Purpose: The aim of the study was to analyze the impact of economic sanctions on diplomatic relations: a comparative analysis Methodology: This study adopted a desk methodology. A desk study research design is commonly known as secondary data collection. This is basically collecting data from existing resources preferably because of its low cost advantage as compared to a field research. Our current study looked into already published studies and reports as the data was easily accessed through online journals and libraries. Findings: Economic sanctions wielded by the United States impact diplomatic relations in multifaceted ways. While they can isolate adversaries economically, they often strain diplomatic ties, escalating tensions. Success hinges on factors like target country resilience and international support. Unilateral actions may undermine US diplomatic credibility. Diplomatic efforts, like negotiations and exemptions, are vital for mitigating consequences and fostering conflict resolution. Unique Contribution to Theory, Practice and Policy: Theory of economic coercion, theory of reciprocity and tit-for-tat & theory of economic interdependence may be used to anchor future studies on impact of economic sanctions on diplomatic relations: a comparative analysis. Diplomatic practitioners should prioritize sustained engagement and dialogue as essential tools for managing the diplomatic fallout of economic sanctions, leveraging both traditional and non-traditional diplomatic channels. Policymakers should adopt flexible and context-specific approaches to economic sanctions, recognizing that a one-size-fits-all approach may not effectively achieve diplomatic objectives.