Osteoarthritis is the most prevalent chronic joint disease. The most common symptoms include joint pain, swelling and stiffness. It is characterized by loss of joint cartilage, which leads primarily to loss of function of the knee and hip joints. However, none of the current clinical methods or approaches has significant value in terms of early diagnosis of osteoarthritis or monitoring of its progression or treatment response. Recently, a number of studies have suggested that ultrasound may be of significant value for early detection and treatment of osteoarthritis. Compared with current clinical methods, ultrasound is a valuable modality owing to its high patient acceptability, overall assessment of osteoarthritic joints, safety, quick performance and absence of radiation. The ultrasound technique has been introduced in the specialty of rheumatology, and is a valuable tool for the assessment of osteoarthritis. It can be used safely to monitor osteoarthritis progression and response to treatment. Osteoarthritis treatment with ultrasound-guided intra-articular injection is an economical and safe local procedure; furthermore, it can be performed accurately and is well-tolerated by patients. Operator-dependent and incomplete visualization of the joint structure are the main limitations in the clinical application of ultrasound in cases of osteoarthritis. Further research is needed in order to examine the role of ultrasound in the management and diagnosis of osteoarthritis.