This investigation aims to propose the compound intensity measure and establish the seismic performance assessment framework considering multiple uncertainties for aqueduct structures. For this purpose, taking the typical three-span aqueduct structure as an engineering case, the uncertainty sample pairs are generated by Latin Hypercube Sampling. The seismic response under different ground motion intensities is obtained by incremental dynamic analysis (IDA), and the mapping relationship between structural damage characteristics and limit states is clarified. According to statistical analysis, quantitative recommendation values for the record-to-record, design parameters, performance index values, limit states and finite element model fidelity uncertainties are determined. Then, the multivariate compound intensity measure IMC is developed by taking into account the correlation between single intensity measure. Furthermore, the seismic performance assessment framework of aqueduct structures is established by the single and compound intensity measures. The total dispersion by multiple uncertainty factors is determined by the square-root-sum-of-squares (SRSS) method and the effects of uncertainty factors on the seismic fragility analysis results of aqueduct structures is explored. Subsequently, based on the seismic fragility function and the seismic hazard function, the seismic risk assessment method considering multiple uncertainties is proposed. The analysis results show that with the increase of uncertainty factors, the seismic fragility curves of the aqueduct structure under different limit states rotate clockwise along the IMR. The 50-year exceedance probabilities considering multiple uncertainties is 2.57∼3.14 (PGV) and 1.92∼2.28 (IMC) times that of considering only record-to-record and structural design parameters, further revealing the traditional method can overestimate the potential seismic risk of aqueduct structures. On the other hand, compared with the IMC, the effect of uncertainty factors on the 50-year exceedance probabilities obtained by PGV is more significant. In a word, the compound intensity measure and the multiple uncertainty analysis method proposed in this investigation can be utilized for the seismic performance assessment system of aqueduct structures.
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