compared with the control. There was a strong significant positive relationship between Catalase and Vit. D, SOD and Vit. D (r= 0.896, 0.869 respectively, P&lt;.001) in NS. While a weak non significant positive relationship occurred between HDL and Vit. D, GPX and Vit D (r=0.0585, 0.0236 respectively, P &gt;.001). A weak negative relationship occurred between TG and Vit. D, TC and Vit. D, LDL and Vit. D (r=-0.0432,-0.219, -0.231 respectively, P&gt;.001), in NS. Thus, vitamin D insufficiency influences serum lipid profiles and antioxidants in paediatric Idiopathic NS.