Ultrasonic Atomization Research Articles

Study on the influence of aerosol atomization by ultrasonic atomization on coal spontaneous combustion

ABSTRACT Influenced by the complex environment and the nature of process materials in goaf, the prevention and control of spontaneous combustion of coal (CSC) in the deep part of goaf were facing many difficulties. To investigate the performance of ultrasonic atomized aerosols, a series of atomization experiments were conducted using a self-developed ultrasonic atomization device. The main conclusions are as follows: under the same atomization conditions, the atomized particle sizes of several inhibitors (except PAS-W) are concentrated in the <8 μm range, with a content of more than 88%, indicating that the aerosol particles produced by ultrasonic atomization are small in size and uniform in distribution. Compared with water and MgCl2 inhibitors, aerosol particles produced by PAS-W are less likely to pass through the voids of the coal body, and have poorer permeability and diffusivity. As the temperature increases, the viscosity and surface tension of the inhibitor decrease, and the percentage of aerosol particles with particle size <8 μm produced by ultrasonic atomization is more than 88%, indicating that the atomization effect is improved. After increasing the temperature, the contact angle between PAS-W inhibitor and coal reduces from 54.7° to 40.8°, and the wettability is better. Compared with raw coal, the final temperature of the PAS-W aerosol treated coal sample is delayed 21.86°C, and has significant retarding property. When the wind speed is 3 m/s, the effect of PAS-W aerosol particle generation, permeability, and particle size distribution is the best. The results of the study are of great significance in improving the ultrasonic atomized aerosol fire prevention technology and realizing large-scale CSC prevention in goaf.

Application of Quantitative Magnetic Resonance Imaging (QMRI) to Evaluate the Effectiveness of Ultrasonic Atomization of Water in Truffle Preservation.

Truffles of the Tuber genus (Pezizales, Ascomycetes) are among the most valuable and expensive foods, but their shelf life is limited to 7-10 days when stored at 4 °C. Alternative preservation methods have been proposed to extend their shelf life, though they may alter certain quality parameters. Recently, a hypogeal display case equipped with an ultrasonic humidity system (HDC) was developed, extending the shelf life to 2-3 weeks, depending on the truffle species. This study assesses the efficacy of HDC in preserving Tuber melanosporum and Tuber borchii ascomata over 16 days, using quantitative magnetic resonance imaging (QMRI) to monitor water content and other parameters. Sixteen T. melanosporum and six T. borchii ascomata were stored at 4 °C in an HDC or a static fridge (SF) as controls. QMRI confirmed that T. borchii has a shorter shelf life than T. melanosporum under all conditions. HDC reduced the rate of shrinkage, water, and mass loss in both species. Additionally, the Apparent Diffusion Coefficient (ADC), longitudinal relaxation time (T1), and transverse relaxation time (T2), which reflect molecular changes, decreased more slowly in HDC than SF. QMRI proves useful for studying water-rich samples and assessing truffle preservation technologies. Further optimization of this method for industrial use is needed.

Impact of piezoelectric driving waveform on performance characteristics of vibrating mesh atomizer (VMA)

Vibrating mesh atomizer (VMA) is a specific type of ultrasonic atomizer known for its low power consumption and production of uniformly fine droplets. While previous research has provided a basic understanding of VMA operation, it has primarily focused on driving the piezoelectric actuator with continuous and symmetrical waveforms, such as sine and square waveforms. This study aims to experimentally investigate the impact of different driving waveforms on the ultrasonic atomization process and the associated performance characteristics. Specifically, the effects of pulse waveforms (Gauss and Lorentz pulse) were analyzed with high rates of energy deposition and asymmetrical hybrid waveforms (trapezia and absolute sine), featuring distinct negative cycles, by comparing them with conventional symmetrical waveforms (sine and square). Pulse waveforms suppress the growing stage but provide a high flux of input energy, facilitating the detachment of liquid into fine droplets, resulting in uniformly distributed droplets with VMDs of 5.84 μm and 4.71 μm for Gauss and Lorentz waveforms, respectively. Conversely, shorter negative cycles in asymmetrical hybrid waveforms reduce liquid suction into the micronozzle, leading to higher energy flux during subsequent positive cycles that promote the growing stage, producing larger droplets with VMDs of 10.82 μm and 11.86 μm for trapezia and absolute (abs) sine waveforms, respectively. Additionally, high-speed imaging reveals irregular pulsating behaviors in the atomization process when using pulse waveforms, suggesting a reciprocating-pump-like operation mechanism in VMA atomization. These new insights contribute to an improved understanding of the atomization mechanism in VMAs.

Effect of Spray Characteristic Parameters on Friction Coefficient of Ultra-High-Strength Steel against Cemented Carbide.

Ultra-high-strength steels have been considered an essential material for aviation components owing to their excellent mechanical properties and superior fatigue resistance. When machining these steels, severe tool wear frequently results in poor surface quality and low machining efficiency, which is intimately linked to the friction behavior at the tool-workpiece interface. To enhance the service life of tools, the adoption of efficient cooling methods is paramount. However, the understanding of friction behavior at the tool-workpiece interface under varying cooling conditions remains limited. In this work, both air atomization of cutting fluid (AACF) and ultrasonic atomization of cutting fluid (UACF) were employed, and their spray characteristic parameters, including droplet size distribution, droplet number density, and droplet velocity, were evaluated under different air pressures. Discontinuous sliding tests were conducted on the ultra-high-strength steel against cemented carbide and the effect of spray characteristic parameters on the adhesion friction coefficient was studied. The results reveal that ultrasonic atomization significantly improved the uniformity of droplet size distribution. An increase in air pressure resulted in an increase in both droplet number density and droplet velocity under both AACF and UACF conditions. Furthermore, the thickness of the liquid film was strongly dependent on the spray characteristic parameters. Additionally, UACF exhibited a reduction of 4.7% to 9.8% in adhesion friction coefficient compared to AACF. UACF provided the appropriate combination of spray characteristic parameters, causing an increased thickness of the liquid film, which subsequently exerted a positive impact on reducing the adhesion friction coefficient.

Numerical analysis of multistage ultrasonic atomization enhanced ammonia-water falling film absorption

The absorption refrigeration system is a widely used system that utilizes waste heat and is environmentally friendly. However, many current systems still suffer from challenges such as large volume, and high initial investment. Meanwhile, optimizing the absorber is crucial for enhancing system performance as it is one of the main components. In this study, a novel absorber model is proposed and its influencing factors of performance are comprehensively analyzed. In this model, the traditional falling film absorber is divided into multiple stages, with an ultrasonic atomizer (UA) installed in each stage to enhance absorption. In each stage, falling film and atomization absorption occur simultaneously, and their outputs are combined and weighted at the exit to maintain continuous droplet absorption, effectively utilizing the entire absorber volume. In this process, the vapor–liquid contact area is increased through atomization, and simultaneously, generated heat is removed by the cooling water during mixing. As a result, the absorber’s absorption capacity increases, and the outlet solution temperature decreases. The results demonstrate that compared to the traditional falling film absorber, the proposed absorber, when divided into two stages with a droplet diameter of 50 μm and an atomization rate x = 0.7, shows a 60.64 % increase in ammonia absorbed rate. Additionally, compared to double-stage absorber, triple-stage absorber increases the ammonia absorption by 9.52 %. As the number of stages increased, the strengthening effect persisted, albeit with a gradually diminishing rate of increase. Scaling up to ten stages results in a 152.63 % absorption rate increase and a size optimization of 60.43 %. In this paper, multi-stage ultrasonic atomization is innovatively introduced into the falling film absorber, which enhances ammonia absorption and reduces the volume of the absorber. Additionally, the multi-stage atomization offers an innovative method to improve the droplet absorption process.

Layer formation, morphology and photoluminescent properties of ultrasonic spray of pre-formed YVO4:Eu and SiO2 coated ZnS:Mn nanoparticles

In this work, we study the coating process and coating quality of photoluminescent particles deposited on a glass surface in terms of particle distribution and associated film continuity. The dispersion process of commercial ZnS:Mn particles and YVO4:Eu particles synthesized by microwave reactor in aqueous solutions onto solid surface was performed using an ultrasonic atomizer. Two methods of particle deposition were used, one by moving the substrates while spraying and in the second the substrates were not moved. The measured zeta potential values of 42.9 mV and 45.3 mV, respectively, show that the dispersion of YVO4:Eu nanoparticles, in water, is stable at concentrations of 1.2 wt% and 2.4 wt% without the addition of capping agents. It was also found that the dispersion area increases as the flow rate increases from 1 ml/min to 3 ml/min at constant suspension concentration and spraying time. To stabilize the ZnS:Mn particles in solution, either surfactants or a silica capping layer prepared by a sol-gel process were used.The dispersion area encompassing the major amount of dispersed particles was evaluated, The SEM images demonstrate the effectiveness of the ultrasonic atomizer spraying procedure in the disaggregation nanoparticles, as seen by the reduced mean particle size in the sprayed layer compared to the as prepared powder. Finally, this study suggest that the dispersion process of photoluminescent nanoparticles on a substrate holds the potential for optical traceability.

High-precision ultrasonic atomization using oscillating microchannels: Interplay of three-dimensional vibrational modes and droplet ejection mechanisms

Ultrasonic atomization is a critical process for producing micrometer-diameter droplets, widely utilized in aerosol drug delivery, spectrometry, and printing. The geometry of the vessel containing the fluid being atomized and the oscillations of its sidewalls play a crucial role in controlling the wave patterns and hence the droplet ejection process, especially at actuation frequencies exceeding 1 MHz. However, the mechanisms behind droplet ejection under high-frequency ultrasonic actuation remain poorly understood. We employ oscillating high-aspect-ratio Silicon microchannels to create ideal conditions where capillary forces, microchannel geometry, and oscillatory motion work together to precisely confine a liquid film and generate droplets with controlled diameters. We show that the three-dimensional vibrations of the microchannels, particularly the interplay between actuation frequency, amplitude, and channel geometry, can be used to effectively tune the ligament development and droplet breakup. This understanding allows us to establish conditions to reduce actuation power and hence minimize heating, control shear stresses and tune the droplet size on-demand without compromising uniformity and throughput.

Impact of Chemical Composition Changes during Ultrasound Atomization and Laser Powder Bed Fusion of Low Alloy Steel

This study investigates the effect of changing the chemical composition during ultrasonic atomization (UA) and laser powder bed fusion (LPBF) of low‐alloy steel. UA is used to produce a spherical powder with d50 equal to 49 μm. During UA, the chemical composition of the material changes, which is associated with selective evaporation of Mn from 1.42% to 0.35% and B from 0.0012% to &lt;0.0001%. Thermodynamic calculations confirm that during atomization, mostly Mn and Fe evaporate. To achieve a high density of 3D printed parts, in situ remelting in LPBF is applied. A microstructure consisting of fine grains of tempered martensite and bainite in crystallized meltpools is observed. The selected high‐quality LPBF samples are austenitized in the temperature range of 900–1200 °C for 20 min and quenched in oil. The samples are characterized by light and scanning electron microscopy, as well as Vickers hardness. Changes in chemical composition result in a decrease in the hardenability of the material, and quenching only at 1200 °C produces a martensitic microstructure. LPBF samples show a hardness higher than that of the postheat‐treated sample, but still significantly lower than that of the as‐delivery condition, which is related to the change in chemical composition.

Ultrasonic atomization technique for enhancing humidification process in thermal desalination

The need for desalination is expected to evolve, and interests in novel techniques to enhance thermal desalination are developing. Research studies on ultrasonic atomization for desalination application has been observed in the last few years. Hence, this study aims to examine humidification process enhancement using ultrasonic atomization and interaction of atomized droplets with hot air in the humidifier. In the Humidification and Dehumidification (HDH) desalination system examined, the humidifier is equipped with a single ultrasonic atomizer unit which operates continuously with preheated hot air entering the humidifier chamber. The system is investigated for different air flowrates (40 – 100 LPM) and hot air temperatures (40, 50, and 60 °C). The average relative humidity at the humidifier outlet was maximum reaching 94 % for the highest flowrate. The results indicate that increasing hot air temperatures have significant improvement in droplet evaporation which causes higher relative humidity at the outlet, and increasing hot air flowrates have significant impact on the faster response of the humidification process to reach equilibrium.

Enhanced TiO2-Based Photocatalytic Volatile Organic Compound Decomposition Combined with Ultrasonic Atomization in the Co-Presence of Carbon Black and Heavy Metal Nanoparticles.

Volatile organic compounds (VOCs) are representative indoor air pollutants that negatively affect the human body owing to their toxicity. One of the most promising methods for VOC removal is photocatalytic degradation using TiO2. In this study, the addition of carbon black (CB) and heavy metal nanoparticles (NPs) was investigated to improve the efficiency of a TiO2-based photocatalytic VOC decomposition system combined with ultrasonic atomization and ultraviolet irradiation, as described previously. The addition of CB and Ag NPs significantly improved the degradation efficiency. A comparison with other heavy metal nanoparticles and their respective roles are discussed.

Crack-Resistant Si-C Hybrid Microspheres for High-Performance Lithium-Ion Battery Anodes.

To effectively solve the challenges of rapid capacity decay and electrode crushing of silicon-carbon (Si-C) anodes, it is crucial to carefully optimize the structure of Si-C active materials and enhance their electron/ion transport dynamic in the electrode. Herein, a unique hybrid structure microsphere of Si/C/CNTs/Cu with surface wrinkles is prepared through a simple ultrasonic atomization pyrolysis and calcination method. Low-cost nanoscale Si waste is embedded into the pyrolysis carbon matrix, cleverly combined with the flexible electrical conductivity carbon nanotubes (CNTs) and copper (Cu) particles, enhancing both the crack resistance and transport kinetics of the entire electrode material. Remarkably, as a lithium-ion battery anode, the fabricated Si/C/CNTs/Cu electrode exhibits stable cycling for up to 2300 cycles even at a current of 2.0 A g-1, retaining a capacity of ≈700 mAh g-1, with a retention rate of 100% compared to the cycling started at a current of 2.0 A g-1. Additionally, when paired with an NCM523 cathode, the full cell exhibits a capacity of 135 mAh g-1 after 100 cycles at 1.0C. Therefore, this synthesis strategy provides insights into the design of long-life, practical anode electrode materials with micro/nano-spherical hybrid structures.

Effect of wettability on paper literature deacidification by ultrasonic atomization

Effect of wettability on paper literature deacidification by ultrasonic atomization

Assessment of thermoeconomic and thermoenvironmental impacts of a novel solar desalination system using a heat pump, evacuated tubes, cover cooling, and ultrasonic mist

Various desalination methods have been introduced to address the growing demand for freshwater. Among these methods, solar stills have emerged as one of the simplest approaches. However, their performance has been hindered by low reliability, particularly due to heavy reliance on solar energy year-round. Addressing this issue, this study presents a novel and reliable solar desalination unit incorporating an evacuated tube water solar heater as a heat collector and a 250 W heat pump unit for condensation. Additionally, ultrasonic atomizers are integrated to facilitate vapor generation and accelerate its separation from the hot water fed into the desalination unit. The research commences with the selection of the optimal number of atomizers, followed by a comprehensive analysis encompassing environmental, economic, exergy, and energy (4E) considerations for the system with the optimal atomizer configuration. Furthermore, cover cooling is implemented to enhance condensation rates. Results indicate that the system, equipped with a single atomizer, yields 19.565 L/m2 per day of distilled water, with daily energy and exergy efficiencies of 62.39 % and 6.04 %, respectively. Following cover cooling, the system achieves production of 20.95 L/m2 of distilled water per day, accompanied by energy and exergy efficiencies of 65.48 % and 6.67 %, respectively. These improvements represent enhancements in freshwater production, energy efficiency, and exergy efficiency by 431.7 %, 57.82 %, and 74.61 %, respectively. Additionally, the system demonstrates a cost reduction of 14.36 % and a decrease in carbon dioxide emissions by 11.17 tons CO2, underscoring its economic and environmental benefits.

Comprehensive analysis of ultrasonically atomized 316L stainless steel powder using adjusted additive manufacturing suitability factor

This study focuses on the 316L stainless steel powder produced by using an innovative ultrasonic atomization (UA) method. The production process was optimized at electrical currents with 120 A and vibration amplitude with 80% proving the most effective for maximizing productivity. The study extensively evaluated particle size and shape, bulk and tapped densities, Hausner's ratio, and Carr index, finding the UA steel powder to possess high sphericity, minimal satellite particles, and excellent flowability, qualities crucial for additive manufacturing (AM). A new approach for calculating the additive manufacturing suitability factor was developed, incorporating custom weighting factors for rheological parameters to reduce the influence of parameters with high uncertainty or statistical insignificance, thus improving accuracy. When compared using this method, the UA powder demonstrated superiority over its commercial counterparts by approximately 1% and 10%, underscoring its promise for AM applications.

Remote-Controlled Sensing and Drug Delivery via 3D-Printed Hollow Microneedles.

Remote health monitoring and treatment serve as critical drivers for advancing health equity, bridging geographical and socioeconomic disparities, ensuring equitable access to quality healthcare for those in underserved or remote regions. By democratizing healthcare, this approach offers timely interventions, continuous monitoring, and personalized care independent of one's location or socioeconomic status, thereby striving for an equitable distribution of health resources and outcomes. Meanwhile, microneedle arrays (MNAs), revolutionize painless and minimally invasive access to interstitial fluid for drug delivery and diagnostics. This paper introduces an integrated theranostic MNA system employing an array of colorimetric sensors to quantitatively measure -pH, glucose, and lactate, alongside a remotely-triggered system enabling on-demand drug delivery. Integration of an ultrasonic atomizer streamlines the drug delivery, facilitating rapid, pumpless, and point-of-care drug delivery, enhancing system portability while reducing complexities. An accompanying smartphone application interfaces the sensing and drug delivery components. Demonstrated capabilities include detecting pH (3 to 8), glucose (up to 16mm), and lactate (up to 1.6mm), showcasing on-demand drug delivery, and assessing delivery system performance via a scratch assay. This innovative approach confronts drug delivery challenges, particularly in managing chronic diseases requiring long-term treatment, while also offering avenues for non-invasive health monitoring through microneedle-based sensors.

A selective separation method for microplastics using ultrasonic jet atomization

This paper reveals that ultrasonic jet atomization using a diaphragm enables the enclosure of microplastics in water into atomized mist, emitting them into the air. In particular, a strong correlation is found between the sizes of the atomized mist and the acrylic particles enclosed in the mist: Acrylic particles with an average diameter of 1.5 μm or smaller are selectively enclosed within the atomized mist with an average diameter of 2.2 μm. This result indicates that jet atomization has the ability to select particles with diameters of 1.5 μm or less from numerous micro-particles with different diameters and separate them into individual particles without aggregation. The results of this study can be applicable to the process of analyzing microplastics dispersed in rivers, lakes, and oceans for separating particles of a targeted diameter from numerous particles of different diameters without aggregation.

Effects of operating parameters on single-stage ultrasonic separation of ethanol from its aqueous solutions

The effects of operating parameters on separation of ethanol from its aqueous solutions using ultrasonic atomization were investigated in a single-stage process. With an experimental setup similar to those used in previous work, we measured the degree of enrichment and the combined molar collection rate of ethanol and water for a single combination of the ultrasound power and frequency at 126 combinations of bulk liquid depth, composition, and temperature; carrier-gas inlet/outlet elevation and flow rate; and collection temperature. Enrichment depends strongly on bulk liquid composition, reaching a maximum at an ethanol mole fraction below 0.1, with the maximum enrichment depending on bulk liquid depth and inlet/outlet elevation. The collection rate depends strongly on inlet/outlet elevation and bulk liquid pool depth, and for high ethanol mole fractions is nearly independent of bulk liquid composition. Enrichment and collection rate increase with increasing bulk liquid temperature and decreasing collection temperature. The fact that increasing the carrier-gas flow rate increases the collection rate and decreases enrichment is interpreted in terms of size-selective transport of drops from the ultrasonically-generated fountain where they are atomized, to the cold trap where they are collected. The results are discussed in terms of operating parameters, transport phenomena (including evaporation and gravitational settling of atomized drops), the ultrasonically-induced fountain, and previously reported drop-size distributions. The duration of the experiments, conducted in batch, was such that the results should be relevant to both batch and continuous-flow operation. The work provides guidance and critical data for process scale-up.

Novel titanium-based sulfur-containing BMG for PBF-LB/M

This paper investigates the additive manufacturing route for a novel glass-forming titanium-based sulfur-containing alloy of the composition Ti60Zr15Cu17S8\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$${\ ext{Ti}}_{60} {\ ext{Zr}}_{15} {\ ext{Cu}}_{17} {\ ext{S}}_{8}$$\\end{document}. This system is a promising candidate for medical devices since the lack of toxic components is combined with a high corrosion resistance and strength. Preliminary experiments and simulations show a general processability of bulk material by powder bed fusion technologies. TEM and XRD reveal an amorphous microstructure of laser-treated surfaces. Ultrasonic atomization is used to fabricate a flowable powder feed stock with spherical morphology and crystalline microstructure, which is suitable for processing in powder bed fusion. Correlations between detected crystalline phase formations and melt pool dynamics are revealed by SEM and EDX. It is shown that bulk samples with a high relative density and partially crystalline microstructure can be manufactured.

THE POTENTIALS OF ULTRASONIC ATOMIZER AUGMENTED THE SEA SALT PRODUCTIONS

Ultrasonic atomizers can potentially augment the production of sea salt through a process known as ultrasonic nebulization. While the traditional method of sea salt production primarily relies on natural evaporation, ultrasonic atomization can accelerate the evaporation process. The process typically involves the following steps: collection of seawater, evaporation, brine crystallization and then harvesting process of the sea salt. After processing, the sea salt is typically dried and packaged for distribution and sale. In this project, influencing of ultrasonic atomizer in the process a saline water into the brine, before crystallization can be proceeded. The ultrasonic atomization process significantly increases the surface area of the seawater by converting it into fine droplets. Droplets evaporate more efficient due to large surface area of the droplets. According to testing of the research apparatus which had been conducted, an ultrasonic atomization can increase the salinity by brine evaporation or of droplet productivity of sea salt. This result had been shown that this process can be used to increasing the salinity of sea water. For further steps, this technique can potentially augment the production of sea salt.

Recognition of antitussive components in Farfarae Flos based on grey relational analysis and partial least squares regression.

Farfarae Flos has the effect of cough suppression and phlegm elimination, with cough suppression as the main function. Studies have revealed that certain components of Farfarae Flos may be related to its cough suppressant effect, and some components have been confirmed to have cough suppressant activity. However, the antitussive material basis of Farfarae Flos has not been systematically elucidated. This study aims to elucidate the group of active ingredients in Farfarae Flos with cough suppressant activity by correlating the high performance liquid chromatography (HPLC) fingerprint of Farfarae Flos extract with its cough suppressant activity. HPLC was used to establish the fingerprint profiles of 10 batches of Farfarae Flos extract and obtain their chemical composition data. Guinea pigs were selected as experimental animals and the citric acid-induced cough model was used to evaluate the antitussive efficacy data of 10 batches of Farfarae Flos extract. SPF-grade healthy male Hartley guinea pigs were randomly divided into the S1 to S10 groups, a positive control group, and a blank control group (12 groups in total), with 10 guinea pigs in each group. The S1 to S10 groups were respectively administered Farfarae Flos extract S1 to S10 (4 g/kg), the positive control group was administered pentoverine citrate (10 mg/kg), and the blank control group was administered purified water. Each group received continuous oral administration for 5 days. The guinea pigs were placed in 5 L closed wide-mouth bottles, and 17.5% citric acid was sprayed into the bottle with an ultrasonic atomizer at the maximum spray intensity for 0.5 minutes. The cough latency period and cough frequency in 5 minutes were recorded for each guinea pig. Grey relational analysis (GRA) and partial least squares regression (PLSR) were used to conduct spectral-effect correlation analysis of the chemical composition data of Farfarae Flos extract and the antitussive efficacy data, and predict the group of active ingredients in Farfarae Flos with antitussive activity. The bioequivalence verification was conducted to verify the predicted group of active ingredients in Farfarae Flos with antitussive activity: SPF-grade healthy male Hartley guinea pigs were randomly divided into a S9 group, an active ingredient group, a positive control group, and a blank control group (4 groups in total), with 10 guinea pigs in each group. The S9 group was administered Farfarae Flos extract S9 (4 g/kg), the active ingredient group was administered the predicted combination of antitussive active ingredients (dose equivalent to 4 g/kg of Farfarae Flos extract S9), the positive control group was administered pentoverine citrate (10 mg/kg), and the blank control group was administered purified water. Each group received continuous oral administration for 5 days, and animal modeling and observation of efficacy indicators were the same as above. The HPLC fingerprint of 10 batches of Farfarae Flos extract was established, and the peak area data of 14 main common peaks were obtained. The antitussive effect data of 10 batches of Farfarae Flos extract were obtained. Compared with the blank control group, the cough latence in the positive control group and S1, S2, S3, S4, S6, S7, S8, S9, S10 groups was prolonged (all P<0.01), while the cough frequency in 5 minutes in the positive control group and S1, S2, S4, S6, S8, S9, S10 groups was decreased (all P<0.05). The analysis of spectrum-effect relationship revealed that isochlorogenic acid C, isochlorogenic acid A, chlorogenic acid, isochlorogenic acid B, isoquercitrin, and rutin had high contribution to the antitussive effect of Farfarae Flos, and the 6 components were predicted to be the antitussive component group of Farfarae Flos. The verification of bioequivalence showed that there were no statistically significant differences in the antitussive effect between the S9 group and the antitussive component composition group(all P>0.05), which confirmed that isochlorogenic acid C, isochlorogenic acid A, chlorogenic acid, isochlorogenic acid B, isoquercetin, and rutin were the antitussive component group of Farfarae Flos. The analysis of spectrum-effect relationship combined with the verification of bioequivalence could be used to study the antitussive material basis of Farfarae Flos. The antitussive effect of Farfarae Flos is the result of the joint action of many components.