In Classical wide-field Fluorescence and Single Molecule Localization (SMLM) Microscopies, gaussian-shaped illuminations induce non-uniform excitation at the sample plane. This drastically hampers quantitative analysis of fluorescence processes and greatly wastes available laser power. Many strategies have been developed to provide wide uniform illuminations: fibers, micro-lens arrays or refractive beam-shaping elements effectively provide uniform excitation but their implementation tends to prevent their application to TIRF optical sectioning and are often constrained to a fixed field of view (FOV) size. In SMLM, where 5 to 10kW/cm² excitation power is needed to ensure single molecule regime, it leads to the use of cumbersome 4-5W power to cover a wide 200∗200μm² FOV. We will present an illumination technique which is based on a classical 300mW, 647nm laser and benefits from the flexibility of a scanning-mirror system to achieve uniform illumination over the (200μm)² FOV of a CMOS camera. By focusing the laser on the scanning mirrors, we can control its position in the sample plane and uniformly spread laser power on any FOV size. This hybrid scanning/wide field excitation can be applied from epifluorescence to TIRF excitation where it provides uniform sectioning depth and speckle free illumination over a controlled field of view. This homogeneous sectioning improves the signal to noise ratio, and in SMLM offers similar precision over the whole FOV. This setup can control various acquisitions parameters, such as balancing between fluorophore density and image resolution and faster reconstruction times. For example, this allows super-resolution imaging of mitochondria at the whole cell level and at low laser power, and stitching of wide high-content images for efficient simultaneous analysis of multiple cells over unlimited FOV size. Performances in super-resolution will be illustrated on nano-rulers, as well as on various biological applications.