Event Abstract Back to Event The Protein Synthesis Inhibitor Anisomycin Impairs Consolidation and Extinction of Spatial Reference Memory in Wistar Rats Viviana Vargas1*, Marisol Lamprea2 and Alejandro Munera2 1 Universidad Pablo de Olavide, Spain 2 Universidad Nacional de Colombia, Colombia The purpose of this study was to determinate the role of protein synthesis de novo in the formation of spatial reference memory as well as in its extinction. 27 male Wistar rats received eight reinforced trials (acquisition) in the Barnes maze and were tested in one reinforced trial 24 hours after training (retrieval). Next day, animals were randomly assigned to one of four groups: a) Anisomycin/Extinction, b) Vehicle/Extinction, c) Anisomycin/No-Extinction or d) Vehicle/No-Extinction. Animals received an intra-cerebro-ventricular microinjection of Anisomycin or Vehicle, and half of them were trained in the maze with eight non-reinforced trials of four minutes (Extinction), whereas, the rest of the animals stayed in their homecage (No-Extinction). Next day animals were tested in one non-reinforced trial of four minutes. Results showed that animals treated with Anisomycin, and No-Extinction, performed worse than those treated with Vehicle. On the other hand, animals treated with Anisomycin and Extinction showed the conditionated preference that was extinct the day before, while those treated with Vehicle showed no preference. These results indicate that protein synthesis is a cellular process necessary for the consolidation of memory and extinction, and involves more than one wave of synthesis. This data also supports the idea that extinction shares some basic cellular processes whit acquisition, and it is an active process, different from forgetting. Conference: 41st European Brain and Behaviour Society Meeting, Rhodes Island, Greece, 13 Sep - 18 Sep, 2009. Presentation Type: Poster Presentation Topic: Poster presentations Citation: Vargas V, Lamprea M and Munera A (2009). The Protein Synthesis Inhibitor Anisomycin Impairs Consolidation and Extinction of Spatial Reference Memory in Wistar Rats. Conference Abstract: 41st European Brain and Behaviour Society Meeting. doi: 10.3389/conf.neuro.08.2009.09.338 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 15 Jun 2009; Published Online: 15 Jun 2009. * Correspondence: Viviana Vargas, Universidad Pablo de Olavide, Sevilla, Spain, dvvarlop@alumno.upo.es Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Viviana Vargas Marisol Lamprea Alejandro Munera Google Viviana Vargas Marisol Lamprea Alejandro Munera Google Scholar Viviana Vargas Marisol Lamprea Alejandro Munera PubMed Viviana Vargas Marisol Lamprea Alejandro Munera Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.