Uniform Enhancement Research Articles

5086 Approaching the Enigma: Unveiling a Pituitary Stalk Lesion with Imaging and Hormonal Patterns

Abstract Disclosure: N. Rodriguez-Morales: None. P. Guido: None. Background: Pituitary stalk lesions (PSL) pose a diagnostic dilemma for endocrinologists. Multiple studies have attempted to associate hormonal imbalances and imaging patterns to a specific etiology (1,2). However, the diagnosis remains a mystery on many occasions. We describe a case of secondary hypogonadism and central DI attributed by a PSL. Clinical Case: A 39-year-old male presented with symptoms of hypogonadism and polyuria. Initial workup was consistent with secondary hypogonadism; decreased free and total testosterone levels (1.8 pg/dL and 9 ng/dL, n>35 pg/dL, n>250 ng/dL), LH (0.2 mIU/mL, n>1.5 mIU/mL), and FSH (<0.7 mIU/mL, n>1.6 mIU/mL). The remaining anterior pituitary hormones were within normal limits. The patient was also polyuric (6.5L urine output in 24hr). HgbA1c was normal. Urine Na, urine Osm demonstrated water diuresis (13 mmol/L and 54 mOsm/kg, respectively). A water deprivation test was performed. Initial urine Osm after water restriction was 119 mOsm/kg, which more than tripled to 575 mOsm/kg after administration of desmopressin, diagnostic of central DI. Pituitary MRI showed a well-circumscribed thickening of the pituitary stalk (6x6x5mm), with uniform enhancement. Evaluation for etiology to rule out germ cell tumor, lymphoma, sarcoidosis, opportunistic infection, tuberculosis, Langerhans cell histiocytosis showed a normal serum hCG, HIV, ACE, LDH, AFP. A lumbar puncture demonstrated normal cytology and was negative for AFB. Whole body bone scintigraphy and chest X-ray were normal. Pituitary deficits were treated with hormone replacement (testosterone and desmopressin), and a repeat MRI showed a stable lesion. Conclusion: Noninvasive testing is key to the evaluation of a pituitary stalk lesion. Careful consideration of inflammatory, infectious, and neoplastic etiologies along with attention to pituitary deficits is very important. Our patient most likely has a craniopharyngioma based on data from other case series (1,2). This case serves to bring additional data to the body of literature on this complicated clinical scenario.

Are all starbursts equal? Star-formation-rate profiles in merger versus secular starbursts

Aims. Galaxy interactions can trigger drastic changes in the resolved star-forming properties of their constituents, but it remains unclear as to whether those changes are discernible from secular starburst triggers. In this Letter we investigate whether or not post-merger galaxies create unique star-forming trends on a kiloparsec scale. Methods. We present radial trends in star-formation-rate (SFR) surface density (ΣSFR) for 150 post-merger galaxies with moderate to extremely heightened global SFRs using observations from the Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey. We juxtapose these profiles with those of noninteracting galaxies (excluding both galaxy pairs and post-merger galaxies) with similarly enhanced global SFRs. Results. Post-merger galaxies have a much stronger central starburst than isolated galaxies with similar global star-formation enhancements. Indeed, isolated starburst galaxies (SBs) lack a marked central enhancement and instead show a fairly uniform enhancement in ΣSFR with radius. Moreover, the difference in central star formation between post-merger galaxies and noninteracting galaxies is more radially extended and pronounced when the global enhancement in star formation is larger. We conclude that post-merger galaxies create a unique signature in their resolved star-forming properties that is distinct from secular processes that can trigger similar global SFR enhancements.

Research on the thermal balance of a novel independent heat extraction-release double helix energy pile in long-term operation

Ground source heat pump buried pipes offer potential in civil defense due to their concealment and reliability, yet face thermal imbalance issues. This paper adopts a double helix energy pile with independent heat extraction-release capacity and develops an experiment to compare the performance of independent operation versus joint operation. Furthermore, a verified 2D model facilitated extensive simulations for long-term thermal balance, integrating refrigeration load, principles of water use in an underground engineering, and heat pump model. Comparative experiments show that joint operation can effectively alleviate soil heat accumulation by more than 20%. Extended simulations reveal that as accumulated heat is removed, the unit's performance is improved, and soil heat accumulation can boost heat extraction. However, under domestic water heat extraction, the heat-extracting pipe shows low flow rates, leading to thermal accumulation, necessitating the use of water for equipment or additional feed water to improve heat extraction. Compared to uniform enhancement heat extraction, centralized enhanced heat extraction boosts overall heat extraction capacity by 35.1%, which can more effectively mitigate thermal imbalances and improve unit performance, and achieving thermal balance in the geotechnical area requires an enhanced extraction flow rate above 10.5 L/h, with over 56 m3 of water passing through the heat-extracting pipe.

Solitary Fibrous Tumors: A Rare Tumor Arising from Ubiquitous Anatomical Locations.

Solitary Fibrous Tumors (SFTs) are uncommon mesenchymal tumors of fibroblastic/myofibroblastic origin that stem from various anatomical sites. Most SFTs are asymptomatic and noticed incidentally by various imaging modalities. Although SFTs were initially identified in the pleura and erroneously considered to originate solely from serosal layers, extrapleural SFTs have been reported more commonly than their pleural counterparts. Imaging features are similar in different anatomical locations and are mainly related to the tumor's size and collagen content, characteristically displaying low signal intensity on Magnetic Resonance Imaging (MRI). Smaller tumors typically exhibit uniform enhancement, yet necrotic regions may become evident as the tumor size increases, resulting in heterogeneous enhancement. Less than 30% of SFTs demonstrate unfavorable clinical outcomes regardless of their histological features, warranting surgery as the preferred treatment with long-term follow-up. In this article, we have reviewed the clinical manifestations and imaging features of SFTs, discussed their differential diagnosis based on anatomical site, and provided diagnostic pearls.

Detection of coal gangue based on MSRCR algorithm and improved lightweight YOLOv8n

ABSTRACT Traditional methods for coal gangue sorting exhibit low efficiency, significant safety hazards, and limited applicability. Existing machine vision-based coal gangue image recognition methods struggle to balance model recognition speed and accuracy. In response to these challenges, this paper first utilizes the improved MSRCR algorithm to process images, enhancing the dark areas of coal gangue images while ensuring uniform brightness enhancement and image clarity. Furthermore, a novel lightweight coal gangue recognition method is proposed based on YOLOv8n, aiming to reduce data redundancy and improve recognition accuracy. Experimental results demonstrate that the improved lightweight model has a computational load of 7.1 GFLOPs, representing only 86.6% of the original model. The model detection rate is 73 fps, a 17 fps improvement over the original model. The accuracy, recall rate, and average precision reach 98.1%, 97.6%, and 98.9%, respectively, with improvements of 1.1, 0.9, and 0.5% points over the original model. The missing detection phenomenon is avoided effectively, and the accuracy and portability of the model are improved.

Label-Free Detection of DNA Base Mutation and Hybridized DNA by an Electrostatically Modified 3D Plasmonic Array.

Surface-enhanced Raman scattering (SERS) represents a promising avenue for DNA detection as it offers intrinsic chemical insights with high sensitivity compared to conventional methods. However, label-free and quantitative detection of unmodified DNA by SERS remains a major challenge in DNA analysis. To overcome this challenge, we propose a positively charged plasmonic nanosurface for DNA capture and quantitative analysis. Highly sensitive and uniform SERS enhancement was realized by a three-dimensional plasmonic array supporting well-designed hybrid plasmonic modes. Subsequently, the plasmonic array was modified with an electrostatically functionalized PDDA (poly(diene-dimethylammonium-chloride)) self-assembled monolayer in a single step. The effectiveness of the resulting PDDA-SERS substrate was demonstrated by the label-free and quantitative detection of base content and base mutation in hybridized DNA. The PDDA-SERS substrate provides a robust platform for SERS analysis not only of DNA but also of other electronegative analytes.

Japanese spotted fever complicated with pleural effusion in Zhejiang province, China: a case report and literature review.

Japanese spotted fever (JSF) mainly occurs in Japan; however, it has been increasingly reported in China. JSF is typically characterized by fever, rash, and eschar, in addition to non-specific symptoms. Yet, reports on the pulmonary indicators in JSF are limited. Herein, we report an unusual case of JSF associated with pleural effusion and pneumonia, in which the pathogen was identified via blood next-generation sequencing (NGS). We report a case of a 33-year-old woman who presented with fever for five days, rash for two days, and myalgia, fatigue, and edema for one day. She had recently been on vacation when an unknown insect bit her. The doctors at the local primary hospital considered a bacterial infection and administered dexamethasone, ceftriaxone, indomethacin, and anti-allergy agents, but the symptoms persisted. A rash without pruritus or pain developed gradually over the entire body and face. We considered rickettsial infection and administered doxycycline and levofloxacin. Metagenomic NGS from blood confirmed the presence of Rickettsia japonica (R. japonica). Abdominal computed tomography revealed bilateral pleural effusion with two atelectasis; patchy shadows with blurred edges, and uniform enhancement in both lower lungs. After several days of treatment, the symptoms and laboratory results improved. A literature review of the epidemiology of R. japonica and JSF in China, characteristics of JSF, and related pulmonary changes, and technology to diagnose JSF is provided. JSF has a variety of symptoms and is becoming increasingly popular in China. Clinical doctors need to identify it carefully.

Uniform plasmon enhanced luminescence of Eu-PMMA films for sensitive and single droplet detection of malachite green

The sensitively detection of malachite green (MG) is very important because it is a low-cost and effective fungicide and insecticide in the aquatic industry. In this study, the gold nanorods (Au NRs) are prepared and incorporated into Eu-poly(methylmethacrylate) (PMMA) films in a simple and convenient way. The Au NRs embedded Eu-PMMA films reveal a significant and uniform luminescence enhancement due to the LSPR effect of plasmonic nanostructures. Based on the enhanced luminescence, the sensitive and single droplet (<10 μL) detection of malachite green is achieved through the fluorescence resonance energy transfer between Eu and MG. The detected lowest concentration for MG is reduced from 0.01 mg L-1 to 0.001 mg L-1. Further more, the Au NRs embedded Eu-PMMA films as the platform exhibits the excellent recyclability and stability, which not only reduces waste but also enhances the platform’s environmental friendliness. This work not only provides an enhanced fluorescence for the detection of MG, but also provides a novel strategy for the design of fluorescent sensor toward different biomolecules.

Primary glomus tumor of the thymus in a 66-year-old patient

We report a unique case of a 66-year-old man who was incidentally identified to have a mass in the thymus region by computerized tomography scan. CT revealed a well-defined 1.6 × 1 × 0.9 cm thymus mass with moderate uniform enhancement. Thoracoscopic thymectomy was performed, and the pathological diagnosis was primary glomus tumor of the thymus. There were no atypia or malignant histological features, and no primary tumors in other sites. To our knowledge, this is the first case of primary thymic glomus tumor reported in the literature.

Tunable uniform field enhancement in a subwavelength air pillar by photonic doping in epsilon-near-zero medium

In this study, a novel electric field compressor is proposed by doping a metal-air-metal pillar in epsilon-near-zero medium within a metallic waveguide, which effectively enhances the background electric fields in a sub-wavelength air pillar with high uniformity. The field enhancement factor can be analytically determined through theoretical derivations from Maxwell’s equations, reaching its maximum value by appropriately selecting the size of the air pillar. Furthermore, the proposed compressor can achieve a tunable electric field enhancement effect within the deep sub-wavelength air pillar by adjusting the height of the air pillar through movement of two metal pillars inserted into the waveguide. Both theoretical analysis and numerical simulations are employed to validate the performance of the electric field compressor, which exhibits a wide range of tunable field enhancement effect (i.e., continuously adjustable enhancement factor between 20 and 800) with uniformity below 1.5 within the deep sub-wavelength air pillar (wherein the air volume is smaller than λ0/10 × λ0/10 × λ0/16). Finally, a practical model is proposed for the realization of the electric field compressor in the microwave range, where specially placed metal pillars and wires are incorporated into a rectangular metallic waveguide structure. The field enhancement and tunable effects of this practical model have been verified through simulations.

Localized surface plasmon resonance (LSPR) excitation on single silver nanoring with nanoscale surface roughness

With the expansion of the application of high-sensitivity Surface-enhanced Raman scattering (SERS) technique, micro SERS-active substrates with rich optical properties and high-level functions are desired. In this study, silver nanorings with nanoscale surface roughness were fabricated as a new type of enclosed quasi-2D micro-SERS-active substrate. Highly-crystalline spherical and hemispherical silver nanoprotrusions were densely and uniformly distributed over the entire surface of the nanorings. The SERS signals were significantly enhanced on the roughened silver nanorings which were mainly derived from the maximal localized surface plasmon resonance (LSPR) points at the junctions between adjacent coupled nanoprotrusions on the roughened nanorings. The mapping image shows a uniform and intense LSPR enhancement over the nanorings, owing to the uniform and dense distribution of silver nanoprotrusions and the resulting uniform distribution of maximal LSPR points on the roughened nanorings. The dark-field spectra further indicated that the single roughened silver nanoring had significant LSPR enhancement, a wide LSPR frequency-range response, and adaptability for SERS enhancement. Notably, both the measured and simulated results demonstrate that the maximal LSPR enhancement at the junctions between the nanoprotrusions, which are distributed on the inner surface of the silver nanoring, is higher than that on the outer surface because of the plasmon-focusing effect of the enclosed silver nanoring, which leads to the lateral asymmetrical distribution of LSPR intensity, indicating more LSPR and SERS features. These results indicate that single roughened silver nanorings exhibit excellent performance as a new type of enclosed quasi-2D silver nanoring micro-SERS-active substrate, microzone LSPR catalysis, and micro/nanodevices.

Platelet-Rich Plasma (PRP) in the Treatment of Long COVID Olfactory Disorders: A Comprehensive Review.

Background: Long COVID has brought numerous challenges to healthcare, with olfactory dysfunction (OD) being a particularly distressing outcome for many patients. The persistent loss of smell significantly diminishes the affected individual's quality of life. Recent attention has been drawn to the potential of platelet-rich plasma (PRP) therapy as a treatment for OD. This comprehensive review aims to evaluate the effectiveness of PRP therapy in ameliorating OD, especially when associated with long-term COVID-19. Methods: We executed a comprehensive search of the literature, encompassing clinical trials and observational studies that utilized PRP in treating OD limited to COVID-19. We retrieved and comprehensively discussed data such as design, participant demographics, and reported outcomes, focusing on the efficacy and safety of PRP therapy for OD in COVID-19 patients. Results: Our comprehensive analysis interestingly found promising perspectives for PRP in OD following COVID-19 infection. The collective data indicate that PRP therapy contributed to a significant improvement in olfactory function after COVID-19 infection. Conclusions: The evidence amassed suggests that PRP is a promising and safe therapeutic option for OD, including cases attributable to Long COVID-19. The observed uniform enhancement of olfactory function in patients receiving PRP highlights the necessity for well-designed, controlled trials. Such studies would help to refine treatment protocols and more definitively ascertain the efficacy of PRP in a broader, more varied patient cohort.

Pathological and imaging features, treatment, and prognosis of primary intraventricular lymphoma: A review of cases from a single center

PurposeThe purpose of this retrospective study was to analyze the imaging and pathological features, treatment, and prognosis of patients with primary intraventricular lymphomas (PIL) in order to enhance physicians' understanding of the diagnosis and treatment of PIL. MethodsA retrospective analysis was conducted on 13 cases of PIL that were hospitalized in our institution. Clinical and imaging data of the patients were collected and compared with the pathology data to summarize and analyze the qualitative diagnostic value of magnetic resonance (MR) features. ResultsAmong the enrolled patients, there were nine males and four females, with an average age of (56 ± 9.0) years. The major clinical features observed in PIL patients were headache and dizziness. All 13 patients underwent plain and contrast-enhanced MR scans, revealing multiple foci in 7 cases and single foci in 6 cases. The lesions were located in the lateral ventricle in 10 cases, the third ventricle in 4 cases, and the fourth ventricle in 4 cases. Plain MR scans demonstrated an isointense or slightly hypointense signal on T1-weighted imaging (T1WI) and an isointense or slightly hyperintense signal on T2-weighted imaging (T2WI). Contrast-enhanced scans showed uniform and consistent enhancement of the tumors. Surgical treatment was performed in all patients, and postoperative pathology confirmed the presence of diffuse large B-cell lymphoma. ConclusionsPIL exhibits specific imaging and pathological features, with diffuse large B-cell lymphoma being the main pathological type. Pathological examination and immunophenotype analysis serve as the gold standards for PIL diagnosis.

Evaluation of temperature dependent vortex pinning properties in strongly pinned YBa2Cu3O7-δ thin films with Y2BaCuO5 nanoinclusions

The pinning of quantized magnetic vortices in superconducting YBa2Cu3O7- δ(YBCO or Y123) thin films with Y2BaCuO5 (Y211) nanoinclusions have been investigated over wide temperature range (4.2–77 K). The concentration of Y211 nanoinclusions has been systematically varied inside YBCO thin films prepared by laser ablation technique using surface modified target approach. Large pinning force density values (Fp ∼ 0.5 TNm−3 at 4.2 K, 9 T) have been observed for the YBCO film with moderate concentration of Y211 nanoinclusions (3.6 area % on ablation target). In addition, uniform enhancement in critical current density (Jc) was observed in the angular dependent Jc measurement of YBCO+Y211 nanocomposite films. Y211 nanoinclusions have been found to be very efficient in pinning the quantized vortices thereby enhancing the in-field Jc values over a wide range of temperature. Increasing the concentration of Y211 secondary phase into Y123 film matrix results into agglomeration of Y211 phase and observed as increased Y211 nanoparticle size. These larger secondary phase nanoparticles are not as efficient pinning centers at lower temperatures as they are at higher temperatures due to substantial reduction of the coherence length at lower temperatures. Investigation of the temperature dependence of Jc for YBCO+Y211 nanocomposite films has been conducted and possible vortex pinning mechanism in these nanocomposite films has been discussed.

Raman enhancement induced by exciton hybridization in molecules and 2D materials

Surface-enhanced Raman spectroscopy (SERS) is a powerful technique for trace-level fingerprinting. Recently, layered two-dimensional (2D) materials have gained significant interest as SERS substrates for providing stable, uniform, and reproducible Raman enhancement with the potential for trace-level detection. Yet, the development of effective 2D SERS substrates is still hindered by the lack of fundamental understanding of the coupling mechanism between target molecules and substrates. Here, we report a systematic excitation-dependent Raman spectroscopy investigation on the coupling between 2D materials such as SnS2, MoS2, WSe2, and graphene and small organic molecules like rhodamine 6G (Rh 6G). Strong coupling between SnS2 and Rh 6G is found due to their degenerate excitons through Raman excitation profiles (REP), leading to the enhancement of Rh 6G vibrational modes that are observable down to 10−13 M. Our study shows that exciton coupling in the substrate-adsorbate complex plays a vital role in the Raman enhancement effect, opening a new route for designing SERS substrates for high sensitivity.

Enhanced charge transport and broadband photoresponse of MoS2 photodetectors with sparsely distributed Ag@SiO2 core–shell nanostructures

Integrating metal nanostructures with two-dimensional (2D) material photodetectors has been demonstrated that can greatly improve device performance owning to various extraordinary optoelectronic phenomena. For example, metal nanostructures are served as ideal plasmonic materials to maximize local electromagnetic fields leading to light absorption of 2D materials. In this work, other than the widely reported plasmonic effects, we discover the contribution of metal nanostructures in charge transport engineering in 2D material photodetectors, which is important but always ignored in previous studies by others. Notable improvements of carrier mobility and carrier concentration attributing to the integration of sparsely distributed Ag@SiO2 core–shell nanoparticles on the MoS2 detector were experimentally established, originating from reduced carrier scattering and interfacial gating. Consequently, a 1.5-fold broadband (400–1100 nm) uniform photocurrent enhancement was observed, which was entirely derived from the improved charge transport. These findings open up a new research perspective for the precise identification and objective evaluation of different effects of metal nanostructures on optoelectronic devices.

The value of color doppler ultrasonography combined with computed tomography angiography and magnetic resonance angiography in the preoperative quantification and classification of carotid body tumors: a retrospective analysis

BackgroundComputed tomography angiography (CTA) and magnetic resonance angiography (MRA) provide accurate vascular imaging information, but their use may be contraindicated. Color Doppler ultrasonography (CDU) provides simple, safe, noninvasive, and reproducible imaging. We therefore investigated the role of preoperative CDU combined with CTA and MRA in the quantification, typing, and diagnosis of carotid body tumors (CBTs).MethodsWe retrospectively analyzed patients with CBTs categorized into group A (type I [n = 1] and type II [n = 10]) or group B (type III [n = 56]) per the intraoperative Shamblin classification. CDU, CTA, and MRA characteristics of CBTs were observed, surgical results were correlated, and the diagnostic threshold of the CBT classification was calculated.ResultsCBTs were usually located at the common carotid artery bifurcation, encircling the carotid artery. An increased angle was found between the internal and external carotid arteries. On CDU, CBTs primarily presented as homogeneous hypoechoic masses with clear boundaries, rich flow signals, and a high-speed, low-resistance artery-like flow spectrum. CTA showed uniform or heterogeneous marked enhancement. MRA showed mixed T1 and slightly longer T2 signals and uniform or uneven obvious enhancement. With increases in the lesion size, amount of blood transfused, and operation time, the intraoperative classification level and possibility of skull-base invasion increased. When the maximum diameter of the lesion, the volume of the tumor, the distance between the upper margin of the tumor to the mastoid and the mandibular angle were 3.10 cm, 10.15 cm3, − 3.26 cm, and 0.57 cm, respectively, the largest Youden index was the best diagnostic boundary value for Shamblin type III tumors.ConclusionsCDU combined with CTA and MRA can accurately evaluate the size and classification of CBTs.

Direct laser induced writing of high precision gold nanosphere SERS patterns.

The high sensitivity and molecular fingerprint capability of Surface-Enhanced Raman Spectroscopy (SERS) have lead to a wide variety of applications ranging from classical physics, chemistry over biology to medicine. Equally, there are numerous methods to fabricate samples owing to the desired properties and to create the localized surface plasmon resonances (LSPRS). However, for many applications the LSPRs must be specifically localized on micrometer sized areas and multiple steps of lithography are needed to achieve the desired substrates. Here we present a fast and reliable direct laser induced writing (DIW) method to produce SERS substrates with active areas of interest in any desired size and shape in the micrometer regime. Afterwards, the SERS substrates have been functionalized with phthalocyanines. The DIW fabricated samples realize sub-monolayer sensitivity and an almost uniform enhancement over the entire area, which make this production method suitable for many sensing applications.

Attention modulates early visual processing: An association between subjective contrast perception and early C1 ERP component.

The question of whether spatial attention can modulate initial afferent activity in area V1, as measured by the earliest visual event-related potential (ERP) component "C1", is still the subject of debate. Because attention always enhances behavioral performance, previous research has focused on finding evidence of attention-related enhancements in visual neural responses. However, recent psychophysical studies revealed a complex picture of attention's influence on visual perception: attention amplifies the perceived contrast of low-contrast stimuli while dampening the perceived contrast of high-contrast stimuli. This evidence suggests that attention may not invariably augment visual neural responses but could instead exert inhibitory effects under certain circumstances. Whether this bi-directional modulation of attention also manifests in C1 and whether the modulation of C1 underpins the attentional influence on contrast perception remain unknown. To address these questions, we conducted two experiments (N = 67 in total) by employing a combination of behavioral and ERP methodologies. Our results did not unveil a uniform attentional enhancement or attenuation effect of C1 across all subjects. However, an intriguing correlation between the attentional effects of C1 and contrast appearance for high-contrast stimuli did emerge, revealing an association between attentional modulation of C1 and the attentional modulation of contrast appearance. This finding offers new insights into the relationship between attention, perceptual experience, and early visual neural processing, suggesting that the attentional effect on subjective visual perception could be mediated by the attentional modulation of the earliest visual cortical response.

Multi Jet Fusion of surface-modified ZnO nanorod–reinforced PA12 nanocomposites

ABSTRACT Metal oxide nanorods exhibit promising potential as reinforcement fillers in various polymer matrices, but their application in the Multi Jet Fusion (MJF) technique is rarely reported. In this work, surface-modified zinc oxide nanorods (SMZnO) were synthesized and incorporated into polyamide 12 (PA12) powder to enhance the mechanical properties of the MJF-printed parts. Compared to ZnO, SMZnO exhibited better dispersion, resulting in markedly enhanced mechanical performances. The ultimate tensile strength and the Young's modulus of the MJF-printed SMZnO/PA12 nanocomposites were 62.02 MPa and 2.28 GPa in the X orientation and 64.07 MPa and 2.34 GPa in the Y orientation, equivalent to 27.85%, 59.44%, 29.12%, and 54.97% increments, respectively. The flexural strength and modulus demonstrated similar improvements in the X and Y orientations, confirming the uniform mechanical enhancement effect of homogenously distributed SMZnO. This work provides a novel and facile approach for the additive manufacturing of polymeric nanocomposites with superior mechanical performance.