A composite anti-disturbance predictive control strategy employing a Multi-dimensional Taylor Network (MTN) is presented for unmanned systems subject to time-delay and multi-source disturbances. First, the multi-source disturbances are addressed according to their specific characteristics as follows: (A) an MTN data-driven model, which is used for uncertainty description, is designed accompanied with the mechanism model to represent the unmanned systems; (B) an adaptive MTN filter is used to remove the influence of the internal disturbance; (C) an MTN disturbance observer is constructed to estimate and compensate for the influence of the external disturbance; (D) the Extended Kalman Filter (EKF) algorithm is utilized as the learning mechanism for MTNs. Second, to address the time-delay effect, a recursive τ−step-ahead MTN predictive model is designed utilizing recursive technology, aiming to mitigate the impact of time-delay, and the EKF algorithm is employed as its learning mechanism. Then, the MTN predictive control law is designed based on the quadratic performance index. By implementing the proposed composite controller to unmanned systems, simultaneous feedforward compensation and feedback suppression to the multi-source disturbances are conducted. Finally, the convergence of the MTN and the stability of the closed-loop system are established utilizing the Lyapunov theorem. Two exemplary applications of unmanned systems involving unmanned vehicle and rigid spacecraft are presented to validate the effectiveness of the proposed approach.