Since the 19th National Congress of the Communist Party of China, the Party building in universities has made significant progress, but also faces great challenge at the same time. Promoting the quality of Party building must feel the key pulse of the era, make the Party building in universities integrate into the implementation of the education of socialism with Chinese characteristics in the new age to analysis and solve problems, to explore inherent law of Party building. This article refer to the core thought of “treating disease according to its root” in the theory of Traditional Chinese Medicine(TCM), embrace the fundamental task of “strengthen moral education and cultivate people”, adhere to the principle of “Moral education makes a man an adult, and cultivation makes a man a talent.”, establish the innovation work system of Party building in universities under a principle called “treating both manifestation and root cause of disease”, answer well to the fundamental problem “why we need to do a good job in the Party building in colleges and universities in new era, how to do a good job in the Party building in colleges and universities in new era”, promote the quality and efficiency of Party building in universities in the new era.