Unambiguous Features Research Articles

Positive-Negative Receptive Field Reasoning for Omni-Supervised 3D Segmentation.

Hidden features in the neural networks usually fail to learn informative representation for 3D segmentation as supervisions are only given on output prediction, while this can be solved by omni-scale supervision on intermediate layers. In this paper, we bring the first omni-scale supervision method to 3D segmentation via the proposed gradual Receptive Field Component Reasoning (RFCR), where target Receptive Field Component Codes (RFCCs) is designed to record categories within receptive fields for hidden units in the encoder. Then, target RFCCs will supervise the decoder to gradually infer the RFCCs in a coarse-to-fine categories reasoning manner, and finally obtain the semantic labels. To purchase more supervisions, we also propose an RFCR-NL model with complementary negative codes (i.e., Negative RFCCs, NRFCCs) with negative learning. Because many hidden features are inactive with tiny magnitudes and make minor contributions to RFCC prediction, we propose Feature Densification with a centrifugal potential to obtain more unambiguous features, and it is in effect equivalent to entropy regularization over features. More active features can unleash the potential of omni-supervision method. We embed our method into three prevailing backbones, which are significantly improved in all three datasets on both fully and weakly supervised segmentation tasks and achieve competitive performances.

Life detection in a universe of false positives: Can the Fatal Flaws of Exoplanet Biosignatures be Overcome Absent a Theory of Life?

Astrobiology aims to determine the distribution and diversity of life in the universe. But as the word "biosignature" suggests, what will be detected is not life itself, but an observation implicating living systems. Our limited access to other worlds suggests this observation is more likely to reflect out-of-equilibrium gasses than a writhing octopus. Yet, anything short of a writhing octopus will raise skepticism about what has been detected. Resolving that skepticism requires a theory to delineate processes due to life and those due to abiotic mechanisms. This poses an existential question for life detection: How do astrobiologists plan to detect life on exoplanets via features shared between non-living and living systems? We argue that you cannot without an underlying theory of life. We illustrate this by analyzing the hypothetical detection of an "Earth 2.0" exoplanet. Without a theory of life, we argue the community should focus on identifying unambiguous features of life via four areas: examining life on Earth, building life in the lab, probing the solar system, and searching for technosignatures. Ultimately, we ask, what exactly do astrobiologists hope to learn by searching for life?

CML-076 The Downregulation of Both Large E3 Ubiquitin Ligases, HERC1 and HERC2, is a Common and Unambiguous Feature of Chronic Myeloid Leukemia

CML-076 The Downregulation of Both Large E3 Ubiquitin Ligases, HERC1 and HERC2, is a Common and Unambiguous Feature of Chronic Myeloid Leukemia

POSTER: CML-076 The Downregulation of Both Large E3 Ubiquitin Ligases, HERC1 and HERC2, is a Common and Unambiguous Feature of Chronic Myeloid Leukemia

POSTER: CML-076 The Downregulation of Both Large E3 Ubiquitin Ligases, HERC1 and HERC2, is a Common and Unambiguous Feature of Chronic Myeloid Leukemia

Single-Frame Characterization of Ultrafast Pulses with Spatiotemporal Orbital Angular Momentum.

Light that carries spatiotemporal orbital angular momentum (ST-OAM) makes possible new types of optical vortices arising from transverse OAM. ST-OAM pulses exhibit novel properties during propagation, transmission, refraction, diffraction, and nonlinear conversion, attracting growing experimental and theoretical interest and studies. However, one major challenge is the lack of a simple and straightforward method for characterizing ultrafast ST-OAM pulses. Using spatially resolved spectral interferometry, we demonstrate a simple, stationary, single-frame method to quantitatively characterize ultrashort light pulses carrying ST-OAM. Using our method, the presence of an ST-OAM pulse, including its main characteristics such as topological charge numbers and OAM helicity, can be identified easily from the unique and unambiguous features directly seen on the raw data—without any need for a full analysis of the data. After processing and reconstructions, other exquisite features, including pulse dispersion and beam divergence, can also be fully characterized. Our fast characterization method allows high-throughput and quick feedback during the generation and optical alignment processes of ST-OAM pulses. It is straightforward to extend our method to single-shot measurement by using a high-speed camera that matches the pulse repetition rate. This new method can help advance the field of spatially and temporally structured light and its applications in advanced metrologies.

The Downregulation of Both Giant HERCs, HERC1 and HERC2, Is an Unambiguous Feature of Chronic Myeloid Leukemia, and HERC1 Levels Are Associated with Leukemic Cell Differentiation.

Large HERC E3 ubiquitin ligase family members, HERC1 and HERC2, are staggeringly complex proteins that can intervene in a wide range of biological processes, such as cell proliferation, DNA repair, neurodevelopment, and inflammation. Therefore, mutations or dysregulation of large HERCs is associated with neurological disorders, DNA repair defects, and cancer. Though their role in solid tumors started to be investigated some years ago, our knowledge about HERCs in non-solid neoplasm is greatly lagging behind. Chronic Myeloid Leukemia (CML) is a model onco-hematological disorder because of its unique and unambiguous relation between genotype and phenotype due to a single genetic alteration. In the present study, we ascertained that the presence of the BCR-ABL fusion gene was inversely associated with the expression of the HERC1 and HERC2 genes. Upon the achievement of remission, both HERC1 and HERC2 mRNAs raised again to levels comparable to those of the healthy donors. Additionally, our survey unveiled that their gene expression is sensitive to different Tyrosine Kinases Inhibitors (TKIs) in a time-dependent fashion. Interestingly, for the first time, we also observed a differential HERC1 expression when the leukemic cell lines were induced to differentiate towards different lineages revealing that HERC1 protein expression is associated with the differentiation process in a lineage-specific manner. Taken together, our findings suggest that HERC1 might act as a novel potential player in blood cell differentiation. Overall, we believe that our results are beneficial to initiate exploring the role/s of large HERCs in non-solid neoplasms.

3044 – TRACING THE FIRST HEMATOPOIETIC STEM CELL GENERATION IN HUMAN EMBRYO BY SINGLE-CELL RNA SEQUENCING

Tracing the emergence of the first hematopoietic stem cells (HSCs) in human embryos, particularly the scarce and transient precursors thereof, is so far challenging, largely due to the technical limitations and the material rarity. Here, using single-cell RNA sequencing, we constructed the first genome-scale gene expression landscape covering the entire course of endothelial-to-HSC transition during human embryogenesis. The transcriptomically defined HSC-primed hemogenic endothelial cells (HECs) were captured at Carnegie stage (CS) 12–14 in an unbiased way, showing an unambiguous feature of arterial endothelial cells (ECs) with the up-regulation of RUNX1, MYB and ANGPT1. Importantly, subcategorizing CD34+CD45− ECs into a CD44+ population strikingly enriched HECs by over 10-fold. We further mapped the developmental path from arterial ECs via HSC-primed HECs to hematopoietic stem progenitor cells, and revealed a distinct expression pattern of genes that were transiently over-represented upon the hemogenic fate choice of arterial ECs, including EMCN, PROCR and RUNX1T1. We also uncovered another temporally and molecularly distinct intra-embryonic HEC population, which was detected mainly at earlier CS 10 and lacked the arterial feature. Finally, we revealed the cellular components of the putative aortic niche and potential cellular interactions acting on the HSC- primed HECs. The cellular and molecular programs that underlie the generation of the first HSCs from HECs in human embryos, together with the ability to distinguish the HSC-primed HECs from others, will shed light on the strategies for the production of clinically useful HSCs from pluripotent stem cells.

Perceptual resolution of ambiguous neural representations for form and chromaticity.

A coherent percept of our visual world is important for functioning. Ambiguities, however, are implicit in visual neural representations and must be resolved for stable perception of objects and scenes. Grouping processes can link multiple neurally ambiguous fragments across the visual field. Experiments here determined how multiple visual features of each fragment contribute to perceptual resolution of ambiguity by grouping. Chromatic interocular-switch rivalry, a technique for presenting competing dichoptic images, was used to induce ambiguous neural representations for equiluminant chromatic discs and gratings. Two dichoptic stimuli were presented simultaneously to measure the amount of time they both appeared the same in at least one feature domain. The two stimuli were grouped when they appeared to share ambiguous features such as color, orientation, and spatial frequency more often than chance. Experiments here tested whether unshared and unambiguous features impeded grouping of the ambiguous components. Overall, the results show that grouping can be driven by neural ambiguity that is common for fragments across the visual field, even when the fragments also have other unshared, unambiguous features.

Tracing the first hematopoietic stem cell generation in human embryo by single-cell RNA sequencing

Tracing the emergence of the first hematopoietic stem cells (HSCs) in human embryos, particularly the scarce and transient precursors thereof, is so far challenging, largely due to the technical limitations and the material rarity. Here, using single-cell RNA sequencing, we constructed the first genome-scale gene expression landscape covering the entire course of endothelial-to-HSC transition during human embryogenesis. The transcriptomically defined HSC-primed hemogenic endothelial cells (HECs) were captured at Carnegie stage (CS) 12–14 in an unbiased way, showing an unambiguous feature of arterial endothelial cells (ECs) with the up-regulation of RUNX1, MYB and ANGPT1. Importantly, subcategorizing CD34+CD45− ECs into a CD44+ population strikingly enriched HECs by over 10-fold. We further mapped the developmental path from arterial ECs via HSC-primed HECs to hematopoietic stem progenitor cells, and revealed a distinct expression pattern of genes that were transiently over-represented upon the hemogenic fate choice of arterial ECs, including EMCN, PROCR and RUNX1T1. We also uncovered another temporally and molecularly distinct intra-embryonic HEC population, which was detected mainly at earlier CS 10 and lacked the arterial feature. Finally, we revealed the cellular components of the putative aortic niche and potential cellular interactions acting on the HSC-primed HECs. The cellular and molecular programs that underlie the generation of the first HSCs from HECs in human embryos, together with the ability to distinguish the HSC-primed HECs from others, will shed light on the strategies for the production of clinically useful HSCs from pluripotent stem cells.

Magnetic hallmarks of viscous electron flow in graphene

We propose a protocol to identify spatial hallmarks of viscous electron flow in graphene and other two-dimensional viscous electron fluids. We predict that the profile of the magnetic field generated by hydrodynamic electron currents flowing in confined geometries displays unambiguous features linked to whirlpools and backflow near current injectors. We also show that the same profile sheds light on the nature of the boundary conditions describing friction exerted on the electron fluid by the edges of the sample. Our predictions are within reach of vector magnetometry based on nitrogen-vacancy centers embedded in a diamond slab mounted onto a graphene layer.

†Sorbinicharax verraesi: An unexpected case of a benthic fish outside Acanthomorpha in the Upper Cretaceous of the Tethyan Sea.

†Sorbinicharax verraesi is a marine teleostean fish from the Upper Cretaceous of Nardò (Italy). It was first attributed to the otophysan order Characiformes, which represents potential evidence for the controversial marine origin of the clade. Through a review of all the available material, we demonstrate that this species is not an otophysan since it lacks key structures that would allow for its inclusion in this group. †Sorbinicharax has a body shape that recalls ground fishes classically assigned to Acanthomorpha. However, no unambiguous feature allows us to relate it to this clade. In fact, the presence of cellular bony tissue supports its exclusion from Eurypterygii. Since no feature permits the definitive attribution of †Sorbinicharax to any teleost group, it remains as Teleostei incertae sedis. We infer that the morphology of †Sorbinicharax indicates a benthic ecology. It displays: an anteriorly wide body with enlarged ribs; large pectoral fins, while anal and dorsal fins are reduced; a large head measuring ¼ of the total body length; and a mouth opening dorsally in a high position. Such morphology was so far undescribed in Nardo. It is surprisingly displayed by a non-eurypterygian teleost fish which means by a fish which does not belong to the clades that diversify since the upper Cretaceous and include the extant families that show ground ecomorphologies.

The glacially overdeepened trough of the Salzach Valley, Austria: Bedrock geometry and sedimentary fill of a major Alpine subglacial basin

Overdeepened valleys are unambiguous features of glacially sculpted landscapes. They result from erosion at the bed of the glacier and their size and shape is determined by ice dynamics and the characteristics of the underlying bedrock. Major overdeepened valleys representing vertical bedrock erosion of several hundreds of meters are characteristic features of many trunk valleys in the formerly glaciated parts of the Alpine mountain belt. The thick sedimentary fill usually hinders attempts to unravel bedrock geometry, formation history and fill characteristics. Based on reflection seismic data and core-logs from multiple deep drillings we construct a detailed bedrock model of the Lower Salzach Valley trough, one of the largest overdeepened valleys in the European Alps. The analysed overdeepened structure characterized by a strongly undulating topography. Two reaches of enhanced erosion can be identified and are suggested to be related to variations in bedrock erodibility and a triple glacier confluence. The sedimentary fill shows clear characteristics of rapid infilling and subaqueous fan delta deposits indicate a strong influence of tributary streams. Associated surface lowering of the valley floor had a major impact on tributary stream incision but also on the available ice accumulation area at subsequent glaciations. The extent to which fills of earlier glaciations have been preserved from erosion during the last glacial maximum remains ambiguous and demands further exploration. To our knowledge the presented bedrock model is one of the best defined of any major overdeepened trunk valley.

Financial Sector-Output Dynamics in the Euro Area: Non-Linearities Reconsidered

We analyze the feedback mechanisms between economic downturns and financial stress for euro area countries. Our study employs newly constructed financial condition indices that incorporate extensively banking variables. We apply a nonlinear Vector Smooth Transition Autoregressive (VSTAR) model for investigating instabilities in the fi nancial sector-output linkages. The VSTAR model appears appropriate since it allows for smooth regime changes and asymmetric dynamics. We find that regime-switching takes place rather smoothly which dampens the negative output response after a shock in the financial sector in the selected euro area countries. Moreover, linearity cannot be rejected for all countries over some extensive time period questioning non-linearities in the financial sector-output nexus as unambiguous feature. In particular, we show that the negative e ffect of financial stress on output typically observed is not always present. This holds specifi cally for the time before the Lehman collapse, even if this is a model-de fined high stress regime. After the collapse, we observe strong ampli fication mechanisms. This suggests that events leading to a strong economic breakdown are rare but large events and related to financial cycles which exhibit low frequency.

A complete mandible of a new amphisbaenian reptile (Squamata, Amphisbaenia) from the late middle eocene (Bartonian, Mp 16) of France

ABSTRACTA new genus of amphisbaenian reptile, Cuvieribaena carlgansi, is decribed from the late middle Eocene of France. This material from the locality of Le Bretou (Phosphorites du Quercy) is an almost completely preserved mandible. The dentary bears six teeth, with the anterior-most one the largest. The anterior teeth are blunt and enlarged (‘amblyodont’), and their size and amblyodonty decrease posteriorly. The presence of well-developed amblyodont teeth indicates a durophagous diet. Durophagy has already been recognized in some amphisbaenids, and their high skull, short jaws, and robust tooth morphology predispose them to this durophagous lifestyle. Several other amphisbaenid specimens have also been recovered from Le Bretou, mainly trunk vertebrae and two incomplete dentaries. This material and the complete mandible show unambiguous morphological features tying them to Blanidae. Cuvieribaena is the earliest secure record of blanid lizards in the fossil record, confirmed by phylogenetic analysis.http://zoobank.org/urn:lsid:zoobank.org:pub:17454922-A121-447F-9D01-E4992ADB7D60SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline.com/UJVP

Reinterpretation of the cranial morphology of Utatsusaurus hataii (Ichthyopterygia) (Osawa Formation, Lower Triassic, Miyagi, Japan) and its systematic implications

ABSTRACT Utatsusaurus hataii is an early member of Ichthyopterygia from the Osawa Formation (Lower Triassic) of Miyagi Prefecture, Japan. Although the holotype of the species lacks a well-preserved cranium, UHR 30691 preserves a near-complete skull and may be referred to Utatsusaurus based on a similar geologic occurrence and, most importantly, the following shared features with the holotype: subthecodont tooth implantation; the presence of distomesially compressed tooth crowns; a humerus that is longer than wide; and an ulnar facet on the humerus that is as wide as the radial facet. The first complete description of the skull of UHR 30691 and the incorporation of data derived from it into a phylogenetic analysis retrieves a monophyletic Ichthyopterygia that is supported by 18 unambiguous synapomorphies. The updated analysis recovers Utatsusaurus in a basal clade with Parvinatator (united by one unambiguous feature), which collectively form the sister group to all other ichthyopterygians. SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline/UJVP

Quasiparticle interference in optimally doped BiS2-layered superconductors

We theoretically investigate the quasiparticle interference (QPI) in the optimally electron-doped BiS2-layered superconductors with a two-orbital model. We show that possible pairing symmetries can be identified from their unique features in the density of states and QPI maps from magnetic or nonmagnetic impurities. Additionally, the inter-orbital nonmagnetic impurity scattering breaks the C4 symmetry and exhibits a clear C2 patterns in the QPI maps, in contrast to its negligible effect in the superconducting state of iron pnictides. The unambiguous features indicated in the QPI patterns can be used to probe the pairing symmetry as well as to uncover the impurity nature in BiS2-layered superconductors with the STM measurement.

‘Francosuchus’ trauthi is not Paleorhinus: implications for Late Triassic vertebrate biostratigraphy

ABSTRACT A rostrum fragment from the marginal marine upper Lunz Formation of Austria (early Late Triassic: late Carnian) was previously identified as a new species of phytosaurian archosauriform, ‘Francosuchus’ trauthi. ‘Francosuchus’ trauthi was subsequently synonymized with the non-phytosaurid phytosaur Paleorhinus, and this synonymy was used as evidence to correlate the ‘Paleorhinus biochron’ and the Otischalkian land-vertebrate faunachron to the marine timescale. Here, I provide a redescription of ‘Francosuchus’ trauthi and document anatomical features that differ substantially from all known species of non-phytosaurid phytosaur. There is no evidence to support synonymy of ‘Francosuchus’ trauthi with Paleorhinus, and no unambiguous features to support a phytosaurian identification. However, ‘Francosuchus’ trauthi possesses a unique combination of characters that distinguish it from all other Triassic tetrapods, and necessitates referral of the species to a new genus, Dolerosaurus, gen. nov. Rejection of the proposed synonymy between ‘Francosuchus’ trauthi and Paleorhinus means that the ‘Paleorhinus biochron’ cannot be tied to the marine late Carnian as previously suggested, and provides further evidence of the problems inherent in attempting to correlate the terrestrial Triassic to the marine timescale.

A new long terminal repeat (LTR) sequence allows to identify J genome from JS and St genomes of Thinopyrum intermedium

A repetitive sequence of 491 bp, named pMD232-500, was isolated from S. cereale cv. Kustro using wheat SSR marker Xgwm232. GenBank BLAST search revealed that the sequence of pMD232-500 was highly similar to a part of retrotransposon Nusif-1. Fluorescence in situ hybridization (FISH) analysis using pMD232-500 as probe indicated that only 14 Thinopyrum intermedium chromosomes and all the chromosomes of S. cereale cv. Kustro bear FISH signals, however, no FISH signals were observed on Dasypyrum villosum chromosomes. In addition, the FISH signals were distributed on whole arms except their terminal regions. Further genomic in situ hybridization (GISH) analysis using genomic DNA from Pseudoroegneria spicata indicated that the 14 Th. intermedium chromosomes bearing FISH signals should belong to J genome. Thereafter, the repetitive elements pMD232-500 showed the unambiguous features of genomic constitution of Th. intermedium. In addition, the results in the present study have indicated the similarity of genomes from Th. intermedium and S. cereale.

Ambiguity measure feature‐selection algorithm

AbstractWith the increasing number of digital documents, the ability to automatically classify those documents both efficiently and accurately is becoming more critical and difficult. One of the major problems in text classification is the high dimensionality of feature space. We present the ambiguity measure (AM) feature‐selection algorithm, which selects the most unambiguous features from the feature set. Unambiguous features are those features whose presence in a document indicate a strong degree of confidence that a document belongs to only one specific category. We apply AM feature selection on a naïve Bayes text classifier. We favorably show the effectiveness of our approach in outperforming eight existing feature‐selection methods, using five benchmark datasets with a statistical significance of at least 95% confidence. The support vector machine (SVM) text classifier is shown to perform consistently better than the naïve Bayes text classifier. The drawback, however, is the time complexity in training a model. We further explore the effect of using the AM feature‐selection method on an SVM text classifier. Our results indicate that the training time for the SVM algorithm can be reduced by more than 50%, while still improving the accuracy of the text classifier. We favorably show the effectiveness of our approach by demonstrating that it statistically significantly (99% confidence) outperforms eight existing feature‐selection methods using four standard benchmark datasets.

Mass ordering of differential elliptic flow and its violation for ϕ mesons

We simulate the dynamics of Au+Au collisions at the Relativistic Heavy Ion Collider (RHIC) with a hybrid model that treats the dense early quark-gluon plasma (QGP) stage macroscopically as an ideal fluid but models the dilute late hadron resonance gas (HG) microscopically using a hadronic cascade. By comparing with a pure hydrodynamic approach we identify effects of hadronic viscosity on the transverse momentum spectra and differential elliptic flow v{sub 2}(p{sub T}). We investigate the dynamical origins of the observed mass ordering of v{sub 2}(p{sub T}) for identified hadrons, focusing on dissipative effects during the late hadronic stage. Within our approach, we find that, at RHIC energies, much of the finally observed mass splitting is generated during the hadronic stage, due to buildup of additional radial flow. The {phi} meson, having a small interaction cross section, does not fully participate in this additional flow. As a result, it violates the mass-ordering pattern for v{sub 2}(p{sub T}) that is observed for other hadron species. We also show that the early decoupling of the {phi} meson from the hadronic rescattering dynamics leads to interesting and unambiguous features in the p{sub T} dependence of the nuclear suppression factor R{sub AA} and of the {phi}/pmore » ratio.« less