Umbrella Term Research Articles

DIGITAL LABOR AND RENTIER PLATFORM CAPITALISM: REFORM OR REVOLUTION?

Digital labor has become an umbrella term for describing a range of digitally mediated practices from paid work in the gig economy (Srnicek 2017) to cultivating a personal brand online (Scolere, Pruchniewska, and Duffy 2018). This wellspring of activities now referred to as labor has muddied the waters, making digital labor an ambiguous concept at best (Gandini 2021; Goodwin 2022). This framing of user activity as labor also has limitations, as it necessarily produces reformist, rather than revolutionary, political ends. Following Sadowski (2020), this paper challenges the conceptual framework of digital labor by re-theorizing the user/platform relation as rentier capitalism. Engels (1970) explained how tenants confront landlords not as sellers of labor-power but buyers of a commodity, and we argue that typical social media users confront platforms in an analogous way. Platforms thus only circulate existing value rather than create it, and this distinction matters in understanding their role in economic crises. Because the digital labor concept misidentifies the user/platform relationship and concedes the commoditization of communication, reformist demands emerge from this discourse, like “Wages for Facebook” (Ptak 2014 as cited in Jung 2014) or data ownership as compensation (Chakravorti 2020). Capitalist data relations (Couldry and Mejias 2020) and the profit motive of corporate platforms cannot be addressed by renumerating users. As platforms attain infrastructural status (Plantin et al. 2018), our politics must reflect the need for their transformation into public utilities with democratic accountability, a revolutionary demand that has been displaced in the turn towards digital labor.

Comparative Study to Assess the Safety and Effectiveness of Allopurinol & Febuxostat in Patients Diagnosed with Gout

Introduction: Gout is placed under the umbrella term ‘arthritis’ - a wide variety of joint illness and joint pain. Some types of arthritis cause inflammation in the joints, while others do not. It is the most prevalent form of inflammatory arthritis which arises due to the elevated levels of Serum Uric acid (SUA), leading to the deposition of Mono Sodium Urate (MSU) crystals in and around joints. burden of gout has risen in recent decades with a prevalence rate of <1% to 6.8% and the patients with gout may have significant medical comorbidity load asociated with pain, disability and activity limitation which inturn affects the patients’ Health-related quality of life (HRQOL). Several drugs are used to treat acute attacks of gout which includes Colchicine, Non steroidal anti inflammatory drugs (NSAIDs), and Corticosteroids. Long term management of gout focuses on lowering SUA level to normal (<0.36mmol/L). There are two major classes of drugs used to reduce SUA levels, Urate-lowering therapy (ULT), specifically Uricosuric drugs and Xanthine oxidase inhibitors (XOIs). Hence, it is necessary to compare the safety and effectiveness of Allopurinol and Febuxostat used in the management of gout and there is a growing need to research the impact of gout on patients’ HRQOL inorder to improve productivity and QOL of patients. Objectives: The goal of the study was to compare the safety and effectiveness of Allopurinol and Febuxostat in patients diagnosed with Gout. The study also aimed to assess the effect of these on renal profile and the study further assessed the Health-related quality of life of the patients. Methodology: This was an observational study conducted in the selected Orthopedic clinics in T. Dasarahalli, Bengaluru District for a period of 6 months by enrolling 50 subjects, based on various inclusion and exclusion criteria. The subject’s demographic details, laboratory data and responses were collected with the help of a self-designed questionnaire. ...........

Hacking Economic Development

This paper explores the potential use of growth hacking as a prescriptive tool in development economics from a system dynamics perspective. Growth hacking is a popular business method, and it stands as the umbrella term for attaining exponential business growth by creating and harnessing non-linear dynamics by forming virtuous cycles with creative ideas, field experimentation, and fast feedback loops. In this sense, growth hacking is inductive, non-linear, and empirical, contrasting the economic literature's deductive, linear, and abstract frameworks. Given this rationale, growth hacking can yield prescriptive and actionable insights that create virtuous cycles, avoid vicious cycles, and regulate linear economic development. Also, this perspective led to a novel definition of the quality of growth. As an extension of this definition, three development archetypes are stylized as “active,” “passive,” and “sustaining” based on reflexivity characteristics of the underlying economic subsystems.

Treatment approaches to Motor Speech Disorders: A step towards Evidence Based Practice.

Motor Speech Disorders is an umbrella term for a set of separate dysfunctions of speech outcome associated with neurological disorders. Motor speech disorders (MSD) are classified as Speech Motor delay (SMD), Childhood dysarthria (CD), Childhood Apraxia of Speech (CAS), and Concurrent CD and CAS. The incidence and prevalence of MSD in population is uncertain. A research gap exists, making evidence-based practice questionable as regards intervention for MSD and is an area of research. Hence, current narrative review was conducted to review and highlight treatment of MSD since evidence-based treatment approach may benefit patient even years after a brain lesion. To achieve this objective literature search was conducted using search engines and data bases including google, google scholar, web of science & PubMed from 1998 to 2023 with keywords "motor speech disorder, dysarthria, apraxia, speech motor delay and combinations of these words with English language and no other limitations. Our search revealed 170 articles, news, publications of which 34 were used for review (Fig.1).

Digital Heterotopias in the Metaverse

At a time when the umbrella term “metaverse” seems to have monopolised the discourse on online social presence, this paper aims to explore the possibility of constructing interactive online spaces that challenge the hegemonic structures of heteronormative society. Before describing the metaverse as a futuristic scenario that catalyses technophobic fears, perhaps we can turn our attention to existing metaverses: one example is the sandbox video game Minecraft, which is characterised by great interactivity and manipulability. Therefore, by analysing the immersive and interactive artwork g(Ender Gallery) by artist Cat Haines, which was created entirely on Minecraft in 2021, I will explore how the platform can be used to build a playful ground and at the same time a critical arena of gender norms and a deep reflection on trans experience.

Scoping Review of the Definitions Used to Describe and Understand Harmful Sexual Behaviors in Children and Young People.

There is a growing body of evidence that adolescents, and other children, are responsible for a significant proportion of sexual abuse against children. However, there are substantial differences in how this phenomenon is defined and conceptualized between and within sectors. This scoping review explored the current definitions of harmful sexual behaviors (HSB), and other similar terms, used across a range of stakeholder groups. In all, 141 papers were reviewed from both empirical and gray literature sources, including key policy and practice documents. Included papers needed to list a clear definition for the behavior of interest. There was disagreement and inconsistency across the included papers in their conceptualization of harmful, abusive, or problematic sexual behavior (PSB) in children and adolescents. Although the term HSB has been adopted as an umbrella term or continuum in many policy, practice, and research settings, there is a large variance in behaviors, treatment needs, etiology, and harms present across different types of sexual behavior. Relying solely on one term to describe a wide range of sexual behaviors in children and young people may limit the understanding of this issue and imply similarities between groups that are not present. We suggest that clearly defined subsets of HSB, such as sexual abuse, technology-assisted HSB, and PSB, may give more context to the behavior of concern and may be helpful in informing further research, prevention, and best practice approaches.

Is a unified model for patient empowerment possible or desirable?

Background: Patient empowerment has a history going back to the 1960’s ( Kayser et al. BMC Health Services Research (2019) 19:242) and originates in the movement for greater citizen participation in societal decision-making (e.g. ‘power to the people’). In the decade of the 1970’s there was a related shift in some healthcare thinking.
 While there has been a proliferation of terms, such as citizen engagement, patient participation, patient empowerment, patient activation and so forth, the fundamental underlying principle is the shift from the patient/citizen as a passive recipient of services to the patient /citizen as active, informed participant in their own health and healthcare.
 These shifts have been reflected in health care policy- person/patient centred care, personalised care and integrated care all put forward models of working that are designed to enhance patient empowerment and a shift from a bio-medical model of health care t a more holistic bio- psychosocial model of care
 Although there had been active proponents of this change, especially in parts of Northern Europe it remains a fragile part of health care
 Method: Unlike some health topics, although patient empowerment is often cited, for example in relation to current work on health technology including mHealth, there appears to be no overarching consensus on a strategy for local implementation, nor even how patient empowerment is defined for strategic purposes. This  survey aimed to gather information which would, when collated, help to address these issues. To explore the current standing of patient empowerment at the beginning of 2021 a survey of experts including people expert in lived experience was carried out in a number of European countries (the final total was 25 responses from 14 countries) 
 This was followed up in 2022 by a international round table event of people of lived experience, researchers, policy makers and leading experts to explore this issue and to record the discussion as a marker for future thinking about the concept.
 Results and conclusions:  Despite significant activity it was clear it was very siloed  and y the concept was diversely defined or interpreted in practice.
 We concluded it seems that the majority of respondents from the 14 countries only use aspects of the concept with no common understanding.
 . If there is such a disparate use of terminology, is it meaningful to refer to ‘empowerment’ as a  definition of anything? Is there a better term to use for an umbrella concept?
 These findings confirm that concepts such as person centred care, personalised care and patient empowerment have considerable variations in how they are understood.
 This has significant implication for their implementation  when there is such diverse understandings at all levels - Macro, Miso and Micro leading to fragmentation  and a lack of a unified approach to evaluation.

RISK FACTOR OF ROTATOR CUFF TENDINOPATHY: A SYSTEMATIC REVIEW

Background: Rotator cuff tendinopathy is an umbrella term that  includes  different  shoulder  conditions  affecting  subacromial structures, such as rotator cuff tendinitis/tendinosis, subacromial bursitis and shoulder impingement  syndrome.  Rotator  cuff  tendinopathy  is  refractory to treatments, results in impaired activities of daily living and has a significant socio-economic burden due to loss of work and treatment costs. The aim: This study aims to show risk factor for rotator cuff tendinopathy. Methods: By comparing itself to the standards set by the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020, this study was able to show that it met all of the requirements. So, the experts were able to make sure that the study was as up-to-date as it was possible to be. For this search approach, publications that came out between 2013 and 2023 were taken into account. Several different online reference sources, like Pubmed and SagePub, were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done. Result: In the PubMed database, the results of our search brought up 75 articles, whereas the results of our search on SagePub brought up 151 articles. The results of the search conducted for the last year of 2013 yielded a total 58 articles for PubMed and 53 articles for SagePub. The result from title screening, a total 7 articles for PubMed and 18 articles for SagePub. In the end, we compiled a total of 10 papers. We included five research that met the criteria. Conclusion: The most well-established RCD risk factor is advanced age, with higher prevalence associated with age in multiple studies. Other important and potentially modifiable risk factors exist, such as occupational physical demands, but few epidemiologic studies have evaluated associations specific to RCD.

Degenerative Thoracic Myelopathy: A Scoping Review of Epidemiology, Genetics, and Pathogenesis.

Literature Review. Myelopathy affecting the thoracic spinal cord can arise secondary to several aetiologies which have similar presentation and management. Consequently, there are many uncertainties in this area, including optimal terminology and definitions. Recent collaborative cervical spinal research has led to the proposal and subsequent community adoption of the name degenerative cervical myelopathy(DCM), which has facilitated the establishment of internationally-agreed research priorities for DCM. We put forward the case for the introduction of the term degenerative thoracic myelopathy(DTM) and degenerative spinal myelopathy(DSM) as an umbrella term for both DCM and DTM. Following PRISMA guidelines, a systematic literature search was performed to identify degenerative thoracic myelopathy literature in Embase and MEDLINE. Conditions encompassed within DTM include thoracic spondylotic myelopathy, ossification of the posterior longitudinal ligament, ossification of the ligamentum flavum, calcification of ligaments, hypertrophy of ligaments, degenerative disc disease, thoracic osteoarthritis, intervertebral disc herniation, and posterior osteophytosis. The classic presentation includes girdle pain, gait disturbance, leg weakness, sensory disturbance, and bladder or bowel dysfunction, often with associated back pain. Surgical management is typically favoured with post-surgical outcomes dependent on many factors, including the causative pathology, and presence of additional stenosis. The clinical entities encompassed by the term DTM are interrelated, can manifest concurrently, and present similarly. Building on the consensus adoption of DCM in the cervical spine and the recent proposal of degenerative cervical radiculopathy(DCR), extending this common nomenclature framework to the terms degenerative spinal myelopathy and degenerative thoracic myelopathy will help improve recognition and communication.

Is cerebral small vessel disease a central nervous system interstitial fluidopathy?

A typical anatomical congregate and functionally distinct multicellular cerebrovascular dynamic confer diverse blood-brain barrier (BBB) and microstructural permeabilities to conserve the health of brain parenchymal and its microenvironment. This equanimity presupposes the glymphatic system that governs the flow and clearance of metabolic waste and interstitial fluids (ISF) through venous circulation. Following the introduction of glymphatic system concept, various studies have been carried out on cerebrospinal fluid (CSF) and ISF dynamics. These studies reported that the onset of multiple diseases can be attributed to impairment in the glymphatic system, which is newly referred as central nervous system (CNS) interstitial fluidopathy. One such condition includes cerebral small vessel disease (CSVD) with poorly understood pathomechanisms. CSVD is an umbrella term to describe a chronic progressive disorder affecting the brain microvasculature (or microcirculation) involving small penetrating vessels that supply cerebral white and deep gray matter. This review article proposes CSVD as a form of “CNS interstitial fluidopathy”. Linking CNS interstitial fluidopathy with CSVD will open a better insight pertaining to the perivascular space fluid dynamics in CSVD pathophysiology. This may lead to the development of treatment and therapeutic strategies to ameliorate the pathology and adverse effect of CSVD.

Significant burden of post-COVID exertional dyspnoea in a South-Italy region: knowledge of risk factors might prevent further critical overload on the healthcare system.

Exertional dyspnoea in post-COVID syndrome is a debilitating manifestation, requiring appropriate comprehensive management. However, limited-resources healthcare systems might be unable to expand their healthcare-providing capacity and are expected to be overwhelmed by increasing healthcare demand. Furthermore, since post-COVID exertional dyspnoea is regarded to represent an umbrella term, encompassing several clinical conditions, stratification of patients with post-COVID exertional dyspnoea, depending on risk factors and underlying aetiologies might provide useful for healthcare optimization and potentially help relieve healthcare service from overload. Hence, we aimed to investigate the frequency, functional characterization, and predictors of post-COVID exertional dyspnoea in a large cohort of post-COVID patients in Apulia, Italy, at 3-month post-acute SARS-CoV-2 infection. A cohort of laboratory-confirmed 318 patients, both domiciliary or hospitalized, was evaluated in a post-COVID Unit outpatient setting. Post-COVID exertional dyspnoea and other post-COVID syndrome manifestations were collected by medical history. Functional characterization of post-COVID exertional dyspnoea was performed through a 6-min walking test (6-mwt). The association of post-COVID exertional dyspnoea with possible risk factors was investigated through univariate and multivariate logistic regression analysis. At medical evaluation, post-COVID exertional dyspnoea was reported by as many as 190/318 patients (59.7%), showing relatively high prevalence also in domiciliary-course patients. However, functional characterization disclosed a 6-mwt-based desaturation walking drop in only 24.1% of instrumental post-COVID exertional dyspnoea patients. Multivariate analysis identified five independent predictors significantly contributing to PCED, namely post-COVID-fatigue, pre-existing respiratory co-morbidities, non-asthmatic allergy history, age, and acute-phase-dyspnoea. Sex-restricted multivariate analysis identified a differential risk pattern for males (pre-existing respiratory co-morbidities, age, acute-phase-dyspnoea) and females (post-COVID-fatigue and acute-phase-dyspnoea). Our findings revealed that post-COVID exertional dyspnoea is characterized by relevant clinical burden, with potential further strain on healthcare systems, already weakened by pandemic waves. Sex-based subgroup analysis reveals sex-specific dyspnoea-underlying risk profiles and pathogenic mechanisms. Knowledge of sex-specific risk-determining factors might help optimize personalized care management and healthcare resources.

CAREGIVER EXPERIENCE WITH FRONTOTEMPORAL DEGENERATION (FTD)

Abstract Frontotemporal degeneration (FTD) is the umbrella term for a group of young onset neurodegenerative disorders affecting the frontal and temporal lobes of the brain. Symptoms include changes in cognition, language, behavior, motor functioning, and personality. The FTD Insights Survey was designed to learn more about the lived experience of this often misunderstood set of disorders. A total of 1,246 past and current caregivers of people with FTD responded to questions regarding their and their loved one’s experiences with FTD. Caregivers most often provided care for more than 80 hours per week and 10% of respondents provided care for more than one person diagnosed with FTD. The majority were caring for someone or had cared for someone who was diagnosed between ages 50 and 69. Only 36% of caregivers reported the person diagnosed was aware or mostly aware of their symptoms and they noted being most distressed by changes in the diagnosed person’s language, personality, mood, and behavior. The caregivers described the impact of their loved one’s symptoms on activities of daily living at home, in the community, and on interpersonal functioning. The caregivers also provided insight into issues such as the length of time they have provided care, the level of functioning of the person diagnosed, and the impact of FTD symptoms on quality of life. It is critical that healthcare professionals and policy makers understand FTD caregiver strain in order to provide wraparound support and make policy decisions with these features in mind.

Assessment of regional digital divide in Türkiye

Technological advancement has not been equally distributed. It has differed from country to country, region to region, and even among individuals. As a result, the digital divide has emerged as an umbrella term to represent these disparities. Recently, the research focus has shifted to the outcomes of information and communication technology usage or tangible benefits (the third-level digital divide). As an emerging economy, Türkiye must overcome the digital divide to maximise tangible benefits. Thus, this research starts by determining the digital divide indicators for Türkiye and goes further to examine the digital divide between regions in Türkiye. The main aim is to present a comprehensive index for the regional scale that is currently missing in the literature. To do so, this research starts with exploring the digital divide indicators. Then, with the help of principal component analysis (PCA), a new index is formulated for Türkiye. The result maps indicate digital inequalities both at regional and city scales, yet inequalities are more remarkable at the city scale. Increasing the diversity of technology usage, focusing on gender equality, expanding R&D expenditures, and supporting initiatives, especially ICT initiatives, will assist Türkiye in reducing digital inequalities.

Exploring new forms of audiovisual translation in the age of digital media: cybersubtitling and cyberdubbing

ABSTRACT The prevalence and popularity of audiovisual content in the current times has resulted in a wide range of practices which have been categorised within audiovisual translation (AVT) research as examples of fan translation, amateur translation, crowdsourcing or collaborative translation, among others. While some practices can be included under these categories, other forms of AVT that have recently emerged are not as clear-cut. Against this backdrop, this article explores the conceptual uncertainties surrounding these new AVT practices, with a focus on dubbing and subtitling, by revisiting the work carried out by the authors, who have previously suggested the use of the umbrella terms ‘cybersubtitling’ and ‘cyberdubbing’. In addition to providing a revised classification, the paper emphasises the need to explore the wider social and ethical consequences of these innovative translational activities. As regards ethical implications, altruist and fan practices are the ones most exposed to malpractice, often because some organisations emulate corporate behaviour but rely on free labour, without any financial retribution or credit towards those involved in these activities. The article also concludes that more critical research should be conducted to unravel the impact of these practices on the role of translation as a socio-professional activity.

Fetal Alcohol Spectrum Disorders and Inadequacy of Care: Importance of Raising Awareness in Clinical Practice.

Prenatal alcohol exposure is one of the major avoidable causes of developmental disruption and health abnormalities in children. Fetal alcohol spectrum disorders (FASDs), a significant consequence of prenatal alcohol exposure, have gained more attention recently. This review aims to provide a narrative approach to the scientific literature on the history, clinical presentation, diagnosis, and management of FASDs. A literature search in PubMed, ScienceDirect, and Google Scholar online databases was conducted. The dates of publications ranged from 2000 to 2023. FASD presentations tend to persist into adulthood, which, combined with environmental factors, potentially lead to secondary psychosocial problems and disabilities. This review covers different aspects of FASDs regarding the concept of the umbrella term and public health, somatic, and psychiatric perspectives. FASD management remains an obstacle to health professionals, and mental health problems are underestimated. Its management involves a multi-disciplinary team, which varies according to the patient's individual needs. FASD diagnosis and management have not been sufficiently established and tailored. Stigma, cultural contexts, knowledge gaps, and the heterogeneity of clinical manifestations are significant barriers to an accurate diagnostic process. Further development of early interventions and the elaboration of complex treatment approaches are needed.

Dem-Aging: autophagy-related pathologies and the "two faces of dementia".

Neuronal ceroid lipofuscinosis (NCL) is an umbrella term referring to the most frequent childhood-onset neurodegenerative diseases, which are also the main cause of childhood dementia. Although the molecular mechanisms underlying the NCLs remain elusive, evidence is increasingly pointing to shared disease pathways and common clinical features across the disease forms. The characterization of pathological mechanisms, disease modifiers, and biomarkers might facilitate the development of treatment strategies.The DEM-AGING project aims to define molecular signatures in NCL and expedite biomarker discovery with a view to identifying novel targets for monitoring disease status and progression and accelerating clinical trial readiness in this field. In this study, we fused multiomic assessments in established NCL models with similar data on the more common late-onset neurodegenerative conditions in order to test the hypothesis of shared molecular fingerprints critical to the underlying pathological mechanisms. Our aim, ultimately, is to combine data analysis, cell models, and omic strategies in an effort to trace new routes to therapies that might readily be applied in the most common forms of dementia.

Metabolic Mentorship

In this editorial, we propose metabolic mentorship as an umbrella term, which includes all activities that are undertaken inorder to achieve and maintain metabolic health. Metabolic mentorship includes not only conventional medical prescription,but also education, counseling and support for effective self-management. Metabolic mentorship facilitates value-addedtherapy (VAT), i.e, the nonpharmacological and pharmacological interventions that help ensure optimal therapeutic outcomes.From a pedagogic perspective, metabolic mentorship implies the learning that health care professionals can gain by interactingand sharing experiences with each other. We suggest that endocrinologists take the responsibility of spearheading metabolicmentorship within, and beyond, the health care sciences

Clinical Features of Vitiligo and Social Impact on Quality of Life.

Vitiligo is the most common cause of depigmentation and its estimated worldwide prevalence ranges from 0.5% to 2%. The disease is characterized by the development of white macules resulting from a loss of epidermal melanocytes. The term vitiligo (nonsegmental) is now a consensus umbrella term for all forms of generalized vitiligo. Two other subsets of vitiligo are segmental vitiligo and unclassified/undetermined vitiligo, which corresponds to focal disease and rare variants. A series of hypopigmented disorders may masquerade as vitiligo, and some of them need to be ruled out by specific procedures including a skin biopsy. The skin plays an important role in our interaction with the world and any change in the skin colour can have important psychological consequences. In this line, vitiligo has a major impact on quality of life.In this review, we will detail the most recent data on the clinical features of vitiligo and its impact on quality of life.

Validity and Reliability of the Malay Questionnaire for Olfactory Disorders.

Olfactory disorders (OD) are an umbrella term for a diverse group of smell problems. Numerous tests and questionnaires have been formulated to identify and test the severity of smell impairment, which is not readily available or translated for the Malaysian population. This study aimed to translate the Questionnaire for Olfactory Disorders (QOD) and validate and test the reliability of the Malay Questionnaire for Olfactory Disorders (mQOD). This cross-sectional study was conducted in two tertiary centres. A forward and backward translation was conducted for the QOD. The translated questionnaire was distributed to subjects with self-reported smell disorders on days 1 and 7. Internal consistency was analysed using Cronbach's alpha and test-retest reliability was tested with an intraclass correlation coefficient. Confirmatory factor analysis was performed to test construct validity. A total of 375 participants were recruited, 52 dropped out and 323 completed the questionnaire a second time. The Cronbach's alpha coefficient was 0.537 for parosmia (P), 0.892 for life quality (LQ), 0.637 for sincerity (S) and 0.865 for visual analogue score (VAS). The intraclass correlation coefficient (ICC) for domain scores was > 0.9, while the ICC for all items was good to excellent. A three-factor model for mQOD showed an acceptable fit with indices chi-square value (CMIN)/degree of freedom (DF) = 3.332, Tucker-Lewis fit index (TLI) = 0.923, comparative fit index (CFI) = 0.939, root mean square error of approximation (RMSEA) = 0.079 and standardised root mean square residual (SRMR) = 0.0574. The mQOD is a valid and reliable tool for assessing OD in patients.

Single cell RNA-sequencing profiling to improve the translation between human IBD and in vivo models.

Inflammatory bowel disease (IBD) is an umbrella term for two conditions (Crohn's Disease and Ulcerative Colitis) that is characterized by chronic inflammation of the gastrointestinal tract. The use of pre-clinical animal models has been invaluable for the understanding of potential disease mechanisms. However, despite promising results of numerous therapeutics in mouse colitis models, many of these therapies did not show clinical benefits in patients with IBD. Single cell RNA-sequencing (scRNA-seq) has recently revolutionized our understanding of complex interactions between the immune system, stromal cells, and epithelial cells by mapping novel cell subpopulations and their remodeling during disease. This technology has not been widely applied to pre-clinical models of IBD. ScRNA-seq profiling of murine models may provide an opportunity to increase the translatability into the clinic, and to choose the most appropriate model to test hypotheses and novel therapeutics. In this review, we have summarized some of the key findings at the single cell transcriptomic level in IBD, how specific signatures have been functionally validated in vivo, and highlighted the similarities and differences between scRNA-seq findings in human IBD and experimental mouse models. In each section of this review, we highlight the importance of utilizing this technology to find the most suitable or translational models of IBD based on the cellular therapeutic target.