BackgroundThe multicriteria assessment of advancing biorefinery to produce biodiesel (fatty acid methyl ester), glycerol, and torrefied pellets is a strategic approach towards sustainable development. MethodsA successive transesterification process was applied to separate lipids with alcohol, with a 1:7 mass-to-mass ratio in the presence of a heterogeneous catalyst of chitosan/polyvinyl alcohol-sodium hydroxide (CS/PVA-NaOH), to produce biodiesel and glycerol. Moreover, the remaining biomass is extracted to produce torrefied pellets by applying torrefaction through hydrothermal liquefication at 200–300 ℃ temperature. The biorefinery system using 613 kg organic fraction of municipal solid waste (OFMSW) produced 127.3 L of biodiesel, 14.5 kg of glycerol, and 387.5 kg of torrefied pellets. The whole systematic approach revealed two distinct areas with required characterized equipment such as dryer (A = 721.28m2), suspended in tank (V = 751.56m3), reactor (V = 721.56m3), cyclone (A = 743.48 m2), grinder (Q = 1352.31 m3/h), compactor (Q = 1367.31 m3/h), correspondingly. A gate-to-gate life cycle assessment (LCA) was performed for life cycle impact assessment (LCIA) through GaBi by using the ReCiPe 2016 Mid-point (H) and Endpoint (H) approach with a functional unit of 1000 kg municipal solid waste (MSW). Significant findingsThe economic assessment reveals the economic feasibility of the biorefinery project. The annual revenue determined the profitability index, which is $ 1.59 million annually, with a payback period of 1.8 years. The environmental analysis determined an eco-friendly production unit which can save 13.6% of carbon emissions by alternate use of photovoltaic energy. Conclusively, the calculated values and findings prove that biorefinery development using OFMSW is scientifically a win-win situation and notably assists in achieving circular bioeconomy and sustainable development goals (SDGs).