Lean is applied in automobile companies to reduce lead time and waste through value stream mapping. Industry 4.0 is a process of industrial systems revolution in companies driven by digitalization and data-oriented techniques. The combination of both is called Lean 4.0. In this sense, the purpose of this paper is to attend Ultra-Light Steel Auto-body (ULSAB) automotive requirements through Lean 4.0 framework applied in the fabrication of B-pillar by hot stamping. Optimization algorithms are important to simulate different scenarios and interact with these processes. The proposal was developed in the case study by assessments based on semi-structured questionnaires, analysis of records and documents. The findings showed overall equipment effectiveness (OEE) was increased by 41.5%. The contribution of this work was to meet ULSAB automotive requirements for hot stamping process by reducing vehicle weight while increasing structural strength.