Purpose: Bleeding from esophageal varices is one of the frequent severe complications in patients with liver cirrhosis. We had defined this study to classify the factors predictive for mortality in Child C cirrhosis patients with risky esophageal varices. Methods: Consecutive 111 patients with both risky esophageal varices and with Child C stage patients from 1985 and 2003 were examined. Bleeding patients underwent emergency endoscopic screlotherapy (EIS) or endoscopic variceal ligation (EVL). We then analysed successful rate and parameters (T.Bil 3mg/dl, Age>60, gender, Alb<3g/dl, Plt< 5 ×104, ascites, encephalopathy, HCC, VP3>, EIS VS EVL) predictive for a 6-week survival using Cox's Proportional Hazard Model. In addition, we analysed the parameters predictive for mortality in 111 patients underwent endoscopic therapy for risky esophageal varices. Result: There were 88 (79%) men and 23 (21%) women, with mean age of 69 y.o (30-81 y.o). Hepatocellurer carcinoma (HCC) was detected in 62 patients. (56%) Endoscopic therapy (EIS and EVL) was successfully done in 52 patients with 94% efficacy. Efficacy of endoscopic theperapy was not different between EIS and EVL (p=0.73). T.Bil level of >3mg/dl is an only parameter (Odds ratio=5.33, 95%CI=1.4-20.4) predictive for a 6-week survival in 52 patients with acute bleeding from esophageal varices. Furthermore, the factors predictive for mortality in 111 Child C cirrhosis patients underwent endoscopic therapy were T.Bil level of > 3mg/dl (OR=2.34, 95%CI=1.28-4.26), the presence of uncontrollable ascites (OR=3.17, 95%CI=1.34-7.52), and encephalopathy (OR=1.82, 95%CI=1.06-3.53), and the presence of HCC (OR=2.72, 95% CI=1.52-4.88). Conclusions: Endoscopic therapy for acute bleeding from esophageal varices is effective.