Uniform Mass Research Articles

Hanging Cables and Spider Threads

Summary It has been known for more than 300 years that the shape of an inelastic hanging cable, chain, or rope of uniform linear mass density is the graph of the hyperbolic cosine, up to scaling and shifting coordinates. But given two points at which the ends of the cable are attached, how exactly should we scale and shift the coordinates? Many otherwise excellent expositions of the problem are vague about that. They might, for instance, give the answer in terms of the tension at the lowest point, but without explaining how to compute that tension. Here we discuss how to obtain all necessary parameters. To obtain the tension at the lowest point, one has to solve a nonlinear equation numerically. When the two ends of the cable are attached at different heights, a second nonlinear equation must be solved to determine the location of the lowest point. When the cable is elastic, like a thread in a spider’s web, the two equations can no longer be decoupled, but they can be solved using two-dimensional Newton iteration.

Clinical and ultrasound features of uterine perivascular epithelioid cell tumors: case series and literature review.

To describe the clinical and ultrasonographic features of uterine perivascular epithelioid cell tumor (PEComa) using standardized terminology. This was a retrospective analysis of patients with uterine PEComa diagnosed and confirmed by pathology and immunohistochemistry at West China Second University Hospital, Sichuan University, Sichuan, China, between January 2010 and September 2023. The Morphological Uterus Sonographic Assessment (MUSA) consensus and the International Endometrial Tumor Analysis (IETA) consensus were utilized for the standardized description of the sonographic characteristics of uterine PEComa. We summarized the clinical and ultrasound features of uterine PEComa in cases from our center and those found in a review of the literature conducted using PubMed from 1 January 2013 to 30 September 2023 (inclusive). Five patients, aged 33-57 (median, 52) years with a total of six uterine PEComa lesions were included in our cohort. All cases had complete ultrasonographic and pathological images. None of the patients had a history of tuberous sclerosis complex. Two patients had malignant PEComa (one patient had two lesions) and three had benign PEComa, originating from the cervix, myometrium or uterine cavity. Patients presented with symptoms including increased vaginal discharge, vaginal bleeding and pelvic or abdominal pain. The three patients with benign PEComa underwent total hysterectomy and bilateral adnexectomy, tumor excision and conservative management, respectively, while both malignant cases underwent total hysterectomy and bilateral adnexectomy followed by chemotherapy. Regular follow-up (from 6 to 24 months) revealed recurrence in one case. Two lesions were misdiagnosed as uterine fibroids, two as cervical cancer, one as metastatic cervical cancer (with myometrial invasion) and one was indeterminate. Ultrasound examination showed that most lesions displayed regular round or ovoid shapes (66.7%), uniform echoes (66.7%) and hypoechogenicity (66.7%), with one (16.7%) malignant PEComa showing cystic areas and one (16.7%) benign PEComa showing punctate calcifications. All lesions lacked shadowing and the majority showed moderate to abundant vascularity (color score of 3-4, 83.3%). The color score was 2-4 in the periphery in 100% of cases and internally in 83.3% of cases. The three benign PEComas showed similar characteristics in vascular distribution, with scattered internal vessels and peripheral vessels exhibiting a circular pattern. The literature search identified 11 articles describing the ultrasonographic appearance of 18 cases of uterine PEComa, with similar characteristics to those in our cohort. The sonographic features of uterine PEComa include a uniform or non-uniform hypoechogenic mass, typically round or ovoid with regular margins, occasionally containing cystic areas or calcifications, lacking shadowing and often showing moderate to abundant vascularity. Although the preoperative ultrasound diagnosis of uterine PEComa remains challenging, particularly given the non-specific nature of the sonographic characteristics described here, dispersed intratumoral vessels and a peripheral circular vascular distribution may serve as diagnostic clues for uterine PEComa, but more cases are needed for confirmation. © 2024 International Society of Ultrasound in Obstetrics and Gynecology.

Investigation on the effect of vertical baffle plate on droplet size distribution and mixing efficiency in Taylor Reactor

The Taylor reactor is a dynamic mixer based on the principles of Taylor vortex flow. However, traditional Taylor reactors feature smooth inner and outer cylinder surfaces, presenting challenges in achieving uniform mixing and efficient mass transfer. These limitations do not meet the requirements of modern chemical processes for highly efficient mixing equipment. This article introduces a novel Taylor reactor equipped with vertical baffle plates, designed to overcome these challenges. A comprehensive methodology combining CFD-PBM and experimental techniques was employed to investigate both droplet size distribution and mixing performance in the annular gap. Compared to traditional designs, the new device demonstrates significantly lower COV at 0.018 and Sauter mean diameter at 38.3 μm. Optimal mixing efficiency is achieved at rotating Reynolds number (Re) of 1.17 × 105 and inlet Reynolds number (Rei) of 2.65 × 103. Numerical simulation results suggest that vertical baffles effectively enhance liquid-liquid interactions including collision, interface contact, and droplet residence time within the annular gap. Moreover, increased turbulent stress in the flow field contributes to greater vorticity, turbulence intensity, and turbulent kinetic energy resulting in smaller droplet sizes and improved mixing efficiency. These findings provide a theoretical foundation for hydraulic structural optimization design as well as widespread application of Taylor reactors.

An improved Chinese load code method for the evaluation of wind‐induced base shear force on base‐isolated buildings

AbstractThe isolator units in a seismically isolated structure shall have a surplus yield strength under wind loads. The isolation interface must have enough strength to state at an elastic stage under wind loads. This necessitates an accurate evaluation of wind‐induced base shear force. Initially, to calculate the equivalent static wind load (ESWL) and the base shear force of a base‐isolated building, the validity of the inertial wind load (IWL) method and Chinese load code (CLC) method, the simplification based on the IWL method, are examined via comparison with response‐history analysis results. Comparative analysis reveals that the IWL method was more accurate in evaluating the ESWL and the base shear force of base‐isolated building, while the CLC method underestimated them due to the following reasons: inaccurate fundamental modal shape, a reduced peak factor, the omission of the ESWL contribution from the isolation interface, and flawed assumptions of uniform mass distribution. Subsequently, an improved CLC method that combined the exponential modal shape and first modal generalized mass modification coefficient is proposed and verified by a case study. Compared with the CLC method, the fluctuating base shear force calculated by the improved CLC method increased by 10% in the case study. Finally, the effect of non‐uniformly distributed mass is further considered in the proposed method by devising a mass conversion coefficient, and the case study has also validated this method. Without considering the effect of the non‐uniform mass, the fluctuating base shear force will be underestimated by 7.8% in the case study.

Analytical Investigation of the Effects of Additional Load Mass on the Fundamental Frequency of Pedestrian Beam Bridges

The aspect of resonant vibrations due to pedestrian movement is of great significance in engineering practice. Therefore, understanding the variations in the natural frequency of bridge structures under varying positions of additional mass is of particular interest. This paper presents a procedure for the straightforward determination of the natural frequencies of a beam pedestrian bridge for various positions of pedestrians or a service vehicle based on derived analytical solutions. The calculation takes into account the inertial effects of the additional load mass, modeled as either uniformly distributed or concentrated. The importance of additional load mass effects on the fundamental frequency of a beam pedestrian bridge and its dynamic response to a moving pedestrian load is demonstrated on a bridge example. The proposed solutions are also applicable to other girder system structures with uniform mass and stiffness along their span.

Control of a building system with sudden nonlinearity using the sliding mode technique

In civil engineering application such as the seismic resistant structural design, a building system often enters into its nonlinear range to minimize the force transfer to the superstructure. An ideal control design should enhance the usefulness of the nonlinear behavior by diminishing its adverse effects at a minimal control input. This study developed a unified feedback mechanism based on the sliding mode control approach that fostered the multiple selected modal control of a structural system undergoing linear and nonlinear stages of hysteretic deformations. The ideal sliding surface for controlling a specific mode was designed based on the interaction characteristics between two modes at two different stages of deformation. An ′ S′ type functional form of the control force was developed on either side of the sliding surface based on the velocity feedback of the system by ensuring reachability to the ideal sliding surface. To demonstrate the effectiveness of the adopted control, a five-story shear building with uniform mass and initial stiffness distribution with concentrated nonlinearity at the base column was considered under 10 earthquake excitations. The system was studied under the proposed control along with the uncontrolled system. In addition to the adopted control, a popular and existing LQG control technique was also implemented based on the equivalent linearized structural system for comparison. The adopted control provided the desired performance of the structural system while keeping the effectiveness of the system’s nonlinearity under earthquake excitations. Considering the system’s responses and the input control force, the efficiency of the adopted mechanism outperformed the LQG control, which was found to amplify the unfavorable effects of the system’s nonlinearity.

Soret Effect of Unsteady Parabolic Flow Past an Accelerated Vertical Plate with Constant Temperature and Mass Diffusion in t he Presence of Rotation

Objective: Circular force's detrimental effects on inhomogeneous parabola circulation over an upright slab that rapidly accelerates in uniform temperature and continuous mass dispersion are discussed. There is no electrical conductivity in the liquid in question. Methods: The solutions for the temperature, concentration, and velocity profiles were identified through the Laplace transformation methodology. Findings: Graphical drawings displaying several specifications, include the acceleration parameter, Schmidt value, Soret value, Hartmann number, thermal Grashof number are used to illustrate the results that were obtained. It is noted that as the values - thermal Grashof number -increase, speed also increases. Regarding Schmidt and Prandtl numbers, the tendency is the opposite. Novelty: The unique aspect of this work is its thorough analysis of the Soret Effect in an erratic, rotating, parabolic flow past an accelerating vertical plate with mass diffusion and constant heat. The work closes gap in the literature by addressing these particular conditions and offers insightful conclusions and useful techniques that may be used to a variety of scientific and engineering issues. This study investigates the impact of rotating effects and Soret impact on erratic convective movement in a vertical plate. Results show that Schmidt number and wall thickness increase over time, while temperature patterns rise with increasing Sr and Sc levels. The Prandtl number depends on air and water temperatures. The study fills a literature gap and provides valuable insights for various scientific and practical applications. Keywords: Soret effect, Turning, Mass dissemination, Parabolic, Vertical surface

Rotation and Dufour Impact on Unsteady Flow Past a Parabolic Accelerated Vertical Plate with Uniform Temperature and Mass Diffusion

Objective : Fluid dynamics and heat transfer theory examine the Dufour phenomenon and the rotational influence of unstable parabolic flow across an accelerating infinite vertical plate. This scenario involves several parameters, including the "mass Grashof number (Gr), thermal Grashof number (Gc), Prandtl number (Pr), Hartmann number (Ha), Schmidt number (Sc), Dufour number (Dc), and acceleration parameter". Method : We have applied the Laplace transform method to the resulting PDE. This method converts the equations to algebraic form, making it easier to solve for velocity, temperature, and concentration in terms of time and space. Graphs can show the relationship between the acceleration parameter and numerous parameters such as mass and thermal Grashof, Hartmann (Ha), and Dufour (Df), as well as the consequent velocity profile. If the velocity increases when these variables change, we'll look at the physical reasons that generate this behaviour. We will examine the conclusions using experimental data or existing theoretical models, considering the model's assumptions and limits. Finally, highlight the significant facts and insights gained from the analysis. We will discuss potential future research possibilities, such as exploring more complex geometries or accounting for new physical effects. Findings : The increase in Dufour parameter value causes an increase in temperature and level trends, demonstrating the significant influence of these factors on the researched phenomena. Novelty: This research advances our understanding of heat and mass transfer phenomena by isolating the Dufour effect in a novel scenario involving unsteady flow around a rotating vertical plate, filling a gap in the existing body of knowledge that is dominated by MHD-inclusive investigations. Suggestions: This approach is fairly general and may be applied to find analysis of heat and mass transfer on Dufour effect for other effects such as Soret effect, Hall current of heat and mass transfer. Keywords: Uniform Temperature, Thermo diffusion (Dufour), Inverse Laplace, Rotational, Constant Mass

In situ constructing fluorine/nitrogen-enriched interface on highly lithiophilic carbon fiber/MXene/ZnS skeleton for stable lithium anodes

Metallic lithium (Li) is an excellent electrode material for high-energy-density batteries; however, the continuous growth of Li dendrites and the poor deposited volume consistency of Li severely influence the stability of Li anodes. Herein, a LiF-Li3N/LiNxOy-enriched SEI is prepared in situ using a strongly lithiophilic 3D carbon fiber/MXene/ZnS (CMZ) skeleton. Multiscale in situ and ex situ characterizations reveal the mechanisms for Li nucleation and growth on the CMZ skeleton, proving that Li grows tightly over CMZ fibers. This behaviour is attributed to the CMZ skeleton, which provides abundant atomic-level active sites for the uniform and dense nucleation of Li. Electrochemical tests confirm that SEI enriched with LiF-Li3N/LiNxOy can effectively improve Li deposition kinetics, ensure uniform mass transfer and rapid migration of lithium ions in the SEI, and guarantee uniform growth of Li. Consequently, a half cell with a Li-CMZ electrode delivers a high Coulombic efficiency (99.83 %), an ultralong cycling life (17,860 h), and an excellent rate performance (30 mA cm−2). Moreover, full cells consisting of a Li-CMZ anode and different cathodes exhibit superior cycling stabilities. For Li-CMZ ‖ LiFePO4 pouch cell, 84 % capacity is maintained after 300 cycles at 1 C.

Coupled Vibration of a Vehicle Group–Bridge System and Its Application in the Optimal Strategy for Bridge Health Monitoring

The accuracy of bridge performance monitoring and evaluation is easily affected by unfavorable factors such as vehicle coupling and test noise. In order to accurately evaluate the dynamic response and health monitoring threshold of the bridge under different operating conditions, a time-varying dynamic vehicle group model including the main uniform mass and the coupling mass was established, and the influence of road roughness was considered in the coupling equation. A bridge monitoring strategy considering signal noise ratio and vehicle–bridge interaction was proposed, and the effectiveness of the monitoring strategy was verified by taking a simple supported beam as an example. The results showed that the proposed time-varying dynamic vehicle group model could accurately consider the influence of road roughness and estimate the threshold of health monitoring, and the proposed bridge monitoring strategy could filter out a large amount of low signal-to-noise ratio or meaningless data, thus saving computing resources and realizing the lightweight safety monitoring of bridges.

A Modular Robotic Arm Configuration Design Method Based on Double DQN with Prioritized Experience Replay

Abstract: The modular robotic arms can achieve desired performances in different scenarios through the combination of various modules, and concurrently hold the potential to exhibit geometric symmetry and uniform mass symmetry. Therefore, selecting the appropriate combination of modules is crucial for realizing the functions of the robotic arm and ensuring the elegance of the system. To this end, this paper proposes a double deep Q-network (DDQN)-based configuration design algorithm for modular robotic arms, which aims to find the optimal configuration under different tasks. First, a library of small modules of collaborative robotic arms consisting of multiple tandem robotic arms is constructed. These modules are described in a standard format that can be directly imported into the software for simulation, providing greater convenience and flexibility in the development of modular robotic arms. Subsequently, the DDQN design framework for module selection is established to obtain the optimal robotic arm configuration. The proposed method could deal with the overestimation problem in the traditional deep Q-network (DQN) method and improve the estimation accuracy of the value function for each module. In addition, the experience replay mechanism is improved based on the SumTree technique, which enables the algorithm to make effective use of historical experience and prevents the algorithm from falling into local optimal solutions. Finally, comparative experiments are carried out on the PyBullet simulation platform to verify the effectiveness and superiority of the configuration design method developed in the paper. The simulation results show that the proposed DDQN-based method with experience replay mechanism has higher search efficiency and accuracy compared to the traditional DQN scheme.

Improving heat transfer and compressed air consumption in low pressure die casting of aluminum wheels

Automotive wheels made from aluminum alloys are generally manufactured using the Low-Pressure Die Casting (LPDC) method. The molten aluminum is pressurized and filled into the cavities between the molds, and it is cooled using cooling channels in the LPDC. While the cooling fluid can be either air or water in industrial applications, only air cooling is utilized within the scope of this study. The primary expenditures of the process are attributed to the cycle time and the consumption of compressed air. In industrial settings, the primary coolant supply, emanating from either one or two inlet sources, is systematically channeled through a series of nozzles. These nozzles are strategically designed to impinge air onto specific areas of the mold pockets, ensuring efficient cooling.This research focuses on enhancing the cooling channels and mold pocket regions in LPDC through a combination of experiments and Computational Fluid Dynamics (CFD) integrated with Conjugate Heat Transfer (CHT) analyses. The study involves designing cooling channels to achieve a uniform mass flow distribution at the nozzle outlets, and optimizing the mold pocket regions. This optimization resulted in a 46% reduction in compressed air flow while maintaining comparable levels of heat transfer in the optimized mold pocket design. Moreover, flow rate non-uniformity at nozzle outlets was reduced from 11.5% to 2.0% to achieve uniform cooling and temperature distribution across the wheel spokes. An experimental setup with a cooling pipe network allowed simultaneous flow rate measurements from 20 outlets using flow rate sensors.The improved cooling channel and mold pocket design were adapted to the LPDC, and 20 aluminum alloy wheels were successfully cast with a 46% lower mass flow rate. All these wheels were tested in accordance with the relevant test specifications and the results obtained were assessed as compliant according to certain limits.

Investigating the properties of mixed finite elements

The paper considers quadrature-cubic interpolation in problems of restoration of functions of two arguments. The properties of the most common finite elements Q12 (Lagrange version) and Q10 (Serendipity version) are investigated as finite elements. For more than fifty years, researchers of the finite element method have known the procedure of converting the Lagrangian model to the serendipity model. But, as is known, not all results when using this procedure satisfy users, especially proponents of physical interpretation. We are talking about the magnitude of the nodal loads of the uniform mass force of the serendipity finite element. Thus, if we consider the finite element Q10, it receives the physical inadequacy of the "spectrum" as an inheritance from the "parent" pair of Lagrangian finite elements Q8 and Q12. In Pascal's scheme, there is also a hidden connection between the finite element Q10 and the finite element Lagrangian Q12. The analysis of the inherited properties suggests that it is fundamentally possible for a Q10 substitute-base to exist in nature with the same local and integral characteristics. It turns out that the search for such a base goes beyond the capabilities of traditional modeling methods. An alternative substitute-basis Q10 was found by nonmatrix condensation of the prototype of element Q10, i.e., by using the Lagrangian model Q12. The universal nature of the non-matrix transformation of Q12 into Q10 opens up the possibility of designing a model series of mixed finite elements with physically adequate spectra of nodal loads.

축소사회에서의 주거권 및 주거정책에 대한 고찰

Housing rights simultaneously embody the characteristics of civil, environmental, and social rights. From a social rights perspective, these rights, involving significant state financial investment, are often referred to as the right to survival that relies on state finances. It is a natural conclusion that alleviating floor area ratio restrictions to attract market funding while reducing the state’s financial burden is an effective way to supply rental housing and similar facilities. As society transitions into a shrinking one, significant concerns arise about the current generation’s consideration of future generations. In this context, uniform mass production and consumption-based developmental strategies are no longer valid or practical. Supply-oriented housing development can deprive future generations of developmental opportunities, severely undermining their housing rights. Current generations exploiting the floor area ratio may diminish development profitability for future generations, ultimately rendering development unfeasible. This is where the floor area ratio becomes a point of contention between current and future generations. The Transfer of Development Rights(‘TDR’) system enables landowners who cannot fully utilize their floor area ratio to transfer their “unused” floor area ratio to a third party, allowing that party to pursue high-density development. The TDR system is crucial for fostering equity between current and future generations while maintaining the total of overall floor area ratio. Moreover, it holds significant value in realizing housing rights within today’s shrinking society.

Bi-Interlayer Strategy for Modulating NiCoP-Based Heterostructure toward High-Performance Aqueous Energy Storage Devices.

Nickel-cobalt (NiCo) phosphides (NCPs) possess high electrochemical activity, which makes them promising candidates for electrode materials in aqueous energy storage devices, such as supercapacitors and zinc (Zn) batteries. However, the actual specific capacitance and rate capability of NCPs require further improvement, which can be achieved through reasonable heterostructural design and loading conditions of active materials on substrates. Herein, novel hierarchical Bi-NCP heterogeneous structures with built-in electric fields consisting of bismuth (Bi) interlayers (electrodeposited on carbon cloth (CC)) are designed and fabricated to ensure the formation of uniform high-load layered active materials for efficient charge and ion transport. The resulting CC/Bi-NCP electrodes show a uniform, continuous, and high mass loading (>3.5mg) with a superior capacitance reaching 1200 Fg-1 at 1 Ag-1 and 4129 mFcm-2 at 1 mAcm-2 combined with high-rate capability and durable cyclic stability. Moreover, assembled hybrid supercapacitors (HSCs), supercapatteries, and alkaline Zn-ion (AZBs) batteries constructed using these electrodes deliver high energy densities of 64.4, 81.8, and 319.1 Whkg-1, respectively. Overall, the constructed NCPs with excellent aqueous energy storage performance have the potential for the development of novel transition metal-based heterostructure electrodes for advanced energy devices.

Suppressing lithium dendrite via hybrid interface layers for high performance quasi-solid-state lithium metal batteries

The quasi-solid-state metal battery stands out as a promising candidate for the advancement of scalable, safe, and high-performance battery technologies. However, a major challenge remains in the form of short circuits arising from dendrite penetration, a consequence of uneven lithium deposition at the solid electrolyte/lithium anode interface. To address this issue, an in-situ constructed three-dimensional LiCl/Li-Al hybrid protective layer was implemented to inhibit the growth of dendrites. The enhanced interfacial dynamics were meticulously elucidated through a synergistic analysis of simulation and experimental results, highlighting the facilitation of Li+ flux distribution and uniform mass transfers introduced by the lithiophilic Li-Al alloy component. As a result, the modified Li anode enables stable Li stripping/plating cycling at a high current density of 1.0 mA·cm−2 and over 500 h at 0.2 mA·cm−2 for 0.2 mAh·cm−2 in the quasi-solid-state symmetric batteries. Additionally, the full cell with a LiFePO4 cathode maintains a high discharge capacity of 136.2 mAh/g after 400 cycles at 0.5C with a capacity retention of approximately 90 %. These findings demonstrate the application potential of Li anodes with a surface treatment for quasi-solid-state lithium metal battery applications.

MEMS Resonant Beam with Outstanding Uniformity of Sensitivity and Temperature Distribution for Accurate Gas Sensing and On-Chip TGA.

Micromechanical resonators have aroused growing interest as biological and chemical sensors, and microcantilever beams are the main research focus. Recently, a resonant microcantilever with an integrated heater has been applied in on-chip thermogravimetric analysis (TGA). However, there is a strong relationship between the mass sensitivity of a resonant microcantilever and the location of adsorbed masses. Different sampling positions will cause sensitivity differences, which will result in an inaccurate calculation of mass change. Herein, an integrated H-shaped resonant beam with uniform mass sensitivity and temperature distribution is proposed and developed to improve the accuracy of bio/chemical sensing and TGA applications. Experiments verified that the presented resonant beam possesses much better uniformity of sensitivity and temperature distribution compared with resonant microcantilevers. Gas-sensing and TGA experiments utilizing the integrated resonant beam were also carried out and exhibited good measurement accuracy.

Immunopathological investigation and genetic evolution of Avian leukosis virus Subgroup-J associated with myelocytomatosis in broiler flocks in Egypt

BackgroundAvian leukosis virus Subgroup-J (ALV-J) is a rapidly oncogenic evolving retrovirus infecting a variety of avian species; causing severe economic losses to the local poultry industry.MethodsTo investigate ALV-J, a total of 117 blood samples and 57 tissue specimens of different organs were collected for virological, and pathological identification, serological examinations, molecular characterization, and sequencing analysis. To the best of our knowledge, this is the first detailed report recorded in broiler flocks in Egypt. The present study targets the prevalence of a viral tumor disease circulating in broiler flocks in the El-Sharqia, El-Dakahliya, and Al-Qalyubiyya Egyptian governorates from 2021 to 2023 using different diagnostic techniques besides ALV-J gp85 genetic diversity determination.ResultWe first isolated ALV-J on chicken embryo rough cell culture; showing aggregation, rounding, and degeneration. Concerning egg inoculation, embryonic death, stunting, and curling were observed. Only 79 serum samples were positive for ALV-J (67.52%) based on the ELISA test. Histopathological investigation showed tumors consist of uniform masses, usually well-differentiated myelocytes, lymphoid cells, or both in the liver, spleen, and kidneys. Immunohistochemical examination showed that the myelocytomatosis-positive signals were in the spleen, liver, and kidney. The PCR assay of ALV-J gp85 confirmed 545 base pairs with only 43 positive samples (75.4%). Two positive samples were sequenced and submitted to the Genbank with accession numbers (OR509852–OR509853). Phylogenetic analysis based on the gp85 gene showed that the ALV-J Dakahlia-2 isolate is genetically related to ALV-EGY/YA 2021.3, ALV-EGY/YA 2021.4, ALV-EGY/YA 2021.14, and ALV-EGY/YA 2021.9 with amino acid identity percentage 96%, 97%; 96%, 96%; respectively. Furthermore, ALV-J Sharqia-1 isolate is highly genetically correlated to ALV-EGY/YA 2021.14, and ALV-EGY/YA 2021.9, ALV-J isolate QL1, ALV-J isolate QL4, ALV-J isolate QL3, ALV-EGY/YA 2021.4 with amino acid identity percentage 97%, 97%; 98%, 97%, 97%, 95%; respectively.ConclusionsThis study confirmed that ALV-J infection had still been prevalent in broilers in Egypt, and the genetic characteristics of the isolates are diverse.

The rigid-flexible coupling vibration of assembled disk-composite conical shell structure of electric aircraft in hygrothermal circumstance

A novel theoretical formulation for addressing the coupling vibration of the rigid disc and flexible composite conical shell structure (RDFCCSs) in hygrothermal circumstances is established to investigate the vibration evolution of the rigid-flexible composite thin-walled coupled structure of new energy electric aircraft. According to Donnell's thin shell theory, the potential energy of the composite conical shell under hygrothermal load is calculated. A uniform mass model and a set of artificial springs distributed on the interface of the shell and disk are imported to simulate the RDFCCSs. The governing equation of the RDFCCSs with arbitrary foundations in hygrothermal circumstances is deduced according to the Rayleigh-Ritz variational procedure. Systematic experiments and finite element simulations have been demonstrated to confirm the accuracy of the proposed method. Three new rigid-flexible coupling vibration modes of the RDFCCSs that differ from the traditional single thin-walled conical shell element due to the influence of the disk have been revealed. After that, the unique vibration characteristics of RDFCCSs under various masses, axial loads, hygrothermal environments and interface connection stiffnesses are discussed in detail.

FARKLI SÜPER DAĞITICILARIN KETOPROFEN İÇEREN AĞIZDA DAĞILAN TABLETLERİN İN VİTRO KARAKTERİZASYON PARAMETRELERİ ÜZERİNDEKİ ETKİSİNİN DEĞERLENDİRİLMESİ

Objective: Orally Disintegrating Tablets (ODTs) have revolutionized pharmaceutical drug delivery, offering a patient-friendly alternative for those struggling with conventional tablet swallowing. This study delves into the impact of superdisintegrants (crospovidone, sodium starch glycolate, and croscarmellose sodium) on the in vitro characterization of Ketoprofen-containing ODTs. ODTs are designed to rapidly disintegrate in the oral cavity without water, enhancing patient compliance, ensuring faster therapeutic onset, and providing convenience. Material and Method: The micromeritic properties of pre-compression Ketoprofen ODT blends were assessed for bulk density, tapped density, Hausner ratio, and compressibility index. ODTs were formulated using a direct compression method to maintain component uniformity. Comprehensive characterization included weight variation, tablet hardness, friability, wetting time, and in vitro disintegration time assessments. The drug content was determined through UV spectrophotometry of dissolved ODTs, and dissolution studies were conducted in pH 6.8 phosphate buffer using USP apparatus XXIV. Result and Discussion: Results showed uniform tablet mass and favorable powder mixture flowability, ensuring ODT physical properties. Tablets exhibited excellent mechanical resistance with consistent hardness and low friability loss. All formulations demonstrated high and uniform drug content. Different superdisintegrants influenced wetting, disintegration, and dissolution times. Crospovidone exhibited the fastest wetting time but longer disintegration times, attributed to increased tablet hardness. Dissolution studies revealed that crospovidone-containing ODTs had faster drug release compared to croscarmellose sodium and sodium starch glycolate, aligning with literature findings. The study emphasized the importance of considering both wetting and disintegration times for a comprehensive evaluation of ODT performance. Croscarmellose sodium and sodium starch glycolate hindered drug release, forming gel-like masses impeding dissolution, while crospovidone enhanced drug release in formulated ODTs. In conclusion, the study provides valuable insights for pharmaceutical development and patient-centric drug delivery solutions, showcasing the influence of superdisintegrants on ODT performance and emphasizing the importance of considering various parameters for comprehensive evaluation.