Unique Properties Of Nanomaterials Research Articles

Nanotechnology for Nasopharyngeal Cancer Therapy and Improving Drug Stability and Biodistribution

AbstractNasopharyngeal cancer (NPC) is a challenging malignancy with a poor prognosis due to late diagnosis and resistance to conventional treatments. Nanotechnology offers promising solutions to address these limitations by enabling targeted drug delivery, enhancing therapeutic efficacy, and facilitating multimodal treatment strategies. By leveraging the unique properties of nanomaterials and nanocarrier systems, innovative approaches for early detection, targeted treatment, and multimodal therapy can be developed, paving the way for more effective and personalized management of NPC. This review provides a comprehensive overview of recent developments and applications of nanotechnology in NPC therapy, focusing on improving drug stability, biodistribution, and targeted delivery to NPC tumors.

Opinion: Smart nanofertilizers for growth enhancement and stress resilience in agriculture

Smart nanofertilizers (NFs) represent a promising frontier in agricultural technology, offering precise nutrient delivery and stress resilience to enhance crop growth and productivity while minimizing the environmental impact. This opinion article explores the potential of smart NFs in revolutionizing traditional fertilization practices and addressing the challenges facing modern agriculture. By harnessing the unique properties of nanomaterials, smart NFs including noble metal nanoparticles, green NFs, and novel NFs from industrial waste enable targeted nutrient delivery, enhanced nutrient use efficiency, and stress tolerance in plants. However, their widespread adoption faces regulatory, safety, and scalability challenges that require interdisciplinary collaboration and concerted efforts from stakeholders. Despite these hurdles, smart NFs hold immense promise for promoting sustainable agriculture and ensuring food security in frequently changing global climatic conditions.

Nanomaterials in electronics: Advancements and challenges in high-performance devices

Nanomaterials, such as graphene, carbon nanotubes, and metal oxides, are revolutionizing the field of electronics by enabling the development of high-performance devices. This study provides a comprehensive overview of the synthesis, characterization, and application of these nanostructured materials. The unique properties of nanomaterials, including exceptional electrical conductivity, thermal management capabilities, and potential for device miniaturization, offer significant advantages over traditional materials. Graphene, for instance, exhibits remarkable electrical and thermal conductivity, making it an ideal candidate for applications in transistors and sensors. Carbon nanotubes, known for their strength and conductivity, enhance the performance of various electronic components, while metal oxides play a crucial role in semiconductor applications. Despite these advancements, several challenges remain. Issues related to scalability hinder the large-scale production of nanomaterials, while reproducibility concerns affect the reliability of devices fabricated from these materials. Moreover, the environmental impact of synthesizing and disposing of nanomaterials raises significant ethical considerations that must be addressed as the field progresses. This paper aims to provide insights into the current research trends and potential future directions, highlighting the need for sustainable practices in the synthesis and application of nanomaterials in electronics. By addressing these challenges, we can pave the way for the next generation of high-performance electronic devices that are not only efficient but also environmentally responsible.

Assessing the Toxicity of Metal- and Carbon-Based Nanomaterials In Vitro: Impact on Respiratory, Intestinal, Skin, and Immune Cell Lines.

The field of nanotechnology has experienced exponential growth, with the unique properties of nanomaterials (NMs) being employed to enhance a wide range of products across diverse industrial sectors. This study examines the toxicity of metal- and carbon-based NMs, with a particular focus on titanium dioxide (TiO2), zinc oxide (ZnO), silica (SiO2), cerium oxide (CeO2), silver (Ag), and multi-walled carbon nanotubes (MWCNTs). The potential health risks associated with increased human exposure to these NMs and their effect on the respiratory, gastrointestinal, dermal, and immune systems were evaluated using in vitro assays. Physicochemical characterisation of the NMs was carried out, and in vitro assays were performed to assess the cytotoxicity, genotoxicity, reactive oxygen species (ROS) production, apoptosis/necrosis, and inflammation in cell lines representative of the systems evaluated (3T3, Caco-2, HepG2, A549, and THP-1 cell lines). The results obtained show that 3T3 and A549 cells exhibit high cytotoxicity and ROS production after exposure to ZnO NMs. Caco-2 and HepG2 cell lines show cytotoxicity when exposed to ZnO and Ag NMs and oxidative stress induced by SiO2 and MWCNTs. THP-1 cell line shows increased cytotoxicity and a pro-inflammatory response upon exposure to SiO2. This study emphasises the importance of conducting comprehensive toxicological assessments of NMs given their physicochemical interactions with biological systems. Therefore, it is of key importance to develop robust and specific methodologies for the assessment of their potential health risks.

Twenty years of in vitro nanotoxicology: how AI could make the difference.

More than two decades ago, the advent of Nanotechnology has marked the onset of a new and critical field in science and technology, highlighting the importance of multidisciplinary approaches to assess and model the potential human hazard of newly developed advanced materials in the nanoscale, the nanomaterials (NMs). Nanotechnology is, by definition, a multidisciplinary field, that integrates knowledge and techniques from physics, chemistry, biology, materials science, and engineering to manipulate matter at the nanoscale, defined as anything comprised between 1 and 100nm. The emergence of nanotechnology has undoubtedly led to significant innovations in many fields, from medical diagnostics and targeted drug delivery systems to advanced materials and energy solutions. However, the unique properties of nanomaterials, such as the increased surface to volume ratio, which provides increased reactivity and hence the ability to penetrate biological barriers, have been also considered as potential risk factors for unforeseen toxicological effects, stimulating the scientific community to investigate to which extent this new field of applications could pose a risk to human health and the environment.

Gold Nanoparticles in Nanobiotechnology: From Synthesis to Biosensing Applications.

Nanobiotechnology has ushered in a new era of scientific discovery where the unique properties of nanomaterials, such as gold nanoparticles, have been harnessed for a wide array of applications. This review explores gold nanoparticles' synthesis, properties, and multidisciplinary applications, focusing on their role as biosensors. Gold nanoparticles possess exceptional physicochemical attributes, including size-dependent optical properties, biocompatibility, and ease of functionalization, making them promising candidates for the development of biosensing platforms. The review begins by providing a comprehensive overview of gold nanoparticle synthesis techniques, highlighting the advantages and disadvantages of various approaches. It then delves into the remarkable properties that underpin their success in biosensing, such as localized surface plasmon resonance and enhanced surface area. The discussion also includes the functionalization strategies that enable specific binding to biomolecules, enhancing the sensitivity and selectivity of gold-nanoparticle-based biosensors. Furthermore, this review surveys the diverse applications of gold nanoparticles in biosensing, encompassing diagnostics, environmental monitoring, and drug delivery. The multidisciplinary nature of these applications underscores the versatility and potential of gold nanoparticles in addressing complex challenges in healthcare and environmental science. The review emphasizes the pressing need for further exploration and research in the field of nanobiotechnology, particularly regarding the synthesis, properties, and biosensing applications of gold nanoparticles. With their exceptional physicochemical attributes and versatile functionalities, gold nanoparticles present a promising avenue for addressing complex challenges in healthcare and environmental science, making it imperative to advance our understanding of their synthesis, properties, and applications for enhanced biosensing capabilities and broader scientific innovation.

Next-Generation Vaccine Development with Nanomaterials: Recent Advances, Possibilities, and Challenges.

Nanomaterials are becoming important tools for vaccine development owing to their tunable and adaptable nature. Unique properties of nanomaterials afford opportunities to modulate trafficking through various tissues, complement or augment adjuvant activities, and specify antigen valency and display. This versatility has enabled recent work designing nanomaterial vaccines for a broad range of diseases, including cancer, inflammatory diseases, and various infectious diseases. Recent successes of nanoparticle vaccines during the coronavirus disease 2019 (COVID-19) pandemic have fueled enthusiasm further. In this review, the most recent developments in nanovaccines for infectious disease, cancer, inflammatory diseases, allergic diseases, and nanoadjuvants are summarized. Additionally, challenges and opportunities for clinical translation of this unique class of materials are discussed.

Sustainable nanomaterials' role in green supply chains and environmental sustainability

The review explores the pivotal role of sustainable nanomaterials in promoting green supply chains and advancing environmental sustainability. Nanotechnology has emerged as a promising field for developing innovative materials with enhanced properties and reduced environmental impacts. Sustainable nanomaterials, characterized by their eco-friendly synthesis methods, biodegradability, and low toxicity, offer transformative opportunities for enhancing the sustainability of supply chains across diverse industries. This review examines the potential applications of sustainable nanomaterials in green supply chains, encompassing areas such as renewable energy, water purification, waste management, and sustainable packaging. By leveraging the unique properties of nanomaterials, such as high surface area-to-volume ratio, catalytic activity, and tunable properties, businesses can develop sustainable solutions to address pressing environmental challenges. Case studies and examples highlight successful integration of sustainable nanomaterials into supply chain practices, showcasing their ability to reduce resource consumption, minimize waste generation, and mitigate environmental impacts. The review also discusses challenges and considerations associated with the adoption of sustainable nanomaterials, including regulatory compliance, risk assessment, and ethical considerations. Strategies for promoting responsible nanotechnology practices and fostering collaboration among stakeholders are proposed, emphasizing the importance of interdisciplinary approaches and stakeholder engagement in achieving sustainable supply chain goals. In conclusion, the integration of sustainable nanomaterials into green supply chains holds immense potential for driving environmental sustainability, innovation, and long-term prosperity. Keywords: Sustainable Nanomaterials, Green Supply Chains, Environmental Sustainability, Circular Economy, Nanotechnology, Supply Chain Optimization

Nanotechnology's potential in advancing renewable energy solutions

Nanotechnology has emerged as a promising frontier in the quest for sustainable energy solutions, offering transformative opportunities to address pressing challenges in renewable energy generation, storage, and conversion. This review explores the potential of nanotechnology in advancing renewable energy solutions, encompassing a wide range of applications spanning solar energy, wind energy, energy storage, and fuel cells. By leveraging the unique properties of nanomaterials, such as high surface area-to-volume ratio, tunable optical and electronic properties, and enhanced catalytic activity, researchers and engineers can develop innovative materials and devices with unprecedented performance and efficiency. Nanotechnology-enabled advancements in solar photovoltaics include the development of next-generation solar cells incorporating nanostructured materials, such as quantum dots, nanowires, and perovskite-based solar cells, to enhance light absorption, charge transport, and overall power conversion efficiency. In the realm of energy storage, nanomaterials hold promise for improving the performance and longevity of batteries, supercapacitors, and other energy storage devices through enhanced electrode materials, electrolytes, and nanostructured architectures. Furthermore, nanotechnology-driven innovations in wind energy, such as lightweight and durable nanocomposite materials for turbine blades, and advancements in fuel cell technologies, including catalyst nanoparticles for efficient hydrogen production and conversion, exemplify the diverse applications and transformative potential of nanotechnology in renewable energy. Through a comprehensive analysis of recent research and development efforts, this abstract underscores the critical role of nanotechnology in accelerating the transition to a sustainable and renewable energy future. Keywords: Nanotechnology, Renewable Energy, Solar Energy, Wind Energy, Energy Storage, Nanomaterials.

Influence of the alcohol and water grades on surfactant-free colloidal syntheses of gold nanoparticles in alkaline water-alcohol mixtures

To make the most of the unique properties of nanomaterials, and to bridge the gap between fundamental and applied research, controlled, green, cheap and energy efficient syntheses of nanoparticles are required. In this respect, room and low temperature surfactant-free colloidal syntheses of nanoparticles obtained in low viscosity and low boiling point solvents, without additives or nature-derived extracts, are promising to develop more active (electro)catalysts. Recently, a room temperature synthesis of surfactant-free gold nanoparticles has been documented (Chem. Mater. 2023, 35, 5, 2173) that requires only water, a base such as NaOH, an alcohol and HAuCl4. Unfortunately, the syntheses of nanomaterials are often sensitive to multiple parameters and it is well acknowledged that reproducibility is a general challenge in the chemical sciences, where the synthesis of nanomaterials is no exception. Here, we investigate the effect of the water conductivity and solvent grade on the surfactant-free low temperature (ca. 30 °C) synthesis of colloidal gold nanoparticles obtained in alkaline mixtures of ethanol and water. The synthesis can be performed with relatively low-grade ethanol but requires high purity water. The importance of water with low conductivity is also stressed for syntheses where ethylene glycol and glycerol are used as source of reducing agents. The results of this study over 100 samples pave the way to greener, more controlled and scalable syntheses of surfactant-free gold nanomaterials.

Multifunctional Ti3C2Tx MXene-reinforced thermoplastic starch nanocomposites for sustainable packaging solutions

Starch-derived films exhibit significant potential for packaging applications owing to their low cost, biodegradable characteristics, and natural abundance. Nonetheless, there is a demand to enhance their mechanical properties and moisture resistance to broaden their use. In this study, high performing sorbitol-plasticized starch/Ti3C2Tx MXene nanocomposites, reinforced with ultra-low filler contents, were fabricated for the first time in literature. The MXene nanoplatelets were well-dispersed within the starch matrix while there was a tendency for the fillers to align in-plane, as revealed by polarized Raman spectroscopy. The produced nanocomposite films demonstrate remarkable effectiveness in blocking UV light, offering an additional valuable attribute in food packaging. The Young's modulus and tensile strength of starch films containing 0.75 wt% MXene increased from 439.9 and 11.0 MPa to 764.3 and 20.8 MPa, respectively. The introduction of 1 wt% MXene nanoplatelets reduced the water vapour permeability of starch films from 2.78 × 10−7 to 1.80 × 10−7 g/m h Pa due to the creation of highly tortuous paths for water molecules. Micromechanical theories were also implemented to understand further the reinforcing mechanisms in the biobased nanocomposites. The produced starch nanocomposites not only capitalize on the biodegradable and renewable nature of starch but also harness the unique properties of nanomaterials, paving the way for sustainable and high-performance packaging solutions that align with both consumer and environmental demands.

Exposure control measures proposed by different organizations: the curious case of nanomaterial-involved activities

Objectives. The unique properties of nanomaterials have turned them into an emerging threat for humans and the environment. This study therefore aimed to review exposure control measures proposed for nanomaterial-involved activities. Methods. This study is based on the published guidelines of different organizations on safe handling of nanomaterials. The search for documents was provided using the keywords ‘Exposure controls’, ‘Good practices’, ‘Working safely’, ‘Safe practices’, ‘Handling safely’, ‘Safety guide’ and ‘Safety and health’, combined with ‘Nanomaterials’, ‘Nanotechnology’ and ‘Nanoparticles’ on different databases and websites. Results. Thirty-one guidelines from 27 organizations were included. Most of the guidelines recommended engineering controls, administrative controls and personal protective equipment (PPE). Changing the physical form of nanomaterials or the process, using prevention through design (PtD) and using green chemistry principals were other suggestions to reduce exposure to nanomaterials. Conclusions. Considering the difficulty of implementation and case specificity of the solutions of the first two priorities of the hierarchy of controls (elimination and substitution), the emphasis of the guidelines on the next three priorities for controlling exposure to nanomaterials is understood. The type and method of using PPE and engineering controls should be resolved by referring to cutting-edge articles.

Potential of Surface Functionalized Nanomaterials in Innovative Drug Development: A Mini-review

Abstract: The unique properties of nanomaterials (NMs) make them special entities for biomedical innovation and research. Early diagnosis and follow-up of diseases are easily possible with the help of nanotechnology and nanomedicine, which can help combat any medical condition. Surface functionalization with specific molecules might impart marked properties to NMs, leading to the modification of cellspecific interactions within the biological systems. This modification may provide excellent phenomena for innovative drug development. Modified NMs might play essential roles in various applications, i.e., in vivo diagnostics, magnetic resonance imaging (MRI), positron emission tomography (PET), etc. Functionalization of NMs with appropriate ligands, small molecules, or polymers assigned them enhanced stability, biocompatibility, and functionality for their novel and improved biological applications. Surface functionalized NMs might display enhanced antimicrobial, antidiabetic, and drug delivery potential for various applications. Different studies reported the potential of functionalized metallic nanoparticles in regenerative medicines. Conjugation of NMs with various molecules such as peptides, small ligands, polysaccharides, proteins, saturated and polyunsaturated fatty acids, siRNA, plasmids, and DNA, might be achieved by various reactions. Biomolecule-conjugated nanoparticles result in the production of hybrid NMs with specific and novel biological interactions in biological systems. Chemical treatment methods are considered among the most trusted and efficient functionalization methods. Some commonly used techniques and strategies of functionalization involve grafting to and grafting from methods, ligand exchange technique, covalent bonding, chemisorption, non-covalent interactions, electrostatic adsorption, etc. This brief review is dedicated to the surface functionalization of NMs with the latest development

Nanomedicines: Emerging Platforms in Smart Chemotherapy Treatment-A Recent Review.

Cancer continues to pose one of the most critical challenges in global healthcare. Despite the wide array of existing cancer drugs, the primary obstacle remains in selectively targeting and eliminating cancer cells while minimizing damage to healthy ones, thereby reducing treatment side effects. The revolutionary approach of utilizing nanomaterials for delivering cancer therapeutic agents has significantly enhanced the efficacy and safety of chemotherapeutic drugs. This crucial shift is attributed to the unique properties of nanomaterials, enabling nanocarriers to transport therapeutic agents to tumor sites in both passive and active modes, while minimizing drug elimination from delivery systems. Furthermore, these nanocarriers can be designed to respond to internal or external stimuli, thus facilitating controlled drug release. However, the production of nanomedications for cancer therapy encounters various challenges that can impede progress in this field. This review aims to provide a comprehensive overview of the current state of nanomedication in cancer treatment. It explores a variety of nanomaterials, focusing on their unique properties that are crucial for overcoming the limitations of conventional chemotherapy. Additionally, the review delves into the properties and functionalities of nanocarriers, highlighting their significant impact on the evolution of nanomedicine. It also critically assesses recent advancements in drug delivery systems, covering a range of innovative delivery methodologies. Finally, the review succinctly addresses the challenges encountered in developing nanomedications, offering insightful perspectives to guide future research in this field.

The application of peroxidase mimetic nanozymes in cancer diagnosis and therapy

In recent decades, scholarly investigations have predominantly centered on nanomaterials possessing enzyme-like characteristics, commonly referred to as nanozymes. These nanozymes have emerged as viable substitutes for natural enzymes, offering simplicity, stability, and superior performance across various applications. Inorganic nanoparticles have been extensively employed in the emulation of enzymatic activity found in natural systems. Nanoparticles have shown a strong ability to mimic a number of enzyme-like functions. These systems have made a lot of progress thanks to the huge growth in nanotechnology research and the unique properties of nanomaterials. Our presentation will center on the kinetics, processes, and applications of peroxidase-like nanozymes. In this discourse, we will explore the various characteristics that exert an influence on the catalytic activity of nanozymes, with a particular emphasis on the prevailing problems and prospective consequences. This paper presents a thorough examination of the latest advancements achieved in the domain of peroxidase mimetic nanozymes in the context of cancer diagnosis and treatment. The primary focus is on their use in catalytic cancer therapy, alongside chemotherapy, phototherapy, sonodynamic therapy, radiation, and immunotherapy. The primary objective of this work is to offer theoretical and technical assistance for the prospective advancement of anticancer medications based on nanozymes. Moreover, it is anticipated that this will foster the investigation of novel therapeutic strategies aimed at achieving efficacious tumor therapy.

Harnessing glucose metabolism with nanomedicine for cancer treatment.

The significance of metabolic processes in cancer biology has garnered substantial attention, as they are essential for meeting the anabolic demands and maintaining the redox balance of rapidly dividing cancer cells. A distinctive feature of tumors is that cancer cells, unlike normal cells, exhibit an increased rate of glucose metabolism. They predominantly relying on aerobic glycolysis to metabolize glucose, which enables these cells to supply energy and produce the necessary building blocks for growth. Targeting glucose metabolism has led to the development of various cancer treatments. However, these agents often have limited efficacy due to factors such as poor stability and solubility, rapid clearance and an insufficient amount of the drug reaching the target site. These limitations can be overcome by preparing nano dosage forms through nanotechnology, which leverages the unique properties of nanomaterials to deliver drugs more precisely to target tissues with controlled release. In this review, we provide a comprehensive overview of the latest advancements in nanomedicine, focusing on the modulation of glucose metabolism in cancer cells. We discuss the design and application of various strategies that have been engineered to target the metabolic hallmarks of cancer. These nanomedicine strategies aim to exploit the metabolic vulnerabilities of cancer cells, thereby offering novel approaches to cancer therapy. The review highlights the innovative nanomaterials and their potential to deliver therapeutic agents more effectively, as well as the challenges and considerations in translating these nanomedicines from bench to bedside. By targeting the glucose metabolism of cancer cells, these nanoscale interventions hold promise for improving treatment outcomes and potentially overcoming the resistance that often plagues conventional cancer therapies.

Nanomaterials and nanotechnology : A comprehensive study of synthesis, characterization and multifaceted applications

This paper presents a comprehensive study of nanomaterials and nanotechnology, encompassing synthesis methodologies, advanced characterization techniques and diverse applications. Nanomaterials, engineered at the nanoscale, exhibit unique properties and hold immense promise for revolutionizing various industries. The study covers five key subheadings, addressing synthesis approaches, characterization methods, multifaceted applications in medicine, energy, electronics and future prospects in the field. The core of this comprehensive study delves into the multifaceted applications of nanomaterials, covering a broad spectrum of fields ranging from medicine and pharmaceuticals to environmental science and renewable energy. In the medical realm, the paper discusses the revolutionary impact of nanomaterials in drug delivery systems, targeted cancer therapies, and diagnostic tools. The unique properties of nanomaterials, such as increased surface area and reactivity, are shown to enhance the efficacy of drugs and treatment methods. The interdisciplinary nature of nanomaterials and their vast potential make this field a cornerstone of future advancements in science and engineering.

Nano-Technological Bioremediation: Revolutionizing Environmental Cleanup

Abstract: Bioremediation, the use of living organisms or their byproducts to eliminate pollutants from contaminated environments, has emerged as a promising strategy for environmental cleanup. In recent years, the integration of nanotechnology with bioremediation has opened up new frontiers in this field. Nano-technological bioremediation represents a groundbreaking approach that combines the unique properties of nanomaterials with the capabilities of microorganisms for enhanced pollutant degradation. This review article provides an overview of the recent advances in nano-technological bioremediation, highlighting its potential applications, challenges, and future prospects.

Challenges and Prospective of Enhancing Hydatid Cyst Chemotherapy by Nanotechnology and the Future of Nanobiosensors for Diagnosis.

Hydatid cysts have been widely recognized for decades as a common medical problem that affects millions of people. A revolution in medical treatment may be on the prospect of nanotechnology enhancing chemotherapy against hydatid cysts. An overview of nanotechnology's impact on chemotherapeutics is presented in the current review. It discusses some of the challenges as well as some of the opportunities. The application of nanotechnology to enhance chemotherapy against hydatid cysts is what this review will explore. Nanotechnology is a critical component of delivering therapeutic agents with greater precision and efficiency and targeting hydatid cysts with better efficacy, and minimizing interference with surrounding tissue. However, there are biodistribution challenges, toxicity, and resistance problems associated with nanotherapeutics. Additionally, nanobiosensors are being investigated to enable the early diagnosis of hydatid cysts. A nanobiosensor can detect hydatid cysts by catching them early, non-invasively, rapidly, and accurately. The sensitivity and specificity of diagnostic tests can be enhanced with nanobiosensors because they take advantage of the unique properties of nanomaterials. By providing more precise and customized treatment options for hydatid cysts, nanotechnology may improve therapeutic options and strategies for diagnosing the disease. In conclusion, treatment with nanotechnology to treat hydatid cysts is potentially effective but presents many obstacles. Furthermore, nanobiosensors are being integrated into diagnostic techniques, as well as helping to diagnose patients earlier and more accurately.

Nanotechnology in coronary heart disease.

Coronary heart disease (CHD) is one of the major causes of death and disability worldwide, especially in low- and middle-income countries and among older populations. Conventional diagnostic and therapeutic approaches have limitations such as low sensitivity, high cost and side effects. Nanotechnology offers promising alternative strategies for the diagnosis and treatment of CHD by exploiting the unique properties of nanomaterials. In this review, we use bibliometric analysis to identify research hotspots in the application of nanotechnology in CHD and provide a comprehensive overview of the current state of the art. Nanomaterials with enhanced imaging and biosensing capabilities can improve the early detection of CHD through advanced contrast agents and high-resolution imaging techniques. Moreover, nanomaterials can facilitate targeted drug delivery, tissue engineering and modulation of inflammation and oxidative stress, thus addressing multiple aspects of CHD pathophysiology. We discuss the application of nanotechnology in CHD diagnosis (imaging and sensors) and treatment (regulation of macrophages, cardiac repair, anti-oxidative stress), and provide insights into future research directions and clinical translation. This review serves as a valuable resource for researchers and clinicians seeking to harness the potential of nanotechnology in the management of CHD. STATEMENT OF SIGNIFICANCE: Coronary heart disease (CHD) is the one of leading cause of death and disability worldwide. Nanotechnology offers new strategies for diagnosing and treating CHD by exploiting the unique properties of nanomaterials. This review uses bibliometric analysis to uncover research trends in the use of nanotechnology for CHD. We discuss the potential of nanomaterials for early CHD detection through advanced imaging and biosensing, targeted drug delivery, tissue engineering, and modulation of inflammation and oxidative stress. We also offer insights into future research directions and potential clinical applications. This work aims to guide researchers and clinicians in leveraging nanotechnology to improve CHD patient outcomes and quality of life.