ABSTRACT This article presents a theory of mind whereby interoception (i.e., a sense of signals originating from the body) provides a transdisciplinary framework in which theories from diverse fields may be conformed to ideas from other areas of science. Through a science of interoception, the mind itself investigates the mind and thus can explore how the universe and consciousness came about and understand how interoceptive processing is shaped by experience. Interoception provides a metastable network that enables individuals to compute the significance of stimuli as physiological changes in its complex global context. Both sensory and much cognitive discrimination and integration are affected by the flow of interoceptive information that acts as cues whereby unconscious events may be correlated with conscious events and the reportable content of mental life. Heightened interoceptive sensitivity and individuals who show augmented interoceptive sensitivity are susceptible to a wide range of neuropsychiatric as well as general medical conditions. Physiological responses can be measured and interoceptive awareness cultivated to generate well-being and stress resilience in the treatment of emotional dysregulation and interoceptive abnormalities.